scholarly journals Therapies with Emerging Evidence of Efficacy: Avotermin for the Improvement of Scarring

2010 ◽  
Vol 2010 ◽  
pp. 1-6 ◽  
Author(s):  
Jim Bush ◽  
Karen So ◽  
Tracey Mason ◽  
Nick L. Occleston ◽  
Sharon O'Kane ◽  
...  
Keyword(s):  
Normal Skin ◽  
Phase Iii ◽  
Non Invasive ◽  
Wide Range ◽  
The Us ◽  
Invasive Techniques ◽  
Visible Body ◽  
The Eu ◽  
Phase I And Ii

Many patients are dissatisfied with scars on both visible and non-visible body sites and would value any opportunity to improve or minimise scarring following surgery. Approximately 44 million procedures in the US and 42 million procedures in the EU per annum could benefit from scar reduction therapy. A wide range of non-invasive and invasive techniques have been used in an attempt to improve scarring although robust, prospective clinical trials to support the efficacy of these therapies are lacking. Differences in wound healing and scar outcome between early fetal and adult wounds led to interest in the role of the TGFβfamily of cytokines in scar formation and the identification of TGFβ3 (avotermin) as a potential therapeutic agent for the improvement of scar appearance. Extensive pre-clinical and human Phase I and II clinical trial programmes have confirmed the scar improving efficacy of avotermin which produces macroscopic and histological improvements in scar architecture, with improved restitution of the epidermis and an organisation of dermal extracellular matrix that more closely resembles normal skin. Avotermin is safe and well tolerated and is currently in Phase III of clinical development, with the first study, in patients undergoing scar revision surgery, fully recruited.

Role of Cardiac MRI in Detecting Familial Hypertrophic Cardiomyopathy: Review

2016 ◽  
Vol 1 (1) ◽  
pp. 4
Author(s):  
Marymol Koshy ◽  
Bushra Johari ◽  
Mohd Farhan Hamdan ◽  
Mohammad Hanafiah
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Magnetic Resonance ◽  
Genetic Disorder ◽  
Familial Hypertrophic Cardiomyopathy ◽  
Non Invasive ◽  
Wide Range ◽  
Proper Diagnosis ◽  
Magnetic Resonance Imaging Mri ◽  
Potential Use

Hypertrophic cardiomyopathy (HCM) is a global disease affecting people of various ethnic origins and both genders. HCM is a genetic disorder with a wide range of symptoms, including the catastrophic presentation of sudden cardiac death. Proper diagnosis and treatment of this disorder can relieve symptoms and prolong life. Non-invasive imaging is essential in diagnosing HCM. We present a review to deliberate the potential use of cardiac magnetic resonance (CMR) imaging in HCM assessment and also identify the risk factors entailed with risk stratification of HCM based on Magnetic Resonance Imaging (MRI).

CT scan and 3D reconstructions of Pre-Dynastic child mummy 527 B* (Museum of Anthropology and Ethnography of Turin)

1970 ◽  
Vol 80 (1) ◽  
Author(s):  
Raffaella Bianucci ◽  
Rosa Boano ◽  
Gino Carnazza ◽  
Rudy Lallo ◽  
Grazia Mattutino ◽  
...  
Keyword(s):  
Ct Scan ◽  
Spiral Ct ◽  
Whole Body ◽  
Age At Death ◽  
Non Invasive ◽  
Thin Slices ◽  
Invasive Techniques ◽  
The University ◽  
Reconstruction Interval

Mummy 527 B* belongs to the “Giovanni Marro” Egyptian Collection of the Museum of Anthropology and Ethnography of the University of Turin. This mummy of a oneyear- old pre-dynastic child was found in Gebelein in 1935 in a small necropolis discovered during excavations of the “Missione Archeologica Italiana” led by G. Farina, the new Director of the Egyptian Museum of Turin, with the participation of Prof. G. Marro as anthropologist. A whole body spiral CT scan with thin slices (1,00 mm thickness, 0,5 mm reconstruction interval) was followed by multiplanar and 3D reconstruction. The aim was to evaluate the child’s age at death and the presence of lethal pathologies. This study confirms the fundamental role of non-invasive techniques in the study of such rare pre-dynastic specimens.

scholarly journals Jan Hornat: Transatlantic Democracy Assistance. Promoting Different Models of Democracy.

2019 ◽  
Vol 54 (2) ◽  
pp. 70-73
Author(s):  
Veronika Bílková
Keyword(s):  
Political Theory ◽  
Democratic Governance ◽  
Us Foreign Policy ◽  
Democracy Promotion ◽  
Democracy Assistance ◽  
Constructivist View ◽  
The Us ◽  
Definition Of ◽  
The Eu

The approaches of EU institutions and the US to democracy assistance often vary quite significantly as both actors choose different means and tactics. The nuances in the understandings of democracy on the part of the EU and the US lead to their promotion of models of democratic governance that are often quite divergent and, in some respects, clashing. This book examines the sources of this divergence and by focusing on the role of the actors’ "democratic identity" it aims to explain the observation that both actors use divergent strategies and instruments to foster democratic governance in third countries. Taking a constructivist view, it demonstrates that the history, expectations and experiences with democracy of each actor significantly inform their respective definition of democracy and thus the model of democracy they promote abroad. This book will be of key interest to scholars, students and practitioners in democracy promotion, democratization, political theory, EU and US foreign policy and assistance, and identity research.

scholarly journals The Pandemic and the Crisis in the System of International Relations

2020 ◽  
Vol 13 (5) ◽  
pp. 6-19
Author(s):  
Al. A. Gromyko
Keyword(s):  
International Relations ◽  
International Institutions ◽  
Competitive Advantages ◽  
Direct Impact ◽  
The Us ◽  
The World ◽  
World Economic ◽  
Strategic Autonomy ◽  
The Eu

The research is focused on several key problems in the system of international relations influenced by the COVID-19 pandemic. It is shown that the events caused by it and broadly identified as a coronacrisis have a direct impact on the world economic contradictions (pandenomica) and political ones, including the sphere of security. These particular aspects are chosen as the main objects of the research. The author contends that the factor of the pandemic has sharpened the competition between regional and global players and has increased the role of a nation- state. In the conditions of transregional deglobalisation, regionalism and “protectionism 2.0” get stronger under the banners of “strategic vulnerability” and “economic sovereignty”. A further weakening of multilateral international institutions continues. The EU endeavours to secure competitive advantages on the basis of relocalisation, industrial and digital policies and the Green Deal. The article highlights the deterioration in the relations among Russia, the US, the EU and China, the unfolding decoupling between Washington and its European allies, which stimulates the idea of the EU strategic autonomy. An urgent need for the deconfliction in Russia – NATO interaction is stated.

The role of public diplomacy in defending national and coalition interests (for example, the US, NATO and the EU)

2020 ◽  
pp. 61-69
Author(s):  
V. I. Vinokurov
Keyword(s):  
Public Diplomacy ◽  
The Us ◽  
Definition Of ◽  
The Eu

The article gives a definition of public diplomacy, reveals the dualism of its functions, emphasizes the role and place of public diplomacy in upholding national and bloc interests.

Hungary: the policy of maneuvering between the EU, USA, China, and Russia

2021 ◽  
pp. 58-70
Author(s):  
Oleg G. Volotov ◽  
◽  
Sergei O. Volotov ◽  
Keyword(s):  
Economic Development ◽  
Point Of View ◽  
Political Rights ◽  
Special Position ◽  
Anti Semitism ◽  
The Us ◽  
Social And Economic Development ◽  
Standing Up ◽  
The Eu

In recent years, Hungary has frequently declared its special position on various issues, which differs from the point of view represented by Brussels. Brussels has, in return, criticized the Hungarian administration for restricting political rights, the growing role of state in the country's social and economic development, its persistent refusal to accept compulsory migrant quotas, its confrontation with Ukraine, and even its alleged anti-Semitism. The disaffection of Brussels with Hungarian Government policies was reflected in the Sargentini Report, which led to the threat of launching a procedure under Article 7 of the Treaty of Lisbon, which would have potentially suspended Hungary's voting rights in the EU and cut off its EU funding. Despite the existing divisions, Hungary values its EU and NATO memberships, as well as the improvements in relations with the US, although it still strives for independence while standing up for its own sovereignty. One of the tools of Hungarian foreign policy is the turn to the East, first and foremost to China and Russia, that allows Hungary to maneuver in a more effective way between the contemporary centers of power.

7. Challenging EU action or inaction

2019 ◽  
pp. 312-355
Author(s):  
Elspeth Berry ◽  
Matthew J. Homewood ◽  
Barbara Bogusz
Keyword(s):  
Member States ◽  
The Rule Of Law ◽  
Locus Standi ◽  
Wide Range ◽  
Complete Series ◽  
Explanatory Text ◽  
The Relationship ◽  
Primary Materials ◽  
The Eu

Titles in the Complete series combine extracts from a wide range of primary materials with clear explanatory text to provide readers with a complete introductory resource. This chapter discusses the role of the Court of Justice in ensuring that the rule of law in the EU is observed both by Member States and EU Institutions. The chapter examines infringement actions under Article 258 TFEU, and financial penalties for Member States under Article 260 TFEU. The discussion of judicial review considers acts that may be challenged; who can bring an action under Article 263 TFEU; permissible applicants under Article 263 TFEU; non-privileged applicants; reforming the criteria for locus standi for non-privileged applicants. The chapter also explains the grounds for annulment; the effect of annulment; the plea of illegality; failure to act; and the relationship between Article 263 TFEU and Article 265 TFEU.

The Role of Regulatory Impact Assessment in Fighting Climate Change and the Economic Downturn: A EU-US Perspective

2010 ◽  
Vol 1 (3) ◽  
pp. 251-257 ◽  
Author(s):  
Jacopo Torriti ◽  
Ragnar Lofstedt
Keyword(s):  
Climate Change ◽  
Impact Assessment ◽  
The United States ◽  
Regulatory Competition ◽  
Economic Downturn ◽  
The European Union ◽  
The Us ◽  
Regulatory Impact ◽  
The Eu

In times of low economic growth and post-Copenhagen climate talks, a number of reasons for regulatory competition and cooperation between the United States and the European Union coexist. This paper discusses the role of Impact Assessment between the US and the EU on responses to the economic downturn and climate change. It is argued that, in the future, IAs will be an instrument through which it will be possible to read the level of cooperation and competition between the US and the EU, particularly on economic trade and environmental regulation.

scholarly journals Aflibercept in the Treatment of Metastatic Colorectal Cancer

2012 ◽  
Vol 6 ◽  
pp. CMO.S7432 ◽  
Author(s):  
Tzu-Fei Wang ◽  
Albert Craig Lockhart
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Progression Free Survival ◽  
Phase Iii ◽  
Phase Iii Trial ◽  
Free Survival ◽  
The Third ◽  
Common Cancer ◽  
The Us

Colorectal cancer is the third most common cancer in the US. In recent decades, an improved understanding of the role of the angiogenesis pathway in colorectal cancer has led to advancements in treatment. Bevacizumab has been shown to improve the progression-free survival and overall survival when combined with cytotoxic chemotherapy in patients with metastatic colorectal cancer, and at present is the only antiangiogenesis agent approved for the treatment of this cancer. Aflibercept is a novel angiogenesis-targeting agent, and has demonstrated efficacy in treating metastatic colorectal cancer in a recent randomized Phase III trial. Here we review the role of angiogenesis in the tumorigenesis of colorectal cancer, strategies for targeting angiogenesis, and the clinical development of aflibercept.

scholarly journals Spontaneous Intracerebral and Intraventricular Hemorrhage

Neurosurgery ◽  
2014 ◽  
Vol 74 (suppl_1) ◽  
pp. S142-S150 ◽  
Author(s):  
Mahua Dey ◽  
Agnieszka Stadnik ◽  
Issam A. Awad
Keyword(s):  
Randomized Trials ◽  
Lessons Learned ◽  
National Institutes Of Health ◽  
Phase Iii ◽  
Recent Experience ◽  
Preliminary Treatment ◽  
Phase Ii Trials ◽  
Invasive Techniques ◽  
The Impact

Abstract Optimal management of spontaneous intracerebral hemorrhage (ICH) remains one of the highly debated areas in the field of neurosurgery. Earlier studies comparing open surgical intervention with best medical management failed to show a clear benefit. More recent experience with minimally invasive techniques has shown greater promise. Well-designed phase II trials have confirmed the safety and preliminary treatment effect of thrombolytic aspiration and clearance of spontaneous ICH and associated intraventricular obstructive hemorrhage. Those trials are reviewed, including respective protocols and technical nuances, and lessons learned regarding patient selection, the concept of hemorrhage stabilization, optimization of the surgical procedure, and thrombolytic dosing decisions. These concepts have been incorporated in the design of ongoing definite phase III randomized trials (MISTIE and CLEAR) funded by the National Institutes of Health. These are presented including the role of surgical leadership in the training and monitoring of the surgical task and quality assurance. The impact of these techniques on neurosurgical practice is discussed.

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