ID: 34: ASSOCIATION BETWEEN VITAMIN D AND GASTRIC CANCER

2016 ◽  
Vol 64 (4) ◽  
pp. 941.2-942
Author(s):  
N Vyas ◽  
H Alkhawam ◽  
R Sogomonian ◽  
RA Ching Companioni ◽  
A Walfish ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Gastric Adenocarcinoma ◽  
Gastric Cancer Cell Line ◽  
Control Group ◽  
P Value ◽  
Gastrointestinal Malignancies ◽  
Increased Risk ◽  
Vitamin D Levels

Background and ObjectivesVitamin D deficiency is linked to several gastrointestinal malignancies including gastric cancer and affects a multitude of cellular processes involved in tumorigenesis. Vitamin D is presumed to have anticancer actions by inducing differentiation and cell cycle arrest in malignant cells. Furthermore, it significantly promotes apoptosis in the undifferentiated gastric cancer cell line HGC-27. The aim of this study was to determine whether there is an increased risk of gastric adenocarcinoma (GA) associated with vitamin d deficiency.MethodologyA retrospective case-control study was conducted at Elmhurst Hospital Center from 2005–2015. Three hundred and four patients who were diagnosed with GA were selected as cases. Of 304 individuals with GA, 255 were excluded, because they did not have vitamin D levels, 49 patients were included in our study. The data was compared to a matched control group of 49 patients with no known malignancies who had vitamin D levels. Prevalence of vitamin D deficiency was compared between cases and controls using odds ratios (ORs) and 95% confidence intervals.ResultsThe mean age of the case sample was 63.96 vs 60.43% in the control group. The gender distribution was the same, 49% male and 51% female. Hispanic patients were predominant in both samples accounting for 61.2% of the groups (table 1). Of 49 patients with GA included in our study, 20.48% were stage I; 36.7% were stage II; 24.9% were stage III, and 18.4% were stage IV. The prevalence of vitamin D deficiency in the case group (GA) was significantly higher than in the control group 19[38.8%] vs 7[14.3%] respectively (OR: 3.8, 95% CI 1.42–10.18, P value 0.0079) figure 1.ConclusionThe results of our study suggest that there is a positive correlation between vitamin D deficiency and gastric adenocarcinoma. More specifically patients with vitamin D deficiency have an increased association with GA. Additional multicenter randomized double blind clinical trials are required to further assess this association and the potential benefit of vitamin D supplementation in preventing gastric adenocarcinoma.Abstract ID: 34 Figure 1

scholarly journals Correlation of psoriasis and serum vitamin D

2021 ◽  
Vol 7 (4) ◽  
pp. 320-323
Author(s):  
Ritika Gujrati ◽  
Krishnendra Varma ◽  
Ujjwal Kumar
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Psoriasis Vulgaris ◽  
Systemic Disease ◽  
Serum Vitamin ◽  
Psoriatic Skin ◽  
Control Group ◽  
P Value ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Psoriasis is an immuno-mediated chronic systemic disease involving cytokines of helper Th1 pathway. Vitamin D has an effect on keratinocyte proliferation, differentiation and immune modulation of immune system especially Th1 pathway, which is altered in psoriatic skin suggesting that Vitamin D may have a role in pathogenesis of psoriasis. To study correlation between psoriasis vulgaris and serum vitamin D. To evaluate serum vitamin D level in psoriasis cases and in control group and correlating vitamin D level with severity and duration of the psoriasis. 57 cases (>15years of age) with psoriasis and 57 healthy subjects were recruited. Psoriasis was clinically diagnosed and severity evaluated by PASI scale. Vitamin D was analysed by enhanced chemilumine scence on vitrus Eci autoanalyzer of Orth clinical diagnostic. Vitamin D deficiency defined as <20ng/ml, insufficiency 20-30ng/ml and sufficient 30-100ng/ml. Vitamin D deficiency in the study was 22.8% in patients and 14% in control group. Vitamin D insufficiency was found in 42.1% of cases and 19.3% of control. According to chi-square the p-value is 0.003 showing significant association. There was a tendency towards decrease in vitamin D level with increase in disease duration. There was negative correlation between vitamin D and PASI score. The study found a significant relationship between vitamin D and psoriasis. Further metanalysis involving larger study population will be required to establish whether vitamin D levels benefits patient with psoriasis vulgaris.

scholarly journals A Comparative Study of Serum 25-Hydroxy Vitamin D Levels in Children with Seizures Receiving Monotherapy and Polytherapy

2021 ◽  
Vol 11 (01) ◽  
pp. e331-e337
Author(s):  
Nazeem Fathima A. ◽  
Radha Kumar ◽  
Dev Kumar V. ◽  
Devanand Gulab Chaudhary
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Tertiary Care ◽  
Hospital Setting ◽  
P Value ◽  
Care Hospital ◽  
Cross Sectional ◽  
Increased Risk ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D

AbstractThe association between serum 25-hydroxy vitamin D (25(OH)D) antiepileptic drugs (AEDs) and bone health in individuals with epilepsy has been recognized for more than 30 years. Several studies indicate an increased risk for bone loss in patients on antiepileptic medication as well as low levels of serum 25(OH)D. Patients on polytherapy AED are at a higher risk of adverse drug effects compared with those on monotherapy. The present study assessed serum 25(OH)D levels in children receiving AED and compares those children receiving monotherapy versus polytherapy. This is a prospective cross-sectional study conducted in a tertiary care hospital setting on children with seizures receiving AEDs for period of more than 6 months. Participants were enrolled in three groups: 25 children on monotherapy, 25 children on polytherapy, and 25 healthy controls. Serum 25(OH)D level was performed for all children and analyzed. Serum 25(OH)D levels were normal in 52%, insufficient levels in 43.3%, and deficient in 6.7% of children. Vitamin D level was insufficient in 40% of children receiving monotherapy and 52% receiving polytherapy AED. Vitamin D deficiency was present in 4% in monotherapy group and 16% in polytherapy group which was statistically significant (p-value 0.047). Vitamin D deficiency was higher in children receiving AED compared with normal controls. Vitamin D deficiency and insufficiency were higher in children on polytherapy. Our study emphasized the importance of monitoring vitamin D levels in children receiving AED to detect abnormalities in vitamin D levels.

scholarly journals THE POSSIBLE LINK BETWEEN VITAMIN D LEVELS AND RESTLESS LEG SYNDROME: A HOSPITAL-BASED CASE-CONTROL STUDY FROM KASHMIR, INDIA

2021 ◽  
Vol 9 (5) ◽  
pp. 1362-1367
Author(s):  
Rehana Amin ◽  
◽  
Seema Batool ◽  
Yuman Kawoos ◽  
Masood Maqbool ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Case Control Study ◽  
Case Control ◽  
Nervous System Development ◽  
Control Group ◽  
P Value ◽  
Restless Leg Syndrome ◽  
Vitamin D Levels ◽  
Control Study

Background & Objectives: Various pathophysiological mechanisms and risk factors have been identified in patients with restless leg syndrome and there exist other factors also that are yet to be identified and are under-researched. Evidence suggests a possible link between Vitamin D deficiency and Restless leg syndrome.The aim was to study the Vitamin D levels in patients diagnosed with RLS and to find a correlation between Vitamin D and RLS. Methods: This was a case-control study carried out in the outpatient department of the Institute of Mental Health and Neurosciences Kashmir.A total of 144 subjects were enrolled in the study. Fifty-one were diagnosed cases of RLS and 93 were healthy controls.The Vitamin D levels were analysed by the chemiluminescent immunoassay method in both cases as well as controls.The descriptive statistics were used for various socio-demographic and clinical variables.The data were analysed by chi-square test, t-test and multivariate logistic regression analysis. Results: The vitamin D levels were significantly low in the RLS group in comparison to the control group. There was a significant correlation between vitamin D levels, vitamin D deficiency and restless leg syndrome (OR= 1.01, p-value 0.005 and OR= 5.40, p-value <0.0001 respectively). Interpretation &conclusions: Vitamin D levels were low in patients with RLS. This signifies vitamin D may have some role in the pathophysiology of RLS.Vitamin D regulates the nervous system development and function therefore, its use can be considered in the management of RLS when other modalities cannot prove as a promising agent.

Lower Vitamin D Status in Patients with Differentiated Thyroid Carcinoma

2018 ◽  
Vol 69 (9) ◽  
pp. 2472-2475
Author(s):  
Andra Cocolos ◽  
Adina Ghemigian ◽  
Nicoleta Dumitru ◽  
Eugeniya Nedeltcheva Petrova ◽  
Mircea Ghemigian ◽  
...  
Keyword(s):  
Vitamin D ◽  
Thyroid Cancer ◽  
Vitamin D Deficiency ◽  
The United States ◽  
Genetic Alterations ◽  
Tnm Staging ◽  
Control Group ◽  
P Value ◽  
Cross Sectional ◽  
Vitamin D Levels

Thyroid cancer (TC) has become the most rapidly increasing type of cancer representing 1-1.5% of all cancers diagnosed annually probably due to intensive screening. It is estimated that the death rate of TC has slowly increased from 0.49 to 0.51/100.000 in the last 10 years and 53.990 new cases will be diagnosed in 2018 in the United States. Therefore, efforts are being made in order to stop the increasing incidence and genetic alterations are thoroughly studied. One of the most recent incriminated factors in TC etiology and physiopathology is vitamin D deficiency. Besides the well-known role in bone metabolism, vitamin D has extra-skeletal effects exerted through the vitamin D receptor (VDR) and has been shown to interfere with many cellular functions such as inhibiting cell proliferation, stimulating differentiation and malignant cell apoptosis in different types of cancer. Cross-sectional, retrospective study which included 114 patients (71 with confirmed thyroid cancer and 43 patients in the control group with benign pathology). Preoperative levels of 25(OH)vitamin D, PTH, biochemical and thyroid panel were measured. The histopathologic features were analyzed. Mean values of vitamin D was 16.31 � 7.14 ng/mL with lower levels in patients with thyroid cancer (14.95 � 5.91 ng/mL) in comparison to patients with benign thyroid pathology (18.55 � 8.41 ng/mL), with a p value of 0.008. Majority of the cases were papillary thyroid cancer (97.18%) in stage 3 (45.07%). Vitamin D levels also correlated negatively with TNM staging. The necessity of further studies is a reality in order to establish if vitamin D deficiency is a possible risk factor for thyroid cancer and its correction can be considered an additional therapy.

Prevalence of Vitamin-D Deficiency in Patients with Acute Coronary Syndrome in Syria

2016 ◽  
Vol 9 (6) ◽  
pp. 3544-3548
Author(s):  
Aya Hallak ◽  
Malhis Mahmoud ◽  
Yaser Abajy Mohammad
Keyword(s):  
Vitamin D ◽  
Acute Coronary Syndrome ◽  
Vitamin D Deficiency ◽  
Hypovitaminosis D ◽  
Control Group ◽  
Coronary Syndrome ◽  
Normal Individuals ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D ◽  
Coronary Syndromes

The objectives of this study were to estimate the prevalence of vitamin D deficiency in patients with acute coronary syndrome in comparison with normal individuals and study the correlation between these two conditions. We measured the plasma 25-hydroxy vitamin D (25-OH-D) levels in 60 patients with acute coronary syndromes (ACS) of both gender and in 30 age matched control individuals of both gender without any known cardiovascular or systemic diseases. The levels of 25-OH-D were measured by ELISA method and the results were statically analyzed to find out any possible correlation. We classified the cases according to their plasma 25(OH)D levels. 25(OH)D levels of ≥ 30 ng/ml were considered normal, levels < 30 and > 20 ng/ml were classified as insufficient, while levels of ≤ 20 ng/ml were classified as deficient. In the current study the prevalence of hypovitaminosis D in the patients group was much higher than it was in the control group. Vitamin D deficiency was observed in 80% and insufficiency in 13% of total patients of ACS, there by bringing the total count to 93%. Whereas only 7% of the patients had adequate vitamin D levels. Thus, these results indicate the existence of a significant correlation between the vitamin D deficiency and ACS in comparison to healthy controls

Association between vitamin D deficiency and prostate cancer: Prospective case-control study

2021 ◽  
pp. 205141582199360
Author(s):  
Ghanshyam Kumawat ◽  
Vijay Chaudhary ◽  
Anurag Garg ◽  
Nishkarsh Mehta ◽  
Gagan Talwar ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Case Control Study ◽  
Serum Vitamin ◽  
P Value ◽  
Serum Vitamin D ◽  
Severe Vitamin ◽  
Vitamin D Levels ◽  
Control Study

Objective: We aimed to find out the association of low serum vitamin D levels with the incidence of prostate cancer through a prospective case-control study. Material and methods: This study was carried out in the tertiary care hospital (India). All newly diagnosed patients of prostate cancer and age-matched controls were included. Serum vitamin D levels were measured in all of them. Vitamin D status (ng/mL) was classified as severe deficiency <10, moderate deficiency 10–<30, normal 30–100, and toxicity >100. Normality of the data was tested by the Kolmogorov–Smirnov test, statistical analysis was done with Statistical Package for the Social Sciences version 26.0, p-value of <0.05 was considered significant. Results: In our study, 320 cases and 320 controls were included. The mean vitamin D levels in cases and controls were 15.71 ± 6.5 (ng/mL) and 17.63 ± 4.54 (ng/mL), respectively, ( p-Value <0.01). Patients with severe vitamin D deficiency (73.58%) had a Gleason score ⩾8 on biopsy and 79.24% of them had a serum prostate specific antigen (PSA) level >20 ng/mL. Conclusion: We had concluded that there was no significant association between vitamin D deficiency and increased risk of prostate cancer, although patients with higher-grade prostate cancer and with higher PSA level had severe vitamin D deficiency. Level of evidence: Not applicable for this multicentre audit.

scholarly journals A clinical study to determine the relationship between serum vitamin D levels and severity of asthma

2017 ◽  
Vol 4 (4) ◽  
pp. 1397
Author(s):  
Pragalatha Kumar ◽  
Aruna Gowdra ◽  
Arathi Arathi ◽  
Ananya Sampath
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Asthma Severity ◽  
Severe Form ◽  
P Value ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Children With Asthma ◽  
Age And Sex

Background: Vitamin D deficiency has been rediscovered as a public health problem worldwide. Few studies have shown that vitamin D deficiency is associated with asthma severity. The objective of present work was to study the serum vitamin D levels and its relationship with asthma severity in children.Methods: A prospective cohort study of 100 children with asthma between the age group of 5 to 15 years and age and sex matched 40 healthy controls who had come to Indira Gandhi Institute of Child Health, Bengaluru was done. These children’s serum vitamin D levels were estimated and correlated with asthma severity.Results: A total of 100 children with asthma and 40 healthy age and sex matched controls were evaluated. The study group had lower vitamin D (34.95 ng/ml) levels as compared to the control group (57.94 ng/ml) which was statistically significant (p<0.05). 68.4% children had significantly low vitamin D levels and severe form of asthma (p value <0.001). There was also a marked rise in absolute eosinophil count in those who had low vitamin D levels (56.6%) (p-value <0.0001).Conclusions: Vitamin D deficiency is an important risk factor for asthma severity. It modifies the immune system and reduces the inflammation. In the present study, low serum vitamin D levels were significantly correlated with severe form of asthma. There was a significant rise in the absolute eosinophil count in those who exhibited deficiency of vitamin D.  

scholarly journals The Relationship between Vitamin D Deficiency and Pulmonary Hypertension

2013 ◽  
Vol 114 (3) ◽  
pp. 154-161 ◽  
Author(s):  
Mehmet Demir ◽  
U. Uyan ◽  
S. Keçeoçlu ◽  
C. Demir
Keyword(s):  
Vitamin D ◽  
Pulmonary Hypertension ◽  
Pulmonary Artery ◽  
Vitamin D Deficiency ◽  
Pulmonary Artery Pressure ◽  
Control Group ◽  
Systolic Pulmonary Artery Pressure ◽  
Control Groups ◽  
Artery Pressure ◽  
Vitamin D Levels

Vitamin D deficiency actives renin-angiotensin-aldosterone system (RAAS) which affects cardiovascular system. Activation of RAAS is associated with pulmonary hypertension (PHT). Relation between vitamin D deficiency and PHT could be therefore suggested. In  our study we compared pulmonary artery pressure between vitamin D deficiency and control groups. 115 consecutive patients (average age: 61.86 ± 5.86) who have detected very low vitamin D (vitamin D levels < 10 ng/ml) were enrolled. 117 age matched persons (average age: 61.74 ± 5.99) were selected as the control group. All groups underwent transthoracic echocardiography. Routine biochemical measurement of 25-OH vitamin D and parathormon (PTH) levels were performed. Baseline characteristics of the study groups were comparable. Systolic pulmonary artery pressure (SPAP) of patients in  the low vitamin D group was higher than the control groups. As a  result our study, a  relation between vitamin D deficiency and pulmonary artery hypertension was revealed.

scholarly journals Association of serum vitamin D levels and transient tachypnea of newborn: a case control study

2017 ◽  
Vol 4 (3) ◽  
pp. 827 ◽  
Author(s):  
Gurmeet Singh ◽  
Reena Sood ◽  
Gursharan Singh Narang ◽  
Harnoorjit Kaur Brar ◽  
Amanjeet Kaur Bagga
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Transient Condition ◽  
Control Group ◽  
Term Neonates ◽  
Serum Vitamin D ◽  
Increased Risk ◽  
Vitamin D Levels ◽  
Control Study ◽  
Structured Questionnaire

Background: Transient tachypnea of newborn (TTN) is a common cause of respiratory distress in newborns with estimated incidence of 1-2% of all newborns. Although a self-limiting transient condition but it may cause severe morbidities. This study was conducted to find association of serum vitamin D levels in neonates who develop TTN as compared to normal healthy neonates.Methods: With thorough history with structured questionnaire and lab tests, serum vitamin D levels of 45 neonates who develop TTN were compared with 56 healthy neonates in control group.Results: Out of 45 neonates who develop TTN 39(86.7%) were deficient in vitamin D as compared to control group where 33(58.9%) out of 56 healthy neonates were deficient in vitamin D.Conclusions: Lower vitamin D levels at birth in term neonates is associated with increased risk of developing TTN and vitamin D may have a role in its pathogenesis. 

scholarly journals Relation of serum 25(OH) D with variables of thyroid and lipid profile in perimenopausal women

2017 ◽  
Vol 6 (3) ◽  
pp. 1087
Author(s):  
Poonam Rani ◽  
Seema Gupta ◽  
Gaurav Gupta
Keyword(s):  
Cardiovascular Disease ◽  
Vitamin D ◽  
Lipid Profile ◽  
Vitamin D Deficiency ◽  
Serum Levels ◽  
The Body ◽  
P Value ◽  
Thyroid Disorder ◽  
Vitamin D Levels ◽  
Perimenopausal Women

Background: Deficiency of vitamin D is quite prevalent among elderly population or postmenopausal women worldwide and may affect various function of the body. The status of its deficiency with their relation with other variables are not well explored in perimenopausal women.Methods: 100 perimenopausal women from the department of obstetrics and gynaecology were selected without having known risk of thyroid disorder and cardiovascular disease. The age group criteria for these women were 40 to 50 years. Thyroid profile including TSH, T3, and T4 were estimated by using enzyme linked immunesorbent assay. Serum levels of 25(OH) D3 was estimated by using spectrophotometric method. Lipid profile including TC, TG and HDL-C were estimated CHOD-POD method, GPO-PAP method, and CHOD-POD/Phosphotungustate method. LDL-C was calculated by friedewald formula.Results: There 58 women were presented with insufficient amount of vitamin D. They were characterised with increased BMI, elevated thyrotropin alongwith lower concentrations of T3 and T4. Increased levels of TC, TG and LDL-cholesterol alongwith lower concentration of HDL-C were also observed in women with vitamin d deficiency. Women having vitamin D deficiency were presented with overweight (OR-18.0, p-value=<0.001) and dyslipidemia (OR-12.13, p-value≤0.001). Vitamin D was negatively correlated with variable i.e. BMI, TSH, TC, TG and LDL-C. This negative association was significant (<0.001) while HDL-C and T4 were positively correlated with vitamin D levels in this study population.Conclusions: Vitamin D deficiency frequently occurs in middle aged perimenopausal women. Negative correlation of it with BMI, TSH and lipid variables may suggest the development of cardiovascular disease and hypothyroidism in coming years. Vitamin D supplements or vitamin D containing diet and regular exposure to sun is highly recommended to perimenopausal women.

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