scholarly journals Tangential Biopsy Thickness versus Lesion Depth in Longitudinal Melanonychia: A Pilot Study

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Nilton Di Chiacchio ◽  
Walter Refkalefsky Loureiro ◽  
Nilceo Schwery Michalany ◽  
Felipe Veiga Kezam Gabriel
Keyword(s):  
Nail Plate ◽  
Histopathological Diagnosis ◽  
Total Thickness ◽  
Thickness Measure ◽  
Histopathologic Diagnosis ◽  
The Matrix ◽  
General Average ◽  
The Mean ◽  
Longitudinal Melanonychia ◽  
Hematoxylin Eosin

Longitudinal melanonychia can be caused by melanocyte activation (hypermelanosis) or proliferation (lentigo, nevus or melanoma). Histopathologic examination is mandatory for suspicious cases of melanomas. Tangential biopsy of the matrix is an elegant technique avoiding nail plate dystrophy, but it was unknown whether the depth of the sample obtained by this method is adequate for histopathologic diagnosis. Twenty-two patients with longitudinal melanonychia striata were submitted to tangential matrix biopsies described by Haneke. The tissue was stained with hematoxylin-eosin and the specimens were measured at 3 distinct points according to the total thickness: largest (A), intermediate (B) and narrowest (C) then divided into 4 groups according to the histopathologic diagnosis (G1: hypermelanosis; G2: lentigos; G3: nevus; G4: melanoma). The lesions were measured using the same method. The mean specimen/lesion thickness measure values for each group was: G1: 0,59/0,10 mm, G2: 0,67/0,08 mm, G3: 0,52/0,05 mm, G4: 0,58/0,10 mm. The general average thickness for all the specimens/lesions was 0,59/0,08 mm. We concluded that the tangential excision, for longitudinal melanonychia, provides an adequate material for histopathological diagnosis.

scholarly journals Subungual Glomus Tumor: A Review of 15 Cases Treated with Partial Nail Plate Excision Technique

2021 ◽  
Author(s):  
Mahmoud Farzan ◽  
Mahdi Neshan ◽  
Amir Reza Farhoud ◽  
Abbas Abdoli
Keyword(s):  
Glomus Tumor ◽  
Nail Plate ◽  
Tumor Location ◽  
Tumor Treatment ◽  
Nail Bed ◽  
Nail Deformity ◽  
Surgical Methods ◽  
The Matrix ◽  
The Mean

Background: Although there are various surgical methods for subungual glomus tumor treatment, there is no consensus on the optimal surgical approach. Methods: We analyzed the outcomes of 15 patients treated with partial nail plate excision technique. The medial or lateral section of the nail plate was excised longitudinally based on the tumor location. After incision of the nail bed and tumor removal, the matrix was repaired carefully. Results: In this study, 15 people, including 11 men and four women, were studied. The mean onset of symptoms until diagnosis was 88 months. In the postoperative evaluation, the mean follow-up was 20 months. Two patients had recurrent tumors, and one had postoperative nail deformity. Conclusion: Meticulous nail bed repair and complete tumor excision are key treatment points needed to prevent nail deformity and recurrence.  

Development of Prolonged Delivery of Tramadol and Dissolution Translation by Statistical Data Treatment

2011 ◽  
Vol 4 (1) ◽  
pp. 1331-1337
Author(s):  
P B Parejiya ◽  
B S Barot ◽  
P K Shelat
Keyword(s):  
Drug Release ◽  
Study Data ◽  
Stability Study ◽  
Dissolution Time ◽  
Matrix Tablet ◽  
Burst Effect ◽  
The Matrix ◽  
The Mean ◽  
The Difference ◽  
Dissolution Efficiency

The present study was carried out to fabricate a prolonged design for tramadol using Kollidon SR (Polyvinyl acetate and povidone based matrix retarding polymer). Matrix tablet formulations were prepared by direct compression of Kollidon SR of a varying proportion with a fixed percentage of tramadol. Tablets containing a 1:0.5 (Drug: Kollidon SR) ratio exhibited a rapid rate of drug release with an initial burst effect. Incorporation of more Kollidon SR in the matrix tablet extended the release of drug with subsequent minimization of the burst effect as confirmed by the mean dissolution time, dissolution efficiency and f2 value. Among the formulation batches, a direct relationship was obtained between release rate and the percentage of Kollidon SR used. The formulation showed close resemblance to the commercial product Contramal and compliance with USP specification. The results were explored and explained by the difference of micromeritic characteristics of the polymers and blend of drug with excipients. Insignificant effects of various factors, e.g. pH of dissolution media, ionic strength, speed of paddle were found on the drug release from Kollidon-SR matrix. The formulation followed the Higuchi kinetic model of drug release. Stability study data indicated stable character of Batch T6 after short-term stability study.

An Overall Approach for Microcrack and Inhomogeneity Toughening in Brittle Solids

1999 ◽  
Vol 15 (2) ◽  
pp. 57-68
Author(s):  
Huang Hsing Pan
Keyword(s):  
Poisson Ratio ◽  
Crack Density ◽  
Mean Field ◽  
Analytic Form ◽  
Density Parameter ◽  
Brittle Solids ◽  
The Matrix ◽  
Microcrack Toughening ◽  
Average Quantity ◽  
The Mean

ABSTRACTBased on the weight function theory and Hutchinson's technique, the analytic form of the toughness change near a crack-tip is derived. The inhomogeneity toughening is treated as an average quantity calculated from the mean-field approach. The solutions are suitable for the composite materials with moderate concentration as compared with Hutchinson's lowest order formula. The composite has the more toughened property if the matrix owns the higher value of the Poisson ratio. The composite with thin-disc inclusions obtains the highest toughening and that with spheres always provides the least effective one. For the microcrack toughening, the variations of the crack shape do not significantly affect the toughness change if the Budiansky and O'Connell crack density parameter is used. The explicit forms for three types of the void toughening and two types of the microcrack toughening are also shown.

Theoretical analysis of a rolling-sliding elastohydrodynamic lubrication line contact with a subsurface inclusion

2019 ◽  
Vol 233 (8) ◽  
pp. 1197-1207
Author(s):  
Armando Félix Quiñonez ◽  
Guillermo E Morales Espejel
Keyword(s):  
Elastohydrodynamic Lubrication ◽  
Element Model ◽  
Von Mises Stress ◽  
Transient Effects ◽  
Mean Velocity ◽  
The Matrix ◽  
Soft Inclusion ◽  
The Mean ◽  
Von Mises ◽  
Fully Coupled

This work investigates the transient effects of a single subsurface inclusion over the pressure, film thickness, and von Mises stress in a line elastohydrodynamic lubrication contact. Results are obtained with a fully-coupled finite element model for either a stiff or a soft inclusion moving at the speed of the surface. Two cases analyzed consider the inclusion moving either at the same speed as the mean velocity of the lubricant or moving slower. Two additional cases investigate reducing either the size of the inclusion or its stiffness differential with respect to the matrix. It is shown that the well-known two-wave elastohydrodynamic lubrication mechanism induced by surface features is also applicable to the inclusions. Also, that the effects of the inclusion become weaker both when its size is reduced and when its stiffness approaches that of the matrix. A direct comparison with predictions by the semi-analytical model of Morales-Espejel et al. ( Proc IMechE, Part J: J Engineering Tribology 2017; 231) shows reasonable qualitative agreement. Quantitatively some differences are observed which, after accounting for the semi-analytical model's simplicity, physical agreement, and computational efficiency, may then be considered as reasonable for engineering applications.

Lead inclusions in aluminium

1989 ◽  
Vol 157 ◽  
Author(s):  
E. Johnson ◽  
L. Gråbaek ◽  
J. Bohr ◽  
A. Johansen ◽  
L. Sarholt-Kristensen ◽  
...  
Keyword(s):  
Hysteresis Loop ◽  
Room Temperature ◽  
Noble Gas ◽  
Melting Transition ◽  
X Ray Diffraction ◽  
Free Surfaces ◽  
The Matrix ◽  
Mean Size ◽  
The Mean ◽  
Spontaneous Phase

ABSTRACTIon implantation at room temperature of lead into aluminium leads to spontaneous phase separation and formation of lead precipitates growing topotactically with the matrix. Unlike the highly pressurised (∼ 1–5 GPa) solid inclusions formed after noble gas implantations, the pressure in the lead precipitates is found to be less than 0.12 GPa.Recently we have observed the intriguing result that the lead inclusions in aluminium exhibit both superheating and supercooling [1]. In this paper we review and elaborate on these results. Small implantation-induced lead precipitates embedded in an aluminium matrix were studied by X-ray diffraction. The (111) Bragg peak originating from the lead crystals was followed during several temperature cycles, from room temperature to 678 K. The melting temperature for bulk lead is 601 K. In the first heating cycle we found a superheating of the lead precipitates of 67 K before melting occurred. During subsequent cooling a supercooling of 21 K below the solidification point of bulk lead was observed. In the subsequent heating cycles this hysteresis at the melting transition was reproducible. The full width of the hysteresis loop slowly decreased to 62 K, while the mean size of the inclusions gradually increased from 14.5 nm to 27 nm. The phenomena of superheating and supercooling are thus most pronounced for the small crystallites. The persistence of the hysteresis loop over successive heating cycles demonstrate that its cause is intrinsic in nature, and it is believed that the superheating originates from the lack of free surfaces of the lead inclusions.

Vesseg: An Open-Source Tool for Deep Learning-Based Atherosclerotic Plaque Quantification in Histopathology Image

2021 ◽  
Author(s):  
J.M. Murray ◽  
P. Pfeffer ◽  
R. Seifert ◽  
A. Hermann ◽  
J. Handke ◽  
...  
Keyword(s):  
Deep Learning ◽  
Open Source ◽  
Atherosclerotic Plaque ◽  
State Of The Art ◽  
The Mean ◽  
Time Savings ◽  
Plaque Quantification ◽  
Atherosclerosis Research ◽  
Hematoxylin Eosin ◽  
Microscopy Images

Objective: Manual plaque segmentation in microscopy images is a time-consuming process in atherosclerosis research and potentially subject to unacceptable user-to-user variability and observer bias. We address this by releasing Vesseg a tool that includes state-of-the-art deep learning models for atherosclerotic plaque segmentation. Approach and Results: Vesseg is a containerized, extensible, open-source, and user-oriented tool. It includes 2 models, trained and tested on 1089 hematoxylin-eosin stained mouse model atherosclerotic brachiocephalic artery sections. The models were compared to 3 human raters. Vesseg can be accessed at https://vesseg .online or downloaded. The models show mean Soerensen-Dice scores of 0.91±0.15 for plaque and 0.97±0.08 for lumen pixels. The mean accuracy is 0.98±0.05. Vesseg is already in active use, generating time savings of >10 minutes per slide. Conclusions: Vesseg brings state-of-the-art deep learning methods to atherosclerosis research, providing drastic time savings, while allowing for continuous improvement of models and the underlying pipeline.

scholarly journals Nanometer Scale Tomographic Investigation of Fine Scale Precipitates in a CuFeNi Granular System by Three-Dimensional Field Ion Microscopy

2012 ◽  
Vol 18 (5) ◽  
pp. 1129-1134 ◽  
Author(s):  
Sophie Cazottes ◽  
François Vurpillot ◽  
Abdeslem Fnidiki ◽  
Dany Lemarchand ◽  
Marcello Baricco ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Precise Determination ◽  
Atomic Scale ◽  
Granular System ◽  
Field Ion Microscopy ◽  
Mean Diameter ◽  
The Matrix ◽  
The Mean ◽  
Ion Microscopy

AbstractThe microstructure of Cu80Fe10Ni10 (at. %) granular ribbons was investigated by means of three-dimensional field ion microscopy (3D FIM). This ribbon is composed of magnetic precipitates embedded in a nonmagnetic matrix. The magnetic precipitates have a diameter smaller than 5 nm in the as-spun state and are coherent with the matrix. No accurate characterization of such a microstructure has been performed so far. A tomographic characterization of the microstructure of melt spun and annealed Cu80Fe10Ni10 ribbon was achieved with 3D FIM at the atomic scale. A precise determination of the size distribution, number density, and distance between the precipitates was carried out. The mean diameter for the precipitates is 4 nm in the as-spun state. After 2 h at 350°C, there is an increase of the size of the precipitates, while after 2 h at 400°C the mean diameter of the precipitates decreases. Those data were used as inputs in models that describe the magnetic and magnetoresistive properties of this alloy.

scholarly journals Effect of Methotrexate in the Treatment of Distal Interphalangeal Joint Extensor Tendon Enthesopathy in Patients with Nail Psoriasis

2018 ◽  
Vol 7 (12) ◽  
pp. 546 ◽  
Author(s):  
Magdalena Krajewska-Włodarczyk ◽  
Agnieszka Owczarczyk-Saczonek ◽  
Waldemar Placek ◽  
Maja Wojtkiewicz ◽  
Joanna Wojtkiewicz
Keyword(s):  
Nail Plate ◽  
Extensor Tendon ◽  
Interphalangeal Joint ◽  
Response To Treatment ◽  
Distal Interphalangeal Joint ◽  
Nail Psoriasis ◽  
The Matrix ◽  
Tendon Thickness ◽  
Distal Interphalangeal ◽  
Methotrexate Treatment

To assess the effect of methotrexate on the development of distal interphalangeal joint extensor tendon enthesopathy in psoriasis, thirty-two people aged 34 to 57 years with nail psoriasis and distal interphalangeal joint extensor tendon enthesopathy (19 patients with Ps (psoriasis) and 13 with PsA (psoriatic arthritis) were started on methotrexate at 15 to 25 mg/week and the treatment was continued for 6 months). A total of 319 nails were examined. After six months of treatment, the thicknesses of the nail plate, nail bed and nail matrix were found to decrease in both groups of patients. Methotrexate treatment resulted in a decrease in the joint extensor tendon thickness only in patients with Ps (0.94 ± 0.05 vs. 0.96 ± 0.04, p < 0.001), where the tendon thickness after treatment correlated with the matrix thickness (r = 0.337, p = 0.018) and with the bed thickness (r = 0.299, p = 0.039). Methotrexate treatment resulted in a decrease in the extensor tendon thickness only in patients with Ps but not in PsA. The findings of this study may suggest the effectiveness of systemic treatment of nail psoriasis in patients without arthritis and the use of US nail examinations in Ps and PsA patients in morphological change assessment and response to treatment.

scholarly journals LIVER BIOPSY

2011 ◽  
Vol 18 (04) ◽  
pp. 709-714
Author(s):  
FUAD AHMAD SIDDIQI ◽  
RIZWANA KITCHLEW ◽  
ASIF HASHMI
Keyword(s):  
Liver Biopsy ◽  
Liver Tissue ◽  
Blood Donors ◽  
Carrier State ◽  
Military Hospital ◽  
Histopathologic Diagnosis ◽  
Right Lobe ◽  
The Mean ◽  
One Year ◽  
Made In

Objective: To study the safety and efficacy of Surecut needle in obtaining the liver tissue by percutaneous liver biopsy. Design: Single centered prospective hospital based study. Place and duration of study: Department of Internal medicine (Unit-1) & Family ward, Combined military hospital Lahore for more than one year from August 2002 to March 2004. Materials and Methods: One hundred and fifty patients of either gender having asymptomatic hepatitis C carrier state, healthy blood donors, with positive HCV-PCR were included in study. The patients liver biopsy was done with Surecut needle 16G with patient breath suspended in expiration from the periphery of right lobe of liver. Result: Majority of patients, 135 ( 90% ) were male and 15 (10%) were female. The mean age was 30.3 years with range of 25-55years. In 146(97.31%)patients successful biopsy was done while the biopsy was non-diagnostic in 4(2.69%) patients. Mean core length of liver tissue obtained was Mean+sd(1.2+0.42cm) and histopathologic diagnosis was made in 97.31% cases. Total number of attempts were 1-2. In 99% single attempt was done. No major complications related to procedure was seen. Conclusions: liver biopsy with Surecut needle is safe and effective in establishing the diagnosis of Chronic hepatitis.

scholarly journals The Histopathological Analysis of 122 Cases of Ovarian Lesions

2021 ◽  
Vol 15 (6) ◽  
pp. 1397-1399
Author(s):  
Z. Kashif ◽  
S. Z. Warriach ◽  
M. B. Pasha ◽  
S. S. Ali ◽  
A. U Rehman ◽  
...  
Keyword(s):  
Marital Status ◽  
Retrospective Review ◽  
Malignant Neoplasm ◽  
Ovarian Cysts ◽  
Histopathological Analysis ◽  
Histopathological Diagnosis ◽  
The Mean ◽  
Final Histological Diagnosis ◽  
Bilateral Lesions ◽  
Ovarian Involvement

Aim: To outline various histopathological types of ovarian cysts received in our teaching hospital along with their prevalence and mode of presentation and to assess the proportion of physiologic versus pathological cysts and benign versus malignant ovarian cysts. Duration of study: From Jan 2019 to March 2021. Methods: Histopathology Department of Bakhtawar Amin Medical & Dental College & Hospital, Multan. A retrospective review of 122 ovarian lesions including physiological/functional cysts, pathological non neoplastic cysts as well as benign, borderline and malignant neoplasm. Histopathology reports of all ovarian specimens were reviewed and counted. Details like age, marital status, parity, presenting complaints, procedure opted, laterality, size, gross and microscopic details and final histological diagnosis etc were recorded. H&E stained slides of all cases were reviewed. In difficult suspicious cases, immunohistochemistry was also carried out. Percentage and proportions were calculated for all the variables. Relevant tables and charts were computed. Results: A total of 122 ovarian specimens with some lesion were segregated in histopathology department of Bakhtawar Amin Hospital from 117 patients with 5 patients having bilateral lesions. The mean age was 33.2 years (ranging from 13-71 years). Most ladies presented between 25-45 years of age. Out of these 117 patients, 18 ladies were unmarried. Out of the 99 married, 12 were nulliparous. Sixty four ladies (54.7%) found to have cysts/neoplasm in right sided ovary, forty eight (41%) presented with left sided ovarian involvement and 5 (4.3 %) presented with bilateral ovarian lesions. Conclusion: Non neoplastic ovarian cysts are more frequent as compared to neoplastic masses. Histopathological diagnosis is mandatory for final confirmatory diagnosis. Keywords: Ovarian lesions, reproductive cells, cyst

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