scholarly journals Recent Trends in Multifunctional Liposomal Nanocarriers for Enhanced Tumor Targeting

2013 ◽  
Vol 2013 ◽  
pp. 1-32 ◽  
Author(s):  
Federico Perche ◽  
Vladimir P. Torchilin
Keyword(s):  
Cancer Detection ◽  
Blood Circulation ◽  
Tumor Targeting ◽  
Selective Distribution ◽  
The Past ◽  
Tumor Lesion ◽  
Recent Trends ◽  
Stimuli Sensitive ◽  
Multifunctional Nanocarriers ◽  
Tumor Cell Killing

Liposomes are delivery systems that have been used to formulate a vast variety of therapeutic and imaging agents for the past several decades. They have significant advantages over their free forms in terms of pharmacokinetics, sensitivity for cancer diagnosis and therapeutic efficacy. The multifactorial nature of cancer and the complex physiology of the tumor microenvironment require the development of multifunctional nanocarriers. Multifunctional liposomal nanocarriers should combine long blood circulation to improve pharmacokinetics of the loaded agent and selective distribution to the tumor lesion relative to healthy tissues, remote-controlled or tumor stimuli-sensitive extravasation from blood at the tumor’s vicinity, internalization motifs to move from tumor bounds and/or tumor intercellular space to the cytoplasm of cancer cells for effective tumor cell killing. This review will focus on current strategies used for cancer detection and therapy using liposomes with special attention to combination therapies.

Multifunctional Dendrimers for Drug Nanocarriers

2017 ◽  
pp. 245-276 ◽  
Author(s):  
Tingbin Zhang ◽  
Chunqiu Zhang ◽  
Jinfeng Xing ◽  
Jing Xu ◽  
Chan Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gene Delivery ◽  
Topological Structure ◽  
Tumor Targeting ◽  
Branched Polymers ◽  
Good Biocompatibility ◽  
Or Gene ◽  
Stimuli Sensitive ◽  
Multifunctional Nanocarriers ◽  
Drug Nanocarriers

Dendrimers are nanosized, monodisperse, highly branched polymers with well-defined topological structure which have attracted much attention for drug delivery recently. To further improve the performance of dendrimers in drug delivery, various functional dendrimers are developed by decorating the dendrimers with targeting agents, imaging agents, or stimuli-sensitive moieties. They show good biocompatibility, visibility, tumor targeting and stimuli-sensitive properties for drug or gene delivery. This chapter will focus on the design of multifunctional nanocarriers based on the dendrimers. Therefore, the chapter will provide the ideas for designing the dendrimers based nanocarriers for controllable drug delivery and let more people know the development of dendrimers for drug delivery in recent years.

Multifunctional Dendrimers for Drug Nanocarriers

2017 ◽  
pp. 439-470
Author(s):  
Tingbin Zhang ◽  
Chunqiu Zhang ◽  
Jinfeng Xing ◽  
Jing Xu ◽  
Chan Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gene Delivery ◽  
Topological Structure ◽  
Tumor Targeting ◽  
Branched Polymers ◽  
Good Biocompatibility ◽  
Or Gene ◽  
Stimuli Sensitive ◽  
Multifunctional Nanocarriers ◽  
Drug Nanocarriers

Dendrimers are nanosized, monodisperse, highly branched polymers with well-defined topological structure which have attracted much attention for drug delivery recently. To further improve the performance of dendrimers in drug delivery, various functional dendrimers are developed by decorating the dendrimers with targeting agents, imaging agents, or stimuli-sensitive moieties. They show good biocompatibility, visibility, tumor targeting and stimuli-sensitive properties for drug or gene delivery. This chapter will focus on the design of multifunctional nanocarriers based on the dendrimers. Therefore, the chapter will provide the ideas for designing the dendrimers based nanocarriers for controllable drug delivery and let more people know the development of dendrimers for drug delivery in recent years.

Application of Nanotechnology in Biomedicine: A Major Focus on Cancer Therapy

2015 ◽  
Vol 35 ◽  
pp. 55-66 ◽  
Author(s):  
Hadi Zare-Zardini ◽  
Farzad Ferdowsian ◽  
Hossein Soltaninejad ◽  
Adel Ghorani Azam ◽  
Safoura Soleymani ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Cancer Detection ◽  
Tumor Targeting ◽  
Medical Applications ◽  
Nano Materials ◽  
Major Focus ◽  
The Past ◽  
New Compounds ◽  
Cancer Diseases

Most of mortality worldwide occurs because of cancer diseases. Nanostructures are the new compounds that have become one of the most important technologies for using in different fields over the past two years especially in medicine. In between, nanotechnology has the potential to cancer detection and therapy. This study is a review of prospects in applications of nano-materials for cancer detection and treatment. We have summarized the nano-materials (metal nanospheres, nanorods, nanoshells and nanotubes) in medical applications targeting cancer. We also discuss advances in established nanoparticle technologies such as liposomes, polymer micelles, and functionalization about tumor targeting, controlled release and drug delivery. This paper will discuss the therapeutic applications of different nano-materials with a major focus on their applications for the treatment of cancer. Briefly, the toxicity of conventional nanostructures was also mentioned in this paper.

scholarly journals Inactivation of the Nuclear Receptor Coactivator RAP250 in Mice Results in Placental Vascular Dysfunction

2003 ◽  
Vol 23 (4) ◽  
pp. 1260-1268 ◽  
Author(s):  
Per Antonson ◽  
Gertrud U. Schuster ◽  
Ling Wang ◽  
Björn Rozell ◽  
Elin Holter ◽  
...  
Keyword(s):  
Nuclear Receptors ◽  
Nuclear Receptor ◽  
Blood Circulation ◽  
Transcriptional Activity ◽  
Vascular Dysfunction ◽  
Diverse Group ◽  
Placental Development ◽  
Nuclear Receptor Coactivator ◽  
The Past ◽  
Placental Blood

ABSTRACT Coactivators constitute a diverse group of proteins that are essential for optimal transcriptional activity of nuclear receptors. In the past few years many coactivators have been identified but it is still unclear whether these proteins interact indiscriminately with all nuclear receptors and whether there is some redundancy in their functions. We have previously cloned and characterized RAP250 (ASC-2/PRIP/TRBP/NRC), an LXXLL-containing coactivator for nuclear receptors. In order to study its biological role, Rap250 null mice were generated by gene targeting. Here we show that genetic disruption of Rap250 results in embryonic lethality at embryonic day (E) 13.5. Histological examination of placentas revealed a dramatically reduced spongiotrophoblast layer, a collapse of blood vessels in the region bordering the spongiotrophoblast, and labyrinthine layers in placentas from Rap250−/− embryos. These findings suggest that the lethality of Rap250−/− embryos is the result of obstructed placental blood circulation. Moreover, the transcriptional activity of PPARγ is reduced in fibroblasts derived from Rap250−/− embryos, suggesting that RAP250 is an essential coactivator for this nuclear receptor in the placenta. Our results demonstrate that RAP250 is necessary for placental development and thus essential for embryonic development.

Knowledge of Testicular Cancer Risk and Need for Self-Examination in College Students: A Call for Equal Time for Men in Teaching of Early Cancer Detection Techniques

PEDIATRICS ◽  
1984 ◽  
Vol 74 (6) ◽  
pp. 1093-1096
Author(s):  
John M. Goldenring ◽  
Elizabeth Purtell
Keyword(s):  
Testicular Cancer ◽  
Cancer Detection ◽  
Early Cancer ◽  
Early Cancer Detection ◽  
Men And Women ◽  
Equal Time ◽  
Detection Techniques ◽  
The Past ◽  
Knowledge And Practice ◽  
Self Examination

College athletes were surveyed about their knowledge and practice of early cancer detection techniques. Males were almost completely unaware of their risk for testicular cancer (87%). Only 9.6% had been taught testicular self-examination and only half of these by their physician. Six percent actually examined themselves regularly. In comparison, more than 60% of women had been taught breast self-examination (75% by a physician) and about one third were doing regular examinations. More than 90% of the young men and women had been seen by physicians for a physical examination within the past 3 years. Physicians need to begin educating males about testicular cancer and its early detection.

Su1932 - Despite Surveillance and Increased use of Biologics and Immunosuppressives Colorectal Cancer Detection in IBD Patients Remains Unchanged over the Past 10 Years

2018 ◽  
Vol 154 (6) ◽  
pp. S-637
Author(s):  
Uday N. Shivaji ◽  
Samuel C. Smith ◽  
Rahul Hejmadi ◽  
Subrata Ghosh ◽  
Marietta Iacucci
Keyword(s):  
Colorectal Cancer ◽  
Cancer Detection ◽  
The Past

scholarly journals Advances in Research on Bladder Cancer Targeting Peptides: a Review

2021 ◽  
Author(s):  
Bin Zheng ◽  
Pu Zhang ◽  
Heng Wang ◽  
Jinxue Wang ◽  
Zheng Hong Liu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bladder Cancer ◽  
Clinical Outcomes ◽  
Malignant Tumor ◽  
Tumor Targeting ◽  
Cancer Targeting ◽  
Male Population ◽  
Genitourinary System ◽  
The Past ◽  
Chinese Male

AbstractBladder cancer (Bca) is the second most common malignant tumor of the genitourinary system in Chinese male population with high potential of recurrence and progression. The overall prognosis has not been improved significantly for the past 30 years due to the lack of early theranostic technique. Currently the early theranostic technique for bladder cancer is mainly through the intravesical approach, but the clinical outcomes are poor due to the limited tumor-targeting efficiency. Therefore, the targeting peptides for bladder cancer provide possibility to advance intravesical theranostic technique. However, no systematic review has covered the wide use of the targeting peptides for intravesical theranostic techniques in bladder cancer. Herein, a summary of original researches introduces all aspects of the targeting peptides for bladder cancer, including the peptide screening, the targeting mechanism and its preclinical application.

scholarly journals Corporate governance, ownership and control: A review of recent scholarly research

2018 ◽  
Vol 14 (1) ◽  
pp. 50-56 ◽  
Author(s):  
Alex Kostyuk ◽  
Yaroslav Mozghovyi ◽  
Dmytro Govorun
Keyword(s):  
Corporate Governance ◽  
Corporate Ownership ◽  
Board Diversity ◽  
Existing Problems ◽  
The Past ◽  
Corporate Governance Mechanisms ◽  
Wide Range ◽  
Recent Trends ◽  
Performance Auditing ◽  
And Control

This manuscript is aimed at highlighting the most recent trends in corporate governance, ownership and control based on the manuscripts presented at the international conference “Corporate Governance, Ownership and Control” that took place in Rome on February 27, 2018. We have also used reputable papers published in the relevant academic journals in the past to support the arguments stated by the authors of the papers, presented at the conference. This paper covers a wide range of corporate governance topics in corporate ownership and control toward corporate governance mechanisms, such as board of directors, the board diversity, directors’ remuneration, firm performance, auditing and accounting, etc. We saw a growing interest of researchers to widen the scope of their major research to link it to corporate ownership and control issues. Currently, corporate governance research follows two major routs: classical empirical corporate governance research and multidisciplinary research aimed at findings non-conventional methods to solution of existing problems.

5. Understanding recent trends in crime

2018 ◽  
pp. 52-63
Author(s):  
Tim Newburn
Keyword(s):  
Second World War ◽  
Crime Trends ◽  
World War ◽  
England And Wales ◽  
The Past ◽  
Victimization Surveys ◽  
Recent Trends ◽  
Post War ◽  
Second World ◽  
Western Democracies

What is happening to crime? Are things getting better or worse, and in what ways? ‘Understanding recent trends in crime’ examines recorded crime trends and data from victimization surveys from America, Canada, England and Wales, and Australia. All four Western democracies display similar patterns: rising crime in the post-war years, hitting a peak somewhere between the late 1980s and late 1990s, then falling steeply for the fifteen‒twenty-five years since. This leaves two big questions: why did crime increase in the early decades after the Second World War; and, why has it been declining in the past fifteen‒twenty-five years? The reasons for the post-war crime explosion are discussed.

Recent Trends in the Chinese Economy

1973 ◽  
Vol 53 ◽  
pp. 1-33 ◽  
Author(s):  
Thomas G. Rawski
Keyword(s):  
Economic Policy ◽  
Income Distribution ◽  
Agricultural Production ◽  
Chinese Economy ◽  
The Past ◽  
Official Policy ◽  
Recent Trends ◽  
Economic Specialization

The past 15 years have been eventful ones for the Chinese economy. They have seen an ambitious attempt at economic acceleration decline into agricultural crisis, a major reversal of the direction of economic policy, agricultural recovery and resurgent economic momentum. These years have brought major changes to the Chinese economy: whole new industries have appeared; official policy towards such diverse areas as education, income distribution, regional dispersion of industry and economic specialization has shifted repeatedly; the organization of agricultural production has also changed.

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