scholarly journals Bioaccumulation, Subacute Toxicity, and Tissue Distribution of Engineered Titanium Dioxide Nanoparticles in Goldfish (Carassius auratus)

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Mehmet Ates ◽  
Veysel Demir ◽  
Ragip Adiguzel ◽  
Zikri Arslan
Keyword(s):  
Titanium Dioxide ◽  
Carassius Auratus ◽  
Sublethal Effects ◽  
Titanium Dioxide Nanoparticles ◽  
Exposure Dose ◽  
The Body ◽  
Control Group ◽  
High Exposure ◽  
Nanosized Materials ◽  
Goldfish Carassius Auratus

The increased use of nanosized materials is likely to result in the release of these particles into the environment. It is, however, unclear if these materials are harmful to aquatic animals. In this study, the sublethal effects of exposure of low and high concentrations of titanium dioxide nanoparticles (TiO2NPs) on goldfish (Carassius auratus) were investigated. Accumulation of TiO2NPs increased from 42.71 to 110.68 ppb in the intestine and from 4.10 to 9.86 ppb in the gills of the goldfish with increasing exposure dose from 10 to 100 mg/L TiO2NPs. No significant accumulation in the muscle and brain of the fish was detected. Malondialdehyde as a biomarker of lipid oxidation was detected in the liver of the goldfish. Moreover, TiO2NPs exposure inhibited growth of the goldfish. Although there was an increase (8.1%) in the body weights of the goldfish for the control group, in the low and high exposure groups 1.8% increase and 19.7% decrease were measured, respectively. The results of this study contribute to the current understanding of the potential ecotoxicological effects of nanoparticles and highlight the importance of characterization of NPs in understanding their behavior, uptake, and effects in aquatic systems and in fish.

Phytotherapy of ulcerative dermatitis induced by Aeromonas hydrophila infection in goldfish ( Carassius auratus )

2010 ◽  
Vol 58 (1) ◽  
pp. 29-37 ◽  
Author(s):  
Ramasamy Harikrishnan ◽  
Chellam Balasundaram ◽  
Young-Gun Moon ◽  
Man-Chul Kim ◽  
Ju-Sang Kim ◽  
...  
Keyword(s):  
Body Length ◽  
Aeromonas Hydrophila ◽  
Carassius Auratus ◽  
Curcuma Longa ◽  
Treated Group ◽  
The Body ◽  
Sublethal Dose ◽  
Ocimum Sanctum ◽  
Goldfish Carassius Auratus ◽  
Successful Recovery

Goldfish ( Carassius auratus ) weighing 13 ± 2 g were administered intramuscularly a sublethal dose (1.8 × 10 3 cfu/ml) of Aeromonas hydrophila to induce ulcerative dermatitis. On day 3 and day 6 after infection the fish were dip-treated (for 5 min/day) with a tri-herbal concoction of Curcuma longa, Ocimum sanctum and Azadirachta indica (1%). The LD 50 value was recorded at a concentration of 2.3 × 10 4 between 30 and 36 days after infection. In the infected untreated group the cumulative mortality was higher, while in the early-treated group (day 3) there was no mortality. In the late-treated group (6th day) the mortality increased to 23.3% on day 36. In the infected group the size of ulcers progressively increased from 43.3% of the body length on day 18 to 86.7% on day 36. In the early-treated fish the size of ulcers was 23.3% of the body length on day 18; by day 36 after treatment the ulcer had completely healed. In contrast, there was only a moderate recovery in the late-treated group. From the results it can be concluded that early tri-herbal treatment ensures successful recovery from ulcerative dermatitis induced by A. hydrophila .

scholarly journals Evaluation of the Transverse Strength of the Heat Cure PMMA Resin Reinforced with Various Concentrations of Two Different Nanoparticles: An In vitro Study

2019 ◽  
pp. 1-8
Author(s):  
Kusha Thakur ◽  
Archana Nagpal ◽  
Rajeev Gupta ◽  
Ramit Verma ◽  
Rohit Saini ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Testing Machine ◽  
Bending Test ◽  
Control Group ◽  
Transverse Strength ◽  
Heat Cure ◽  
Group 3 ◽  
Post Hoc ◽  
Pmma Resin

Purpose: The purpose of the study was to evaluate the effect of titanium dioxide and zirconia nanoparticles on transverse strength of heat cure PMMA resin routinely used for complete denture fabrication. Methods: One hundred samples of PMMA resin were made and divided into five groups (20 samples for each group). The test specimens were divided into five groups depending on the concentration of reinforcing nanoparticles as Group 1,2,3,4 and 5; Group 1: PMMA unreinforced (control group), Group 2: PMMA reinforced with 2.5% nanozirconia, Group 3: PMMA reinforced with 5% nanozirconia, Group 4: PMMA reinforced with 2.5% titanium dioxide nanoparticles, and Group 5: PMMA reinforced with 5% titanium dioxide nanoparticles. Universal testing machine was used to conduct a three-point bending test and evaluate the transverse strength of samples. Comparison of mean transverse strength for various groups was carried out by employing one‑way analysis of variance and Bonferroni post hoc tests. Results: The highest and lowest mean transverse strength were observed in Group 3 and 1, respectively. Bonferroni post hoc test showed increase in transverse strength after reinforcement to be statistically significant between all the groups (P = .05) except between the samples of group G1 and G5 and G2 and G3. Conclusion: Addition of nanoparticles in all concentrations significantly increased transverse strength of heat cure PMMA resin as compared to control group. The best result was obtained after adding 5% of nanozirconia particles to the conventional heat polymerized acrylic resin.

scholarly journals Internalization of Titanium Dioxide Nanoparticles Is Cytotoxic for H9c2 Rat Cardiomyoblasts

Molecules ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 1955 ◽  
Author(s):  
Elizabeth Huerta-García ◽  
Iván Zepeda-Quiroz ◽  
Helen Sánchez-Barrera ◽  
Zaira Colín-Val ◽  
Ernesto Alfaro-Moreno ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Cycle ◽  
Cell Proliferation ◽  
Cell Death ◽  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Membrane Integrity ◽  
The Body ◽  
Potential Health ◽  
Tio2 Nps

Titanium dioxide nanoparticles (TiO2 NPs) are widely used in industry and daily life. TiO2 NPs can penetrate into the body, translocate from the lungs into the circulation and come into contact with cardiac cells. In this work, we evaluated the toxicity of TiO2 NPs on H9c2 rat cardiomyoblasts. Internalization of TiO2 NPs and their effect on cell proliferation, viability, oxidative stress and cell death were assessed, as well as cell cycle alterations. Cellular uptake of TiO2 NPs reduced metabolic activity and cell proliferation and increased oxidative stress by 19-fold measured as H2DCFDA oxidation. TiO2 NPs disrupted the plasmatic membrane integrity and decreased the mitochondrial membrane potential. These cytotoxic effects were related with changes in the distribution of cell cycle phases resulting in necrotic death and autophagy. These findings suggest that TiO2 NPs exposure represents a potential health risk, particularly in the development of cardiovascular diseases via oxidative stress and cell death.

scholarly journals Histological Effects of Titanium Dioxide Nanoparticles Size 10 Nm in Mice Testes

2017 ◽  
Vol 5 (2) ◽  
pp. 158 ◽  
Author(s):  
Imad Taher Abdulla
Keyword(s):  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Testicular Tissue ◽  
Germinal Epithelium ◽  
Seminiferous Tubules ◽  
Control Group ◽  
Histological Changes ◽  
Low Concentrations ◽  
High Concentrations ◽  
Histological Effect

In the present study, the histological effect of titanium dioxide nanoparticles (TDN) on testicular tissue of mature Mus musculus mice was investigated. The animals were divided into six groups, control group treated with TDN free saline and five groups treated with TDN as follow 5, 10, 50, 100 and 150 mg/kg B.W. The results showed that TDN has histological effects on testicular tissue like sever congestion, mild edema between seminiferous tubules (STs) and decrease the thickness of germinal epithelium at low concentrations, While, the histological changes at high concentrations involved disturbance in STs diameters, sever edema between STs, sever vaculation in the germinal epithelium and necrosis in spermatogonia, germinal epithelium and Sertoli cells.

The Nacteous (Mottled) Group of the Goldfish (Carassius auratus L.), with an Analysis of the Colours Seen in these Fish

1952 ◽  
Vol 3 (2) ◽  
pp. 126 ◽  
Author(s):  
RJ Affleck
Keyword(s):  
Carassius Auratus ◽  
Yellow Pigment ◽  
The Body ◽  
Red Pigment ◽  
Orange Pigment ◽  
Black Smoke ◽  
Goldfish Carassius Auratus ◽  
Orange Yellow ◽  
Yellow Pigments ◽  
First Time

The colours of nacreous (mottled) fish are usually mottled but specimens do occur in which only one kind of the black, orange, or yellow chromatophores is present, while some lack pigments over most of the body. The colours appear metallic, pearl, or matt depending on the presence or absence of reflecting tissue in two definite layers. The hues seen in these fish are black, smoke, blue, orange, yellow, blood-red, and silver, which occur singly or in combinations. These hues are produced by black, orange, and yellow pigments in chromatophores, silver reflectillg tissue, and haemoglobin in the blood. The presence of a yellow pigment — a carotenoid — is reported for the first time. Although the colour red has been reported no red pigment has ever been described. An intense orange pigment will produce a red effect on a pale blood-red background. The nacreous (mottled) group of the goldfish is intermediate between the metallic (scaled) and matt (transparent) groups with regard to the amount of reflecting tissue. The colours of these fish may not be used as criteria of the groups.

The distribution and tissue retention of mercury-203 in the goldfish (Carassius auratus)

1973 ◽  
Vol 51 (2) ◽  
pp. 143-150 ◽  
Author(s):  
Melvin Weisbart
Keyword(s):  
Gall Bladder ◽  
Half Life ◽  
Carassius Auratus ◽  
Head Kidney ◽  
Linear Increase ◽  
The Body ◽  
Swim Bladder ◽  
Intestinal Tissue ◽  
Goldfish Carassius Auratus ◽  
Constant Rate

Goldfish injected intraperitoneally with 203Hg(NO3)2 lost mercury at an apparent constant rate resulting in a biological half-life of 568 h. Correlated with this loss was a linear increase in the amount of mercury in the water.The mercury-203 content in the tissues displayed four different responses.(1) Gall bladder, gonad, and spleen tissues showed no significant regressions.(2) Eye, kidney, and intestinal tissue manifested significant losses of mercury, but the rate of loss was not significantly different from that of the body as a whole.(3) Gill, heart, skin, and swim bladder tissues lost mercury at rates faster than the body as a whole.(4) Brain, liver, muscle, and head kidney tissues showed no significant losses of mercury.

scholarly journals Effects of Titanium Dioxide Nanoparticles Toxicity on the Kidney of Male Rats

2016 ◽  
Vol 10 (1) ◽  
pp. 65-69 ◽  
Author(s):  
Fatemeh Mohammadi Fartkhooni ◽  
Ali Noori ◽  
Abdolrasool Mohammadi
Keyword(s):  
Titanium Dioxide ◽  
Uric Acid ◽  
Titanium Dioxide Nanoparticles ◽  
Life Sciences ◽  
Kidney Tissue ◽  
Male Rats ◽  
Control Group ◽  
Biological And Medical Applications ◽  
Bowman's Capsule ◽  
Nanoparticles Toxicity

Nanoparticles have many characteristics that make them suitable for biological and medical applications. These special features cause some adverse effects. Despite the widespread use of titanium dioxide nanoparticles, few studies were conducted on the toxicity of these nanoparticles in biological systems. In this study, the effects of intraperitoneal injections of TiO2 nanoparticles (30,50,70 mg/kg ) were investigated on kidney function and histology. The creatinine levels did not change but the amount of urea and uric acid showed the significant changes in comparison with control group. But, by passing the time, the uric acid changes back to normal. In kidney tissue, the changes such as deposition of hyaline-like materials, the swelling, dilatation of Bowman's capsule and degenerations were seen. It seems by passing time, The temporary disorders have been removed and the renal function has returned toward normal. However, further investigations are needed to measure the oxidative stress.International Journal of Life Sciences 10 (1) : 2016; 65-69

Biodistribution and Toxicity Study of Titanium Dioxide Nanoparticles of Different Sizes after Intravenous Injection in Mice

2014 ◽  
Vol 998-999 ◽  
pp. 196-199
Author(s):  
Jie Fang ◽  
Lu Lu Yuan ◽  
Chen Jie Yao ◽  
Yan Li Wang ◽  
Ming Hong Wu
Keyword(s):  
Titanium Dioxide ◽  
Biochemical Parameters ◽  
Titanium Dioxide Nanoparticles ◽  
Control Group ◽  
Quantitative Distribution ◽  
Blood Biochemical ◽  
Long Time ◽  
Liver And Kidney ◽  
Kidney Functions

Titanium dioxide nanoparticles (TiO2-NPs) are widely used in many fields. The bio-distribution and toxicology of different sizes (25 nm and 50 nm) of TiO2-NPsin vivois evaluated in this paper. The results of quantitative distributionin vivoshow that it is difficult for TiO2-NPs to excretion clearly from tissues and organs. At the endpoint of experiment of different groups, there are still many TiO2-NPs located in the main organs such as spleen, liver and lung after 120 days. Blood biochemical parameters keep unchanged compared with control group. However, pathological results show that lesions in spleen, liver and lung where TiO2-NPs particles are mainly accumulated and retained are getting serious with the time prolonging. The results indicate that TiO2-NPs are low toxic to mice but may have some potential effects on liver and kidney functions after exposure long time. The fundamental importance information gained from such a study will give the guidance on the application of TiO2-NPs.

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