scholarly journals Individual response to exercise training - a statistical perspective

2015 ◽  
Vol 118 (12) ◽  
pp. 1450-1459 ◽  
Author(s):  
Anne Hecksteden ◽  
Jochen Kraushaar ◽  
Friederike Scharhag-Rosenberger ◽  
Daniel Theisen ◽  
Stephen Senn ◽  
...  
Keyword(s):  
Exercise Training ◽  
Predictive Accuracy ◽  
Signal To Noise Ratio ◽  
Interactive Effects ◽  
Control Group ◽  
Individual Response ◽  
Individual Level ◽  
Exercise Training Program ◽  
The Individual ◽  
Response To Exercise

In the era of personalized medicine, interindividual differences in the magnitude of response to an exercise training program (subject-by-training interaction; “individual response”) have received increasing scientific interest. However, standard approaches for quantification and prediction remain to be established, probably due to the specific considerations associated with interactive effects, in particular on the individual level, compared with the prevailing investigation of main effects. Regarding the quantification of subject-by-training interaction in terms of variance components, confounding sources of variability have to be considered. Clearly, measurement error limits the accuracy of response estimates and thereby contributes to variation. This problem is of particular importance for analyses on the individual level, because a low signal-to-noise ratio may not be compensated by increasing sample size (1 case). Moreover, within-subject variation in training efficacy may contribute to gross response variability. This largely unstudied source of variation may not be disclosed by comparison to a control group but calls for repeated interventions. A second critical point concerns the prediction of response. There is little doubt that exercise training response is influenced by a multitude of determinants. Moreover, indications of interaction between influencing factors of training efficacy lead to the hypothesis that optimal predictive accuracy may be attained using an interactive rather than additive approach. Taken together, aiming at conclusive inference and optimal predictive accuracy in the investigation of subject-by-training interaction entails specific requirements that are deducibly based on statistical principles but beset with many practical difficulties. Therefore, pragmatic alternatives are warranted.

scholarly journals Repeated testing for the assessment of individual response to exercise training

2018 ◽  
Vol 124 (6) ◽  
pp. 1567-1579 ◽  
Author(s):  
Anne Hecksteden ◽  
Werner Pitsch ◽  
Friederike Rosenberger ◽  
Tim Meyer
Keyword(s):  
Exercise Training ◽  
Training Trial ◽  
Training Group ◽  
Control Individual ◽  
Individual Response ◽  
Repeated Testing ◽  
Individual Level ◽  
The Individual ◽  
Response To Exercise ◽  
Analytical Approaches

Observed response to regular exercise training differs widely between individuals even in tightly controlled research settings. However, the respective contributions of random error and true interindividual differences as well as the relative frequency of nonresponders are disputed. Specific challenges of analyses on the individual level as well as a striking heterogeneity in definitions may partly explain these inconsistent results. Repeated testing during the training phase specifically addresses the requirements of analyses on the individual level. Here we report a first implementation of this innovative design amendment in a head-to-head comparison of existing analytical approaches. To allow for comparative implementation of approaches we conducted a controlled endurance training trial (1 yr walking/jogging, 3 days/wk for 45 min with 60% heart rate reserve) in healthy, untrained subjects ( n = 36, age = 46 ± 8 yr; body mass index 24.7 ± 2.7 kg/m2; V̇o2max 36.6 ± 5.4). In the training group additional V̇o2max tests were conducted after 3, 6, and 9 mo. Duration of the control condition was 6 mo due to ethical constraints. General efficacy of the training intervention could be verified by a significant increase in V̇o2max in the training group ( P < 0.001 vs. control). Individual training response of relevant magnitude (>0.2 × baseline variability in V̇o2max) could be demonstrated by several approaches. Regarding the classification of individuals, only 11 of 20 subjects were consistently classified, demonstrating remarkable disagreement between approaches. These results are in support of relevant interindividual variability in training efficacy and stress the limitations of a responder classification. Moreover, this proof-of-concept underlines the need for tailored methodological approaches for well-defined problems. NEW & NOTEWORTHY This work reports a first implementation of a repeated testing training trial for the investigation of individual response. This design amendment was recently proposed to address specifically the statistical requirements of analyses on the individual level. Moreover, a comprehensive comparison of previously published methods exemplifies the striking heterogeneity of existing approaches.

scholarly journals miRNA-based “Fitness Score” to Assess the Individual Response to Diet, Metabolism and Exercise

2021 ◽  
Author(s):  
Ulrike Dagmar Barbara Krammer ◽  
Sylvia Tschida ◽  
Julia Berner ◽  
Stephanie Lilja ◽  
Olivier Jerome Switzeny ◽  
...  
Keyword(s):  
Exercise Training ◽  
Cardiovascular Fitness ◽  
The Body ◽  
Hydration Status ◽  
Control Group ◽  
Individual Response ◽  
Detailed Knowledge ◽  
Fitness Score ◽  
Epigenetic Biomarkers ◽  
The Individual

Abstract Background: Regular, especially sustained exercise training plays an important role in the prevention and treatment of multiple chronic diseases. Some of the underlying molecular and cellular mechanisms behind the adaptive response to physical activity are still unclear, but recent findings suggest a possible role of epigenetic mechanisms, especially miRNAs, in the progression and management of exercise related changes. Due to the combination of the analysis of epigenetic biomarkers (miRNAs), the intake of food and supplements, and genetic dispositions, a “fitness sore” was evaluated to assess the individual response to nutrition, metabolism and exercise.Methods: In response to a 12-week sport intervention we analyzed genetic and epigenetic biomarkers in capillary blood, including Line-1 methylation, three SNPs and ten miRNAs using HRM and qPCR analysis. These biomarkers were also analyzed in a control group without intervention. Food frequency intake, including dietary supplement intake, and general health questionnaires were surveyed under the supervision of trained staff.Results: Exercise training decreased the expression of miR-20a, -22 and -505 (p < 0.02) and improved the “fitness score”, which estimates eight different lifestyle factors to assess, nutrition, inflammation, cardiovascular fitness, injury risk, regeneration, muscle- and hydration status as well as stress level. In addition, we were able to determine correlations between individual miRNAs, miR-20a, -22 and -101 (p < 0.04), and the genetic predisposition for endurance and / or strength and for obesity risk (ACE, ACTN3 and FTO), as well as between miRNAs and the body composition (p < 0.05). And we identified two miRNAs, miR-19b and -378a (p < 0.05), which could potentially provide information about the micronutrient / vitamin requirements of an athlete.Conclusions: Due to the detailed knowledge of individual regulatory mechanisms in the metabolism of sport intervention and / or nutritional behavior, this knowledge and our results can be used for personalized interventions and in the context of the new field of precision nutrition and precision training.

scholarly journals Interactive effects between travel behaviour and COVID-19: a questionnaire study

2021 ◽  
Author(s):  
Jinbao Zhang ◽  
Jaeyoung Lee
Keyword(s):  
Early Stage ◽  
Travel Behaviour ◽  
Interactive Effects ◽  
Factors Affecting ◽  
Individual Level ◽  
Passenger Volume ◽  
Spatial Autoregressive ◽  
Railway Passenger ◽  
The Individual ◽  
And Control

Abstract This study has two main objectives: (i) to analyse the effect of travel characteristics on the spreading of disease, and (ii) to determine the effect of COVID-19 on travel behaviour at the individual level. First, the study analyses the effect of passenger volume and the proportions of different modes of travel on the spread of COVID-19 in the early stage. The developed spatial autoregressive model shows that total passenger volume and proportions of air and railway passenger volumes are positively associated with the cumulative confirmed cases. Second, a questionnaire is analysed to determine changes in travel behaviour after COVID-19. The results indicate that the number of total trips considerably decreased. Public transport usage decreased by 20.5%, while private car usage increased by 6.4%. Then the factors affecting the changes in travel behaviour are analysed by logit models. The findings reveal significant factors, including gender, occupation and travel restriction. It is expected that the findings from this study would be helpful for management and control of traffic during a pandemic.

scholarly journals How to Improve the Functional Capacity of Frail and Pre-Frail Elderly People? Health, Nutritional Status and Exercise Intervention. The EXERNET-Elder 3.0 Project

2020 ◽  
Vol 12 (15) ◽  
pp. 6246 ◽  
Author(s):  
Ángel Iván Fernández-García ◽  
Alba Gómez-Cabello ◽  
Ana Moradell ◽  
David Navarrete-Villanueva ◽  
Jorge Pérez-Gómez ◽  
...  
Keyword(s):  
Exercise Training ◽  
Training Program ◽  
Functional Capacity ◽  
Exercise Intervention ◽  
Intervention Group ◽  
Residual Effects ◽  
Control Group ◽  
Healthy Habits ◽  
Exercise Training Program ◽  
Frail Elderly People

Aging is associated with the impairment of health and functional capacity, and physical exercise seems to be an effective tool in frailty prevention and treatment. The purpose of this study was to present the methodology used in the EXERNET-Elder 3.0 project that aims to evaluate the immediate and residual effects and of a multicomponent exercise training program called Elder-fit on frailty, fitness, body composition and quality of life, and also to analyse a possible dietary intake interaction according to health and metabolic status. A total of 110 frail and pre-frail elders participated in this study and were divided into a control group (CG = 52) and an intervention group (IG = 58). The IG performed a supervised multicomponent exercise training program of 6 months and 3 days per week, which included strength, endurance, balance, coordination and flexibility exercises, while the CG continued with their usual daily activities. Both groups received four speeches about healthy habits along the project. Four evaluations were performed: at baseline, after 3 months of training, at the end of the training program (6 months) and 4 months after the program had ended to examine the effects of detraining. Evaluating the efficacy, safety and feasibility of this program will help to develop efficacious physical interventions against frailty. Further, protocols should be described accurately to allow exercise programs to be successfully replicated.

scholarly journals Voluntary Language Switching in the Context of Bilingual Aphasia

2020 ◽  
Vol 10 (9) ◽  
pp. 141
Author(s):  
Nicholas Grunden ◽  
Giorgio Piazza ◽  
Carmen García-Sánchez ◽  
Marco Calabria
Keyword(s):  
Group Performance ◽  
Ecological Validity ◽  
Control Group ◽  
Control Mechanisms ◽  
Reactive Control ◽  
Language Switching ◽  
Individual Level ◽  
Language Control ◽  
Bilingual Aphasia ◽  
The Individual

As studies of bilingual language control (BLC) seek to explore the underpinnings of bilinguals’ abilities to juggle two languages, different types of language switching tasks have been used to uncover switching and mixing effects and thereby reveal what proactive and reactive control mechanisms are involved in language switching. Voluntary language switching tasks, where a bilingual participant can switch freely between their languages while naming, are being utilized more often due to their greater ecological validity compared to cued switching paradigms. Because this type of task had not yet been applied to language switching in bilingual patients, our study sought to explore voluntary switching in bilinguals with aphasia (BWAs) as well as in healthy bilinguals. In Experiment 1, we replicated previously reported results of switch costs and mixing benefits within our own bilingual population of Catalan-Spanish bilinguals. With Experiment 2, we compared both the performances of BWAs as a group and as individuals against control group performance. Results illustrated a complex picture of language control abilities, indicating varying degrees of association and dissociation between factors of BLC. Given the diversity of impairments in BWAs’ language control mechanisms, we highlight the need to examine BLC at the individual level and through the lens of theoretical cognitive control frameworks in order to further parse out how bilinguals regulate their language switching.

Definiteness in written Swedish by Finnish-speaking immersion pupils at the end of immersion

2018 ◽  
Vol 6 (1) ◽  
pp. 57-84
Author(s):  
Eeva-Liisa Nyqvist
Keyword(s):  
Control Group ◽  
Group Level ◽  
Individual Level ◽  
Definite Form ◽  
Spontaneous Writing ◽  
Acquisition Order ◽  
The Individual ◽  
The Right ◽  
Better Than

Abstract There are two primary goals for this study – first, to analyse definiteness and article use in spontaneous writing in Swedish by 15-year-old Finnish immersion students (n = 162) and secondly, to compare their performance with that of non-immersion students at the same age (n = 67). Analyses at the group level show that immersion students usually perform significantly better than the control group, but they also reveal similar problems to what L2-Swedish non-immersion students have demonstrated in previous studies, such as omission of indefinite articles and difficulty in choosing the right definite form of the noun. Still, these inaccuracies occurred less often in the data from the immersion students. The studied constructions also show at the group level an acquisition order similar to that reported in previous studies, explainable by different aspects of complexity and cross-linguistic influence. Analyses on the individual level, however, show different acquisition orders depending on the criteria being used.

Changes in Sedentary Time and Physical Activity in Response to an Exercise Training and/or Lifestyle Intervention

2014 ◽  
Vol 11 (7) ◽  
pp. 1324-1333 ◽  
Author(s):  
Sarah Kozey-Keadle ◽  
John Staudenmayer ◽  
Amanda Libertine ◽  
Marianna Mavilia ◽  
Kate Lyden ◽  
...  
Keyword(s):  
Physical Activity ◽  
Exercise Training ◽  
Lifestyle Intervention ◽  
Sedentary Time ◽  
Moderate Intensity ◽  
Control Group ◽  
Activity Levels ◽  
Exercise Training Program ◽  
Quasi Experimental ◽  
Multiple Behaviors

Background:Individuals may compensate for exercise training by modifying nonexercise behavior (ie, increase sedentary time (ST) and decrease nonexercise physical activity [NEPA]).Purpose:To compare ST and NEPA during a 12-week exercise training and/or lifestyle intervention.Methods:Fifty-seven overweight/obese participants (19 M/39 F) completed the study (mean ± SD; age 43.6 ± 9.9 y, BMI 35.1 ± 4.6 kg/m2). There were no between-group differences in activity levels at baseline. Four-arm quasi-experimental intervention study 1) EX: exercise 5 days per week at a moderate intensity (40% to 65% VO2peak) 2) rST: reduce ST and increase NEPA, 3) EX-rST: combination of EX and rST and 4) CON: maintain habitual behavior.Results:For the EX group, ST did not decrease significantly (mean ((95% confidence interval) 0.48 (–2.2 to 3.1)% and there was no changes in NEPA at week-12 compared with baseline. The changes were variable, with approximately 50% of participants increasing ST and decreasing NEPA. The rST group decreased ST (–4.8 (0.8 to 7.9)% and increased NEPA. EX-rST significantly decreased ST (–5.1 (–2.2 to 7.9)% and increased time in NEPA at week-12 compared with baseline. The control group increased ST by 4.3 (0.8 to 7.9)%.Conclusions:Changes in nonexercise ST and NEPA are variable among participants in an exercise-training program, with nearly half decreasing NEPA compared with baseline. Interventions targeting multiple behaviors (ST and NEPA) may effectively reduce compensation and increase daily activity.

scholarly journals Predictors of Neuropsychological Improvement Following Cognitive Rehabilitation in Patients with Gliomas

2010 ◽  
Vol 17 (2) ◽  
pp. 256-266 ◽  
Author(s):  
Karin Gehring ◽  
Neil K. Aaronson ◽  
Chad M. Gundy ◽  
Martin J.B. Taphoorn ◽  
Margriet M. Sitskoorn
Keyword(s):  
Test Performance ◽  
Cognitive Rehabilitation ◽  
Practical Implication ◽  
Neuropsychological Test ◽  
Patient Characteristics ◽  
Rehabilitation Program ◽  
Control Group ◽  
Specific Patient ◽  
Individual Level ◽  
The Individual

AbstractThis study investigated the specific patient factors that predict responsiveness to a cognitive rehabilitation program. The program has previously been demonstrated to be successful at the group level in patients with gliomas, but it is unclear which patient characteristics optimized the effect of the intervention at the individual level. Four categories of possible predictors of improvement were selected for evaluation: sociodemographic and clinical variables, self-reported cognitive symptoms, and objective neuropsychological test performance. Hierarchical logistic regression analyses were conducted, beginning with the most accessible (sociodemographic) variables and ending with the most difficult (baseline neuropsychological) to identify in clinical practice. Nearly 60% of the participants of the intervention were classified as reliably improved. Reliable improvement was predicted by age (p = .003) and education (p = .011). Additional results suggested that younger patients were more likely to benefit specifically from the cognitive rehabilitation program (p = .001), and that higher education was also associated with improvement in the control group (p = .024). The findings are discussed in light of brain reserve theory. A practical implication is that cognitive rehabilitation programs should take the patients’ age into account and, if possible, adapt programs to increase the likelihood of improvement among older participants. (JINS, 2011, 17, 256–266)

scholarly journals Aerobic exercise training reduces blood pressure, angiotensin II and oxidative stress of patients with resistant hypertension: the EnRiCH trial

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
S Lopes ◽  
J Mesquita-Bastos ◽  
M Teixeira ◽  
D Figueiredo ◽  
J Oliveira ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Angiotensin Ii ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Resistant Hypertension ◽  
Exercise Group ◽  
Aerobic Exercise Training ◽  
Control Group ◽  
Exercise Training Program ◽  
And Oxidative Stress

Abstract Introduction Resistant hypertension is a major challenge of modern cardiovascular medicine, as it is a puzzling problem without a clear solution. Exercise training clearly reduces blood pressure (BP) and oxidative stress in patients with hypertension, however evidence is limited regarding resistant hypertension. Purpose To determine the effect of an aerobic exercise training program in BP, angiotensin II and oxidative stress in patients with resistant hypertension. Methods EnRicH is a prospective, two-center, single-blinded, randomized controlled trial with a parallel two-arm group. Sixty patients with resistant hypertension were randomly assigned in a 1:1 ratio to undergo a 12-week aerobic exercise training program (exercise) or usual care (control). The powered primary efficacy measure was 24-hour ambulatory systolic BP change from baseline. Secondary outcome measures included daytime and nighttime ambulatory BP, office BP, cardiorespiratory fitness, and oxidative stress and inflammatory biomarkers: Interferon-gamma (IFN-y), Angiotensin II, vascular endothelial growth factor (VEGF), and superoxide dismutase (SOD). Results Fifty-three patients (exercise n=26, control n=27) completed the study. Patients were mainly women (54.7%), with an office BP of 140.7±15.9/84.2±9.4 mm Hg and taking an average of 4.6 antihypertensive medications (median, 5; range, 3 to 7). At baseline, no differences were found between groups for the study outcomes and patient characteristics. Ambulatory systolic BP was reduced −7.1 mm Hg (95% CI, −12.8 to −1.4; P=0.015) in the exercise group (127.4±12.2 to 121.2±12.2, p=0.007) compared to control group (126.1±17.2 to 126.9±15.2, p=514) over 24-hour. In addition, 24-hour ambulatory diastolic BP (−5.1 mm Hg, −7.9 to −2.3, P=0.001), daytime ambulatory systolic (−8.4 mm Hg, −14.3 to −2.5, P=0.006), and diastolic BP (−5.7 mm Hg, −9.0 to −2.4, P=0.001) were also reduced in the exercise group compared to the control group. There were no differences in the change of nighttime ambulatory BP between groups. Cardiorespiratory fitness improved in the exercise group by 14% (4.7 ml.kg-1.min-1, P&lt;0.001), while it remained unchanged in the control group (−0.37 ml.kg-1.min-1, P=0.442). A significant between-group difference in favor of exercise group was found for IFN-y (−4.3 pg/mL, 95% CI: −7.1 to −1.5; P=0.003), Angiotensin II (−157.0 pg/mL, 95% CI: −288.1 to −25.9; P=0.020), VEGF (10.53 pg/mL, 95% CI: 0.60 to 22.54; P=0.035), and SOD (0.35 pg/mL, 95% CI: 0.10 to 0.58; P=0.009). Conclusions A 12-week moderate intensity aerobic exercise program reduced ambulatory BP, angiotensin II and oxidative stress in patients with resistant hypertension. The antihypertensive effects of exercise in patients with resistant hypertension may be mediated by positive changes in oxidative stress and inflammatory biomarkers. FUNDunding Acknowledgement Type of funding sources: Foundation. Main funding source(s): European Union through European Regional Development Fund – Operational Competitiveness Factors Program (COMPETE)Portuguese Government through FCT - Foundation for Science and Technology

scholarly journals Toward understanding three phases of individual responses to paradox

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Gunnar Birkelund
Keyword(s):  
Future Research ◽  
Individual Response ◽  
Content Type ◽  
Individual Level ◽  
Three Phase ◽  
Paradox Theory ◽  
The Individual ◽  
The Relationship ◽  
Three Phases

PurposeThe purpose of this study is to further paradox research at the individual level through applying a framework of three phases of individual response to paradox – recognition, understanding and behaviour.Design/methodology/approachCritical and integrative review of previous studies of individual responses to paradox.FindingsThe role of individual understanding is limited in extant research on individual responses to paradox. Individual understanding tends to be equated with behaviour, and thus knowledge of understanding is not differentiated enough, neither is the link between understanding and behaviour sufficiently developed.Research limitations/implicationsThe review does not consider the relationship to interactional, organisational and environmental contexts. The recommendation for future research is to explore individual responses to paradox more entirely, to provide an adequate ground for extending paradox theory across individual and broader levels of analysis.Originality/valueThe review contributes to paradox theory by separating individual understanding and then providing a framework in which recognition, understanding and behaviour can be reintegrated in new ways. In addition to more accurate discernment of individual understanding and of combinations of responses across phases, the three-phase framework facilitates investigation of more intricate influences across phases and paths of evolution of such responses over time.

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