scholarly journals Precancerous Lesions in Colorectal Cancer

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Fayez Sandouk ◽  
Feras Al Jerf ◽  
M. H. D. Bassel Al-Halabi

Colorectal cancer (CRC) is the third most common cause of cancer death in the world. The incidence rate (ASR) and age distribution of this disease differ between most of African-Middle-Eastern (AMAGE) and North America and Europe for many reasons. However, in all areas, “CRC” is considered as one of the most preventable cancers, because it might develop from variant processes like polyps and IBD in addition to the genetic pathogenesis which became very well known in this disease. We tried in this paper to review all the possible reasons of the differences in incidence and age between the west and AMAGE. Also we reviewed all the mutations that lead to the hereditary and familiar clustering of this disease with the correlations with the surrounding food and environment of different areas. Then, we focused on the precancerous pathology of this disease with special focusing on early detection depending on new endoscopy technology and most important genetic studies. We lastly reviewed the evidence of some of the surveillance and put suggestions about future surveillance programs and how important those programs are on the psychological aspect of the patients and their families.

Author(s):  
Michael P. Steinberg

This article discusses the West-Eastern Divan Orchestra, a musical group composed of various musicians from Palestine and other Middle Eastern countries. They show how music is a thing of the world, through their performances of works by various composers, such as Johann Wolfgang von Goethe. The article takes a look at the double agenda of the Divan, its pedagogical transformations, and their translations, techniques, and use of melancholy.


2019 ◽  
Vol 44 (2) ◽  
pp. 36-44
Author(s):  
Shahd Adnan M. Qzeih ◽  
Rafooneh Mokhtarshahi Sani

Wars and conflicts have caused millions of people to seek asylum outside their homelands and the issue of refugee camps has become a pressing subject in international policy discussions. Conflicts continue to escalate in different parts of the world, especially in Middle Eastern countries. In 1948, the Palestinian-Israeli conflict forced displacement of many Palestinian people. The resulting camps have developed into cluster camp shelters of three to four stories in the West Bank, Gaza, and other regions around historical Palestine; some are perceived to be like gated communities. Being self-sufficient environments, refugee camps have rarely been approached from the perspective of urban psychology. This research deals with sensory perceptual analysis of Balata, the largest refugee camp in the West Bank of Palestinian Territories. Balata is situated in Nablus and has raised four generations of refugees since its establishment. In order to explore the spatial characteristics of such specific environmental experiences, the research adopted a mixed-method approach – systematically evaluating the related literature on sensory perceptual spaces and applying content analysis methods. The study modified the sensory slider tool of Malnar and Vodvarka according to the framework matrix based on the content analysis. Moreover, the case study analysis consisted of observation of the chosen area and 30 in-depth interviews with refugees who were forced out of their homes and settled in the camp as well as some who were born in the camp. The research results show that investigating what camp residents perceive of the five senses can capture meaningful sensory perceptual experiences and can generate a holistic mental image of the refugee camp. Particularly, perceptions of the built environment reflect the difficulty of life experiences. The study concludes that the characteristics of camps in this seventy-year-old conflict environment may not be found in other parts of the world.


Author(s):  
Anthony Ossa-Richardson

This chapter discusses the Old Rhetoric, sketching the long persistence in the West—from Aristotle to the early twentieth century—of a ‘single meaning model’ of language, one that takes ambiguity for granted as an obstacle to persuasive speech and clear philosophical analysis. In Aristotle's works are the seeds of three closely related traditions of Western thought on ambiguity: the logicosemantic, the rhetorical, and the hermeneutic. The first seeks to eliminate ambiguity from philosophy because it hinders a clear analysis of the world. The second seeks to eliminate ambiguity from speech because it hinders the clear and persuasive communication of argument. The third, an extension of the second, seeks to resolve textual ambiguity because it hinders the reader's ability to grasp the writer's intention. The chapter then considers Aristotle's two types of verbal ambiguity: homonym and amphiboly. The solution to both—whether their presence in a discussion is accidental or deliberate—is what Aristotle calls diairesis or distinction, that is, the explicit clarification of the different meanings involved.


2020 ◽  
Vol 21 (15) ◽  
pp. 5353 ◽  
Author(s):  
Hsiuying Wang

Colorectal cancer (CRC) is the third leading cause of cancer death in the world, and its incidence is rising in developing countries. Treatment with 5-Fluorouracil (5-FU) is known to improve survival in CRC patients. Most anti-cancer therapies trigger apoptosis induction to eliminate malignant cells. However, de-regulated apoptotic signaling allows cancer cells to escape this signaling, leading to therapeutic resistance. Treatment resistance is a major challenge in the development of effective therapies. The microRNAs (miRNAs) play important roles in CRC treatment resistance and CRC progression and apoptosis. This review discusses the role of miRNAs in contributing to the promotion or inhibition of apoptosis in CRC and the role of miRNAs in modulating treatment resistance in CRC cells.


2020 ◽  
Vol 21 (11) ◽  
pp. 4105
Author(s):  
Alessandro Passardi ◽  
Emanuela Scarpi ◽  
Paola Ulivi

Colorectal cancer (CRC) is the third most frequently diagnosed cancer in the world [...]


2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Gaia Peluso ◽  
Paola Incollingo ◽  
Armando Calogero ◽  
Vincenzo Tammaro ◽  
Niccolò Rupealta ◽  
...  

Background. Colorectal cancer (CRC) is one of the most spread neoplasia types all around the world, especially in western areas. It evolves from precancerous lesions and adenomatous polyps, through successive genetic and epigenetic mutations. Numerous risk factors intervene in its development and they are either environmental or genetic.Aim of the Review. Alongside common screening techniques, such as fecal screening tests, endoscopic evaluation, and CT-colonography, we have identified the most important and useful biomarkers and we have analyzed their role in the diagnosis, prevention, and prognosis of CRC.Conclusion. Biomarkers can become an important tool in the diagnostic and therapeutic process for CRC. But further studies are needed to identify a noninvasive, cost-effective, and highly sensible and specific screening test for their detection and to standardize their use in clinical practice.


Author(s):  
Zaid Najah Merzah ◽  
Alaa Ahmed Idrees

Ecological consciousness poetry is considered as a modern literary movement, it has its roots in the west side of the world originated in the United States of America on the second half of 20th century. The concept of nature was the major theme in the Romantic era. On the other hand, eco-writers have their consideration of nature. This research highlighting on one of the most important parts in this movement which is "ecopoetry" by explaining its implications of nature in Gary Snyder's poetry, who is one of the pioneers of beat generation. The first section of the research concerns with Gary Snyder's early life and highlights on his most significant perspectives. The second one is a kind of a critical part, which concerns with eco-critical approach, its roots, concept, and a list of a critical questions which asks by its critics. The third section is the most important one in my opinion, which is the implication of ecological consciousness poetry in Gary Snyder's poems and how he reads this kind of poetry. And last but not least, a conclusion which sums up my perspectives and readings to the ecocriticism in general, and Gary Snyder's poetry in special. <p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/edu_01/0821/a.php" alt="Hit counter" /></p>


2018 ◽  
Vol 8 (2) ◽  
pp. 23-26
Author(s):  
Narad Prasad Thapaliya ◽  
Krishna Prasad Khanal ◽  
Bhuwan Poudel ◽  
Sharad Pokharel ◽  
Ruckmeni Sharma

Introduction: Cholelithiasis is common cause for surgical outpatient consultation. Cholecystectomy is most common surgical procedure performed as elective basis in Lumbini Zonal Hospital, Butwal. The aim of this study is to show the mirror of surgeries of gall stones diseases in Lumbini Zonal Hospital, Butwal. Methods: A retrospective analysis of cholecystectomy performed in Lumbini Zonal Hospital over a period of 5 years (Biasakh 2069BS- Chaitra 2073BS) was done after the approval from ethical committee. Demographic profiles, complications and other required information were retrieved from the documents available in medical record section. Results: Total of 372 cholecystectomies were done for different spectrum of gallstones diseases during the study period. Most of the patients were female (341, 92%). The age distribution of the operated patients was 17 years to 75 years. Most of the operated patients (190, 51.07%) were in their productive age (17- 40 years). Most common complications found post operatively were chest infection, SSI. Mid hospital stay was 3.16 days (1-6 days). Total bile duct injury was 1 (0.26%) comparable to other studies. Conclusion: Cholecystectomy is one of the most common operative procedures performed in our hospital with postoperative outcomes comparable to reported outcomes of other institutions of the world.


2016 ◽  
Vol 60 (1) ◽  
pp. 17-29
Author(s):  
A. Lukin

The article explores characteristics of the international relations bipolar system, changes occurred after its collapse and the future of post-bipolar world, focusing on the role of non-Western actors in it. On one hand, the bipolar system provided stability of international relations, but on the other – lead to competition between the U.S. and the USSR for the influence on the third countries, which sometimes resulted in armed conflicts in the third states. The collapse of the Soviet Union convinced the West both in the universality of its development model and the necessity to spread it all over the world. Now it is clear that the “democratism” ideology failed politically and culturally. The Western model has neither become a panacea for eliminating disparities between countries on different stages of development, nor the only example of successful and strong governance. New power centers, such as Russia, China, India and Brazil, have been successfully developing after the collapse of the Soviet Union. Their influence has been growing along with that of the West, and even though they did not necessarily directly confront it, they never shared all its values, yet never actively imposed their positions on the rest of the world. Regional powers (Nigeria, Venezuela, etc.) are also playing a more significant role in the emerging system, although sometimes they may join the alliances with more powerful countries to achieve their goals (as Vietnam does with the U.S. in its conflict with China). Russia’s reluctance to follow the West in its development created the first serious alternative to the existing unipolar world model and its values, so naturally and widely accepted by the Western actors. Whereas China with its rapid economic development is also posing a challenge to the ideology of "democratism" proving that the economic welfare is achievable outside the Western political model. As for Russia, its role in the modern world is still not defined. The Russian Federation wants to become an independent power unit and a center of the Eurasian integration. However, it is not clear whether it has resources of all kinds to implement this idea, – moreover, its economic dependence on the West is still too strong to insist on further confrontation. Instead, Russia (as well as its partners in the Eurasian Economic Union) could use Eurasian integration platforms to act as an "ambassador" of Asia in Europe and that of Europe in Asia. Acknowledgements. The article has been supported by the grant of the Faculty of World Economy and International Affairs, National Research University Higher School of Economics in 2016.


2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Justin L. Sovich ◽  
Zachary Sartor ◽  
Subhasis Misra

Background.Worldwide, colorectal cancer (CRC) is the third most common cancer in men and second most common in women. It is the fourth most common cause of cancer mortality. In the United States, CRC is the third most common cause of cancer and second most common cause of cancer mortality. Incidence and mortality rates have steadily fallen, primarily due to widespread screening.Methods.We conducted keyword searches on PubMed in four categories of CRC screening: stool, endoscopic, radiologic, and serum, as well as news searches in Medscape and Google News.Results.Colonoscopy is the gold standard for CRC screening and the most common method in the United States. Technological improvements continue to be made, including the promising “third-eye retroscope.” Fecal occult blood remains widely used, particularly outside the United States. The first at-home screen, a fecal DNA screen, has also recently been approved. Radiological methods are effective but seldom used due to cost and other factors. Serum tests are largely experimental, although at least one is moving closer to market.Conclusions.Colonoscopy is likely to remain the most popular screening modality for the immediate future, although its shortcomings will continue to spur innovation in a variety of modalities.


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