Gene of the month: NKX3.1
Keyword(s):
NKX3.1 is a multifaceted protein with roles in prostate development and protection from oxidative stress. Acting as a pioneer factor, NKX3.1 interacts with chromatin at enhancers to help integrate androgen regulated signalling. In prostate cancer, NKX3.1 activity is frequently reduced through a combination of mutational and post-translational events. Owing to its specificity for prostate tissue, NKX3.1 has found use as an immunohistochemical marker in routine histopathology practice.
2015 ◽
Vol 115
(1)
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pp. 68-74
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Keyword(s):
2018 ◽
Vol 53
(8)
◽
pp. 450-456
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Keyword(s):
Keyword(s):