scholarly journals Lifetime duration of lactation and chronic inflammation among middle-aged women with a history of gestational diabetes

2020 ◽  
Vol 8 (2) ◽  
pp. e001229
Author(s):  
Sylvia H Ley ◽  
Jorge E Chavarro ◽  
Stefanie N Hinkle ◽  
Mengying Li ◽  
Michael Y Tsai ◽  
...  
Keyword(s):  
Gestational Diabetes ◽  
Chronic Inflammation ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Health Study ◽  
Gamma Glutamyl Transferase ◽  
Middle Aged ◽  
History Of ◽  
Glutamyl Transferase

IntroductionLonger duration of lactation is associated with lower cardiometabolic disease risk, but pathogenic pathways involved in the disease progression are unclear, especially among high-risk women. We aimed to examine the associations of lifetime lactation duration with cardiometabolic biomarkers among middle-aged women with a history of gestational diabetes (GDM).Research design and methodsWomen with a history of GDM participating in the Nurses’ Health Study II, a prospective cohort study, were identified and followed through biennial questionnaires beginning in 1991. Lactation history was asked in three follow-up questionnaires to calculate lifetime duration. In 2012–2014, fasting blood samples were collected through the Diabetes & Women’s Health Study to measure inflammatory (C-reactive protein (CRP), interleukin (IL) 6), liver enzyme (alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transferase), and lipid biomarkers (total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol).ResultsAt follow-up blood collection, women were at median age 58.2 (95% CI 51 to 65) years and 26.3 (95% CI 15.7 to 34.1) years since GDM index pregnancy. After multiple adjustment including prepregnancy body mass index (BMI), longer duration of lactation was significantly associated with lower CRP (least squares (LS) mean 1.90 mg/L (95% CI 1.47 to 2.45) for 0-month lactation, 1.98 mg/L (95% CI 1.68 to 2.32) for up to 12-month lactation, 1.67 mg/L (95% CI 1.42 to 1.97) for 12–24 month lactation, and 1.39 mg/L (95% CI 1.19 to 1.62) for >24-month lactation; p trend=0.003) and IL-6 (1.25 pg/L (95% CI 0.94 to 1.68), 1.19 pg/L (95% CI 0.99 to 1.42), 1.04 pg/L (95% CI 0.87 to 1.25), and 0.93 pg/L (95% CI 0.78 to 1.11); p trend=0.04). Longer duration of lactation was associated with lower risk for chronic inflammation using CRP 3 mg/L cut-off in middle-aged women (OR 0.81 (95% CI 0.69 to 0.940 per 1-year increase) with multiple adjustment.ConclusionsLonger lifetime duration of lactation was associated with favorable inflammatory biomarker concentrations in middle-aged women with a history of GDM. Chronic inflammatory pathways may be responsible for previously reported associations between lactation and long-term risk for cardiometabolic diseases.

scholarly journals Visit-to-Visit Variability of Lipids Measurements and the Risk of Stroke and Stroke Types: A Prospective Cohort Study

2020 ◽  
Vol 22 (1) ◽  
pp. 119-129 ◽  
Author(s):  
Anxin Wang ◽  
Haibin Li ◽  
Jinhuan Yuan ◽  
Yingting Zuo ◽  
Yijun Zhang ◽  
...  
Keyword(s):  
Hemorrhagic Stroke ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
History Of ◽  
Variability Index ◽  
Stroke Type ◽  
Average Real Variability ◽  
Adjusted Model

Background and Purpose Previous studies suggested increased visit-to-visit variability of total cholesterol (TC) is associated with stroke. This study aimed to investigate the associations of various lipids measurements variability and the risk of stroke and stroke type (ischemic and hemorrhagic stroke).Methods Fifty-one thousand six hundred twenty participants in the Kailuan Study without history of myocardial infarction, stroke, and cancer who underwent three health examinations during 2006 to 2010 were followed for incident stroke. Variability in TC, triglycerides, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) measurements were measured using the coefficient of variation (CV), standard deviation (SD), variability independent of the mean (VIM), and average real variability (ARV).Results During a median of 6.04 years of follow-up, 1,189 incident stroke (1,036 ischemic and 160 hemorrhagic stroke) occurred. In the multivariable-adjusted model, the hazard ratio (HR) comparing participants in the highest versus lowest quartile of CV of HDL-C were 1.21 (95% confidence interval [CI], 1.02 to 1.45; <i>P</i> for trend=0.013) for ischemic stroke. The highest quartile of CV of LDL-C was associated with 2.17-fold risk of hemorrhagic stroke (HR, 2.17; 95% CI, 1.25 to 3.75; <i>P</i> for trend=0.002) compared with the lowest quartile. We did not observe any significant association between TC and triglycerides variability with any of stroke. Consistent results were obtained when calculating variability index using SD, VIM, or ARV.Conclusions These findings suggest the high visit-to-visit HDL-C and LDL-C variability were associated with an increased incidence of ischemic and hemorrhagic stroke, respectively.

scholarly journals GAMMA-GLUTAMYL TRANSFERASE AS AN INDICATOR OF OBESITY: A CROSS-SECTIONAL STUDY

2016 ◽  
Vol 9 (9) ◽  
pp. 240
Author(s):  
Vinodhini V M ◽  
Sudhan Kb
Keyword(s):  
Insulin Resistance ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Hepatic Insulin Resistance ◽  
Control Group ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Elevated Liver Enzymes ◽  
The Mean ◽  
Glutamyl Transferase

ABSTRACTObjective: Obesity, characterized by an increase in excessive fat accumulation, represents a social problem worldwide and has been recognizedas a major underlying factor in the pathogenesis of several diseases. Gamma-glutamyl transferase (GGT) is a cell-surface protein contributing tothe extracellular catabolism of glutathione. Elevated GGT is strongly associated with obesity and excess deposition of fat in the liver, termed nonalcoholicfatty liver disease, which is thought to cause hepatic insulin resistance and contribute to the development of systemic insulin resistanceand hyperinsulinemia. Therefore, we have investigated the serum GGT levels in obese individuals and the correlation of serum GGT with bodymass index (BMI) and waist circumference.Methods: The study was carried out in 100 obese patients and 100 non-obese individuals.Results: Patients with obesity showed a significant increase in GGT levels when compared to the control group. The mean levels of BMI, WC, totalcholesterol, triglycerides, low-density lipoprotein-cholesterol (LDL-c), very LDL-cholesterol, total protein, and aspartate aminotransferase werefound to be significantly elevated in the obese individuals compared to controls. The mean levels of high-density lipoprotein-cholesterol showed asignificant decrease in the obese participants.Conclusion: Elevated liver enzymes, although in normal ranges, especially at upper quartiles as observed in our study, may play a central role inearly diagnosis of fat overflow to the liver. The findings of our study suggest that serum GGT levels may be a simple and reliable marker of visceral fataccumulation.Keywords: Diabetes mellitus, Gamma-glutamyl transferase, Insulin resistance, Metabolic syndrome, Obesity.

scholarly journals Lifestyle intervention programme for Indian women with history of gestational diabetes mellitus

2019 ◽  
Vol 4 ◽  
Author(s):  
Deksha Kapoor ◽  
Yashdeep Gupta ◽  
Ankush Desai ◽  
Devarsetty Praveen ◽  
Rohina Joshi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Waist Circumference ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Lifestyle Intervention ◽  
Plasma Glucose ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Post Intervention ◽  
History Of

AbstractAimTo evaluate the feasibility and potential effectiveness of a lifestyle intervention (diet and physical activity) among women with history of gestational diabetes mellitus (GDM), delivered by trained facilitators.MethodsFifty-six normoglycaemic or prediabetic women with prior GDM were recruited at mean of 17 months postpartum. Socio-demographic, medical and anthropometric data were collected. Six sessions on lifestyle modification were delivered in groups (total four groups, with 12–15 women in each group). Pre and post intervention (6 months) weight, body mass index (BMI), waist circumference, 75 g oral glucose tolerance test, blood pressure (BP) and lipid parameters were compared.ResultsThe intervention was feasible, with 80% of women attending four or more sessions. Post-intervention analyses showed a significant mean reduction of 1.8 kg in weight, 0.6 kg/m2 in BMI and 2 cm in waist circumference. There was also a significant drop of 0.3 mmol/L in fasting plasma glucose, 0.9 mmol/L in 2 h post glucose load value of plasma glucose, 3.6 mmHg in systolic BP, and 0.15 mmol/L in triglyceride levels. Changes in total cholesterol, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol and diastolic BP were non-significant.ConclusionsThis study showed feasibility of the lifestyle intervention delivered in group sessions to women with prior gestational diabetes.

scholarly journals Gestational diabetes and long-term risk for dyslipidemia: a population-based historical cohort study

2020 ◽  
Vol 8 (1) ◽  
pp. e000870 ◽  
Author(s):  
Gabriel Chodick ◽  
Yaara Tenne ◽  
Yael Barer ◽  
Varda Shalev ◽  
Uriel Elchalal
Keyword(s):  
Gestational Diabetes ◽  
Index Date ◽  
Smoking Status ◽  
Cohort Analysis ◽  
Challenge Test ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Historical Cohort ◽  
Diabetes Status

ObjectivesTo assess the course of lipid levels over time in postpartum women according to gestational diabetes status, taking into account potential confounders, such as comorbid conditions and body weight.MethodsThe data for the present analysis were collected from a 2.3 million member integrated care provider in Israel. Included were all female members aged 15–50 years who performed a 50 g glucose challenge test (GCT) between March 1995 and May 2009. We collected all follow-up lipid consecration tests performed from date of delivery following the GCT (index date) until April 2017. Data analysis was performed for each lipid component individually (triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C)) and the effects of the several risk factors (history of gestational diabetes mellitus (GDM), age at delivery, obesity status and smoking status) were investigated using general linear model taking into account potential confounders.ResultsA total of 160 527 women (6.1 million person-years of actual follow-up) were eligible for the analysis, including 10 234 women with GDM (6.4% of the entire cohort). During the study follow-up period, a total of 2.1 million lipid tests were performed. When adjusting for follow-up time, age at index date, body mass index status, and smoking status, GDM was associated with a 1.8-fold risk (95% CI 1.73 to 1.88) for dyslipidemia defined by TG, 1.45-fold risk (95% CI 1.38 to 1.52) for dyslipidemia defined by LDL-C, and 1.44-fold risk (95% CI 1.39 to 1.50) for dyslipidemia defined by HDL-C.DiscussionThe results of this retrospective cohort analysis indicate that gestational diabetes confers added risk for developing hyperlipidemia post partum, particularly dyslipidemia defined by TG, as compared with women with normal glucose tolerance.

scholarly journals Liver Profile of Atazanavir/Ritonavir in Pregnant Albino Rats

2019 ◽  
Vol 8 (2) ◽  
pp. 47-52
Author(s):  
Elias Adikwu ◽  
James Kemelayefa ◽  
Winifred Ocheiga
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Albino Rats ◽  
Gamma Glutamyl Transferase ◽  
Pregnant Rats ◽  
Control Serum ◽  
Dose Dependent Fashion ◽  
Glutamyl Transferase ◽  
Dose Dependent

Medication use during pregnancy is challenging due to the occurrence of maternal or fetal toxicities. Atazanavir/ritonavir (ATV/r) has hepatotoxic potential hence; use in pregnant patients living with human immunodeficiency virus may cause maternal hepatotoxicity. This study assessed the liver profile of ATV/r in pregnant albino rats. Thirty pregnant albino rats randomized into groups were orally treated daily with ATV/r (4.28/1.43 mg/kg-34.3/11.4 mg/kg) for 16 days. After treatment, the rats were weighed and sacrificed. Blood samples were collected and examined for serum biochemical parameters. Liver samples were weighed and assessed for biochemical and histological changes. Body and liver weights were normal (p>0.05) in ATV/r-treated pregnant rats when compared to control. Serum total cholesterol, triglyceride, low density lipoprotein cholesterol and blood glucose levels were significantly (p<0.01) elevated whereas high density lipoprotein cholesterol level was significantly (p<0.01) decreased in rats treated with ATV/r (34.3/11.4 mg/kg) when compared to control. Liver and serum aminotransferases, alkaline phosphatase, gamma-glutamyl transferase, lactate dehydrogenase, total bilirubin, and conjugated bilirubin levels were significantly increased in a dose-dependent fashion in rats treated with ATV/r; 8.57/2.86 mg/kg (p<0.05), 17.1/5.72 mg/kg (p<0.01) and 34.3/11.4 mg/kg (p<0.001) when compared to control. Liver superoxide dismutase, catalase, glutathione and glutathione peroxidase levels were significantly decreased whereas malondialdehyde levels were significantly increased in a dose-dependent fashion in rats treated with ATV/r; 8.57/2.86 mg/kg (p<0.05), 17.1/5.72 mg/kg (p<0.01) and 34.3/11.4 mg/kg (p<0.001) when compared to control. Necrotic hepatocytes were observed at higher doses of ATV/r. ATV/r may not be hepatotoxic in pregnant women living with HIV at the clinical dose.

Abstract 499: Lipoprotein(A) and Carotid Intimal Medial Thickness

2017 ◽  
Vol 37 (suppl_1) ◽  
Author(s):  
Hiroaki Ikezaki ◽  
Yuya Yokota ◽  
Ernst J Schaefer ◽  
Katalin V Horvath ◽  
Bela F Asztalos ◽  
...  
Keyword(s):  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Men And Women ◽  
Lipoprotein A ◽  
Intimal Medial Thickness ◽  
Carotid Intimal Medial Thickness ◽  
History Of ◽  
The Common ◽  
Ascvd Risk

Introduction: Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of death and disability in both Japan and the United States. Carotid intimal medial thickness (CIMT) has been used as a marker of ASCVD risk. We examined various specialized lipoprotein parameters to determine their utilities for predictor of CIMT progression. Methods: Using plasma samples obtained from fasting men and women (n=2245) living in the Fukuoka area of Japan, (median age 59 years), at baseline we measured direct high density lipoprotein cholesterol (HDL-C), HDL2-C, HDL3-C, low density lipoprotein cholesterol (LDL-C), small dense LDL-C (sdLDL-C), triglycerides (TG), LDL-triglycerides (LDL-TG), lipoprotein(a) or Lp(a), and adiponectin. All assays were measured on an automated high throughput platform (Olympus AU400) using assay kits from the Denka Seiken Corporation (Niigata, Japan) and had within and between run coefficients of variations of < 5%. Blood pressure, body mass index, use of medications, and history of hypertension, dyslipidemia and diabetes were also assessed. CIMT of the common carotid artery was assessed bilaterally at baseline and after 5 years of follow up used trained technicians with analysis coefficients of variation of < 10%. Participants using statin therapy at baseline and during follow up were excluded. Results: After controlling for age and gender, only Lp(a) was significantly associated with change in CIMT over a 5 year period in this population. The data indicated that for every 1 log unit higher Lp(a) level at baseline, there was a 0.06 mm increase in CIMT over 5 years (p=0.02). While relationships were seen with other parameters and CIMT change, none of these other relationships reached statistical significance at p<0.05. We also observed significant relationships (p<0.05) between CIMT progression and age, gender, current smoking, history of hypertension, treatment of hypertension. Conclusions: Our data indicate that lipoprotein (a) as measured by immunoassay in an important predictor of the progression of atherosclerosis in the common carotid arteries of middle aged and elderly Japanese men and women, and serves as a valuable marker of ASCVD risk.

scholarly journals Associations of gamma-glutamyl transferase with cardio-metabolic diseases in people living with HIV infection in South Africa

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0246131
Author(s):  
Kim A. Nguyen ◽  
Nasheeta Peer ◽  
Andre P. Kengne
Keyword(s):  
Plasma Glucose ◽  
Metabolic Diseases ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
People Living With Hiv ◽  
Gamma Glutamyl Transferase ◽  
Regression Analyses ◽  
Cvd Risk ◽  
Glutamyl Transferase ◽  
Living With Hiv

Background Gamma-glutamyl transferase (GGT) has recently been reported as a biomarker for cardiovascular (CVD) risk in general populations. We investigated the associations of GGT with cardio-metabolic diseases and CVD risk in South Africans living with HIV. Methods In this cross-sectional study, HIV-infected adults were randomly recruited across 17 HIV clinics in the Western Cape Province. Homeostatic model assessment for insulin resistance (HOMA-IR), hypertension, diabetes, metabolic syndrome by Joint Interim Statement criteria (JIS-MS), a ≥5% and ≥10% predicted risk for a CVD event within 10 years by the Framingham risk score (10-years-CVD risk) were computed. Associations between GGT and cardio-metabolic trait were explored using linear and binomial logistic regressions adjusted for age, gender, lifestyle behaviours and HIV-related characteristics. Results Among 709 participants (561 women, mean age 38.6 years), log-GGT was positively associated with waist circumference (β=2.75; p<0.001), diastolic blood pressure (β=1.65; p=0.006), total cholesterol (β=0.21; p<0.001), low-density lipoprotein-cholesterol (β=0.16; p<0.001), high-density lipoprotein-cholesterol and log-triglycerides (both β=0.12; p<0.001), fasting plasma glucose (β=0.19; p=0.031), 2-hour-post-glucose-load plasma glucose (β=0.26; p=0.007), HOMA-IR (β=0.13; p=0.001), log-high-sensitivity C-reactive-protein (β=0.3; p<0.001) in linear regression analyses; with hypertension [OR=1.41 (95%CI, 1.13-1.75); p=0.001], JIS-MS [OR=1.33 (1.05-1.68); p=0.016], ≥5% 10-year-CVD risk [OR=1.55 (1.24-1.9400); p<0.001] and ≥10% 10-year-CVD risk [OR=1.56 (1.08-2.23); p=0.016] but not with diabetes [OR=1.24 (0.88-1.71), p=0.205] in logistic regression analyses. Conclusions In this study, GGT levels were associated with cardio-metabolic variables independent of HIV specific attributes. If confirmed in longitudinal studies, GGT evaluation maybe included in CVD risk monitoring strategies in people living with HIV.

scholarly journals Attenuating Effect ofGinkgo bilobaLeaves Extract on Liver Fibrosis Induced by Thioacetamide in Mice

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Atef M. Al-Attar
Keyword(s):  
Liver Fibrosis ◽  
Total Protein ◽  
Chemical Constituents ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Liver Parenchyma ◽  
Lipoprotein Cholesterol ◽  
Gamma Glutamyl Transferase ◽  
Biochemical Alterations ◽  
Glutamyl Transferase

The purpose of this study is to investigate the effect ofGinkgo bilobaleaves extract on experimental liver fibrosis induced by thioacetamide (TAA) in male albino mice. The experimental mice were divided into four groups. The mice of the first group were served as control. The experimental animals of the second group were given 150 mg/kg body weight of TAA by intraperitoneal injection, twice weekly, for 9 weeks. The mice of the third group were exposed to TAA and supplemented withG. bilobaleaves extract. The animals of the fourth group were supplemented withG. bilobaleaves extract. The levels of plasma alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, alkaline phosphatase, triglycerides, cholesterol, and low-density lipoprotein cholesterol were statistically increased while the levels of plasma total protein, albumin, glucose, and high-density lipoprotein cholesterol were significantly decreased. The levels of liver superoxide dismutase, glutathione, glycogen and total protein were notably declined, whereas the level of total lipid was increased in mice of the second group. Furthermore, microscopic examination of liver sections from mice treated with TAA showed an abnormal morphology characterized by nodular transformations in liver parenchyma which surrounded by fibrous septa. Administration ofG. bilobaleaves extract reduced extent and development of fibrous septa, liver cells change, and biochemical alterations in mice exposed to TAA. This study showed thatG. bilobaleaves extract has a potential activity against TAA-induced liver fibrosis and suggested that the chemical constituents ofG. bilobaare effective in modulation of oxidative stress induced by TAA.

Gestational diabetes mellitus: are mothers being followed-up? A retrospective study

2018 ◽  
Vol 68 (suppl 1) ◽  
pp. bjgp18X697469
Author(s):  
Rebecca Ward ◽  
Fahmy W Hanna ◽  
Ann Shelley-Hitchen ◽  
Ellen Hodgson ◽  
Adrian Heald ◽  
...  
Keyword(s):  
Gestational Diabetes ◽  
Median Time ◽  
Post Partum ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Tertiary Referral Centre ◽  
Alternative Approach ◽  
Nice Guidance ◽  
History Of

BackgroundWomen with gestational diabetes (GDM) have an elevated risk of developing type 2 diabetes (T2DM). NICE Guidance recommends women who develop GDM are screened 6 weeks post-partum and annually thereafter.AimTo evaluate conformity to guidance of screening in women with GDM by 6-week post-partum fasting plasma glucose (FPG) and annual FPG and determine time between delivery and development of T2DM.MethodRecords at a tertiary referral centre were used to identify women (n = 54) diagnosed with GDM by antenatal oral glucose tolerance test between July 1999 and January 2007. Data from laboratory records were used to collect investigations of glycaemic status during the follow-up period (median follow-up 12.4 years, range 9.5–17.1 years).ResultsOf 252 women, 102 (40.2%) did not have a FPG at 6 weeks (+/−2 weeks). Of these, median time to first test was 1.2 years (range 0.04–10.8 years), with only 43.1% followed-up within 1 year. In those who had a 6-week FPG, 17 (11.3%) women had no further tests. A total of 84 (33% of those with gestational diabetes in the index pregnancy) women were diagnosed with T2DM; median time from delivery to diagnosis was 5.2 years (range 0.35–15.95). We found the only significant factor for a follow-up test at 1-year post-partum was the use of insulin.ConclusionOur data suggest an alternative approach is needed for monitoring women with a history of GDM. This needs to be appropriate for a generally healthy group in which traditional screening mechanisms may not be adequate or sufficient.

scholarly journals Prediction of subclinical coronary atherosclerosis in patients with high and very high cardiovascular risk

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
N Pogosova ◽  
NP Kachanova ◽  
YM Yufereva ◽  
OY Sokolova ◽  
IE Koltunov ◽  
...  
Keyword(s):  
Family History ◽  
Ct Angiography ◽  
Coronary Atherosclerosis ◽  
Subclinical Atherosclerosis ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Diagnostic Model ◽  
History Of ◽  
Hs Crp ◽  
Very High

Abstract Funding Acknowledgements Type of funding sources: None. Background Coronary atherosclerosis has a long subclinical period. It’s early detection may offer a possibility of timely initiation of preventive interventions Purpose To develop a diagnostic rule for detection of patients (pts) with high probability of subclinical atherosclerosis among those with high or very high cardiovascular (CV) risk. Methods This cross-sectional study enrolled 52 pts (32 men [62%]), aged 40 to 65 years [mean age 54.6 ± 8.0]) with high or very high CV risk (5-9 and ≥10% by The Systematic Coronary Risk Estimation Scale [SCORE], respectively). All participants underwent cardiac computed tomography (CT) angiography and calcium scoring. Traditional risk factors (RFs) (family history of premature CVD, smoking, overweight/obesity and abdominal obesity, hypertension, type 2 diabetes mellitus, lipids parameters (total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides) and lipids-related markers (apolipoprotein A1, apolipoprotein B, ApoB/ApoA1 ratio), biomarkers of inflammation (high-sensitivity C-reactive protein [hs CRP], fibrinogen), indicator carbohydrate metabolism (glucose),  ankle-brachial index,  stress-test, carotid plaques according to ultrasound were evaluated in all pts. Psychological RFs were evaluated using Hospital Anxiety and Depression Scale and DS-14 for type D personality. Results All pts were divided into 2 groups according to the CT angiography results: pts in the main group (n = 21) had any non-obstructive lesions or calcium score &gt;0, pts in the control group (n = 31) had intact coronary arteries. The groups did not differ in age or gender. 26 multiple linear logistic models for any subclinical atherosclerosis were developed based on obtained diagnostic features. Taking into account R-square = 0.344 (p = 0.0008), the best fitting model was follows:  subclinical coronary atherosclerosis= -1.576 + 0.234 x SCORE ≥5%  + 0.541 x hs CRP &gt;2 g/l + 0.015 x heart rate  (bpm) + 0.311 family history of premature CVD.  The developed algorithm had sensitivity of 63% and  specificity of 80%. Conclusions The created diagnostic model diagnostic model suggests the presence of subclinical coronary atherosclerosis in patients with high / very high CV risk with a high degree of probability. This easy-to-use method can be used in routine clinical practice to improve risk stratification and management choices in high-risk pts.

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