scholarly journals Respiratory Function of Witwatersrand Gold-miners: A Comparison between Radiologically Normal Miners and Control Non-mining Subjects.

1958 ◽  
Vol 15 (4) ◽  
pp. 258-261
Author(s):  
S. Zwi ◽  
M. R. Becklake
Keyword(s):  
Respiratory Function ◽  
Gold Miners ◽  
And Control

scholarly journals Inhibition of Human Peptide Deformylase Disrupts Mitochondrial Function

2010 ◽  
Vol 30 (21) ◽  
pp. 5099-5109 ◽  
Author(s):  
Sindy Escobar-Alvarez ◽  
Jeffrey Gardner ◽  
Aneesh Sheth ◽  
Giovanni Manfredi ◽  
Guangli Yang ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Oxidative Phosphorylation ◽  
Respiratory Function ◽  
Aerobic Glycolysis ◽  
Peptide Deformylase ◽  
Protein Accumulation ◽  
Human Homolog ◽  
Mitochondrial Translation ◽  
And Control

ABSTRACT Deformylases are metalloproteases in bacteria, plants, and humans that remove the N-formyl-methionine off peptides in vitro. The human homolog of peptide deformylase (HsPDF) resides in the mitochondria, along with its putative formylated substrates; however, the cellular function of HsPDF remains elusive. Here we report on the function of HsPDF in mitochondrial translation and oxidative phosphorylation complex biogenesis. Functional HsPDF appears to be necessary for the accumulation of mitochondrial DNA-encoded proteins and assembly of new respiratory complexes containing these proteins. Consequently, inhibition of HsPDF reduces respiratory function and cellular ATP levels, causing dependence on aerobic glycolysis for cell survival. A series of structurally different HsPDF inhibitors and control peptidase inhibitors confirmed that inhibition of HsPDF decreases mtDNA-encoded protein accumulation. Therefore, HsPDF appears to have a role in maintenance of mitochondrial respiratory function, and this function is analogous to that of chloroplast PDF.

scholarly journals INVESTIGATION INTO IRRITANT CONSEQUENCES OF EMBALMING CHEMICALS ON RESPIRATORY TRACTS OF EMBALMERS Investigación sobre las consecuencias irritantes de los productos químicos de embalaje en los tractos respiratorios de los embalsantes

2019 ◽  
Vol 11 (3) ◽  
pp. 120-128
Author(s):  
Sunday O Popoola ◽  
Olabode O Akintoye ◽  
Olagoke O Erinomo ◽  
Oyesanmi A. Fabunmi ◽  
Samuel A Dada
Keyword(s):  
Respiratory Function ◽  
Statistical Significance ◽  
Health Hazard ◽  
Health Hazards ◽  
Toxic Substances ◽  
Contaminant Exposure ◽  
Precautionary Measures ◽  
Educación Primaria ◽  
Relative Differences ◽  
And Control

Exposure to toxic substances including embalming chemicals was established as health hazard depending on specific properties of contaminant, exposure situations and individual’s health status. Health hazards from embalming practices amongst a fraction of licenced embalmers were investigated: auditing safety and comfortability in embalmment, demonstration of respiratory occupational health hazards and analysis of basic precautionary measures in embalmment. Study conducted in hospitals’ mortuaries and anatomic laboratories. A proforma designed for collection of data was categorized into 4-sections: socio-demographics; mortuary design; pre-employment assessment; and respiratory function. Mortuaries/anatomic laboratories across Ekiti, Nigeria were scheduled by a team of investigators administering proforma on each centre and individuals involved. Controls were drawn from other workers outside embalming/anatomy departments of same institution. Data collated and analysed with statistical-significance as p<0.05. Sixty-eight workers participated with 34 each for case and control. Embalmers’ highest age-group (18-44years) constituted 17(50.0%). Religion: Christianity 31(91.2%) and Islam 3(8.8%). Education: primary 6(17.6%); secondary 14(41.2%) and tertiary 14(41.2%). Respiratory rates, forced expiratory volumes within 1-second and maximum voluntary volumes were statistically-significant while relative differences were observed in tidal volumes. Concordance test (p>0.05) showed inter-dependency amongst the parameters assessing respiratory function. Embalmment was dreadful on respiration of embalmers by deranging lung volumes. Approximative 6% of embalmers developed obstructive respiratory lesion equated to a disaster. Embalming centres in this locality, perhaps, Nigeria at large were rated low due to myriad of unwarranted exposure to embalming fluids. Standard and well-equipped mortuaries/anatomic laboratories were recommended in reducing to the barest minimum: dreadful effects of embalming chemicals, typically, Formaldehyde.   La exposición a sustancias tóxicas, incluidos los productos químicos de embalsamamiento, se estableció como un peligro para la salud dependiendo de las propiedades específicas de los contaminantes, las situaciones de exposición y el estado de salud del individuo. Se investigaron los riesgos para la salud de las prácticas de embalsamamiento entre una fracción de los embalsamadores autorizados: auditar la seguridad y la comodidad en el embalsamamiento, la demostración de los riesgos de salud ocupacional respiratoria y el análisis de las medidas de precaución básicas en el embalsamamiento. Estudio realizado en mortuorios y laboratorios anatómicos de hospitales. Un formulario diseñado para la recopilación de datos se clasificó en 4 secciones: sociodemográficas; diseño mortuorio; evaluación previa al empleo; y función respiratoria. Los laboratorios de anatomía / mortuorios en Ekiti, Nigeria, fueron programados por un equipo de investigadores que administraban proforma en cada centro e individuos involucrados. Los controles se obtuvieron de otros trabajadores fuera de los departamentos de embalsamamiento / anatomía de la misma institución. Datos recopilados y analizados con significación estadística como p <0,05. Sesenta y ocho trabajadores participaron con 34 cada uno por caso y control. El grupo de edad más alto de los embalsamadores (18-44 años) constituía 17 (50.0%). Religión: Cristianismo 31 (91,2%) e Islam 3 (8,8%). Educación: primaria 6 (17,6%); secundaria 14 (41,2%) y terciaria 14 (41,2%). Las tasas respiratorias, los volúmenes espiratorios forzados dentro de 1 segundo y los volúmenes voluntarios máximos fueron estadísticamente significativos, mientras que se observaron diferencias relativas en los volúmenes corrientes. La prueba de concordancia (p> 0.05) mostró interdependencia entre los parámetros que evalúan la función respiratoria. El embalsamamiento fue terrible en la respiración de los embalsamadores al alterar los volúmenes pulmonares. Aproximadamente el 6% de los embalsamadores desarrollaron una lesión respiratoria obstructiva equivalente a un desastre. Los centros de embalsamamiento en esta localidad, tal vez, Nigeria en general, recibieron una calificación baja debido a la miríada de exposición injustificada a los fluidos de embalsamamiento. Se recomendaron laboratorios mortuorios / anatómicos estándar y bien equipados para reducir al mínimo lo más mínimo posible: los terribles efectos de los productos químicos de embalsamamiento, por lo general, formaldehído.

scholarly journals Video Edukasi Animasi 2 Dimensi Mengenai Bahaya Merkuri terhadap Masyarakat Kabupaten Lombok Tengah sebagai Dampak Penambangan Emas Ilegal

2017 ◽  
Vol 3 (02) ◽  
pp. 176-195
Author(s):  
I Made Marthana Yusa ◽  
Laksminta Rukmi
Keyword(s):  
Environmental Pollution ◽  
Health And Safety ◽  
Health Impact ◽  
Educational Video ◽  
Monitoring And Control ◽  
Industry Waste ◽  
Gold Miners ◽  
Gold Industry ◽  
And Control

AbstrakMerkuri adalah salah satu jenis logam berat yang banyak ditemukan di alam dan tersebar dalam batuan, tanah, air dan udara sebagai senyawa anorganik dan organik. Merkuri dapat dimanfaatkan dalam berbagai bidang industri, salah satunya industri emas. Pengelolaan limbah hasil industri pengolahan emas yang tidak sesuai dengan prosedur yang baik dan benar akan menyebabkan pencemaran lingkungan. Merkuri yang telah mengontaminasi lingkungan dalam jangka waktu panjang akan membawa dampak buruk bagi kesehatan manusia yang sering berinteraksi dengan bahan merkuri ini. Dalam penelitian ini, dilakukan perancangan video berbasis animasi 2 dimensi, sebagai salah satu rekomendasi solusi edukasi, untuk pencegahan dampak kesehatan, akibat pencemaran lingkungan oleh merkuri di Lombok Tengah. Dari hasil penelitian didapatkan fakta bahwa responden yang terdiri dari staf Konservasi dan Sumber Daya Alam serta staf Pengawasan dan Pengendalian Lingkungan Kantor Lingkungan Hidup Kabupaten Lombok Tengah menilai video edukasi berbasis animasi 2 dimensi yang dihasilkan sangat baik dari segi desain maupun penyampaian informasinya. Video ini juga bermanfaat untuk mengedukasi masyarakat penambang emas di Lombok Tengah agar lebih mewaspadai merkuri dan bahayanya, juga menghargai kesehatan diri dan keselamatan kerja. Kata Kunci: Animasi 2 Dimensi, Bahaya Merkuri, Merkuri, Metil Merkuri, Video Edukasi AbstractMercury is one of the heavy metals found in nature and spread in rocks, soil, water and air as inorganic and organic compounds. Mercury can be utilized in various industrial fields, one of which is the gold industry. Waste management of gold processing industry that is not in accordance with good and correct procedures will cause environmental pollution. Mercury that has been contaminating the environment over the long term will have adverse effects on human health that often interact with these mercury ingredients. A 2-dimensional animation based video has been designed in this research, as one recommendation of educational solution, for the prevention of health impact, due to environmental pollution by mercury in Central Lombok. From the research results obtained the fact that respondents consisting of staff Conservation and Natural Resources and staff of Environmental Monitoring and Control Environment Office of Lombok Tengah District assessed 2-dimensional animation based animation videos produced very well in terms of design and delivery of information. This video is also useful to educate the gold miners community in Central Lombok to be more aware of mercury and its dangers, also appreciate the Occupational Health and Safety. Keywords: 2 Dimensional Animation, Mercury, Methyl Mercury, Educational Video

Abnormalities of the Respiratory Function and Control of Ventilation in Patients with Anorexia nervosa

Respiration ◽  
2003 ◽  
Vol 70 (5) ◽  
pp. 490-495 ◽  
Author(s):  
J.M.R. González-Moro ◽  
J. de Miguel-Díez ◽  
L. Paz-González ◽  
M.J. Buendía-García ◽  
A. Santacruz-Siminiani ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Respiratory Function ◽  
Control Of Ventilation ◽  
And Control

scholarly journals The Effects of Cervical Stabilization Exercises with Breathing Exercises on Respiratory Function in Subjects with Forward Head Posture

2021 ◽  
Vol 16 ◽  
pp. 486-492
Author(s):  
Lijun Yu ◽  
Qian Gu ◽  
Taeho Kim
Keyword(s):  
Thoracic Spine ◽  
Forced Vital Capacity ◽  
Respiratory Function ◽  
Vital Capacity ◽  
Forced Expiratory Volume ◽  
Forward Head Posture ◽  
Head Posture ◽  
Breathing Exercises ◽  
Before And After ◽  
And Control

This study aimed to compare the effects of cervical stabilization exercises with breathing exercises and cervical stabilization exercises with thoracic spine extension exercises on respiratory function in subjects with forward head posture (FHP). The study included 30 adults with FHP. They were divided into two groups—experimental (EG) and control (CG)—with 15 participants in each group. The EG was asked to perform cervical stabilization exercises with breathing exercises, and the CG was asked to perform cervical stabilization exercises with thoracic spine extension exercises. After 4 weeks of exercise, the changes in respiratory function were measured again. The results showed significant differences in the EG before and after exercise in terms of forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), peak expiratory flow (PEF), and forced vital capacity/vital capacity max (FVC/VCmax%) (p < 0.05). The CG showed only a significant increase in FVC, FEV1, and FVC/VCmax% after the experiment (p < 0.05). In the between-group comparison, there were significant differences noted in FVC, FEV1, PEF, and FVC/VCmax% in the EG compared to the CG (p < 0.05). As a result, cervical stabilization exercises with breathing exercises are recommended to promote respiratory function.

scholarly journals Lung Function Assessment as an Early Biomonitor of Mercury-Induced Health Disorders in Artisanal and Small-Scale Gold Mining Areas in Indonesia

2018 ◽  
Vol 15 (11) ◽  
pp. 2480 ◽  
Author(s):  
Sri Pateda ◽  
Masayuki Sakakibara ◽  
Koichiro Sera
Keyword(s):  
Lung Function ◽  
Pulmonary Function ◽  
Respiratory Function ◽  
Gold Mining ◽  
Atmospheric Mercury ◽  
The Body ◽  
Small Scale ◽  
Hair Samples ◽  
And Control ◽  
The Impact

The evaluation of mercury impact on humans is currently nonspecific because the body characteristics (homeostasis) of each human being varies. Therefore, in the early diagnosis of mercury toxicity, one of the most important monitoring parameters is the respiratory function examination. In this study, respiratory function was examined with a portable spirometer and correlated with the mercury levels in hair from the noses and heads of subjects. Samples were taken from artisanal and small-scale gold mining (ASGM) areas (villages of East Tulabolo and Dunggilata) and control areas (villages of Bongo and Longalo) in Gorontalo Province, Indonesia. A statistical analysis with the Mann–Whitney test (alternative) showed significant differences in lung function between the polluted and control areas (α = 0.03). The analysis of nasal and head hair samples with particle-induced X-ray emissions (PIXE) showed that the mercury levels in the ASGM area were considerably higher than in the more homogeneous control areas. This study confirms that a pulmonary function test is a quick and precise alternative way to monitor the impact of mercury on humans, especially atmospheric mercury, because we detected a negative correlation between pulmonary function and the level of mercury in hair.

scholarly journals The effects of functional training and stationary cycling on respiratory function of elderly with Parkinson disease: a pilot study

2018 ◽  
Vol 31 (0) ◽  
Author(s):  
Raíssa Almeida da Silveira ◽  
Karen Valadares Trippo ◽  
Gabriel Pereira Duarte ◽  
Mansueto Gomes Neto ◽  
Jamary Oliveira Filho ◽  
...  
Keyword(s):  
Respiratory Function ◽  
Vital Capacity ◽  
Forced Expiratory Volume ◽  
Control Group ◽  
Cycle Exercise ◽  
Yahr Stage ◽  
Functional Training ◽  
Before And After ◽  
And Control ◽  
Experimental Group

Abstract Introduction: Respiratory function changes in patients with Parkinson’s disease (PD) contribute to aspiration pneumonia, the main cause of mortality in PD population. Objective: To compare the effects of functional training and cycle exercise in respiratory function of elderly with PD. Methods: Twenty participants were randomised into two groups. Experimental group (EG) (n = 10) performed cycle exercise and control group (CG) (n = 10) was trained with functional training. A blinded researcher evaluated maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP), thoracoabdominal amplitude, forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1) before and after interventions. Results: Both groups did not improve significantly respiratory function. Only CG improved significantly FVC (p = 0.01). No differences were found between groups. Conclusion: 8-week exercise programs are not able to improve the respiratory function of elderly in 2 to 3 PD Hoehn & Yahr stage. Both functional training and cycle exercise do not to improve respiratory function in elderly with PD.

Pathogenetic rationale for the use of intermittent normobaric hypoxytherapy in the rehabilitation of patients with chronic obstructive pulmonary disease

2021 ◽  
Author(s):  
N. P. Masik ◽  
S. V. Nechiporuk
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Respiratory Function ◽  
Clinical Symptoms ◽  
Main Group ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
And Control ◽  
Adaptive Reactions

Objective — to determine affects of the intermittent normobaric hypoxytherapy on the dynamics of general non‑specific adaptive reactions in the complex rehabilitation of patients with chronic obstructive pulmonary disease (COPD). Materials and methods. The treatment and examinations involved 450 patients with COPD, including GOLD 2 in 55.56 % (250 people) and GOLD 3 in 44.44 % (200 patients). The mean age was (52.65 ± 14.80) years, proportion of female and male subjects was equal. All patients received basic drug therapy according to the Order of MoH of Ukraine. The disease duration was 10 to 30 years, the remission stage was established in all patients. Patients were randomized into two groups: main (400 people) and control (50 people) with the same COPD severity distribution. Patients of the main group received additional 30 minutes sessions of interval normobaric hypoxytherapy for 20 days. The examination were performed for the dynamics of clinical symptoms, respiratory function, nonspecific resistance of an organism. Results. Most patients had symptoms of the disease against the background of basic COPD medication even on the remission stage. Unfavorable and intense adaptive reactions were determined in 71.33 % of COPD patients, and eustress reactions only in 16.89 %. Sanogenetic types of adaptive reactions were found in 28.45 % of subjects, maladaptive types — in 21.78 % of persons, pathogenetic — in 63.33 % of patients. At GOLD 2, tense reactions were diagnosed in 69.6 % of subjects, and in GOLD 3 in 73.0 %. As the severity of the disease increased, there was an increase in the development of intense training and activation responses. Upon completion of the course of hypoxytherapy, the exercise tolerance increased, and shortness of breath appeared only after severe physical activity in 90.25 % of patients in the main group, whereas in the control group similar changes were observed only in 20.0 % of patients. The respiratory function indicators in patients of the main group increased on average by 17.52 %, while in the control group — by 3.3 %. In the main group, favorable adaptation reactions prevailed in 88.25 % of patients, while in the control group this indicator was 32.0 %. The percentage of adverse reactions in the main group decreased significantly and was 11.75 % after treatment, the proportion of stress reactions — 46.25 %. In GOLD 2, the proportion of pathogenetic reactions decreased to 17.33 % and 56.00 % of the main and control groups, and in GOLD 3 — in 20.44 % and 44.0 %, respectively (p < 0.05). Conclusions. The use of a course of normobaric hypoxytherapy promoted the reduction of the main clinical COPD symptoms, increase of the frequency of favorable adaptive reactions up to 88.25 %, it raised clinical effectiveness of the treatment, which allowed to avoid disease exacerbations during the year in 80.95 % of patients.  

Control of Metal Alloy Oxidation with Electric Fields

1973 ◽  
Vol 31 ◽  
pp. 164-165
Author(s):  
R. R. Dils ◽  
P. S. Follansbee
Keyword(s):  
Electric Fields ◽  
Oxidation Process ◽  
Base Alloy ◽  
Oxide Surface ◽  
Platinum Electrodes ◽  
Insulating Layer ◽  
Iron Base Alloy ◽  
Alloy Oxidation ◽  
Aluminum Oxide Layer ◽  
And Control

Electric fields have been applied across oxides growing on a high temperature alloy and control of the oxidation of the material has been demonstrated. At present, three-fold increases in the oxidation rate have been measured in accelerating fields and the oxidation process has been completely stopped in a retarding field.The experiments have been conducted with an iron-base alloy, Pe 25Cr 5A1 0.1Y, although, in principle, any alloy capable of forming an adherent aluminum oxide layer during oxidation can be used. A specimen is polished and oxidized to produce a thin, uniform insulating layer on one surface. Three platinum electrodes are sputtered on the oxide surface and the specimen is reoxidized.

Sign in / Sign up

Export Citation Format

Share Document