scholarly journals Inflammation status of healthy young men: initial and specific responses to resistance training

2018 ◽  
Vol 43 (3) ◽  
pp. 252-258 ◽  
Author(s):  
Johanna K. Ihalainen ◽  
Heikki Peltonen ◽  
Göran Paulsen ◽  
Juha P. Ahtiainen ◽  
Ritva S. Taipale ◽  
...  

Our primary aim was to study the effects of a 4-week preparatory resistance-training (RT) period followed by 12 weeks of 2 specific RT protocols (either hypertrophic-strength (HS) or strength-hypertrophy-power training) on inflammation markers and the possible relationship of the changes in abdominal fat and lean mass to the changes in inflammation status. A total of 82 healthy men were included in the study. Maximal concentric leg press strength (1-repetition maximum), total body lean mass, total body and abdominal fat mass, circulating high-sensitivity C-reactive protein, interleukin-6, interleukin-1 receptor antagonist (IL-1ra), monocyte chemoattractant protein 1 (MCP-1), and selected adipocytokines (resistin, adiponectin, and leptin) concentrations were measured before and after 4 (wk4) and 16 weeks (wk16) of RT. After the initial phase of RT, on wk4, abdominal and total fat mass as well as plasma leptin concentrations were significantly reduced (p < 0.05), whereas muscle mass, IL-1ra, resistin, and MCP-1 concentrations were significantly increased (p < 0.05). During specialized training phase, at wk16, only HS led to further reduction in abdominal and total fat mass, resistin, and leptin (p < 0.05), whereas both training modes led to lower MCP-1 concentrations (p < 0.05). Abdominal fat mass and circulating leptin were reduced already after 4 weeks of RT. Simultaneously, circulating MCP-1 and resistin concentrations increased, possibly as markers of muscle adaptation and regeneration. The present findings also suggest that RT with hypertrophic focus is beneficial for further reductions in abdominal fat mass and to decrease circulating inflammatory markers.

2020 ◽  
Vol 30 (6) ◽  
pp. 386-395
Author(s):  
Giuseppe delli Paoli ◽  
Denise van de Laarschot ◽  
Edith C.H. Friesema ◽  
Remco Verkaik ◽  
Antonia Giacco ◽  
...  

Fasting enhances the beneficial metabolic outcomes of exercise; however, it is unknown whether body composition is favorably modified on the short term. A baseline–follow-up study was carried out to assess the effect of an established protocol involving short-term combined exercise with fasting on body composition. One hundred seven recreationally exercising males underwent a 10-day intervention across 15 fitness centers in the Netherlands involving a 3-day gradual decrease of food intake, a 3-day period with extremely low caloric intake, and a gradual 4-day increase to initial caloric intake, with daily 30-min submaximal cycling. Using dual-energy X-ray absorptiometry analysis, all subjects substantially lost total body mass (−3.9 ± 1.9 kg; p < .001) and fat mass (−3.3 ± 1.3 kg; p < .001). Average lean mass was lost (−0.6 ± 1.5 kg; p < .001), but lean mass as a percentage of total body mass was not reduced. The authors observed a loss of −3.9 ± 1.9% android fat over total fat mass (p < .001), a loss of −2.2 ± 1.9% gynoid over total fat mass (p < .001), and reduced android/gynoid ratios (−0.05 ± 0.1; p < .001). Analyzing 15 preselected single-nucleotide polymorphisms in 13 metabolism-related genes revealed trending associations for thyroid state–related single-nucleotide polymorphisms rs225014 (deiodinase 2) and rs35767 (insulin-like growth factor1), and rs1053049 (PPARD). In conclusion, a short period of combined fasting and exercise leads to a substantial loss of body and fat mass without a loss of lean mass as a percentage of total mass.


2020 ◽  
Vol 9 (2) ◽  
pp. 522
Author(s):  
Ulrike H. Mitchell ◽  
Bruce Bailey ◽  
Patrick J. Owen

Aerobic exercise training has many known cardiovascular benefits that may promote healthy aging. It is not known if long-term aerobic exercise training is also associated with structural benefits (e.g., lower fat mass, higher areal bone mineral density (BMD) and greater muscle mass). We evaluated these parameters in middle-aged long-term endurance runners compared to sex-, age-, height-, and weight-matched non-running controls. Total and regional lean and fat mass and areal BMD were assessed by dual-energy X-ray absorptiometry. Sagittal magnetic resonance images captured the cross-sectional area and thickness of the lumbar multifidus. Runners (n = 10; all male) had a mean (standard deviation; SD) age of 49 (4) years, height of 178.9 (4.9) cm, weight of 67.8 (5.8) kg, body mass index (BMI) of 21.4 (1.4) kg/m2 and had been running 82.6 (27.9) km/week for 23 (13) years. Controls (n = 9) had a mean (SD) age of 51 (5) years, height of 176.0 (5.1) cm, weight of 72.8 (7.1) kg, and BMI of 23.7 (2.1) kg/m2. BMI was greater in controls (p = 0.010). When compared to controls on average, runners had a 10 percentage-point greater total body lean mass than controls (p = 0.001) and 14% greater trunk lean mass (p = 0.010), as well as less total body (8.6 kg; p < 0.001), arm (58%; p = 0.002), leg (52%; p < 0.001), trunk (73%; p < 0.001), android (91%; p < 0.001), and gynoid fat mass (64%; p < 0.001). No differences were observed between groups for BMD outcomes or multifidus size. These results underscore the benefits of endurance running to body composition that carry over to middle-age.


2015 ◽  
Vol 9 (1) ◽  
pp. 399-404 ◽  
Author(s):  
Thord von Schewelov ◽  
Håkan Magnusson ◽  
Maria Cöster ◽  
Caroline Karlsson ◽  
Björn E Rosengren

Objective: To determine if primary hand osteoarthritis (OA) is associated with abnormal bone and anthropometric traits. Methods: We used DXA to measure total body bone mineral density (BMD), femoral neck width (bone size) and total body lean and fat mass in 39 subjects with hand OA (primary DIP and/or CMC I) and 164 controls. Data are presented as mean Z-scores or Odds Ratios (OR) with 95% confidence intervals. Results: Women with hand OA had (compared to controls) higher BMD (0.5(0.1,0.9)) but similar bone size (-0.3(-0.8,0.2)), lean mass (0.3(-0.3,0.9)), fat mass (-0.1(-0.6,0.5)) and BMI (0.0(-0.6,0.6)). Men with hand OA had (compared to controls) similar BMD (-0.1(-0.7,0.6)), smaller bone size (-0.5(-1.1,-0.01)), lower lean mass (-0.6(-1.1,-0.04)), and similar fat mass (-0.2(-0.7,0.4)) and BMI -0.1(-0.6,0.6). In women, each SD higher BMD was associated with an OR of 1.8 (1.03, 3.3) for having hand OA. In men each SD smaller bone size was associated with an OR of 1.8 (1.02, 3.1) and each SD lower proportion of lean body mass with an OR of 1.9 (1.1, 3.3) for having hand OA. Conclusion: Women with primary DIP finger joint and/or CMC I joint OA have a phenotype with higher BMD while men with the disease have a smaller bone size and lower lean body mass.


2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A8-A9
Author(s):  
Darin Ruanpeng ◽  
Sikarin Upala ◽  
Anawin Sanguankeo

Abstract Introduction: Time-restricted eating (TRE) or time-restricted feeding (TRF), a form of intermittent fasting (IF) when food consumption is restricted to a 4–12 hour window, poses unique possible health benefits that allow the nutrient to work in harmony with circadian rhythm. Whether TRF is effective in weight loss and cardiometabolic profile compare to usual diet is controversial. We conducted a meta-analysis of randomized control trials to investigate the weight and metabolic effects of TRF in humans. Methods: The systematic review was conducted according to the PRISMA guidelines. The literature search was conducted in MEDLINE, EMBASE, and CENTRAL from database inception to November 30, 2020. The search terms included time restricting feeding, time-restricted eating, periodic fasting, intermittent fasting, and periodic fasting. The eligibility criteria included a randomized controlled trial (RCT) comparing the effect of TRF as an intervention and control diet on weight and cardiometabolic risks in individuals with overweight (BMI 23–26.9 kg/m2 in Asian and 25–29.9 kg/m2 in others) or obesity (BMI≥27 kg/m2 in Asian and ≥30 kg/m2 in others) with study duration of at least 8 weeks. The primary outcome is the change in body weight between preintervention and postintervention. The secondary outcome is the change in total fat mass and lean mass, HDL, LDL, and triglycerides. Pool mean differences (MD) with 95% confidence interval (CI) were calculated for each outcome. Results: Four articles met the inclusion criteria and were included in this systematic review and meta-analysis. There were 511 participants with BMI 24 kg/m2 and above and aged between 18 and 65. TRF was defined as a 4–8 hours ad-lib unrestricted eating in 24 hours. The control diet was defined as ad-lib eating per usual habits. There was a significant improvement in weight and body composition in the TRF group. The mean weight loss was -2.08 kg (95% CI: -3.49 to -0.68) greater among TRF group. There was a significant total fat mass and lean mass loss in the TRF group with the MD of -1.29 kg (95% CI: -2.04 to -0.54) and -0.59 kg (95% CI: -1.15 to -0.03), respectively. There was no significant change in HDL, LDL, or triglycerides comparing between TRF and control diet. Conclusion: This systematic review and meta-analysis of RCT showed that TRF with no calories restriction resulted in significant decreased in weight, fat mass, and a slight decreased in total lean mass compared with control diet. Our findings support TRF as an effective lifestyle intervention for weight loss.


2006 ◽  
Vol 12 (2) ◽  
pp. 30-36
Author(s):  
Chloe ANG ◽  
Teik Hin KOH

LANGUAGE NOTE | Document text in English; abstract also in Chinese.The importance of reducing health risk associated with high abdominal fat is frequently emphasized. Consequently, in Singapore, we have witnessed good sales on motorized mechanical oscillators touted to induce slimming based on the principles of acupressure. However, to date, no study has been done to evaluate the efficacy of such equipment. This pilot study aims to examine the efficacy of motorized mechanical oscillators in reducing waist circumference, weight and abdominal fat percentage over 4 weeks as well as augment the data on acupressure for weight reduction. Two male subjects, one mildly overweight and the other severely overweight, were recruited. They were required to keep to their existing lifestyles and dietary habits and were instructed to wear the oscillator belt for 30 minutes each time, twice a day, as per instructions given in the manual. The machine was operated using the automatic mode. The results show a slight decrease in total body fat % ascertained by DEXA scans. There was also a reduction in waist circumference and an increase in lean mass in the trunk area in both subjects. Specifically, one participant (mildly overweight) lost 1.2% of total body fat, and 0.7cm on the waist girth but gained 1 kg of lean trunk mass. The other participant (severely overweight), although having lost only 0.2% of total body fat and 1.3cm on the waist girth, lost 1.7 kg in total body weight. He also gained in trunk lean mass that resulted in trunk fat reduction of 0.4%. There appears to be some success in such treatment modality particularly with regard to reducing abdominal fat. Certainly, more work needs to be done and future studies are being considered that will involve bigger sample sizes.調查顯示腹部脂肪的累積能引起健康危害,因此減少腹部脂肪的重要性需要廣泛重視的。在新加坡,瘦身產品如動力化的機械擺動瘦身帶都獲得非常好的銷售額。此瘦身帶是以穴位理療原理為依據而設計開發的。可是至今,這類產品的瘦身效果還沒得到科學證明。這項中間試驗的目的是研究在超過4個星期的時間裏,這類瘦身帶對減少腰圍,體重和腹部脂肪的百分數效果;同時也希望增添用穴位理療原理在減肥方面的資料。在二位男性患者當中,一位屬於輕微超重,而另一位屬於嚴重超重。在這項中間試驗調查中,二位患者接受了為期四周的治療療程。療程包括每日使用本瘦身帶二次,一次療程三十分鐘。除此以外,患者需要保持原本的生活方式和飲食習慣。並遵循指導手冊方法操作。此瘦身帶的操作是採用自動化的方法。由DEXA結果顯示二位元患者的脂肪都有顯微的下降,腰圍也有所減小,並且腹部的肌肉有明顯的增加。其中一位患者(輕微肥胖者)的脂肪減少了1.2%,腰圍減少了0.7公分,而肌肉增加了1公斤。第二位患者的身體脂肪減少了0.2%,腰圍減少了 1.3公分,體重也減輕了1.7公斤。同時肌肉也增加了,這使到他的腹部的脂肪減少了0.4%。由此可見,這類瘦身方法對減少腹部脂肪似乎有效。所以,這方面的調查和研究需要更多的工作。接下來希望進行更廣泛,更大規模的研究。


2017 ◽  
Vol 2017 ◽  
pp. 1-7
Author(s):  
Jonathan L. Warren ◽  
Barbara A. Gower ◽  
Gary R. Hunter ◽  
Samuel T. Windham ◽  
Douglas R. Moellering ◽  
...  

Higherin vivofatty acid (FA) oxidation rates have been reported in obese individuals compared to lean counterparts; however whether this reflects a shift in substrate-specific oxidative capacity at the level of the skeletal muscle mitochondria has not been examined. The purpose of this study was to test the hypothesis that in situ measures of skeletal muscle mitochondria FA oxidation would be positively associated with total body fat. Participants were 38 premenopausal women (BMI=26.5±4.3 kg/m2). Total and regional fat were assessed by dual-energy X-ray absorptiometry (DXA). Mitochondrial FA oxidation was assessed in permeabilized myofibers using high-resolution respirometry and a palmitoyl carnitine substrate. We found positive associations of total fat mass with State 3 (ADP-stimulated respiration) (r=0.379,p<0.05) and the respiratory control ratio (RCR, measure of mitochondrial coupling) (r=0.348,p<0.05). When participants were dichotomized by high or low body fat percent, participants with high total body fat displayed a higher RCR compared to those with low body fat (p<0.05). There were no associations between any measure of regional fat and mitochondrial FA oxidation independent of total fat mass. In conclusion, greater FA oxidation in obesity may reflect molecular processes that enhance FA oxidation capacity at the mitochondrial level.


Author(s):  
Lindsey Legg ◽  
Megan Rush ◽  
Jordan Rush ◽  
Stephanie McCoy ◽  
John C Garner ◽  
...  

Background of Study: Associations between measures of body composition and vertical jump height have previously been established using a range of instrumentation and prediction equations. Limited data has presented using gold standard measurements for both variables Objective: This investigation sought to examination the relationship between total body and lower extremity measures of body composition and vertical jump performance using gold standard measurements within an athletic population. Methods: Using a cross-sectional, correlational research design fourteen collegiate female volleyball athletes completed body composition, three countermovement jumps (CMJ) and three squat jumps (SJ) analysis using DXA and force platforms. Results: High to very high positive relationships were seen between total body lean (p < 0.001) and fat mass (p < 0.05), lower extremity lean and fat mass (p < 0.01), and CMJ force and power. High negative relationships were present between total body fat percentage(p < 0.05), total fat mass (p < 0.01) and CMJ jump height. Relationships between all body composition variables and SJ performance tended to be weaker, with the exception of total body lean mass (p < 0.05), lower extremity lean mass, and power output (p < 0.01). Conclusions: These findings support much of the previous literature in that increases of mass have subsequent increases in force and power production; however caution should be taken will increases in mass coming from fat or lean tissue.


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