Role of hydrochloric acid in iron absorption

1964 ◽  
Vol 19 (2) ◽  
pp. 187-188 ◽  
Author(s):  
Peter Jacobs ◽  
Thomas Bothwell ◽  
Robert W. Charlton
Keyword(s):  
Hydrochloric Acid ◽  
Pernicious Anemia ◽  
Iron Absorption ◽  
Gastric Ph ◽  
Ferrous Ascorbate ◽  
Isotope Technique ◽  
The Mean ◽  
The Difference ◽  
Double Isotope

The absorption of 5 mg iron administered in 300 ml water was compared with absorption from 300 ml 0.05 n HCL in 24 subjects with histamine-fast achlorhydria, using a double isotope technique. In ten individuals given ferric chloride the mean absorptions were 2.2% with water and 9.2% in acid; the difference was less marked in the case of the seven subjects to whom ferrous ascorbate was administered (10.9% and 19.3%, respectively). In contrast, acid did not increase the absorption of hemoglobin iron, the mean figures being 13.4% with water and 9.6% with HCL. pernicious anemia; achlorhydria; gastric pH Fe55 and Fe59; radioactive hemoglobin iron Submitted on June 17, 1963

Seasonal trends in the stable isotopic composition of snow and meltwater runoff in a subarctic catchment at Okstindan, Norway

2004 ◽  
Vol 35 (2) ◽  
pp. 119-137 ◽  
Author(s):  
S.D. Gurney ◽  
D.S.L. Lawrence
Keyword(s):  
Isotopic Composition ◽  
Mean Value ◽  
Mean Values ◽  
Stable Isotopic Composition ◽  
Meltwater Runoff ◽  
Stable Isotopic ◽  
The Mean ◽  
The Difference ◽  
Δ18o And Δd

Seasonal variations in the stable isotopic composition of snow and meltwater were investigated in a sub-arctic, mountainous, but non-glacial, catchment at Okstindan in northern Norway based on analyses of δ18O and δD. Samples were collected during four field periods (August 1998; April 1999; June 1999 and August 1999) at three sites lying on an altitudinal transect (740–970 m a.s.l.). Snowpack data display an increase in the mean values of δ18O (increasing from a mean value of −13.51 to −11.49‰ between April and August), as well as a decrease in variability through the melt period. Comparison with a regional meteoric water line indicates that the slope of the δ18O–δD line for the snowpacks decreases over the same period, dropping from 7.49 to approximately 6.2.This change points to the role of evaporation in snowpack ablation and is confirmed by the vertical profile of deuterium excess. Snowpack seepage data, although limited, also suggest reduced values of δD, as might be associated with local evaporation during meltwater generation. In general, meltwaters were depleted in δ18O relative to the source snowpack at the peak of the melt (June), but later in the year (August) the difference between the two was not statistically significant. The diurnal pattern of isotopic composition indicates that the most depleted meltwaters coincide with the peak in temperature and, hence, meltwater production.

scholarly journals The Role of Volume, Conductivity, Scatter Changes of Neutrophils and Monocytes in Diagnosis of Megaloblastic Anemia

2020 ◽  
Vol 7 (12) ◽  
pp. A563-569
Author(s):  
Deepa Sowkur Anandarama Adiga ◽  
Debarshi Saha ◽  
Karthick R G ◽  
Vishnu Priya M ◽  
Purnima S Rao ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Megaloblastic Anemia ◽  
Serum Vitamin ◽  
Volume Conductivity ◽  
Degree Of Certainty ◽  
Normochromic Anemia ◽  
The Mean ◽  
The Difference ◽  
And Control

Background: Megaloblastic anemias are macrocytic normochromic anemia with mean corpuscular volume (MCV) of 100 fl-140 fl and caused by deficiency of either cobalamin (vitamin B12) or folate. However, increased MCV is not specific for megaloblastic anemia, nor is Vitamin B12 assay by chemiluminescence. We undertook this study to evaluate the possible role of Volume, Conductivity and Scatter (VCS) of WBCs derived from standard hematology analyzer to indicate megaloblastic anemia. Methods: We performed a case control study comparing data of 60 patients with low serum vitamin B12 or folate levels with 60 healthy volunteers. Comparison of the volume, conductivity and scatter parameters for neutrophils and monocytes of cases and control were done. Result: The mean neutrophil volume of cases (158.37±18.13fl) was significantly higher (p= 0.0001) compared to controls (141.26±4.22fl). Similarly, mean monocyte volume of cases (183.34±16.90fl) was significantly (p=0.0001) higher compared to controls (166.55±8.66fl). The difference in the mean conductivity of both neutrophils and monocytes between cases and controls were insignificant (p=0.43). Conclusion: Our study suggests analysis of VCS parameters for neutrophils and monocytes was a simple and objective method that substantiates the existence of subclinical deficiency of vitamin B 12 and folate with fair degree of certainty.

Spreader grafts: functional or just aesthetical?

2015 ◽  
Vol 53 (4) ◽  
pp. 332-339
Author(s):  
R. Xavier ◽  
S. Azeredo-Lopes ◽  
A. Papoila
Keyword(s):  
Functional Improvement ◽  
Nasal Airway ◽  
Nasal Airflow ◽  
Functional Effect ◽  
Nasal Breathing ◽  
The Mean ◽  
The Difference ◽  
The Aesthetic ◽  
Peak Nasal Inspiratory Flow

Objective: Spreader grafts are commonly used in rhinoplasty to achieve an aesthetic improvement of the nose or a functional improvement of the nasal airway. Currently, the aesthetic role of spreader grafts is well established. The functional effect of these grafts, however, has been controversial due to the lack of studies clearly demonstrating an increase on nasal airflow assigned to spreader grafts. The purpose of this study is to evaluate the effect of spreader grafts on nasal breathing. Methods: Nasal breathing of 72 consecutive patients undergoing rhinoplasty was evaluated by measuring peak nasal inspiratory flow (PNIF) before surgery and six months after surgery. Results: The mean preoperative PNIF of the 72 patients included in this study was 79.44 l/min and the mean postoperative PNIF was 110.42 l/min (p < 0.001). In 37 patients of this study no spreader grafts were used. In this group of patients the mean PNIF values changed from 73.24 l/min before surgery to 99.46 l/min after surgery. In the group of 35 patients in whom spreader grafts were used the mean PNIF values changed from 86.00 l/min before surgery to 122.00 l/min after surgery. The increase in the mean PNIF value after rhinoplasty was slightly higher in the group of patients with spreader grafts than in the group of patients without spreader grafts. The difference in the postoperative increase of PNIF between these two groups of patients, however, is not statistically significant. Conclusions: This study suggests that patients undergoing rhinoplasty have a statistically significant improvement in nasal breathing after surgery. However, patients receiving spreader grafts in a non-randomized way do not have statistically significant greater benefit than those who do not.

Iron Absorption in Chronic Renal Disease

1970 ◽  
Vol 38 (2) ◽  
pp. 191-196 ◽  
Author(s):  
J. W. Eschbach ◽  
J. D. Cook ◽  
C. A. Finch
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Renal Disease ◽  
Iron Overload ◽  
Iron Absorption ◽  
Chronic Renal Disease ◽  
Iron Depletion ◽  
Isotope Technique ◽  
Double Isotope

1. Absorption of inorganic iron was studied in thirty-four patients with chronic renal failure by a double isotope technique. 2. Eight patients with normal iron balance had a mean absorption of 3·5%, ten patients with iron overload had a mean absorption of 3·6%, and sixteen patients with iron depletion had a mean absorption of 58%. Thus, alterations in absorption appeared to be related to disturbances in iron balance. 3. The rate of erythropoiesis had no evident effect on iron absorption nor did the degree of anaemia. 4. The presence of renal disease and the degree of azotaemia likewise did not appear to affect absorption.

scholarly journals Probiotic strainLactobacillus plantarum299v increases iron absorption from an iron-supplemented fruit drink: a double-isotope cross-over single-blind study in women of reproductive age

2015 ◽  
Vol 114 (8) ◽  
pp. 1195-1202 ◽  
Author(s):  
Michael Hoppe ◽  
Gunilla Önning ◽  
Anna Berggren ◽  
Lena Hulthén
Keyword(s):  
Iron Absorption ◽  
Iron Bioavailability ◽  
Reproductive Age ◽  
Whole Body ◽  
Women Of Reproductive Age ◽  
Body Counting ◽  
Fruit Drink ◽  
The Difference ◽  
Single Blind ◽  
Double Isotope

Iron deficiency is common, especially among young women. Adding probiotics to foods could be one way to increase iron absorption. The aim of this study was to test the hypothesis that non-haem iron absorption from a fruit drink is improved by addingLactobacillus plantarum299v (Lp299v). Iron absorption was studied in healthy women of reproductive age using a single-blind cross-over design in two trials applying the double-isotope (55Fe and59Fe) technique. In Trial 1, iron absorption from a fruit drink containing 109colony-forming units (CFU) Lp299v was compared with that from a control drink without Lp299v. Trial 2 had the same design but 1010CFU were used. The test and control drinks contained approximately 5 mg of iron as ferrous lactate and were labelled with59Fe (B) and55Fe (A), respectively, and consumed on 4 consecutive days in the order AABB. Retention of the isotopes was measured with whole-body counting and in blood. Mean iron absorption from the drink containing 109CFU Lp299v (28·6(sd12·5) %) was significantly higher than from the control drink (18·5(sd5·8) %),n10,P<0·028). The fruit drink with 1010CFU Lp299v gave a mean iron absorption of 29·1(sd17·0) %, whereas the control drink gave an absorption of (20·1(sd6·4) %) (n11,P<0·080). The difference in iron absorption between the 109CFU Lp299v and the 1010CFU Lp299v drinks was not significant (P=0·941). In conclusion, intake of probiotics can increase iron absorption by approximately 50 % from a fruit drink having an already relatively high iron bioavailability.

scholarly journals A Note on the Role of Mean Flows in Doppler-Shifted Frequencies

2013 ◽  
Vol 43 (2) ◽  
pp. 432-441 ◽  
Author(s):  
Theo Gerkema ◽  
Leo R. M. Maas ◽  
Hans van Haren
Keyword(s):  
Doppler Shift ◽  
Wave Dispersion ◽  
The Other ◽  
Mean Flow ◽  
Fixed Position ◽  
Doppler Shifts ◽  
The Mean ◽  
The Difference ◽  
The One

Abstract The purpose of this paper is to resolve a confusion that may arise from two quite distinct definitions of “Doppler shifts”: both are used in the oceanographic literature but they are sometimes conflated. One refers to the difference in frequencies measured by two observers, one at a fixed position and one moving with the mean flow—here referred to as “quasi-Doppler shifts.” The other definition is the one used in physics, where the frequency measured by an observer is compared to that of the source. In the latter sense, Doppler shifts occur only if the source and observer move with respect to each other; a steady mean flow alone cannot create a Doppler shift. This paper rehashes the classical theory to straighten out some misconceptions. It is also discussed how wave dispersion affects the classical relations and their application.

scholarly journals Dietary ascorbic acid raises iron absorption in anaemic rats through enhancing mucosal iron uptake independent of iron solubility in the digesta

1997 ◽  
Vol 77 (1) ◽  
pp. 123-131 ◽  
Author(s):  
K. J. H. Wienk ◽  
J. J. M. Marx ◽  
M. Santos ◽  
A. G. Lemmens ◽  
E. J. Brink ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Iron Uptake ◽  
Iron Absorption ◽  
Iron Solubility ◽  
Fe Uptake ◽  
Isotope Technique ◽  
Proximal Intestine ◽  
Liquid And Solid Phases ◽  
Double Isotope

We studied Fe absorption from FeSO4 in rats with Fe deficiency-induced anaemia that were given an Fe-sufficient purified diet without or with ascorbic acid (10·4 g/kg diet). Attention was focused on mucosal Fe uptake as measured in vivo by a double-isotope technique. Haemoglobin repletion and liver Fe levels were not affected when the ascorbic acid-supplemented diet was given, but apparent Fe absorption and retention of orally administered 59Fe were significantly enhanced. The distribution of Fe between liquid and solid phases of contents of both the stomach and the proximal intestine was not affected by the feeding of the ascorbic acid, but ascorbic acid significantly enhanced mucosal Fe uptake. It is concluded that ascorbic acid in the diet raises mucosal Fe uptake through a mechanism independent of the intestinal Fe solubility.

scholarly journals Role of the Rossby Waves in the Broadening of an Eastward Jet

2012 ◽  
Vol 42 (3) ◽  
pp. 476-494 ◽  
Author(s):  
Genta Mizuta
Keyword(s):  
Potential Vorticity ◽  
Rossby Waves ◽  
Equation Model ◽  
Transient Region ◽  
Interior Flow ◽  
The Mean ◽  
The Difference ◽  
Vorticity Flux ◽  
The Waves

Abstract To investigate the effect of the Rossby waves on an eastward jet such as the Kuroshio or Gulf Stream Extensions, a series of numerical experiments is conducted using a primitive equation model. In these experiments, an inflow and an outflow imposed on the western and eastern boundaries drive an unstable narrow jet and a broad interior flow in the western and eastern regions of the model domain, respectively. The barotropic Rossby waves are radiated from the transient region between the two regions. The eddy potential vorticity flux by the waves tends to compensate for the difference in the mean potential vorticity along mean streamlines between both sides of the transient region. Instability of the jet is insufficient for this compensation and weakens the mean potential vorticity gradient too much. Moreover, as the potential vorticity of the outflow is increased, the Rossby waves are intensified in order to compensate for the increase in the difference in the mean potential vorticity. These features strongly suggest that the Rossby waves are substantial in matching a jet with an interior flow. The speed of the waves and properties of eddies in recirculations of the jet are consistent with a two-layer analytic model, which indicates that the Rossby waves are radiated from eddies in recirculations. These eddies as well as the Rossby waves increase in amplitude with the transport of the recirculation near the surface presumably because of mean advection. Therefore, the mean potential vorticity of the interior flow, the intensity of the Rossby waves, and the transport of the recirculation change consistently with one another.

Simultaneous Measurement of 59Fe and 51Cr in Iron Absorption Studies Using a Whole-Body Scanner with Mobile Shielding

1980 ◽  
Vol 19 (03) ◽  
pp. 140-145 ◽  
Author(s):  
Bep van den Beld ◽  
R. van Dongen ◽  
L.H. Strackee ◽  
J.J. M. Marx
Keyword(s):  
Iron Absorption ◽  
Background Radiation ◽  
The Body ◽  
Whole Body ◽  
Absorption Studies ◽  
Isotope Technique ◽  
Iron Retention ◽  
Body Scanner ◽  
Mucosal Uptake ◽  
Double Isotope

SummaryA whole-body scanner is described with a mobile shadow shield which affords a considerable reduction in space. The scanner has two Nal(Tl) scintillation crystals of 4 x 6", placed at opposite sites of the subject. Background radiation, efficiency and geometric qualities made the scanner very useful for clinical whole-body counting. The equipment was used in iron absorption studies using a double isotope technique with 59Fe and 51Cr. After ingestion of an oral test dose total body kinetics of 59Fe and 51Cr was followed up to 60 days in 4 volunteers. Between days 3 and 10 the 51Cr, which was used as an non-absorbable indicator, had left the body completely. The 59Fe reached a constant value not before day 10, indicating that iron retention cannot be measured before that time. From repeated measurement of 59Fe and 5lCr directly after ingestion until the first defaecation it could be deduced that the coefficient of variation for 59Fe was less than 1.5% with a scanning time of 600 sec, and for 51Cr less than 5%. Extreme variations in geometry, such as measurement of the activity in a beaker and of the same amount after ingestion in the body, yielded practically the same value for 59Fe. The double isotope technique made it possible to measure not only iron retention but also mucosal uptake and mucosal transfer of iron. It is pointed out that measurement of the last two parameters of iron absorption is not possible in patients with serious obstipation or with very low mucosal uptake values.

scholarly journals Simultaneous Measurement of Local Glucose Utilization and Blood Flow in the Rat Brain: An Autoradiographic Method Using Two Tracers Labeled with Carbon-14

1983 ◽  
Vol 3 (1) ◽  
pp. 62-66 ◽  
Author(s):  
Thomas W. Furlow ◽  
Lynn E. Harrison
Keyword(s):  
Blood Flow ◽  
Glucose Utilization ◽  
Local Cerebral Blood Flow ◽  
Local Cerebral Glucose Utilization ◽  
Carbon 14 ◽  
Radionuclide Tracers ◽  
Isotope Technique ◽  
The Difference ◽  
The Brain ◽  
Double Isotope

A simplified technique that uses two radionuclide tracers has been devised to measure local cerebral glucose utilization (lCGU) and local cerebral blood flow (lCBF) in the same rat. The method employs [14C]-2-deoxyglucose and [14C]iodoantipyrine to produce an autoradiogram before and another after extraction into chloroform of the [14C]iodoantipyrine from the brain sections. The chloroform-extracted autoradiogram yields lCGU, and the difference in tissue carbon-14 concentration between the two autoradiograms permits calculation of lCBF. The double-isotope technique provides values of lCGU and lCBF that are statistically indistinguishable from those derived from conventional single-isotope methods.

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