scholarly journals Synthetic nicotine has arrived

2021 ◽  
pp. tobaccocontrol-2021-056626
Author(s):  
Sven-Eric Jordt
Keyword(s):  
High Performance ◽  
Tobacco Product ◽  
Product Line ◽  
Electronic Cigarette ◽  
Legal Analysis ◽  
Application Process ◽  
Regulatory Status ◽  
The Usa ◽  
The 1960S ◽  
Definition Of

The introduction of a new product line of the popular disposable electronic cigarette brand Puffbar, advertised as containing synthetic nicotine, has drawn attention to the increasing use of synthetic nicotine in marketed products and its uncertain regulatory status. A search of the Truth Tobacco Industry Documents revealed that the industry considered using synthetic nicotine already in the 1960s, efforts that were abandoned due to high costs and insufficient purity. Recent patents revealed renewed efforts to develop more efficient strategies for the synthesis of nicotine. Nicotine exists as two stereoisomers, S-nicotine and R-nicotine. While S-nicotine is the prevalent (>99%) form of nicotine in tobacco, a market-leading form of synthetic nicotine contains both stereoisomers at equal amounts, raising concerns about inaccurate labelling and the poorly understood health effects of R-nicotine. Other manufacturers, including a leading vendor of pharmaceutical grade nicotine, developed stereospecific strategies to synthesise pure S-nicotine, now added to electronic cigarette products marketed in the USA and UK. While S-nicotine and R-nicotine can be differentiated by enantioselective High Performance Liquid Chromatography (HPLC), differentiation of synthetic (fossil-derived) from tobacco-derived S-nicotine will require development of methods to measure carbon isotope (14C or 13C) content. Vendors claim that the FDA has no authority to regulate synthetic nicotine as a tobacco product, allowing them to circumvent the premarket tobacco product application process. However, legal analysis suggests that FDA may have the authority to regulate synthetic nicotine as a drug. Alternatively, Congress needs to include nicotine from any source within the legal definition of tobacco products.

Ciguapas in New York: Transcultural Ethnicity and Transracialization in Dominican American Performance

2012 ◽  
Vol 46 (1) ◽  
pp. 139-153 ◽  
Author(s):  
EMILIA MARÍA DURÁN-ALMARZA
Keyword(s):  
New York ◽  
Dominican Republic ◽  
Identity Formation ◽  
The Usa ◽  
And Migration ◽  
The 1960S ◽  
Definition Of ◽  
Dominican Women ◽  
The Impact ◽  
Dominican American

The Dominican American community in New York is perhaps one of the best examples of how processes of transculturation are affecting traditional definitions of ethnic identification. Given the intense economic, social and cultural transnational exchanges between the island and the USA from the 1960s, Dominicanyorks have been challenging the illusion of homogeneity in the definition of Americanness for decades, creating transnational social networks that transcend traditional national and ethnographic boundaries. The theatrical works of Josefina Báez, a Dominican American performer living in New York, and Sherezada (Chiqui) Vicioso, a Dominican poet and playwright who lived and worked in the US metropolis for decades before moving back to the Dominican Republic, lyrically explore issues of diaspora, identity and migration and the impact these phenomena might have in the lives of migrant Dominican women. Presenting diasporic experiences from two differing but interconnected locales – New York and the Dominican Republic – these plays offer two complementary views on the ways in which ethnicity, race, social class, age and geopolitical location interact in the formation of transcultural identities, thus contributing to develop a hemispheric approach to the study of identity formation in the Americas.

scholarly journals Heated tobacco products likely appeal to adolescents and young adults

2018 ◽  
Vol 27 (Suppl 1) ◽  
pp. s41-s47 ◽  
Author(s):  
Karma McKelvey ◽  
Lucy Popova ◽  
Minji Kim ◽  
Benjamin W Chaffee ◽  
Maya Vijayaraghavan ◽  
...  
Keyword(s):  
Health Risks ◽  
Tobacco Industry ◽  
Tobacco Product ◽  
Adolescent And Young Adult ◽  
Tobacco Products ◽  
Design And Implementation ◽  
Philip Morris ◽  
The Us ◽  
The Usa ◽  
The 1960S

BackgroundBeginning in the 1960s in the USA and globally since 1998, tobacco companies have beenaggressively promoting heated tobacco products (HTP). In 2016, Philip Morris International (PMI) applied to the US Food and Drug Administration (FDA) seeking authorisation to market their IQOS HTP system and flavoured ‘HeatSticks’ in the USA as a modified-risk tobacco product (MRTP).MethodsWe systematically evaluated the publicly available data PMI submitted to FDA in its MRTP application to determine whether PMI’s IQOS product meets the US Tobacco Control Act’s standard for MRTP claims. We examined whether PMI provided sufficient data showing tobacco users will not initiate with IQOS, that youth will not misperceive the MRTP-related claims being made concerning IQOS, and how youth perceive health risks associated with IQOS.ResultsPMI’s own studies failed to provide evidence that youth, including non-users and former users, will not find IQOS appealing, will not initiate use of IQOS and will not perceive these products as risk-free. Further, PMI did not refer to independent studies conducted among adolescents which could influence their conclusions. Finally, their studies suffered from design and implementation flaws and cannot be relied on to support the proffered claims.ConclusionPMI’s own data and available evidence from scientific studies conducted independent of the tobacco industry regarding how novel tobacco products are currently being marketed suggest that introduction of IQOS will result in adolescent and young adult non-users initiating tobacco use with IQOS and could also increase poly-use of IQOS along with other tobacco products.

Association of device type, flavours and vaping behaviour with tobacco product transitions among adult electronic cigarette users in the USA

2021 ◽  
pp. tobaccocontrol-2020-055999
Author(s):  
Alyssa F Harlow ◽  
Jessica L Fetterman ◽  
Craig S Ross ◽  
Rose Marie Robertson ◽  
Aruni Bhatnagar ◽  
...  
Keyword(s):  
Cigarette Smoking ◽  
Multinomial Logistic Regression ◽  
Sociodemographic Factors ◽  
Tobacco Product ◽  
Electronic Cigarette ◽  
Health Study ◽  
Cigarette Use ◽  
Use Patterns ◽  
The Usa ◽  
Former Smokers

BackgroundFew studies assess whether electronic cigarette (e-cigarette) device characteristics or flavours impact longitudinal patterns of cigarette and e-cigarette use.DesignWe examined data from waves 2–4 of the Population Assessment of Tobacco and Health Study (2014–2018). Among adult (≥18 years) current e-cigarette users at wave 2 who were current smokers (dual users; n=1759) and former smokers (exclusive e-cigarette users; n=470), we classified participants into four use patterns at wave 3 (~12 months later) and wave 4 (~24 months later): (1) dual use of e-cigarettes and cigarettes; (2) exclusive cigarette smoking; (3) exclusive e-cigarette use; (4) non-use of both products. We used multinomial logistic regression to assess correlates of changing use patterns at 24 months, relative to no change, adjusting for sociodemographic factors.ResultsAt 24 months, 26.5% of baseline exclusive e-cigarette users, and 9% of baseline dual users, abstained from both vaping and smoking. Participants who vaped non-tobacco flavours (vs tobacco flavours), and used refillable tank or modifiable devices (vs disposable, cartridges and other devices) were less likely to transition to non-use of both products and to exclusive cigarette smoking. Baseline daily vaping (vs non-daily) was positively associated with exclusive e-cigarette use at 24 months for baseline daily cigarette smokers, but negatively associated with exclusive e-cigarette use and non-use of both products at 24 months for baseline non-daily smokers.ConclusionsNon-tobacco flavours, daily vaping and modifiable e-cigarette devices may help some smokers abstain from cigarette smoking via transitioning to exclusive e-cigarette use, but are also associated with ongoing exclusive e-cigarette use.

scholarly journals Forming Legal Definitions of Modern Information Technologies under Economic Digitalization

2019 ◽  
Vol 71 ◽  
pp. 04018
Author(s):  
K. K. Taran
Keyword(s):  
Information Technologies ◽  
Specific Situation ◽  
Legal Analysis ◽  
Legal Professionals ◽  
The Usa ◽  
The Subject ◽  
Internet Law ◽  
Definition Of ◽  
Intensive Development ◽  
Complicated Task

During the intensive development of information technologies (IT), the need for their regulation gradually arises. For forming basic regulation of IT-sphere a basis is needed, which determines the subject of regulation. It’s a complicated task, but its solution will help to determine legal relations stemming from IT-usage. The existing technical definitions are accurate, since they are technical in nature. In some situations there are difficulties in their legal application, it complicates the legal analysis of a specific situation. The legal definition of a particular technology will assist legal professionals and theorists, as it will clarify the essence of relations, help to avoid misconception, support Internet law developing. This study discusses a short list of technologies used in practice in legal, medical and other fields. The author provides an overview of legal definitions at various levels: international, regional and national. The author examines the formation of definitions in Russia and the USA. A comparative analysis of terminology allows us to highlight the laws and features inherent in these countries. The author discusses the definitions of well-known, basic concepts such as the Internet, the user and the definition of technology that is currently widely used - a cloud storage of information.

scholarly journals A Comparative Legal Aspect of the Normative Definition of the Purpose of Criminal Procedure Activities

2021 ◽  
Vol 15 (3) ◽  
pp. 392-400
Author(s):  
Nikolay Azarenok
Keyword(s):  
Goal Setting ◽  
Legal Aspect ◽  
Criminal Procedure ◽  
Criminal Court ◽  
Legal Analysis ◽  
Anglo Saxon ◽  
Criminal Procedure Law ◽  
The Usa ◽  
Court Proceedings ◽  
Definition Of

Human activity lies at the foundation of all social processes. The successful development of humanity as a whole depends on its orderly and organized character. An analysis of the structure of activity shows that scholars have not reached consensus on this point. The concept is described through such components as the goal, motives, interests, needs, means, result and the very process of activity. At the same time, philosophers agree that at its highest level of generality, activity is characte­rized through the prism of its goal and means. Choosing a goal to the achievement of which a person will dedicate his activities is called «goal-setting». If an idea cannot be implemented at once and requires a number of consecutive actions, the goal is specified through separate tasks referring to the stages of work. The unification of the goal and tasks into a whole constitutes «goal-setting». This methodological basis is applicable to all types of human activities, including the criminal procedure one. A scholarly definition of goal-setting in Russian criminal court proceedings is impossible without a comparative legal study of this issue in other countries. The author uses two universally recognized systems of law as a basis for this: the Anglo-Saxon system and the Romano-Germanic legal system. Besides, the author presents an analysis of the criminal procedure legislation of ex-USSR countries (Ukraine, Belarus, Kazakhstan, Kirgizstan), Asian countries (the PRC, Japan) and the Middle East (Turkey). As for the legislations of the Anglo-Saxon legal family (England, Wales, the USA), only the American criminal procedure legislation states its goals and tasks. The criminal procedure laws of Austria, the FRG, France, Poland do not include the goal-setting of criminal court proceedings. The criminal procedure codes of Ukraine, Kazakhstan, Kirgizstan state the tasks of criminal court proceedings (process), and the code of Belarus declares tasks of both the criminal procedure law and the criminal process. The criminal procedure legislations of the PRC, Japan, Turkey include the purpose, the goal and tasks. The conducted comparative legal analysis acts as a basis for corresponding conclusions that should be taken into consideration in the process of improving Russian criminal court proceedings.

Ways and Voices in the Psychoanalysis of Links According to Enrique Pichon-Rivière

2016 ◽  
Vol 6 (2) ◽  
Author(s):  
Rosa Jaitin
Keyword(s):  
Couple Therapy ◽  
Clinical Observation ◽  
Clinical Work ◽  
The Core ◽  
The Social ◽  
The 1960S ◽  
Definition Of ◽  
Relationship Of ◽  
The Voice ◽  
Different Levels

This article covers several stages of the work of Pichon-Rivière. In the 1950s he introduced the hypothesis of "the link as a four way relationship" (of reciprocal love and hate) between the baby and the mother. Clinical work with psychosis and psychosomatic disorders prompted him to examine how mental illness arises; its areas of expression, the degree of symbolisation, and the different fields of clinical observation. From the 1960s onwards, his experience with groups and families led him to explore a second path leading to "the voices of the link"—the voice of the internal family sub-group, and the place of the social and cultural voice where the link develops. This brought him to the definition of the link as a "bi-corporal and tri-personal structure". The author brings together the different levels of the analysis of the link, using as a clinical example the process of a psychoanalytic couple therapy with second generation descendants of a genocide within the limits of the transferential and countertransferential field. Body language (the core of the transgenerational link) and the couple's absences and presence during sessions create a rhythm that gives rise to an illusion, ultimately transforming the intersubjective link between the partners in the couple and with the analyst.

Opportunities for improving the insider laws: A comparative analysis of the practice in the USA and Russia

2020 ◽  
Vol 26 (4) ◽  
pp. 796-814
Author(s):  
E.K. Ovakimyan
Keyword(s):  
Financial Markets ◽  
Insider Trading ◽  
Negative Impact ◽  
Business Environment ◽  
Market Manipulation ◽  
Insider Information ◽  
Analysis And Synthesis ◽  
The Usa ◽  
Legislative Perfection ◽  
Definition Of

Subject. The article examines the laws regulating insider trading. Objectives. The study outlines recommendations for refining Law On Countering the Illegal Use of Insider Information and Market Manipulation and Amendments to Some Legislative Acts of the Russian Federation, № 224-ФЗ of July 27, 2010. Methods. The methodological framework includes a general dialectical method, analysis and synthesis, induction and deductions, and some specific methods, such as comparative and formal logic analysis to specify the definition of insider information, structural logic and functional analysis to improve the mechanism for countering insider trading and market manipulation. Results. We discovered key drawbacks to be addressed so as to improve the business environment in Russia. Although the Russia laws mainly mirror the U.S. laws, they present a more extended list of terms concerning the insider information. I believe the legislative perfection should be continued. Conclusions and Relevance. The study helps apply the findings to outline a new legislative regulation or amend the existing ones, add a new mention on the course of financial markets to students’ books, develop new methods for detecting and countering and improving the existing ones. If all parties to insider relationships use the findings, they will prevent insider trading crimes in financial markets and (or) reduce the negative impact of such crimes on the parties.

Hybrid Model using Firefly and BBO for Feature Selection in Software Product Line

2020 ◽  
Vol 13 ◽  
Author(s):  
Hitesh Yadav ◽  
Rita Chhikara ◽  
Charan Kumari
Keyword(s):  
Hybrid Model ◽  
High Performance ◽  
Software Product Line ◽  
Product Line ◽  
Feature Model ◽  
Software Systems ◽  
Feature Sets ◽  
Research Article ◽  
Software Product ◽  
Multiple Variants

Background: Software Product Line is the group of multiple software systems which share the similar set of features with multiple variants. Feature model is used to capture and organize features used in different multiple organization. Objective: The objective of this research article is to obtain an optimized subset of features which are capable of providing high performance. Methods: In order to achieve the desired objective, two methods have been proposed. a) An improved objective function which is used to compute the contribution of each feature with weight based methodology. b) A hybrid model is employed to optimize the Software Product Line problem. Results: Feature sets varying in size from 100 to 1000 have been used to compute the performance of the Software Product Line. Conclusion: The results shows that proposed hybrid model outperforms the state of art metaheuristic algorithms.

FDA’s reduced exposure marketing order for IQOS: why it is not a reliable global model

2021 ◽  
pp. tobaccocontrol-2020-056316
Author(s):  
Lauren Kass Lempert ◽  
Stella Bialous ◽  
Stanton Glantz
Keyword(s):  
Public Relations ◽  
Tobacco Control ◽  
Scientific Evidence ◽  
Tobacco Product ◽  
Tobacco Products ◽  
Sales And Marketing ◽  
Philip Morris ◽  
The Us ◽  
The Usa ◽  
The Difference

The US Food and Drug Administration (FDA) issued orders in July 2020 authorising Philip Morris Products S.A. to market its heated tobacco product (HTP) IQOS inside the USA with claims that it reduces exposure to some dangerous substances. FDA’s ‘reduced-exposure’ orders explicitly prohibit the marketing of IQOS with claims that IQOS will reduce harm or the risk of tobacco-related diseases. Under US law, FDA’s IQOS orders are problematic because FDA disregarded valid scientific evidence that IQOS increases exposure to other dangerous toxins and that Philip Morris Products S.A. failed to demonstrate that consumers understand the difference between reduced-exposure and reduced-harm claims. Unfortunately, both ‘reduced-exposure’ and ‘reduced-harm’ are classified as ‘modified risk tobacco products’ under US law. Exploiting this confusion, Philip Morris International used the FDA decision as the basis for marketing and public relations campaigns outside the USA to press governments to reverse policies that ban or regulate the sales and marketing of HTPs, including IQOS. Parties to the WHO Framework Convention on Tobacco Control should reject tobacco companies’ unsubstantiated explicit or implied claims of reduced harm associated with HTPs and resist Philip Morris International’s and other companies’ calls to relax HTP regulations based on the FDA’s actions. Instead, parties should adopt policies aligned with the Framework Convention on Tobacco Control when dealing with HTPs and other novel tobacco products.

Criteria for Best Performance of Pre-Optimized Solid Dampers

2018 ◽  
Vol 141 (4) ◽  
Author(s):  
Chiara Gastaldi ◽  
Muzio M. Gola
Keyword(s):  
High Performance ◽  
Nonlinear Finite Element ◽  
Design Stage ◽  
Experimental Investigations ◽  
Early Design Stage ◽  
Real Contact ◽  
Starting Point ◽  
Definition Of ◽  
Stiffening Effect ◽  
Contact Parameters

This paper furthers recent research by these authors. The starting point is the pre-optimization of solid dampers, which ensures that all dampers bound to “misbehave” are excluded since the early design stage. The authors now enlarge the scope of their investigations to explore those damper configurations selected inside the admissible design area. The purpose of the paper is to present a set of criteria apt to select a damper configuration which not only avoids unwanted situations, but in addition guarantees high performance under different design conditions. The analysis starts with the definition of a set of requirements a high performance damper should meet. In detail, the present investigation seeks to answer the following questions: in the low excitation regime, what is the frequency shift and the stiffening effect each damper can provide? for increasing excitation levels, which damper will start slipping sooner? in the high excitation regime, which damper provides the maximum dissipation? Like pre-optimization, it does not involve nonlinear finite element calculations, and unlike existing optimization procedures, is not linked to a specific set of blades the damper may be coupled to. The numerical prediction of the blade-damper coupled dynamics is here used only for validation purposes. The approach on which this paper rests is fully numerical; however, real contact parameters are taken from extensive experimental investigations made possible by those purposely developed test rigs which are the distinctive mark of the AERMEC Lab of Politecnico di Torino.

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