Iron deficiency anemia and steady-state work performance at high altitude

1988 ◽  
Vol 64 (5) ◽  
pp. 1878-1884 ◽  
Author(s):  
J. L. Beard ◽  
J. D. Haas ◽  
D. Tufts ◽  
H. Spielvogel ◽  
E. Vargas ◽  
...  

Thirty-seven young adult male highland residents at 3,600–4,100 m in La Paz, Bolivia, performed short-duration cycle ergometry at 60, 80, and 100% of maximal voluntary O2 consumption (VO2max). Three groups of subjects representing the high-altitude population mean hemoglobin (Hb), the 10th percentile Hb, and below the 1st percentile were examined to test the hypothesis that the relationship of exercise performance to Hb concentration is similar to those relationships established at low altitude. Anemic individuals (n = 8) had 23% lower voluntary VO2max and 28% lower maximal work loads compared with controls (n = 17) or marginally anemic subjects (n = 12) although the relationship of VO2 to work load was similar. Anemic individuals maintained significantly higher arterial O2 partial pressures and Hb saturations during heavy exercise (90 +/- 0.5 vs. 85 +/- 0.6%) in conjunction with a greater heart rate up to maximal effort. A significantly decreased erythrocyte 2,3-diphosphoglycerate (2,3-DPG)-to-Hb molar ratio (0.70 +/- 0.04 vs. 1.12 +/- 0.06), suggestive of a left-shifted dissociation curve in anemics, is in contrast to the expected right-shifted curve. Moderate anemics were similar to controls. Anemic individuals did not differ in arterial lactate concentration from controls at absolute work loads; anemics had significantly lower arterial lactate concentrations at maximal effort than controls with no differences in the work load-to-lactate relationship. In conclusion, O2 transport during exercise at high altitude seems unaffected by the Hb concentrations as low as the 10th percentile of the population mean.(ABSTRACT TRUNCATED AT 250 WORDS)

Heliyon ◽  
2021 ◽  
Vol 7 (3) ◽  
pp. e06420
Author(s):  
Caroline Azevedo Martins ◽  
Maria Conceição B dos Santos ◽  
Cassiano Felippe Gonçalves-de-Albuquerque ◽  
Hugo Caire Castro-Faria-Neto ◽  
Mauro Velho Castro-Faria ◽  
...  

2019 ◽  
Vol 26 (2) ◽  
pp. 165
Author(s):  
Abdullah Tamrin

ABSTRACTAnemia is a health problem that is often found in developing countries including indonesia. Iron deficiency anemia often occurs in pregnant women. Other micronutrient deficiencies such as folic and zinc and copper also play a role in the occurrence of anemia in pregnancy. The purpose of the study was to determine the relationship of iron determine the relationship of iron, folid acid, and zinc intake to hemoglobin levels in pregnant women in Paccerakkang health center Biringkanaya district Makassar city. This type of research was observational with a cross sectional stud design. The sample in this study were pregnant women who had normal hemoglobin levels of 15 people and abnormal hemoglobin levels of 17 people who examined at Paccerakkang health center Biringkanaya district, Makassar city. Iron intake, folid acid and zinc were obtained by using the 24 hour recall method and the respondents identity data was obtained from direct interviews using a questionnaire while the hemoglobin data was obtained through hemoglobin examination at Paccerakkang health center Biringkanaya district, Makassar city. The results of the analysis between the relationship between iron intake and hemoglobin levels with p value = 0,010 which means there is a relationship between iron and hemoglobin level.  The results of the analysis between the relationship of folic acid intake with hemoglobin levels with p value=0,020 which means there is a relationship between folid acid intake and hemoglobin level. The results of the analysis between the relationship between zinc intake and hemoglobin level were p=0,015 which means that there is a relationship between zinc intake and hemoglobin level


2019 ◽  
Vol 2019 ◽  
pp. 1-3 ◽  
Author(s):  
Amna Basheer M. Ahmed ◽  
Badr M. Rasheed Alsaleem

The relationship of inflammatory bowel disease (IBD) and chronic recurrent multifocal osteomyelitis (CRMO) is understood as extraintestinal rheumatic manifestations. CRMO is a chronic, relapsing, inflammatory, noninfectious disorder of the skeletal system of unknown origin. The disease course is not always recurrent. The association of CRMO and ulcerative colitis (UC) is very rarely reported. We report a case of a 10-year-old Saudi female who was diagnosed with CRMO, when she developed fever in association with left foot pain, and ulcerative colitis was confirmed endoscopically and histologically based on a previous settled diarrheal illness and severe iron deficiency anemia which required blood. Both conditions responded well to IBD therapy. To the best of our knowledge, this is the first reported case of chronic, multifocal osteomyelitis associated with pediatric UC in Saudi Arabia. This report supports the use of IBD therapy in treating CRMO.


Forests ◽  
2021 ◽  
Vol 12 (12) ◽  
pp. 1726
Author(s):  
Ayushi Gupta ◽  
Prashant K. Srivastava ◽  
George P. Petropoulos ◽  
Prachi Singh

Taxol drugs can be extracted from various species of the taxaceae family. It is an alkaloid (metabolic product) used for the treatment of various types of cancer. Since taxol is a metabolic product, multiple aspects such as edaphic, biochemical, topographic factors need to be assessed in determining the variation in Taxol Content (TC). In this study, both sensor-based hyperspectral reflectance data and absorption-based indices were tested together for the development of an advanced statistical unfolding approach to understand the influencing factors for TC in high altitude Himalayan region. Seriation analysis based on permutation matrix was applied with complete linkage and a multi-fragment heuristic scaling rule along with the common techniques such as Principal Component Analysis (PCA) and correlation to understand the relationship of TC with various factors. This study also tested the newly developed taxol indices to rule out the possibility of overlapping of TC determining bands with the foliar pigment’s wavelengths in the visible region. The result implies that T. wallichiana with a high TC is found more in its natural habitat of deep forest, relating it indirectly to elevation in the case of the montane ecosystem. Taxol is the most varying parameter among the measured variables, followed by hyperspectral Taxol content (TC) indices such as TC 2, TC 5, and carotenoids, which suggests that the indices are well versed to capture variations in TC with elevation.


2019 ◽  
Vol 7 (1) ◽  
Author(s):  
Sri Aminingsih ◽  
Alfinda Choirul Putra

Background: According to Fuady and Bangun's research (2013) iron deficiency anemia in pregnancy is the condition of mothers with hemoglobin levels below 11 gr% in the first and third trimesters or hemoglobin levels <10.5 gr% in the second trimester and is one of the causes of death in pregnant women . In Indonesia the prevalence of pregnancy anemia is relatively high, which is 38% - 71.5% with an average of 63.5%. The results of the analysis in this study knowledge affect the adherence of respondents with p = 0.011 (p <0.05). From the initial survey in Slogoretno Jatisrono Wonogiri Village conducted by researcher in 3 couples of childbearing age, only 1 mother had enough knowledge about anemia. The purpose: Describing the relationship between Knowledge Level About Anemia with Prevention Anemia for pregnancy preparation in couples of childbearing age. The research is analytic with correlation design, this study aimed to analyze the relationship of knowledge about anemia as the independent variable and anemia prevention for pregnancy preparation as the dependent variable with the number of respondents 55 people. The results of the study using the Chi-Square Correlation Test obtained p at 0,000 Results: Couples of childbearing age with high knowledge level were 40 respondents (72.73%), while those with low knowledge level were 15 respondents (27.27%). Prevent anemia performed optimally by couples of childbearing age were 28 respondents (50.91%) while anemia prevention measures were less than 27 respondents (49.09%). The Conclusion: There is a relationship between knowledge level about anemia with anemia prevention for preparation of pregnancy in couples of childbearing age. Keywords: Knowledge about anemia, anemia prevention


2018 ◽  
Vol 9 (02) ◽  
pp. 202
Author(s):  
Anik Setyowati ◽  
Sarwoko .

ABSTRAKLatar belakang : Wanita hamil merupakan salah satu kelompok yang rentan akan masalah gizi terutama anemia akibat kekurangan zat besi (Fe). Hasill RPJMN 2015-2019 ibu Hamil di Indonesia yang mengalami Anemia 37,1%, dengan program RPJMN adalah memberikan suplemen kepada ibu hamil. Target yang diharapkan pada tahun 2019 adalah Menurunkan prevalensi anemia pada ibu hamil menjadi 28%. Anemia hamil disebut “potensial danger to mother and child” (potensial membahayakan ibu dan anak), sehingga memerlukan perhatian serius dari semua pihak yang terkait dalam pelayanan kesehatan pada lini terdepan. Tujuan penelitian : mengetahui hubungan cara mengkonsumsi tablet Fe dengan kejadian anemia pada ibu hamil di Puskesmas Sidoharjo Sragen.Metode Penelitian : Penelitian menggunakan metode observasional analitik dengan pendekatan case control.  Jumlah sampel dalam penelitian ini sebanyak 62 responden, menggunakan teknik purvosive sampling dengan analisa data sperman.Hasil : Hasil dari perhitungan dengan menggunakan komputer program SPSS didapatkan nilai p value sebesar 0,0001 < 0,05, dengan nilai dengan nilai OR= 4,153, dimana cara mengkonsumsi tablet Fe salah beresiko mengalami anemia 4,153%. Kesimpulan : Ada hubungan  yang kuatantara cara mengkonsumsi tablet Fe dengan kejadian anemia ibu hamil.Kata kunci : Cara mengkonsumsi Tablet Fe, Kejadian anemia ibu hamilRELATIONSHIP  TO  TABLET  CONSUMES  Fe PREGNANT WOMEN WITH ANEMIA EVENTSABSTRACTBackground: Pregnant women are one of the groups that are susceptible to nutritional problems, especially iron-deficiency anemia (Fe). Hasill RPJMN 2015-2019 Pregnant women in Indonesia who have anemia 37.1%, with RPJMN program is to provide supplements to pregnant women. The target expected in 2019 is to reduce the prevalence of anemia in pregnant women to 28%. Anemic pregnancy is called "potential danger to mother and child", thus requiring serious attention from all parties involved in health care at the forefront. The objective of the study was to know the relationship of consuming Fe tablet with the incidence of anemia in pregnant mother at Sidoharjo Sragen Public Health Center. Research Method: The research used analytic observational method with case control approach. The number of samples in this study were 62 respondents, using the technique of purvosive sampling with sperman data analysis. Result: The result of calculation by using computer of SPSS program got p value value 0.0001 <0,05, with value with value OR = 4,153, where the consumption of Fe tablets is at risk of anemia 4,153%. Conclusion: There is a strong relationship between how to consume Fe tablets and the incidence of maternal anemiaKeywords: How to consume Fe tablet, Incidence of pregnant woman's anemia


1991 ◽  
Vol 12 (02) ◽  
pp. 241-245 ◽  
Author(s):  
S. Brown ◽  
W. Thompson ◽  
M. Bean ◽  
L. Wood ◽  
K. Nayak ◽  
...  

2011 ◽  
Vol 224 ◽  
pp. 1-7 ◽  
Author(s):  
Qing Wang ◽  
Zhao Yang Ding ◽  
Jing Da ◽  
Kun Ran ◽  
Zhi Tong Sui

Fundamental studies on geopolymer are increased rapidly because of its potential commercial applications. However, little work has been done on the relationship of the interfacial transitional zone between geopolymer and aggregate and its influence on the final chemical and physical properties of geopolymeric products derived from waste materials. In this paper, factors that influencing the interfacial transition zone of geopolymer concrete such as the type of the aggregate and the oxide compositions of raw materials was studied. The microstructure was also observed through relative devices. The presented results show that bonding strength of geopolymer-marble interfacial transitional zone, of which the 28d bonding strength reached up to 7.9 MPa, was higher than that of geopolymer-granite. The bonding strength of geopolymer-marble/geopolymer-granite interfacial transitional zone increased and finally reached up to 7.9 MPa/4.3 MPa with the molar ratio of n(SiO2)/n(Al2O3) increased within the range of 2.6~2.9. Both geopolymer-marble and geopolymer-granite bonding strength decreased as the molar ratio of n(SiO2)/ n(Na2O) increased. The mechanical properties of interfacial transitional zone between geopolymer and stone were affected by the oxide component of the geopolymer and the type of the raw materials.


1981 ◽  
Vol 27 (11) ◽  
pp. 1856-1861 ◽  
Author(s):  
M Samaja ◽  
A Mosca ◽  
M Luzzana ◽  
L Rossi-Bernardi ◽  
R M Winslow

Abstract We describe a new method for tonometry of small amounts of blood (up to 0.25 mL) at known pO2, PCO2, and temperature, in small, reusable, closed Pyrex flasks. Equilibrated blood is analyzed for oxygen saturation, pH, and organic phosphate concentration with standard techniques, and its p50 (the pO2 at which hemoglobin is half-saturated with oxygen) is determined with full control of all the variables known to affect it. The SD in the measurement of p50 is 0.044 kPa (0.33 mmHg). We made 63 determinations of p50 on normal human blood under different conditions of pH and pCO2, and with different concentrations of 2,3-diphosphoglycerate and ATP. Empirical equations and a nomogram were derived, which allow the calculation of p50 from known values of pCO2, pH, and [2,3-DPG]/[Hb4] molar ratio with a SD of 97 and 114 Pa (0.73 and 0.86 mmHg), respectively.


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