SERUM CHOLESTEROL, ACTIVITY, FEED INTAKE, AND BODY WEIGHT IN LINES OF MICE SELECTED FOR GROWTH

1977 ◽  
Vol 19 (3) ◽  
pp. 415-424 ◽  
Author(s):  
E. A. Dunnington ◽  
J. M. White ◽  
W. E. Vinson
Keyword(s):  
Physical Activity ◽  
Weight Gain ◽  
Analysis Of Variance ◽  
Serum Cholesterol ◽  
Feed Intake ◽  
Control Line ◽  
Male Mice ◽  
Activity Data ◽  
Voluntary Physical Activity ◽  
Main Effects

Feed intake, growth and serum cholesterol (SC) were recorded on 102 male mice, and voluntary physical activity and SC were recorded on 113 male mice from lines selected for maximum 21- to 42-day weight gain (H), for minimum 21- to 42-day weight gain (L), and from a random-bred unselected control line (C). Voluntary physical activity in a revolving wheel was recorded for a 22-h period every sixth day from 3 to 10 weeks of age. Growth and feed intake on two different diets (diet 1 containing 4.5% fat and 23.4% protein; diet 2 containing 11% fat and 17% protein) were measured three times per week and rate of weight gain was calculated on a weekly basis. Blood samples were obtained by sinus orbital bleeding at 5 and 10 weeks of age after six hours fasting and analyzed for SC by gas chromatography. A least squares analysis of variance of the SC data using a model including lines, diets, ages and all possible interactions indicated highly significant differences in the main effects and in most of the interactions. SC and growth were higher and feed intake was lower in mice on diet 2. SC values (mg/100 ml) were 143.3, 124.1 and 132.2 at 10 weeks of age for H, C and L line animals fed diet 1 and 220.3, 178.1 and 180.4 for animals fed diet 2. An analysis of variance in the activity data resulted in highly significant differences in the main effects (line and age) but revealed no significance in the interaction. Activity scores (revolutions) for the H, C and L lines were 79234, 107987 and 124409, respectively for eight 22-h periods. Activity reached maximum levels at 56 days of age, then declined slightly. Within line phenotypic correlations between SC and activity and between SC and feed intake were significant throughout ages of testing only in the high line.

SELECTION FOR SERUM CHOLESTEROL, VOLUNTARY PHYSICAL ACTIVITY, 56-DAY BODY WEIGHT AND FEED INTAKE IN RANDOMBRED MICE. II. CORRELATED RESPONSES

1981 ◽  
Vol 23 (3) ◽  
pp. 545-555 ◽  
Author(s):  
E. A. Dunnington ◽  
J. M. White ◽  
W. E. Vinson
Keyword(s):  
Physical Activity ◽  
Body Weight ◽  
Serum Cholesterol ◽  
Feed Intake ◽  
High Weight ◽  
Control Line ◽  
High Intake ◽  
Low Weight ◽  
Voluntary Physical Activity ◽  
High Feed

Randomly bred ICR mice were selected for five generations for high and low serum cholesterol (SC), voluntary physical activity, 56-day body weight and feed intake. An unselected, randomly bred control line was maintained with each pair of selection lines. Significant increases in mature body weight occurred in males of high weight and high intake lines and in females of high SC, high weight and high intake lines. Significant decreases in mature body weights occurred in males of low weight line and in females of low SC and low weight lines. Both high and low selected SC lines had greater (P<0.05) activity scores and consumed more feed than the SC control. Mice selected for high activity consumed more (P<0.05) feed than mice selected for low activity. Mice selected for high 56-day body weight consumed more (P<0.05) feed and had higher SC than mice selected for low 56-day body weight. Mice selected for high feed intake were heavier (P<0.05) and more active (P<0.05) than low feed intake mice but had significantly lower SC levels.

SELECTION FOR SERUM CHOLESTEROL, VOLUNTARY PHYSICAL ACTIVITY, 56-DAY BODY WEIGHT AND FEED INTAKE IN RANDOMBRED MICE. I. DIRECT RESPONSES

1981 ◽  
Vol 23 (3) ◽  
pp. 533-544 ◽  
Author(s):  
E. A. Dunnington ◽  
J. M. White ◽  
W. E. Vinson
Keyword(s):  
Physical Activity ◽  
Body Weight ◽  
Serum Cholesterol ◽  
Feed Intake ◽  
Individual Performance ◽  
Control Line ◽  
Generation Means ◽  
Voluntary Physical Activity ◽  
Males And Females ◽  
Line Generation

A five-generation selection experiment was conducted with randomly bred ICR mice. Lines were developed for high (CH) and low (CL) serum cholesterol (SC), voluntary physical activity (lines AH and AL), 56-day body weight (lines WH and WL), and feed intake (lines IH and IL). An unselected randomly bred control line was maintained with each pair of selection lines (CC, AC, WC and IC, respectively). Selection was based on individual performance in SC, activity and weight lines, and on within-sex, among full-sib family selection in intake lines. Genetic responses (selected line generation means deviated from control line generation means and regressed on generation number) were different from zero (P<0.05) in CH males and females, CL males, AH males and females, AL males, WH males and females, WL males and females, and IH females. Realized heritabilities which did not differ (P<0.05) between sexes were: 0.43±0.05 (line CH), 0.37±0.06 (line CL), 0.26±0.08 (line AH), 0.16±0.04 (line AL), 0.33±0.05 (line WH), 0.40±0.05 (line WL), 0.42±0.06 (line IH). In Line IL heritabilities of males and females differed (P<0.05) from each other (0.08±0.06 and 0.29±0.06, respectively).

scholarly journals Voluntary wheel running is effective on suppressing of obesity but not on blood pressure and insulin resistance in female rats fed with high fructose diet

2021 ◽  
Vol 19 (1) ◽  
pp. 21-28
Author(s):  
P. Tayfur ◽  
K. Gökçe Tezel ◽  
Ö. Barutçu ◽  
S. Yılmaz ◽  
E. Ö. Özgür ◽  
...  
Keyword(s):  
Physical Activity ◽  
Insulin Resistance ◽  
Blood Pressure ◽  
Body Weight ◽  
Weight Gain ◽  
Wheel Running ◽  
Female Rats ◽  
Walking Distance ◽  
Voluntary Activity ◽  
Voluntary Physical Activity

A fructose-rich diet has been known to cause metabolic syndrome effects such as body weight gain, increased blood pressure, blood lipids and glucose levels. The role of voluntary physical activity in these alterations is not known clearly. The aim of this study was to investigate the possible improving effects of voluntary physical activity in rats that were feeding with a fructose-rich diet. Spraque-Dawley female rats were separated as control (C;n=7), voluntary physical activity (A;n=7), fructose (F;n=7) and fructose+activity (F+A;n=7) groups. A and FA groups were kept in cages with running wheels during six weeks. F and FA groups were fed with adding 20% fructose in drinking water. Body weight was measured weekly and Lee Index was used to determine obesity. At the end of the feeding period serum glucose, insulin and lipid levels were measured by enzymatic method and blood pressure was determined with the tail-cuff method. Daily voluntary walking distance in F+A and A groups were similar during six weeks. Fructose intake induced to increase systolic blood pressure (p=0.001), diastolic blood pressure (p=0.002), glucose (p=0.041), insulin (p=0.001), cholesterol (p=0.001), triglyceride (p=0.001) and liver weight (p=0.035). The voluntary activity was found effective on the decrease of weight gain (p=0.018) however we did not observe a significant effect on blood pressure (p=0.917) and insulin resistance (p=0.565) following the fructose-rich diet. We conclude that voluntary activity has preventive effect on obesity but may not to be effective on increased blood pressure and insulin resistance in female rats which were feeding fructose-rich diet during six weeks.

scholarly journals GENETIC PARAMETERS OF SERUM CHOLESTEROL LEVELS, ACTIVITY AND GROWTH IN MICE

Genetics ◽  
1977 ◽  
Vol 85 (4) ◽  
pp. 659-668
Author(s):  
E A Dunnington ◽  
J M White ◽  
W E Vinson
Keyword(s):  
Physical Activity ◽  
Body Weight ◽  
Weight Gain ◽  
Moisture Content ◽  
Serum Cholesterol ◽  
Genetic Parameters ◽  
Body Weight Gain ◽  
Genetic Correlations ◽  
Percent Body Fat ◽  
Cholesterol Levels

ABSTRACT Heritabilities (h  2) of, and phenotypic and genetic correlations among, serum cholesterol (SC), levels of physical activity, growth, and body moisture content were estimated from data on 466 sire-son pairs of random-bred, ICR albino mice. Heritability estimates of SC and body moisture content were 0.31 ± 0.07 and 0.29 ± 0.11, respectively. Estimates of h  2 for activity measured by standard exercise wheels at 28, 49 and 70 days of age were 0.31 ± 0.17, 0.50 ± 0.11 and 0.27 ± 0.14 and for weight at 21, 44 and 67 days of age, were 0.11 ± 0.09, 0.33 ± 0.09 and 0.42 ± 0.08, respectively. The estimates of h  2 for weight gain ranged from 0.22 ± 0.07 to 0.27 ± 0.08. Significant negative phenotypic correlations occurred between activity and rate of body weight gain. A negative genetic correlation of -0.70 ± 0.11 between SC and body moisture implied that SC and percent body fat are positively correlated. Genetic correlations among SC values and activity scores and between SC values and body weight gains were near zero.

Protein, lysine and feed intake level effects on pig growth: I. Main effects

1969 ◽  
Vol 72 (3) ◽  
pp. 379-400 ◽  
Author(s):  
R. Blair ◽  
J.B. Dent ◽  
P.R. English ◽  
J.R. Raeburn
Keyword(s):  
Weight Gain ◽  
Feed Intake ◽  
Live Weight ◽  
Conversion Ratio ◽  
Feed Conversion ◽  
Lean Meat ◽  
Live Weight Gain ◽  
Protein Levels ◽  
Weight One ◽  
Main Effects

SUMMARYA total of 512 pigs were given from 50 lb live weight one of 16 diets, i.e. with 4 lysine levels at each of 12, 14, 16 and 18% protein, at one of 4 levels of intake. They were killed at 100, 150, 200 or 250 lb live weight.Live-weight gain was not improved significantly by increasing the protein level above 16, 14, 12and 12%, respectively, for the 50–100, 100–150, 150–200and200–2501bstages. However, conversion of feed to live-weight gain was improved significantly during the 50–100 lb stage by increasing the protein to 18%. Gain in lean meat and in the efficiency of conversion of feed to lean meat were improved by increasing the above protein levels slightly.Live-weight gain was not improved significantly by increasing the lysine level above 1·04, 0·74, 0·70 and 0·59%, respectively, for the 50–100, 100–150, 150–200 and 200–250 lb stages. However, conversion of feed to live-weight gain was improved significantly during the 50–100 lb stage by increasing the lysine level to 1·22%. Raising the lysine level at each level of protein had no significant effect on the rate and efficiency of lean meat gain.Live-weight gain was significantly improved by increasing the level of feed intake almost to ad libitum levels for the 50–100, 100–150 and 150–200 lb stages. There was a suggestion of a similar effect in the 200–250 lb pigs although it was not statistically significant. Conversion of feed to live-weight gain was improved in the 50–100 lb pigs only by increasing the level of feed intake: in the older pigs increasing the level of feed intake caused a worsening in feed conversion ratio. Increasing the level of feed intake gave a significant improvement in rate of lean meat gain but a significant worsening in the efficiency of conversion of feed to lean meat during all stages up to 200 lb.Interaction effects of these factors and sex, on growth performance, are described.

scholarly journals Pacing in Time-Limited Ultramarathons from 6 to 24 Hours—The Aspects of Age, Sex and Performance Level

2021 ◽  
Vol 13 (5) ◽  
pp. 2705
Author(s):  
Hagen Deusch ◽  
Pantelis T. Nikolaidis ◽  
José Ramón Alvero-Cruz ◽  
Thomas Rosemann ◽  
Beat Knechtle
Keyword(s):  
Analysis Of Variance ◽  
Coefficient Of Variation ◽  
Training Programs ◽  
Performance Level ◽  
Running Speed ◽  
And Performance ◽  
Main Effects ◽  
And Training ◽  
Age And Sex

(1) Background: Compared with marathon races, pacing in time-limited ultramarathons has only been poorly discussed in the literature. The aim of the present study was to analyze the interaction of performance level, age and sex with pacing during 6 h, 12 h or 24 h time-limited ultramarathons. (2) Methods: Participants (n = 937, age 48.62 ± 11.80 years) were the finishers in 6 h (n = 40, 17 women and 23 men), 12 h (n = 232, 77 women and 155 men) and 24 h (n = 665, 166 women and 409 men) ultramarathons. The coefficient of variation (CV), calculated as SD/mean, was used to described pacing. Low scores of CV denoted a more even pacing, and vice versa. A two-way analysis of variance examined the main effects and interactions of sex and race duration on age, race speed and pacing. (3) Results: More men participated in the longer race distances than in the shorter ones and men were older and faster than women. Comparing the 6 h, 12 h and 24 h races, the finishers in the 6 h were the fastest, the finishers in the 12 h were the oldest and the finishers in the 24 h showed the most variable pacing. Furthermore, the faster running speed in the 12 h (women, r = −0.64; men, r = −0.49, p < 0.001) and the 24 h (r = −0.47 in women and men, p < 0.001) was related to less variable pacing. (4) Conclusions: These data might help runners and coaches to choose the the proper duration of a race and training programs for their athletes.

scholarly journals Annual rhythms in adults’ lifestyle and health (ARIA): protocol for a 12-month longitudinal study examining temporal patterns in weight, activity, diet, and wellbeing in Australian adults

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Rachel G. Curtis ◽  
Timothy Olds ◽  
François Fraysse ◽  
Dorothea Dumuid ◽  
Gilly A. Hendrie ◽  
...  
Keyword(s):  
Physical Activity ◽  
Body Weight ◽  
Weight Gain ◽  
Repeated Measures ◽  
Vigorous Physical Activity ◽  
Activity Patterns ◽  
Intervention Strategy ◽  
Temporal Patterns ◽  
Trial Registration ◽  
Multi Level

Abstract Background Almost one in three Australian adults are now obese, and the rate continues to rise. The causes of obesity are multifaceted and include environmental, cultural and lifestyle factors. Emerging evidence suggests there may be temporal patterns in weight gain related, for example, to season and major festivals such as Christmas, potentially due to changes in diet, daily activity patterns or both. The aim of this study is to track the annual rhythm in body weight, 24 h activity patterns, dietary patterns, and wellbeing in a cohort of Australian adults. In addition, through data linkage with a concurrent children’s cohort study, we aim to examine whether changes in children’s body mass index, activity and diet are related to those of their parents. Methods A community-based sample of 375 parents aged 18 to 65 years old, residing in or near Adelaide, Australia, and who have access to a Bluetooth-enabled mobile device or a computer and home internet, will be recruited. Across a full year, daily activities (minutes of moderate to vigorous physical activity, light physical activity, sedentary behaviour and sleep) will be measured using wrist-worn accelerometry (Fitbit Charge 3). Body weight will be measured daily using Fitbit wifi scales. Self-reported dietary intake (Dietary Questionnaire for Epidemiological Studies V3.2), and psychological wellbeing (WHOQOL-BREF and DASS-21) will be assessed eight times throughout the 12-month period. Annual patterns in weight will be examined using Lowess curves. Associations between changes in weight and changes in activity and diet compositions will be examined using repeated measures multi-level models. The associations between parent’s and children’s weight, activity and diet will be investigated using multi-level models. Discussion Temporal factors, such as day type (weekday or weekend day), cultural celebrations and season, may play a key role in weight gain. The aim is to identify critical opportunities for intervention to assist the prevention of weight gain. Family-based interventions may be an important intervention strategy. Trial registration Australia New Zealand Clinical Trials Registry, identifier ACTRN12619001430123. Prospectively registered on 16 October 2019.

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