scholarly journals Vitamin C Intake Reduces the Cytotoxicity Associated with Hyperglycemia in Prediabetes and Type 2 Diabetes

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Silvia Isabel Rech Franke ◽  
Luiza Louzada Müller ◽  
Maria Carolina Santos ◽  
Arcênio Fishborn ◽  
Liziane Hermes ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Dna Damage ◽  
Vitamin C ◽  
Low Dose ◽  
Hemoglobin A1c ◽  
Protein Glycation ◽  
Glycation End Products ◽  
Vitamin C Supplementation ◽  
Type 2 Diabetic

Hyperglycemia leads to the formation of free radicals and advanced glycation end-products (AGEs). Antioxidants can reduce the level of protein glycation and DNA damage. In this study, we compared the levels of vitamin C intake, which is among the most abundant antioxidants obtained from diet, with the levels of fasting plasma glucose (FPG), glycated hemoglobin (A1C), DNA damage, and cytotoxicity in prediabetic subjects and type 2 diabetic subjects. Our results indicated that there was no significant correlation between FPG or A1C and DNA damage parameters (micronuclei, nucleoplasmic bridges, and nuclear buds). FPG and A1C correlated with necrosis (r=0.294;P=0.013andr=0.401;P=0.001, resp.). Vitamin C intake correlated negatively with necrosis and apoptosis (r=-0.246;P=0.040, andr=-0.276;P=0.021, resp.). The lack of a correlation between the FPG and A1C and DNA damage could be explained, at least in part, by the elimination of cells with DNA damage by either necrosis or apoptosis (cytotoxicity). Vitamin C appeared to improve cell survival by reducing cytotoxicity. Therefore, the present results indicate the need for clinical studies to evaluate the effect of low-dose vitamin C supplementation in type 2 diabetes.

scholarly journals Type 2 Diabetes Mellitus And Vitamin C

2019 ◽  
Vol 09 (03) ◽  
pp. 232-236
Author(s):  
Shabzain Ishrat ◽  
Talea Hoor ◽  
Mohammed Sajid Abbas Jaffri
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Vitamin C ◽  
Good Control ◽  
Type 2 Dm ◽  
Vitamin C Supplementation ◽  
Antioxidant Supplements

Type 2 diabetes mellitus (DM) is a chronic disease which deteriorates the quality of life with time. Type 2 DM accounts for more than 90% cases of diabetes mellitus as compared to other types of this disease. There is significant oxidative stress in type 2 DM which plays an important role in the pathogenesis of disease. In order to combat this oxidative stress antioxidant supplements have to be added as add on therapy along with treatment of type 2 DM. Vitamin C is the safest antioxidant which plays significant role in diminishing the oxidative stress. The vitamin C supplementation have good control of FBS and HbA1c and therefore helps in achieving better glycemic control along with prevention of lipid abnormalities.

Effect of Vitamin C Supplementation on Postprandial Oxidative Stress and Lipid Profile in Type 2 Diabetic Patients

2011 ◽  
Vol 14 (19) ◽  
pp. 900-904 ◽  
Author(s):  
Zohreh Mazloom ◽  
Najmeh Hejazi ◽  
Mohammad-Hossein Dabbaghman ◽  
Hamid-Reza Tabatabaei ◽  
Afsane Ahmadi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Lipid Profile ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Vitamin C Supplementation ◽  
Type 2 Diabetic

scholarly journals Effects of Vitamin C Supplementation on Glycemic Control and Cardiovascular Risk Factors in People With Type 2 Diabetes: A GRADE-Assessed Systematic Review and Meta-analysis of Randomized Controlled Trials

2021 ◽  
Author(s):  
Shaun A Mason ◽  
Michelle A Keske ◽  
Glenn D Wadley
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Glycemic Control ◽  
Vitamin C ◽  
Controlled Trials ◽  
Short Term ◽  
Randomized Controlled ◽  
Vitamin C Supplementation

<a><b>BACKGROUND </b></a>Evidence suggests vitamin C supplementation could be a potential therapy in type 2 diabetes. However, its effectiveness and evidence quality require further evaluation. <p><b>PURPOSE</b> To investigate the efficacy of oral vitamin C supplementation in improving glycemic control, cardiovascular risk factors, and oxidative stress in people with type 2 diabetes.</p> <p><b>DATA SOURCES</b> Databases (PubMed, Embase, Scopus, Cochrane Library) and clinical trial registries were searched for randomized controlled trials up to 09/08/2020. </p> <p><b>STUDY SELECTION</b> Trials in adults with type 2 diabetes were included. Trials were excluded if supplements were not exclusive to vitamin C, and if <2 weeks in duration. </p> <p><b>DATA EXTRACTION</b> Primary outcomes were HbA1c, glucose, cholesterol, triglycerides, and blood pressure (BP). Data were extracted for changes in outcomes between vitamin C and control groups. Evidence certainty was assessed using GRADE methods. </p> <p><b>DATA SYNTHESIS</b> Twenty-eight studies (n=1574) were included in the review. Outcomes changed to a statistically and clinically significant extent with Vitamin C were systolic BP (mean difference [MD] −6.27, 95% CI [−9.60, −2.96] mmHg; p=0.0002) with moderate evidence certainty; and HbA1c (MD −0.54 [−0.90, −0.17] %; p=0.004) and diastolic BP (MD −3.77 [−6.13, −1.42] mmHg; p=0.002) with very low evidence certainty. </p> <p><b>LIMITATIONS</b> Studies were predominantly short-term (<6 months) with a small number of participants (n<100).</p> <a><b>CONCLUSION</b> While evidence from short-term studies suggests vitamin C supplementation may improve glycemic control and blood pressure in people with type 2 diabetes, vitamin C supplementation cannot currently be recommended as a therapy until larger, long-term and high quality trials confirm these findings. </a>

scholarly journals The relationship between circulating irisin levels and tissues AGE accumulation in type 2 diabetes patients

2017 ◽  
Vol 37 (3) ◽  
Author(s):  
Zhu Li ◽  
Gang Wang ◽  
Yan-juan Zhu ◽  
Chen-guang Li ◽  
Yun-zhao Tang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vascular Complications ◽  
Diabetic Patients ◽  
Healthy Controls ◽  
Type 2 Diabetic Patients ◽  
Glycation End Products ◽  
The Relationship ◽  
Type 2 Diabetic ◽  
Diabetes Patients

Advanced glycation end-products (AGEs), measured by skin autofluorescence (AF), are a factor in the development or worsening of many degenerative diseases, such as diabetes and atherosclerosis. Irisin levels have been associated with diabetes, endothelial dysfunction and atherosclerosis. The objective of the present study was to investigate whether circulating irisin levels are correlated with skin AF values in type 2 diabetes patients. A total of 362 Chinese type 2 diabetic patients and 100 age- and sex-matched healthy controls were recruited in the present study. Clinical characteristics, blood biochemistry and circulating irisin levels were measured. Skin AF was measured using an AGE reader. Circulating irisin levels were significantly lower, while skin AF values were increased in type 2 diabetes compared with controls (P<0.05 respectively). By dividing the distribution of skin AF values into tertiles, serum irisin levels gradually lowered with increasing skin AF values (P<0.05). After adjusting for covariates, multivariate stepwise regression analysis demonstrated that serum lower irisin levels were independently associated with skin AF (P=0.009). Circulating irisin levels were lower in type 2 diabetes patients compared with healthy controls. Lower levels of irisin are independently associated with elevated skin AF values, indicating that circulating irisin levels could be associated with AGEs accumulation, which is one of the reasons causing vascular complications in diabetic patients.

scholarly journals THE EXTRACT SOYBEAN OF LOCAL VARIETIES AS REDUCE ADVANCED GLYCATION END PRODUCTS AND HEMOGLOBIN A1C IN TYPE 2 DIABETES MICE

2018 ◽  
Vol 11 (11) ◽  
pp. 333 ◽  
Author(s):  
Juliana Christyaningsih ◽  
Taufiqurrahman Taufiqurrahman ◽  
Sujono Sujono
Keyword(s):  
Type 2 Diabetes ◽  
Amino Acids ◽  
Advanced Glycation End Products ◽  
Hemoglobin A1c ◽  
Control Group ◽  
Advanced Glycation ◽  
Local Varieties ◽  
Glycation End Products ◽  
End Products

Objectives: Glucose and amino acids or fat in diabetic patients if were oxidized to form a compound amadori product (hemoglobin A1c [HbA1c]) and intermediate dicarbonyl that uses reactive carbonyl groups to bind with the amino acids to form advanced glycation end products (AGEs). Soybean is classified as a low index glycemic and content of polyphenol compounds are reported to have various biological activities, which are beneficial to health. Project objectives: The aim of this study was to determine the effect of extract soybean of local varieties obtained on AGEs and HbA1c.Methods: This study was a randomized pretest-posttest control group design. The amount of 28 Mus musculus Balb/C was divided into seven groups. The control group was divided four, while the test group was given extracts of three varieties of soybean, that is, Gema, Wilis, and Argomulyo at a dose equivalent to 1 g of soy/kg BW/day for 25 days. Type 2 diabetes (T2D) mice made with the administration of STZ at a dose of 55 mg/kg in mice.Results: There is a sign of differences in HbA1c levels in the group of mice, and there are different levels of AGEs, though not statistically significant in the group of mice.Conclusions: The extract soybean was a positive effect on the levels of AGEs and HbA1c in T2D mice.

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