Fatty Acids: Evolution in Relation to Neurobiology

1993 ◽  
Vol 71 (9) ◽  
pp. 683-683 ◽  
Author(s):  
M. T. Clandinin
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Polyunsaturated Fatty Acids ◽  
Acid Content ◽  
Essential Fatty Acids ◽  
Fatty Acid Content ◽  
Chain Elongation ◽  
Brain Membrane ◽  
The Impact ◽  
Long Chain

Metabolism of long-chain polyunsaturated fatty acids derived from 18:2ω−6 and 18:3ω−3 by chain elongation – desaturation is essential for synthesis of complex structural lipids, leukotrienes, thromboxanes, and prostaglandins. These essential fatty acids are required for normal function in developing tissues and appropriate maturation of a wide variety of physiological processes. During development, fetal accretion of long-chain metabolites of ω−6 and ω−3 fatty acids may result from maternal or placental synthesis and transfer or, alternatively, from the metabolism of 18:2ω−6 and 18:3ω−3 to longer chain homologues by the fetus. After birth the infant must synthesize or be fed the very long chain polyunsaturated fatty acids of C20 and C22 type derived from 18:2ω−6 and 18:3ω−3.Metabolism of ω−6 and ω−3 fatty acids utilizes the same enzyme system and is competitive. When levels of dietary ω−3 and ω−6 C18 fatty acids are altered, the levels of metabolites of these precursor fatty acids change in specific brain membranes, influencing membrane lipid dependent functions. For example, a diet unbalanced in very long chain ω−3 and ω−6 fatty acids may increase brain membrane ω−3 fatty acid content when 20:5ω−3 is fed, while decreasing membrane fatty acid content of the ω−6 series of competing fatty acids. As 20:4ω−6 is quantitatively and qualitatively important to brain phospholipid, significant reduction in brain levels of 20:4ω−6 may be less than optimal. The impact of these compositional changes on brain function is not yet clear.The authors in this symposium address how this general area of essential fatty acid metabolism is relevant to the evolution of man, growth and development of fish, function of the retina and neural tissue, cognitive development of infants, and infant nutrition.

Controversy in fatty acid balance

1993 ◽  
Vol 71 (9) ◽  
pp. 707-712 ◽  
Author(s):  
John E. Van Aerde ◽  
M. T. Clandinin
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Polyunsaturated Fatty Acids ◽  
Fish Oil ◽  
Infant Formula ◽  
Acid Content ◽  
Essential Fatty Acids ◽  
Membrane Phospholipids ◽  
Breast Fed ◽  
Long Chain

It is uncertain whether preterm infants can synthesize C20 and C22 (ω−6) and (ω−3) fatty acids required for structural lipids. Dietary intake of CI8:2ω−6 and C18:3ω−3 in formulae lacking long-chain polyunsaturated fatty acids can result in reduced levels of C20 and C22 homologues in membrane phospholipids as compared with breast-fed infants. Supplementation of fish oil has been shown to alleviate this problem in part only, as synthesis and incorporation of arachidonic acid into membrane phospholipids is reduced. Presently, infant formulae do not contain C20 and C22 fatty acids. Feeding an experimental infant formula with a balance between C20 and C22 (ω−6) and (ω−3) fatty acids within the range of human milk results in plasma phospholipid levels of C20 and C22 long-chain polyunsaturated (ω−6) and (ω−3) fatty acids similar to those in breast-fed infants. On the basis of clinical studies and evolutionary data, an increase of the linolenic and a decrease of the linoleic acid content in infant formula are suggested. Balanced incorporation of both (ω−6) and (ω−3) long-chain polyunsaturated fatty acids seems advisable in view of the lack of knowledge concerning the neonate's ability to chain elongate and desaturate essential fatty acids. Recommendations for the essential fatty acid content of preterm infant formula are suggested.Key words: essential fatty acids, long-chain polyunsaturated fatty acids, infant formula, fish oil, desaturation.

scholarly journals Fatty acid content in fish gastronomy

2020 ◽  
Vol 11 (213) ◽  
pp. 73-77
Author(s):  
Olga Timofeeva ◽  
◽  
Lyudmila Belysheva ◽  
Irina Avsyankina ◽  
Olga Likhoshva
Keyword(s):  
Fatty Acids ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Polyunsaturated Fatty Acids ◽  
Acid Composition ◽  
Acid Content ◽  
Fatty Acid Content ◽  
Network Data ◽  
Trade Network

Based on the analysis of the fatty acid composition of fish gastronomy, presented in the Minsk trade network, data on the content of saturated, monounsaturated and ω-3 and ω-6 polyunsaturated fatty acids and their ratio were obtained.

scholarly journals Variation in Polyunsaturated Fatty Acids Composition of Persian Walnut

1992 ◽  
Vol 117 (3) ◽  
pp. 518-522 ◽  
Author(s):  
L. Carl Greve ◽  
Gale McGranahan ◽  
Janine Hasey ◽  
Ronald Snyder ◽  
Kathy Kelly ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Polyunsaturated Fatty Acid ◽  
Acid Content ◽  
Juglans Regia ◽  
Fatty Acid Content ◽  
Oil Composition ◽  
Walnut Oil ◽  
Polyunsaturated Fatty Acid Content ◽  
The Impact

The variation in polyunsaturated fatty acid content of walnut (Juglans regia L.) oils was determined by analysis of samples isolated from specimens growing in four germplasm collections [California (55 cultivars), Washington (64 seedlings), China (12 cultivars), and France (20 cultivars)]. In addition, the impact of within-state geographic differences on oil composition was examined by comparing samples from three California cultivars (`Ashley', `Hartley', and `Franquette') grown in three locations. Local environmental effects on oil composition of `Chico' were also examined by comparing 1) samples collected from shaded and sun-exposed locations of the same trees and 2) samples collected from trees subjected to three irrigation regimes. Polyunsaturated fatty acid content, as a percentage of total fatty acids, ranged from 47.2% in nuts from PI 142323 from France to 81.0% in `Ashley' from California. However, our data indicate that environment, genotype, nut maturity, and their interactions all contribute significantly to variation in the degree of unsaturation of walnut oil.

Effect of double-muscling in Belgian Blue young bulls on the intramuscular fatty acid composition with emphasis on conjugated linoleic acid and polyunsaturated fatty acids

2001 ◽  
Vol 73 (2) ◽  
pp. 253-260 ◽  
Author(s):  
K. Raes ◽  
S. de Smet ◽  
D. Demeyer
Keyword(s):  
Fatty Acids ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Linoleic Acid ◽  
Polyunsaturated Fatty Acids ◽  
Acid Composition ◽  
Acid Content ◽  
Fatty Acid Content ◽  
Total Fatty Acid Content ◽  
Total Fatty Acids

AbstractThe effect of double-muscling (DM) genotype (double-muscling, mh/mh; heterozygous, mh/+; normal, +/+) of Belgian Blue (BB) young bulls on the intramuscular fatty acid composition, in particular conjugated linoleic acid (CLA) and polyunsaturated fatty acids (PUFA) was examined in five different muscles. The relative fatty acid composition showed only minor differences between muscles within genotypes. However, the DM genotype had a large effect on both the intramuscular total fatty acid content and on the relative fatty acid composition. Across muscles, the mh/mh animals had a lower total fatty acid content compared with the +/+animals (907 v: 2656 mg/100 g muscle;P< 0·01) and a higher PUFA proportion in total fatty acids (27·5 v 11·3 g/100 g total fatty acids;P< 0001), resulting in a higher PUFA/saturated fatty acid ratio (0·55 v 0·18;P< 0·01) and a lower n-6/n-3 ratio (5·34 v. 6·17;P< 0·01). The heterozygous genotype was intermediate between the two homozygous genotypes. The relative CLA content was similar in the mh/mh and +/+ genotypes and approximated 0·4 to 0·5 g/100 g total fatty acids. From the data it is further suggested that differences in the metabolism of the n-3 and n-6 fatty acids could exist between DM genotypes.

scholarly journals Useful properties of independent fatty acids in milk fat of milk of the cow and the influence of genetic factors on their content

2020 ◽  
Vol 27 ◽  
pp. 66-70
Author(s):  
Z. V. Yemets ◽  
A. M. Mamenko
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Lauric Acid ◽  
Acid Content ◽  
Milk Fat ◽  
Genetic Factors ◽  
Essential Fatty Acids ◽  
Fatty Acid Content ◽  
Pentadecanoic Acid ◽  
Dairy Breed

Aim. Useful properties of essential fatty acids contained in cow milk fat and influence on their content (fatty acids) of genetic factors are analyzed in the article. Methods. The research was carried out in the course of a year by sampling of aggregate milk from cows of Ukrainian black-rippled dairy breed and Ukrainian red-rippled dairy breed, farm "Ukrainka Slobidsk" of Kharkiv region of the Institute of animal husbandry of Ukraine, under equilibrium conditions by gas-liquid chromatography. Results. The breed causes variability from 0.1% (lauric acid) to 5.9% (pentadecanoic acid) of fatty acid content in milk. The influence of the father of the cow on the content of essential fatty acids in the milk of dairy cows ranges from 7.2% (heptadecic acid) to 27% (decanoic acid). Conclusions. Genetic Factors - The breed and parent of the cow have a significant influence on the content of essential fatty acids in the cow’s milk. The breed causes variability from 0.1% (lauric acid) to 5.9% (pentadecanoic acid) variability of fatty acid content in milk. Keywords: essential fatty acids, milk fat, black-and-pockmarked, red-and-pockmarked, cow breed, genetic factors.

scholarly journals Occurrence of long-chain fatty acids and glycolipids in the cell-envelope fractions of baker's yeast

1971 ◽  
Vol 125 (4) ◽  
pp. 963-969 ◽  
Author(s):  
T. Nurminen ◽  
H. Suomalainen
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Total Fatty Acid ◽  
Acid Content ◽  
Cell Walls ◽  
Neutral Lipids ◽  
Fatty Acid Content ◽  
Baker's Yeast ◽  
Total Fatty Acid Content ◽  
Long Chain

1. The total yield of fatty acids from the whole envelopes was markedly higher than that obtained from the ordinary cell walls. In both samples the major fatty acids were C16 and C18 acids. 2. The whole envelopes contained C18 acids and long-chain (C19–C26) fatty acids, in a higher proportion than did the ordinary cell walls. Fifteen fatty acids with more than 18 carbon atoms were identified, among which 2-hydroxy-C26:0 and C26:0 acids predominated. 3. A complex sphingolipid containing inositol, phosphorus and mannose was isolated from the whole cell envelopes. The main fatty acids of this lipid were 2-hydroxy-C26:0 and C26:0 acids. It was concluded that this sphingolipid is present both in the ordinary cell wall and in the plasma membrane of baker's yeast. 4. The neutral lipids amounted to over 50% and the glycerophosphatides to about 30% of the total fatty acid content of the whole envelope. The major fatty acids in these lipids were C16:1, C18:1 and C16:0 acids. The proportion of fatty acids with more than 18 carbon atoms was lowest in the neutral lipids, whereas the neutral glycolipids contained the highest percentage of these fatty acids. Acidic glycolipids amounted to 14% of the total fatty acid content of the whole envelope. The presence of a cerebroside sulphate in this lipid fraction was demonstrated, whereas the high content of 2-hydroxy-C26:0 acid found is caused by the complex inositol- and mannose-containing sphingolipid.

scholarly journals Analysis of Fatty Acids in Breastmilk During a 9-month Lactation Period Using Gas Chromatography–Mass Spectroscopy (GC-MS)

2021 ◽  
Vol 2 (1) ◽  
Author(s):  
Titin Aryani ◽  
Dwi Ernawati ◽  
Henny Parida Hutapea
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Polyunsaturated Fatty Acids ◽  
Acid Content ◽  
Saturated Fatty Acids ◽  
Fatty Acid Content ◽  
Acid Methyl Ester ◽  
Monounsaturated Fatty Acids ◽  
Lactation Period ◽  
Omega 6

Breastmilk is very much needed to meet the needs of babies in every way because it contains important nutrients, carbohydrates in the form of lactose, and fatty acids in the form of polyunsaturated fatty acids. Research on fatty acid content in breastmilk with a lactation period of 9 months is needed to provide information to the public related to fatty acid content of breastmilk during 9 months lactation. The study is to analyze fatty acid content in the form of saturated fatty acids or unsaturated fat contained in breast milk. Breastmilk taken in the study was as much as 50 ml in a 250 ml erlenmeyer solution. To the sample 50 ml of concentrated, HCL concentration was added as much as 5 m and then the solution was beat for 15 minutes and was exposed ultrasonic therapy for 1 hour. The solution was then extracted using n-hexane and aquabidest solution until the milk oil solution was separated. Milk oil was extracted by adding 50 ml of Na2SO4 1 m then deciphere was performed. The breastmilk milk extraction oil was weighed 0.1 gram in a Teflon-filled reaction tube. A 15% BF3 solution in methanol was added 0.5 ml and then was heated in an air bath with a temperature of 45 ° C for 30 minutes. After cooling, solution of 0.2 ml of n-hexane was added to form two layers. The upper layer which was fatty acid methyl ester was taken by using syringe and then was injected in GC-MS. In this study, the total saturated fatty acid was 42.54% and the total unsaturated fatty acid was 57.17%. Saturated fatty acids consisted of lauric, myristic, palmitate, and stearate. Omega-6 fatty acids and monounsaturated fatty acids consisted of omega-9 fatty acids. In Mother's Milk with 9 months lactation period there are various fatty acid content of both saturated fatty acids, monounsaturated fatty acids (omega-9) and polyunsaturated fatty acids (omega-6).

scholarly journals Comparison of Fatty Acid Content between New Zealand Grass-Fed and American Grain-Fed Beef Strip Loins Varying in Marbling Level

2019 ◽  
Vol 3 (2) ◽  
Author(s):  
L. W. Lucherk ◽  
T. G. O’Quinn ◽  
J. F. Legako ◽  
J. C. Brooks ◽  
M. F. Miller
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
New Zealand ◽  
Polyunsaturated Fatty Acids ◽  
Polar Lipid ◽  
Acid Content ◽  
Fatty Acid Content ◽  
Fatty Acid Analysis ◽  
Quality Grade ◽  
Beef Steaks

ObjectivesMarbling impacts eating quality and consumer preference of beef as it intensifies flavor, and improves tenderness and juiciness. Triglycerides are the predominate lipid in beef and are considered neutral fatty acids, whereas polar fatty acids are found in the phospholipid portion of beef. Diet of cattle during the finishing period can impact type and saturation of fatty acids in meat.The objective of this research was to evaluate differences in neutral and polar lipid fatty acid content from grass-fed and grain-fed beef of varying quality grades sourced from New Zealand and the United States, respectively.Materials and MethodsBeef strip loins (n = 200) representing two fed cattle types (n = 100/finishing type: grass-finished and grain-finished) and five different USDA quality grades (n = 20 per quality grade: USDA Standard, Select, Low Choice, “Top” Choice: High and Average Choice, and Prime) were acquired from beef processing facilities in New Zealand (grass-fed) and Nebraska (grain-fed). A face steak was cut from the anterior end of each strip loin for fatty acid analysis. Face steaks (n = 200) were frozen and stored at the Gordon W. Davis Meat Science Laboratory until further fabrication. Samples were thawed for 12 to 24 h, trimmed of subcutaneous fat and connective tissue and ground. The ground sample was frozen in liquid nitrogen and homogenized for fatty acid analysis. Lipids were extracted, fractionated into neutral lipid (NL) and polar lipid (PL), derivatized to fatty acid methyl esters and determined by gas chromatography.Statistical analyses were conducted using the procedures of SAS (Version 9.3; SAS Inst. Inc., Cary, NC). Treatment comparisons were tested for significance using PROC GLIMMIX with α = 0.05.ResultsInteractions of cattle diet × marbling level affected the overall concentrations (mg/g) of NL saturated fatty acids (SFA), monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA) (P < 0.05). Saturated fatty acid and MUFA NL concentration decreased as marbling level decreased, as grain-fed Prime was higher (P < 0.05) than all other treatments. Grain-finished and grass-finished Standard had the lowest (P < 0.05) SFA and MUFA NL concentration compared to all other treatments. Concentration of PUFA NL was higher (P < 0.05) for grain-finished Prime than grain-finished Top Choice and grass-finished Prime. No difference was found between grain-finished Low Choice and Select and grass-finished Top Choice NL concentration (P > 0.05), however all were higher (P < 0.05) than grass-finished and grain-finished Standard and grass-finished Select. A cattle diet × marbling level interaction affected the overall PL concentrations of SFA and MUFA (P < 0.05), but not PUFA (P > 0.05). Generally, polar fatty acid content increased as marbling increased for SFA and MUFA. Grain-finished PUFA PL concentration was higher (P < 0.05) than grass-finished samples. Additionally, PUFA PL concentration increased as quality grade decreased (P < 0.05).ConclusionIn conclusion, polar and neutral fatty acid content increased with increasing quality grades except for PL polyunsaturated fatty acids. Additionally, grain-finished beef steaks generally contained a higher SFA and MUFA NL concentration than grass-finished beef steaks for all quality grades except Low Choice and Top Choice.

EPTC Effects on Total Leaflet Fatty Acids and Hydrocarbons

Weed Science ◽  
1970 ◽  
Vol 18 (1) ◽  
pp. 125-128 ◽  
Author(s):  
R. E. Wilkinson ◽  
W. S. Hardcastle
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Acid Content ◽  
Fatty Acid Content ◽  
Gas Liquid Chromatography ◽  
Hydrocarbon Content ◽  
Application Rates ◽  
Herbicide Concentration ◽  
Cuticle Thickness ◽  
Long Chain

Total foliar fatty acid and hydrocarbon content of sicklepod (Cassia obtusifoliaL.) treated with 0, 0.14, 0.28, 0.56, 1.12, 2.24, or 4.48 kg/haS-ethyl dipropylthiocarbamate (EPTC) was measured by gas-liquid chromatography. Total leaflet fatty acid content increased at sublethal rates of the herbicide, but qualitative composition of the fatty acids was not affected. Percent of long chain alkane (≥ C28) content decreased as EPTC application rates increased. Palmitic (23.9%), stearic (9.1%), oleic (3.8%), linoleic (13.6%), and linolenic (33.2%) acids accounted for 83.6% of the total leaflet fatty acid content of sicklepod. Leaflet cuticle thickness of upper and lower epidermal layers decreased 15 and 20%, respectively, as herbicide concentration increased.

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