Exercise-dependent growth hormone release is linked to markers of heightened central adrenergic outflow

2000 ◽  
Vol 89 (2) ◽  
pp. 629-635 ◽  
Author(s):  
Arthur Weltman ◽  
Cathy J. Pritzlaff ◽  
Laurie Wideman ◽  
Judy Y. Weltman ◽  
Jeffery L. Blumer ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Regression Analysis ◽  
Exercise Intensity ◽  
Acute Exercise ◽  
Peak Plasma ◽  
Linear Regression Analysis ◽  
Plasma Concentrations ◽  
Intensity Change ◽  
Plasma Norepinephrine ◽  
The Difference

To test the hypothesis that heightened sympathetic outflow precedes and predicts the magnitude of the growth hormone (GH) response to acute exercise (Ex), we studied 10 men [age 26.1 ± 1.7 (SE) yr] six times in randomly assigned order (control and 5 Ex intensities). During exercise, subjects exercised for 30 min (0900–0930) on each occasion at a single intensity: 25 and 75% of the difference between lactate threshold (LT) and rest (0.25LT, 0.75LT), at LT, and at 25 and 75% of the difference between LT and peak (1.25LT, 1.75LT). Mean values for peak plasma epinephrine (Epi), plasma norepinephrine (NE), and serum GH concentrations were determined [Epi: 328 ± 93 (SE), 513 ± 76, 584 ± 109, 660 ± 72, and 2,614 ± 579 pmol/l; NE: 2.3 ± 0.2, 3.9 ± 0.4, 6.9 ± 1.0, 10.7 ± 1.6, and 23.9 ± 3.9 nmol/l; GH: 3.6 ± 1.5, 6.6 ± 2.0, 7.0 ± 2.0, 10.7 ± 2.4, and 13.7 ± 2.2 μg/l for 0.25, 0.75, 1.0, 1.25, and 1.75LT, respectively]. In all instances, the time of peak plasma Epi and NE preceded peak GH release. Plasma concentrations of Epi and NE always peaked at 20 min after the onset of Ex, whereas times to peak for GH were 54 ± 6 (SE), 44 ± 5, 38 ± 4, 38 ± 4, and 37 ± 2 min after the onset of Ex for 0.25–1.75LT, respectively. ANOVA revealed that intensity of exercise did not affect the foregoing time delay between peak NE or Epi and peak GH (range 17–24 min), with the exception of 0.25LT ( P < 0.05). Within-subject linear regression analysis disclosed that, with increasing exercise intensity, change in (Δ) GH was proportionate to both ΔNE ( P = 0.002) and ΔEpi ( P = 0.014). Furthermore, within-subject multiple-regression analysis indicated that the significant GH increment associated with an antecedent rise in NE ( P = 0.02) could not be explained by changes in Epi alone ( P = 0.77). Our results suggest that exercise intensity and GH release in the human may be coupled mechanistically by central adrenergic activation.

Impact of acute exercise intensity on pulsatile growth hormone release in men

1999 ◽  
Vol 87 (2) ◽  
pp. 498-504 ◽  
Author(s):  
Cathy J. Pritzlaff ◽  
Laurie Wideman ◽  
Judy Y. Weltman ◽  
Robert D. Abbott ◽  
Margaret E. Gutgesell ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Production Rate ◽  
Exercise Intensity ◽  
Acute Exercise ◽  
Pulse Frequency ◽  
Linear Increase ◽  
Exercise Recovery ◽  
Deconvolution Analysis ◽  
The Difference ◽  
Condition C

To investigate the effects of exercise intensity on growth hormone (GH) release, 10 male subjects were tested on 6 randomly ordered occasions [1 control condition (C), 5 exercise conditions (Ex)]. Serum GH concentrations were measured in samples obtained at 10-min intervals between 0700 and 0900 (baseline) and 0900 and 1300 (exercise+ recovery). Integrated GH concentrations (IGHC) were calculated by trapezoidal reconstruction. During Ex subjects exercised for 30 min (0900–0930) at one of the following intensities [normalized to the lactate threshold (LT)]: 25 and 75% of the difference between LT and rest (0.25LT and 0.75LT, respectively), at LT, and at 25 and 75% of the difference between LT and peak (1.25LT and 1.75LT, respectively). No differences were observed among conditions for baseline IGHC. Exercise+recovery IGHC (mean ± SE: C = 250 ± 60; 0.25LT = 203 ± 69; 0.75LT = 448 ± 125; LT = 452 ± 119; 1.25LT = 512 ± 121; 1.75LT = 713 ± 115 μg ⋅ l−1 ⋅ min−1) increased linearly with increasing exercise intensity ( P < 0.05). Deconvolution analysis revealed that increasing exercise intensity resulted in a linear increase in the mass of GH secreted per pulse and GH production rate [production rate increased from 16.5 ± 4.5 (C) to 32.1 ± 5.2 μg ⋅ distribution volume−1 ⋅ min−1(1.75LT), P < 0.05], with no changes in GH pulse frequency or half-life of elimination. We conclude that the GH secretory response to exercise is related to exercise intensity in a linear dose-response pattern in young men.

The disposition of TCNU (tauromustine) in human malignant glioma: pharmacokinetic studies and clinical implications

1990 ◽  
Vol 72 (5) ◽  
pp. 721-725 ◽  
Author(s):  
Ian R. Whittle ◽  
Janet S. MacPherson ◽  
J. Douglas Miller ◽  
John F. Smyth
Keyword(s):  
Malignant Glioma ◽  
High Performance ◽  
Peak Plasma ◽  
Linear Regression Analysis ◽  
Plasma Concentrations ◽  
Tissue Level ◽  
Pharmacokinetic Studies ◽  
Tissue Concentrations ◽  
Content Type ◽  
Chromatography Analysis

✓ Tauromustine (TCNU), 130 mg/sq m, was administered intraoperatively by nasogastric tube to 10 patients with malignant glioma (seven glioblastomas and three anaplastic astrocytomas). High-performance liquid chromatography analysis of 32 tumor specimens for TCNU revealed that tissue concentrations ranged from 0 to 554 ng/gm; TCNU was not detected in necrotic regions of the tumor. Levels of TCNU in brain adjacent to tumor were similar to those recorded within the gliomas (range 0 to 635 ng/gm). The variability in the tissue level of TCNU was partly attributable to variable absorption of the drug, since peak plasma TCNU levels ranged from 164 to 3333 ng/ml. There were close quantitative and temporal relationships between the times of peak plasma levels (median 456 ng/ml at 45 minutes after administration), peak tumor levels (median 250 ng/gm tissue at 55 minutes), and brain adjacent to tumor levels (median 256 ng/gm tissue at 50 minutes). Linear regression analysis of the ratio between tissue and plasma TCNU levels at particular times after drug administration suggest that plasma concentrations can be used to estimate tissue concentrations. This study demonstrates that TCNU enters malignant glioma. In view of the activity of TCNU against a range of tumors, a full clinical evaluation of this new nitrosourea in malignant glioma seems justified.

scholarly journals Pengaruh Penerapan Sistem Control Valve Cooler 1 Berbasis Microcontroller ATmega 2560 Terhadap Moisture Pakan After Mixing dengan Bagging Off di PT. Japfa Comfeed Indonesia, Tbk. Unit Padang

2020 ◽  
Vol 6 (2) ◽  
pp. 80
Author(s):  
Eko Solihin ◽  
Sukardi Sukardi
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Linear Regression Analysis ◽  
Control Valve ◽  
T Test ◽  
Test Results ◽  
Simple Linear Regression ◽  
Simple Linear Regression Analysis ◽  
Regression Test ◽  
The Difference

This research aims to know and analyze the effect of application of control valve Cooler 1 Based On atmega 2560 microcontroller for Moisture feed after mixing with bagging off at PT. JAPFA comfeed Indonesia, Tbk. Unit Padang. The type of research used is the study of surveys with the analysis of data used i.e. simple linear regression analysis. Based on the results of the study, testing of normality obtained the significance value of 0.200 with normal categories and R square test results worth 29.4%. The results of simple linear regression test partially with T test, Mempertlihatkan that the application of the control valve Cooler 1-Base atmega 2560 microcontroller system significantly affects the after-mixing Moisture feed with bagging off. The interpretation is that each temperature reduction of the resulting control valve cooler 1 Microcontroller-Based atmega 2560 in one unit affects the difference of moisture feed after mixing with a bagging off of 2.425.

scholarly journals GAMBARAN SUPERVISI, IKLIM KERJA SERTA KEPUASAN KERJA KARYAWAN PT. TRIBUANA REKAYASA BANDUNG

2018 ◽  
Vol 3 (1) ◽  
pp. 81-86
Author(s):  
Devi Robissalami ◽  
Sumiyati Sumiyati ◽  
Eded Tarmedi
Keyword(s):  
Regression Analysis ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Positive Influence ◽  
Cross Sectional ◽  
Employee Job Satisfaction ◽  
Analysis Technique ◽  
The Difference ◽  
Cross Sectional Design ◽  
The Impact

Purpose - The purpose of this study is to determine the effect of supervision and working climate on employee job satisfactionDesign / methodology / approach - This research was conducted in less than 1 year period, the research design is cross-sectional design. The method used is exolanatory survey, and population 67 employees. The analysis technique used is descriptive, the questionnaire is used as a research instrument to collect data from respondents.Findings - based on the results of the study using multiple linear regression analysis, the result that there is a positive influence of supervision and work climate on employee job satisfaction.Originality / value - this study provides a basis for find out the impact of supervision and working climate on employee job satisfaction. The difference of this study with previous research is on the objects, variables, theories and the references.

scholarly journals Effect of Fear of Success on Employee Career Development with Achievement Motivation as a Moderating Variable at PT. PLN (Persero) Bulukumba Area

2019 ◽  
Vol 1 (1) ◽  
pp. 1-9
Author(s):  
Eka Suhartini ◽  
S Milawati ◽  
Hardin Hardin
Keyword(s):  
Regression Analysis ◽  
Career Development ◽  
Linear Regression ◽  
Achievement Motivation ◽  
Linear Regression Analysis ◽  
Simple Linear Regression ◽  
Fear Of Success ◽  
Moderating Variables ◽  
Saturated Sample ◽  
The Difference

Career development that makes others give different views such as appreciation, recognition, appreciation and higher social status in the eyes of society. This is what makes a person want to develop. But they are confronted with the reality that makes it negative. Require success or goals to be achieved and make someone doubt the ability required to fear success. This study aims to determine the effect of fear of success on career development and interaction on achievement motivation and fear of success on career development. This type of research is quantitative with associative research. The population in this study are companies that work at PT. PLN (Persero) Bulukumba Area. The technique of taking samples uses the saturated sample method. The sample in this study was 70 respondents. Data analysis uses simple linear regression analysis and moderation regression analysis by obtaining approved difference values. The results of research with simple linear regression show a fear of positive and significant success in career development. Analysis of moderating variables with the difference in assessment proves achievement motivation is not able to moderate the fear of success in career development.  

scholarly journals Analisis Interaksi dan Perbedaan Pembelajaran Bersama dan Pembelajaran-Mandiri serta Motivasi terhadap Pengetahuan-diri pada Semester VII Sekolah Tinggi Ilmu Tarbiyah Raden Wijaya Mojokerto

2019 ◽  
Vol 2 (1) ◽  
pp. 51-56
Author(s):  
Mohammad Rodli
Keyword(s):  
High School ◽  
Regression Analysis ◽  
Hypothesis Test ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Analysis Techniques ◽  
Self Knowledge ◽  
The Difference ◽  
Self Learning ◽  
Learning Together

The purpose of this study are: 1) Describe the differences of self-knowledge with Learning together with self-learning in the seventh semester of Tarbiyah High School of Raden Wijaya Mojokerto. 2) Describe the difference of self-knowledge of high motivated and low motivated students in the seventh semester of Tarbiyah High School of Raden Wijaya Mojokerto 3) Describe the interaction between learning together with self-learning and self-knowledge motivation in semester VII Tarbiyah High School Tarriyah Raden Wijaya Mojokerto . The type of this research is survey type research with quantitative approach. Population as object of research is student of semester VII of Tarbiyah High School of Raden Wijaya Mojokerto, This research is included in research of comparative explanation. Data collection techniques used questionnaires, while data analysis techniques used multiple linear regression analysis, with hypothesis test using t test and F test. From the analysis result can be concluded as follows: 1) There is difference of self-knowledge with Learning together with self-learning. 2) There is no difference in self-knowledge that is highly motivated and students with low motivation. 3) There is an interaction between Learning along with self-learning as well as motivation to self-knowledge.

Prostaglandin E1 uptake by isolated cat lungs perfused with physiological salt solution

1981 ◽  
Vol 50 (2) ◽  
pp. 428-434 ◽  
Author(s):  
J. H. Linehan ◽  
C. A. Dawson ◽  
V. M. Wagner-Weber
Keyword(s):  
Regression Analysis ◽  
Salt Solution ◽  
Prostaglandin E1 ◽  
Bolus Injection ◽  
Linear Regression Analysis ◽  
Physiological Salt Solution ◽  
Uptake Mechanism ◽  
Bicarbonate Buffer ◽  
The Difference ◽  
High Doses

The instantaneous extraction of prostaglandin E1 (PGE1) was measured after a bolus injection of PGE1 and [14C]dextran in to the pulmonary artery of isolated cat lungs perfused with a physiological salt solution [Krebs-Ringer-bicarbonate buffer (KRB)]. The extraction ratio vs. time curves exhibited characteristic shapes. For low injected doses of PGE1, the extraction ratios were constant early in time, whereas for high doses, they were concave upward. To evaluate the data, we used a model assuming homogeneous perfusion and a saturable uptake mechanism (Michaelis-Menten kinetics) for the PGE1. The model was used in a linear regression analysis to estimate Vmax and Km. The kinetic parameters were compared with our previous results for blood-perfused lungs, and it was found that the values of Km were significantly smaller than in blood-perfused lungs but that the values of Vmax were not significantly different. These results were consistent with the observation that PGE1 uptake was greater in KRB- than in blood-perfused lungs when the dose of PGE1 was low but that the difference disappeared at high doses. The absence of plasma protein binding in KRB-perfused lungs may be responsible for the lower Km.

Is antiglycolysis required for routine glucose analysis?

1979 ◽  
Vol 25 (12) ◽  
pp. 2038-2039 ◽  
Author(s):  
K Sazama ◽  
E A Robertson ◽  
R A Chesler
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Continuous Flow ◽  
Linear Regression Analysis ◽  
Serum Glucose ◽  
Time Span ◽  
Plasma Samples ◽  
Specimen Handling ◽  
The Difference ◽  
Glucose Analysis

Abstract We obtained -68 pairs of simultaneously drawn serum and fluoride-oxalate plasma samples from patients and analyzed them by a continuous-flow (AutoAnalyzer II) glucose oxidase method. Glucose concentrations ranged from 370 to 3530 mg/L. Glucose concentrations for samples obtained in the fluoride-oxalate preservative averaged 42 +/- 35 mg/L (mean +/- SD) higher than serum. The magnitude of this difference was independent of glucose concentration. Linear-regression analysis of 270 pairs for which the time from collection to separation was recorded indicated that the difference between serum and plasma increased by 0.32 mg/L per minute of delay over a time span of 15 to 295 min. These differences are smaller than those described in standard textbooks. We conclude that, with the specimen-handling process used in our hospital, serum glucose determinations are clinically acceptable.

scholarly journals ACCOUNTANTS MORAL JUDGEMENT IN RELIGIOUS AND NON-RELIGIOUS SCHOOL BACKGROUND’S PERSPECTIVE

2018 ◽  
Vol 2 (2) ◽  
pp. 97
Author(s):  
Hariany Idris ◽  
Warka Syachbrani
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Accounting Students ◽  
Religious School ◽  
Religious Background ◽  
Data Source ◽  
The Difference

This study aims to review the conduct of investigation regarding moral judgements between accountants with religious and non-religious school background using moral indicators (moral judgment). Multiple linear regression analysis used in this study. To review the partially relationships between variables, the study operated using T-test, whereas for review simultaneous relationships between variables the study used F-test. This study using 86 respondents as a data source for review processed. The findings of the research is the Religious Background (X1) significantly affected the Accounting students morality judgement (Y), while the difference of Gender (X2) showed the opposite results.

scholarly journals GAYA HIDUP KONSUMEN DALAM PENGAMBILAN KEPUTUSAN PEMBELIAN

2017 ◽  
Vol 2 (1) ◽  
pp. 57-64
Author(s):  
Ajeng Sri Hartati ◽  
Ratih Hurriyati ◽  
Bambang Widjajanta
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Random Sampling ◽  
Research Study ◽  
Linear Regression Analysis ◽  
Purchase Decision ◽  
Simple Linear Regression ◽  
Cross Sectional ◽  
Analysis Technique ◽  
The Difference

Objective – To describe and determine the influence of lifestyle on purchasing decisions.Design/methodology/approach – This type of research is descriptive and verfikatif with random sampling of 120 respondents. Data analysis technique used is a simple linear regression The design of this study is cross sectional method with a certain period of time.Findings – Based on research results by using simple linear regression analysis showed that there is positive lifestyles of consumers on purchasing decisions.Originality/value – The difference in this study lies in the object of research, study time, measuring tools, literature used, the theory used and the results of research. Keywords: Marketing, Consumer Behavior, Lifestyle Consumer Purchase Decision, Action Cameras, GoPro.Type Article: Research paper

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