scholarly journals Adipo-Myokines: Two Sides of the Same Coin—Mediators of Inflammation and Mediators of Exercise

2013 ◽  
Vol 2013 ◽  
pp. 1-16 ◽  
Author(s):  
Silja Raschke ◽  
Jürgen Eckel
Keyword(s):  
Skeletal Muscle ◽  
Mrna Level ◽  
Cell Types ◽  
The Other ◽  
Target Tissue ◽  
Beneficial Effects ◽  
Mediators Of Inflammation ◽  
The One ◽  
Two Sides ◽  
Kinetics Of

This review summarizes the current literature regarding the most discussed contraction-regulated moykines like IL-6, IL-15, irisin, BDNF, ANGPTL4, FGF21, myonectin and MCP-1. It is suggested that the term myokine is restricted to proteins secreted from skeletal muscle cells, excluding proteins that are secreted by other cell types in skeletal muscle tissue and excluding proteins which are only described on the mRNA level. Interestingly, many of the contraction-regulated myokines described in the literature are additionally known to be secreted by adipocytes. We termed these proteins adipo-myokines. Within this review, we try to elaborate on the question why pro-inflammatory adipokines on the one hand are upregulated in the obese state, and have beneficial effects after exercise on the other hand. Both, adipokines and myokines do have autocrine effects within their corresponding tissues. In addition, they are involved in an endocrine crosstalk with other tissues. Depending on the extent and the kinetics of adipo-myokines in serum, these molecules seem to have a beneficial or an adverse effect on the target tissue.

On Whether the Venetians Should Ally with the Emperor or Stick to the Alliance with the King of France

2017 ◽  
Keyword(s):  
The Other ◽  
Roman Emperor ◽  
Steady Pressure ◽  
Other Hand ◽  
King Of France ◽  
The One ◽  
Two Sides ◽  
Francis I

This chapter considers how, once again, the Venetians had found themselves under steady pressure from two sides — this time between the new king of France, Francis I, and Charles of Habsburg, the king of Spain as well as the Holy Roman Emperor. Although they had not come to a clear rupture with the Emperor, the Venetians had dutifully performed their role in the war on the French side, and were now rather at sea as to what they should do next. On the one hand, Francis incited them to hold on, for he would soon send another army into Italy; on the other hand, Charles was trying to detach them from the French alliance with various reassurances and offers.

Ozonation of bromide-containing drinking waters:a delicate balance between disinfection and bromate formation

2000 ◽  
Vol 41 (7) ◽  
pp. 53-59 ◽  
Author(s):  
U. von Gunten ◽  
U. Pinkernell
Keyword(s):  
Temperature Dependence ◽  
Low Temperatures ◽  
The Other ◽  
Ozone Exposure ◽  
Oh Radicals ◽  
Strong Temperature Dependence ◽  
Control Options ◽  
The One ◽  
Kinetics Of ◽  
Ozonation Process

The occurrence of Cryptosporidium in raw waters and bromate formation during ozonation of bromide-containing waters leads to a difficult optimisation of ozonation processes. On the one hand inactivation of Cryptosporidium requires high ozone exposures, on the other hand under these conditions bromate formation is favored. In order to overcome this problem we need information about (i) the oxidant concentrations (ozone and OH radicals) during an ozonation process, (ii) kinetics of the inactivation of Cryptosporidium, (iii) kinetics and mechanism of bromate formation, and (iv) the reactor hydraulics. The strong temperature dependence of the inactivation of Cryptosporidium which results in a higher ozone exposure (time-integrated action of ozone) at low temperatures makes it more difficult to fulfil disinfection and bromate standards at low temperatures. Underthese conditions control options for bromate formation can be applied. Depressionof pH and addition of ammonia have been selected to be the best options. For a given ozone exposure both measures lead to a reduction of bromate formation in the order of 50%.

scholarly journals Inflammatory Mechanisms Associated with Skeletal Muscle Sequelae after Stroke: Role of Physical Exercise

2016 ◽  
Vol 2016 ◽  
pp. 1-19 ◽  
Author(s):  
Hélio José Coelho Junior ◽  
Bruno Bavaresco Gambassi ◽  
Tiego Aparecido Diniz ◽  
Isabela Maia da Cruz Fernandes ◽  
Érico Chagas Caperuto ◽  
...  
Keyword(s):  
Risk Factors ◽  
Skeletal Muscle ◽  
Physical Exercise ◽  
Muscle Atrophy ◽  
Inflammatory Markers ◽  
The Other ◽  
Stroke Patients ◽  
Beneficial Effects ◽  
Anti Inflammatory

Inflammatory markers are increased systematically and locally (e.g., skeletal muscle) in stroke patients. Besides being associated with cardiovascular risk factors, proinflammatory cytokines seem to play a key role in muscle atrophy by regulating the pathways involved in this condition. As such, they may cause severe decrease in muscle strength and power, as well as impairment in cardiorespiratory fitness. On the other hand, physical exercise (PE) has been widely suggested as a powerful tool for treating stroke patients, since PE is able to regenerate, even if partially, physical and cognitive functions. However, the mechanisms underlying the beneficial effects of physical exercise in poststroke patients remain poorly understood. Thus, in this study we analyze the candidate mechanisms associated with muscle atrophy in stroke patients, as well as the modulatory effect of inflammation in this condition. Later, we suggest the two strongest anti-inflammatory candidate mechanisms, myokines and the cholinergic anti-inflammatory pathway, which may be activated by physical exercise and may contribute to a decrease in proinflammatory markers of poststroke patients.

scholarly journals Polityka wobec zabijania ludzi w konfliktach społecznych. Wykład teoretyczno-metodologiczny

2017 ◽  
Vol 22 ◽  
pp. 154-170
Author(s):  
Andrzej Czajowski
Keyword(s):  
Human Life ◽  
The Other ◽  
Social Conflicts ◽  
Natural Death ◽  
Modern Times ◽  
Nature And Culture ◽  
The One ◽  
Time Kill ◽  
The Relationship ◽  
Two Sides

Politica towards killing people in social conflicts. Theoretical-methodological lectureThere are two sides of life: its continuation to natural death and premature annihilation. These two processes occur in parallel, subjecting to nature and culture. This means that human life, regardless of natural condi­tions, depends in some respects on tradition and politica politics and policy. People primarily protect life, but at the same time kill people and prevent killing in order to meet a number of needs. Often the cause of killing is the clash of those aims and then the killing is used to settle conflicts. Politica has a contradictory role in killing people: on the one hand counteracts this phenomenon, and on the other hand favors. De­pending on the relationship between politica and killing, we differentiate killing politica, politica facilitating killing, anti-killing politica and non-killing politica.The nature and implications of politica involvement in killing of people in conflicts depend on the nature of the conflict. Another is the relation of politica to this phenomenon when the conflict is non-political and the other when it is political.Politica — from its advent to our modern times — is transformed into: apparently killing and encouraging killing, giving way to ever more visible counteracting killing and non-killing.

scholarly journals Redemptive-Historical Approach: Suatu Pendekatan Hermeneutis Injili Yang Kristosentris

2018 ◽  
Vol 17 (2) ◽  
pp. 147-161
Author(s):  
Fitri Yuliana
Keyword(s):  
Historical Context ◽  
The Other ◽  
Historical Approach ◽  
Literary Context ◽  
The Bible ◽  
Other Hand ◽  
Post Modernism ◽  
History Of ◽  
The One ◽  
Two Sides

Di satu sisi, penekanan modernisme pada rasionalitas dan historisitas telah menghasilkan kristologi yang kritis-objektif. Di sisi lain, pascamodernisme yang berepistemologi pluralis menghasilkan kristologi yang subjektif. Menanggapi dan menjembatani dua sisi persoalan ini, pendekatan hermeneutis redemptive-historical diajukan sebagai pendekatan alternatif injili. Pendekatan yang berpusat pada Kristus sebagai kulminasi sejarah penebusan (seperti yang disaksikan Alkitab) ini mengaitkan tiga horizon yaitu: textual, epochal, dan canonical untuk menginterpretasikan teks Kitab Suci secara holistik. Pendekatan ini menganalisis sintaksis, konteks sastra, konteks sejarah dan genre-nya (textual horizon), mengaitkannya dengan sejarah penebusan (epochal horizon), dan melihatnya dalam terang keutuhan kanon (canonical horizon). Penggabungan ketiga unsur tersebut menekankan dinamika pemenuhan janji Allah dalam kulminasi tersebut. Dengan demikian, pendekatan hermeneutis redemptive historical dapat mengarahkan orang Kristen pembacaan dan penafsiran Alkitab yang kristosentris. Kata-kata kunci: Pendekatan Redemptive-Historical, Epistemologi, Kristologi Modern Kristologi Pascamodern, Hermeneutika Injili Kristosentris On the one hand, the emphasis of modernism on rationality and historicity has produced a critical-objective Christology. On the other hand, post-modernism with a pluralist epistemology produces subjective Christology. Responding to, and bridging the two sides of this problem, the redemptive-historical hermeneutical approach is proposed as an alternative evangelical approach. The Christ-centered approach as the culmination of the history of redemption (as witnessed to in the Bible) links three horizons, namely: textual, epochal, and canonical to interpret the text of the Scriptures holistically. This approach analyzes syntax, literary context, historical context and its genre (textual horizon), links it to the history of redemption (epochal horizon), and sees it in the light of the canon (canonical horizon). The combination of these three elements emphasizes the dynamic fulfillment of God’s promises. Thus, the historical redemptive hermeneutical approach can lead Christians to read and interpret the Christocentric Bible. Keywords: Redemptive-Historical Approach, Epistemology, Modernist Christology, Post-modernist Christology, Christ-centered Evangelical Hermeneutics

Martin Luther on Christian Hope and the Hope for Eternal Life

2017 ◽  
Author(s):  
Jeffrey G. Silcock
Keyword(s):  
Final Analysis ◽  
The Other ◽  
Eternal Life ◽  
Other Hand ◽  
God's Word ◽  
The Gift ◽  
Triune God ◽  
The One ◽  
Two Sides ◽  
Theological Concept

Luther does not develop a theology of hope because hope is not the central driver of his mature theology. Central for him is rather faith in the promise of God, which gives rise to hope as well as love. There are two sides to justification that correspond to the now/not-yet character of Luther’s eschatology. On the one hand, we are already righteous through the gift of Christ’s righteousness, which we have in spe but not yet in re. On the other hand, the hope of righteousness strengthens us against sin as we wait for the perfection of our righteousness in heaven. However, in the final analysis, the basis of our hope is not the incipient righteousness which has begun in us (in re) as we gradually grow in holiness and righteousness, but Christ’s own perfect righteousness which he imputes to us through faith (iustitia aliena). For hope can only be rock-solid if it is grounded not on anything within us, but on Christ alone. The early Luther has a very different view of things because, before 1518, he is still very much under the influence of Augustine, which means that justification is primarily a process that goes on within a person’s heart rather than, as in the later Luther, faith in God’s word of promise that comes to a person from outside and gives what it says. The dominant theological concept in Luther’s early work is the theology of humility, which is predicated on the view that God must first humble you and cause you to despair, before he can raise you up and give you hope. Since here faith is not yet oriented to the promise but defined by humility, it has to remain uncertain, as does hope. In the later Luther, on the other hand, faith gives rise to confidence and hope because it is firmly grounded in God’s word of promise, which is always reliable because God does what he says. With his faith firmly grounded in Christ, Luther knows that he can weather all the trials and struggles of life; in fact, he can even look forward to death, since for Christians death is but the door to life with God forever. For Luther, Christ is the only hope for a hopeless world. For him, this is not wishful thinking but is rock-solid because it is based on the promise of the crucified and risen Lord. This is also the basis of the Christian hope for eternal life in the presence of the Triune God, together with the renewed creation and all the hosts of heaven.

Calcium removal kinetics of the sarcoplasmic reticulum ATPase in skeletal muscle

1997 ◽  
Vol 272 (4) ◽  
pp. C1087-C1098 ◽  
Author(s):  
E. E. Burmeister Getz ◽  
S. L. Lehman
Keyword(s):  
Skeletal Muscle ◽  
Steady State ◽  
Sarcoplasmic Reticulum ◽  
Initial Rate ◽  
Troponin C ◽  
The Other ◽  
Physiological Conditions ◽  
Initial Binding ◽  
Kinetics Of ◽  
Transient And Steady State

The models of the sarcoplasmic reticulum (SR) Ca pump used to simulate Ca kinetics in muscle fibers are simple but inconsistent with data on Ca binding or steady-state uptake. We develop a model of the SR pump that is consistent with data on transient and steady-state Ca removal and has rate constants identified under near-physiological conditions. We also develop models of the other main Ca-binding proteins in skeletal muscle: troponin C and parvalbumin. These models are used to simulate Ca transients in cut fibers during and after depolarizing pulses. Simulations using the full SR pump model are contrasted with simulations using a Michaelis-Menten (MM) approximation to SR pump kinetics. The MM pump underestimates the amount of Ca released during depolarization, underestimates the initial rate of Ca binding by the pump, and overestimates the later rate of Ca pumping. These errors are due to fast initial binding by the SR pump, which is neglected in the MM approximation.

Menimbang Kembali Formulasi dan Pewilahan Tari serta Konsep Ketubuhan dalam Masyarakat Urban

Panggung ◽  
2012 ◽  
Vol 22 (2) ◽  
Author(s):  
F.X. - Widaryanto
Keyword(s):  
Urban Communities ◽  
Fast Moving ◽  
The Other ◽  
Other Hand ◽  
The One ◽  
Two Sides

ABSTRACT There are two sides of the paradox associated with the problem of dance formulation and catego- rization that can not be regarded easily. On the one hand, dance is a phenomenon of complexity, in which the intertextuality will embody a complicated contextual phenomenon. On the other hand, the step of categorization has a nature which facilitates someone to observe the existing various phenom- ena in a similarity of properties that tend to lead to a simplification.The development of very fast-moving art is not often followed by adequate category and categori- zation for the purpose of the study. This paper attempts to restore awareness of the concept of corpo- reality with the reality of the complexity, and reconsider and formulate the dance categorization in a creative tradition occured in Urban communities in Bandung in the period of 2000 to 2011. Keywords: corporeality, complexity, categorization, and dance.

scholarly journals ETUDE QUANTITATIVE PAR RADIOAUTOGRAPHIE AU MICROSCOPE ELECTRONIQUE DE L'UTILISATION DE LA DL-LEUCINE-3H PAR LES CELLULES DE L'HYPOPHYSE DU CANARD EN CULTURE ORGANOTYPIQE

1967 ◽  
Vol 35 (3) ◽  
pp. 501-519 ◽  
Author(s):  
A. Tixier-Vidal ◽  
R. Picart
Keyword(s):  
Intracellular Transport ◽  
Cell Types ◽  
The Other ◽  
Prolactin Cells ◽  
Cellular Compartment ◽  
Synthetic Process ◽  
Protein Granules ◽  
The One ◽  
Golgi Zone

The synthesis, intracellular transport, storing, and excretion of proteins by duck hypophyseal cells in organ culture were studied with tritiated DL-leucine and high resolution radioautography (pulse-labeling experiments). Quantitative study of the radioautographs allowed a determination of the relative proportions of cytoplasmic radioactivity located in each cellular compartment (ergastoplasm, Golgi apparatus, and protein granules) as well as the variations in these proportions as a function of time. The number of labeled protein granules as opposed to the total number of granules in the cell was also determined (RSg). These data were separately analyzed for the two types of cells present in the explants: prolactin cells and "MSH" cells. The synthetic process follows a course common to both cell types, each of which is distinguished by its particular modalities. The labeled proteins, synthesized within several minutes in the ergastoplasm, are concentrated in the Golgi zone within 30 min. They then migrate out of this area, the emptying of which is accomplished in about 4 hr. These proteins become equally distributed between the protein granules, on the one hand, and the cytoplasm ("sedentary" proteins), on the other. The RSg reaches its maximum when the Golgi zone is emptied, but this figure remains very low (3%). The RSg then decreases slowly (1% in 40 hr). It is concluded that hypophyseal cells are able to store protein in their granules and that their processes of synthesis and excretion are not continuous. The prolactin cells differ from the "MSH" cells in that they have a slower migration of newly synthesized proteins, and these proteins pass via the dilated ergastoplasmic cisterns in which they may possibly be stored.

Can the Self Survive the Death of its Mind?

1969 ◽  
Vol 5 (1) ◽  
pp. 85-97 ◽  
Author(s):  
John Knox
Keyword(s):  
The Self ◽  
The Other ◽  
Equal Degree ◽  
The One ◽  
Logical Sense ◽  
Two Sides

C. A. Campbell has written: ‘Almost everyone…takes it to be in principle intelligible to ask whether the self can survive the destruction of its body. But it is taken by no one to be in principle intelligible to ask whether the self can survive the destruction of its mind.’ But is it, after all, so clearly nonsense to suppose that a self can survive the destruction of its mind? This at least is the question I shall raise in this paper. The word ‘can’ in my title should thus be understood in its purely logical sense. For the question, really, is whether or not one can intelligibly speak of a self's surviving the destruction of its mind. By the term ‘self’ I refer to that which is supremely unique in what one calls ‘oneself’; to that aspect or element, in other words, which most decisively distinguishes one self-conscious individual from other such individuals. Now the self thus regarded as the source of one's uniqueness on the one hand, and the self conceived of as the source of one's inner unity on the other, would seem to be but two sides of a single coin. For whatever helps to account for an individual's being identical with itself through internal diversity—or for its being a single individual—must also help, and help in an equal degree, to account for its not being identical with any other individual—or for its being a particular individual; and the converse of this seems equally evident.

Sign in / Sign up

Export Citation Format

Share Document