scholarly journals GDF15(MIC1)H6D Polymorphism Does Not Influence Cardiovascular Disease in a Latin American Population with Rheumatoid Arthritis

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Jenny Amaya-Amaya ◽  
Adriana Rojas-Villarraga ◽  
Nicolas Molano-Gonzalez ◽  
Laura Montoya-Sánchez ◽  
Swapan K. Nath ◽  
...  

Objective. Rheumatoid arthritis (RA) is the most common autoimmune arthropathy worldwide. The increased prevalence of cardiovascular disease (CVD) in RA is not fully explained by classic risk factors. The aim of this study was to determine the influence of rs1058587 SNP withinGDF15(MIC1)gene on the risk of CVD in a Colombian RA population.Methods. This was a cross-sectional analytical study in which 310 consecutive Colombian patients with RA and 228 age- and sex-matched controls were included and assessed for variables associated with CVD. The mixed cluster methodology based on multivariate descriptive methods such as principal components analysis and multiple correspondence analyses and regression tree (CART) predictive model were performed.Results. Of the 310 patients, 87.4% were women and CVD was reported in 69.5%. Significant differences concerningGDF15polymorphism were not observed between patients and controls. Mean arterial pressure, current smoking, and some clusters were significantly associated with CVD.Conclusion.GDF15(rs1058587) does not influence the development of CVD in the population studied.

2009 ◽  
Vol 36 (1) ◽  
pp. 12-15 ◽  
Author(s):  
YOUNG HO LEE ◽  
JONG DAE JI ◽  
GWAN GYU SONG

Objective.To determine whether interleukin 1 (IL-1) polymorphisms confer susceptibility to rheumatoid arthritis (RA).Methods.We conducted metaanalyses on associations between IL-1 polymorphisms and RA susceptibility, using fixed or random effects models.Results.A total of 18 separate comparisons were made using 10 European, 7 Asian, and 1 Latin American population samples. Metaanalysis of the IL-1B+3954 CC genotype revealed an association with RA in all subjects (odds ratio = 0.776, 95% confidence interval = 0.609–0.988, p = 0.040). In Asians, an association between IL-1B+3954 and RA was identified. In contrast, no association was found between the IL-1B+3954 polymorphism and RA susceptibility in European populations. Metaanalyses of the IL-1B-511 and IL-1RN VNTR polymorphisms identified no association between these polymorphisms and RA.Conclusion.Our metaanalysis shows that the IL-1B+3954 polymorphism was associated with the development of RA, but only in Asians.


2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Ryan E. K. Man ◽  
Alvin Hong Wei Gan ◽  
Eva K. Fenwick ◽  
Alfred Tau Liang Gan ◽  
Preeti Gupta ◽  
...  

Abstract Background To explore the prevalence and determinants of unawareness of diabetes, hypertension and hypercholesterolemia and its association with poor disease control in a multi-ethnic Asian population without cardiovascular disease (CVD). Methods We included 6904 Chinese, Malay and Indian individuals (mean age [SD] 58.2 [10.2] years; 52.6% female) with diabetes, hypertension and/or hypercholesterolemia from the cross-sectional population-based Singapore Epidemiology of Eye Diseases study (2004–2011). Diabetes was defined as random blood glucose ≥ 11.1 mmol/L or HbA1c > 6.5% or self-reported use of diabetes medication; hypertension as systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg or self-reported use of anti-hypertensive treatment; and hypercholesterolemia as total cholesterol ≥ 6.2 mmol/L or self-reported use of lipid-lowering medications. Unawareness was based on participants’ answers to the questions: “Did your medical practitioner ever tell you that you have diabetes/hypertension/high cholesterol?” The determinants of unawareness, and its association with poor disease control, were assessed using multivariable binary logistic regression models adjusted for known potential confounders. Results Of the 2380 (34.5%), 5386 (78.0%) and 3607 (52.2%) with diabetes, hypertension and hypercholesterolemia, respectively, unawareness rates were 30.7%, 43.1% and 40.9%, respectively. Having a higher BMI, particularly if obese, and Malay ethnicity were associated with greater unawareness of diabetes; Malay and Indian ethnicities and current smoking with greater unawareness of hypertension; and education ≤6 years, current smoking, and blue collar jobs or unemployment with greater unawareness of hypercholesterolemia (all P < 0.05). Lack of awareness of each condition was independently associated with poorer disease control in the case of hypertension and hypercholesterolemia, while the converse was true for diabetes (all P < 0.05). Conclusions Unawareness of diabetes, hypertension, or hypercholesterolemia is high in Singapore, with risk factors varying across all three diseases, although Malay ethnicity is a consistent one. Unawareness was also associated with poor management for hypertension and hypercholesterolemia. Public health education and screening programs should target at-risk individuals, especially Malays, to reduce the likelihood of incident CVD.


2013 ◽  
Vol 2013 ◽  
pp. 1-20 ◽  
Author(s):  
Jenny Amaya-Amaya ◽  
Juan Camilo Sarmiento-Monroy ◽  
Julián Caro-Moreno ◽  
Nicolás Molano-González ◽  
Rubén D. Mantilla ◽  
...  

Objective. This study was performed to determine the prevalence of and associated risk factors for cardiovascular disease (CVD) in Latin American (LA) patients with systemic lupus erythematosus (SLE).Methods. First, a cross-sectional analytical study was conducted in 310 Colombian patients with SLE in whom CVD was assessed. Associated factors were examined by multivariate regression analyses. Second, a systematic review of the literature on CVD in SLE in LA was performed.Results. There were 133 (36.5%) Colombian SLE patients with CVD. Dyslipidemia, smoking, coffee consumption, and pleural effusion were positively associated with CVD. An independent effect of coffee consumption and cigarette on CVD was found regardless of gender and duration of disease. In the systematic review, 60 articles fulfilling the eligibility criteria were included. A wide range of CVD prevalence was found (4%–79.5%). Several studies reported ancestry, genetic factors, and polyautoimmunity as novel risk factors for such a condition.Conclusions. A high rate of CVD is observed in LA patients with SLE. Awareness of the observed risk factors should encourage preventive population strategies for CVD in patients with SLE aimed at facilitating the suppression of cigarette smoking and coffee consumption as well as at the tight control of dyslipidemia and other modifiable risk factors.


2019 ◽  
Vol 24 (3) ◽  
pp. 46-54
Author(s):  
Paola Janett Caballero-Purizaga ◽  
Luis Ernesto Arriola-Guillén ◽  
Gustavo Adolfo Watanabe-Kanno

ABSTRACT Objective: The objective of this research was to demonstrate the efficiency of the overbite depth indicator (ODI) and the anteroposterior dysplasia indicator (APDI) from Kim’s cephalometric analysis, regarding the determination of the vertical and sagittal patterns of Latin American individuals. Methods: Two hundred lateral cephalometric radiographs were selected and divided into four study groups, with 50 radiographs each, for carrying out a cross-sectional study. The control group included radiographs of balanced individuals, and the other three groups had lateral cephalometric radiographs of subjects with Class I, II and III malocclusions and with skeletal open bite. After the pilot test was performed to calibrate the investigator, the ODI and APDI were measured. Descriptive statistics were performed and the one-way ANOVA with post-hoc Tukey HSD, or Kruskal-Wallis and Mann-Whitney U-test were used. Also a multiple linear regression was employed. Results: Statistically significant differences were found for the ODI of all groups (p< 0.001), except between Class I group (65.87 ± 4.26) and Class II open bite group (67.19 ± 3.58), both with similar values to each other. For APDI, statistically significant differences were also found for all groups (p< 0.001). However, no statistically significant differences were found between the balanced group (83.18 ± 1.71) and Class I group with skeletal open bite (81.78 ± 2.69). Conclusions: ODI and APDI are reliable indicators to evaluate the sagittal and vertical patterns of an individual, demonstrating their efficiency when a Latin American population was evaluated.


2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
D E Rebellon-Sanchez ◽  
A Robledo-Colonia ◽  
L Lopez-Erazo ◽  
S Cuenca-Velez ◽  
M A Recio-Gomez ◽  
...  

Abstract Introduction Cardiovascular disease is the leading cause of morbidity and mortality worldwide. In Colombia, a Latin-American country, cardiovascular disease accounts for nearly 30% of total deaths. The country has a high heterogeneity in social conditions, health services and ethnicity across the regions. Health is coverage by two main insurances as subsidized for the poor and contributive for formal workers. Purpose The aim of this study was to identify factors related with cardiovascular mortality Methodology A cross-sectional study using data from the official mortality registries of the National Administrative Department of Statistics of Colombia (DANE). Cardiovascular mortality was defined using the International Classification of Diseases 10 (ICD-10) I00–I09, I10–I15, I20–I25, I26–I45, I47–I49, I51, I46, I50, I60–I69, I70, I71–I99 and the corresponding ICD-9. Measures of frequency by region was estimated. Factors related to cardiovascular death were explored using a multilevel mixed-effects logistic regression. Results There were 2,073,275 deaths in Colombia between 2008 and 2017. 74.0% of them was due to noncommunicable diseases, 14.7% to injuries, and 11.2% to communicable, maternal, neonatal, and nutritional diseases. Of total 30.7% (636,987 deaths) were due to cardiovascular causes and 43.3% (897,502 deaths) to other non-communicable diseases. 29.6% of cardiovascular deaths were in people under 70 years of age. The highest proportion of premature deaths was in the San Andrés Island with 36.5%, following by the Orinoquía (34.8%), the Amazonía (34.1%) and the Caribe region (31.3%). Male had higher cardiovascular mortality (OR=1.11, 95% CI: 1.10–1:12) related to women. Compared with people between 15 and 44 years of age, the chance of cardiovascular death increased in the categories of 45–70 years (OR=1.91, 95% CI: 1.87–1.95) and 70 years or older (OR=2.98, 95% CI: 2.92–3.04). Those with African-Colombian ethnicity were more likely to die from cardiovascular disease (OR=1.13, 95% CI: 1.11–1.15) related to those without ethnic recognition and similarly the raizal ethnic group from San Andrés island, OR=1.35 (95% CI: 1.19–1.52). Illiteracy was related with a 32% (95% CI: 1.29–1.36) higher chance of cardiovascular death compared to having a professional degree. Those affiliated to subsidized were more likely to die from cardiovascular disease than those to the contributive insurance OR 1.26 (95% CI: 1.25–1.27) Conclusion Cardiovascular disease is the leading cause of death in Colombia with little reduction in the proportion of premature deaths over the period. Moreover, in the least wealthy regions the proportion was higher than the national average. Health inequalities was identified related to education, ethnic origin, and type of insurance. A region approach is needed to tackle the determinants of cardiovascular mortality. FUNDunding Acknowledgement Type of funding sources: Public grant(s) – National budget only. Main funding source(s): The researcher David Rebellόn was supported by the Fogarty International Center of the National Institutes of Health under Award Number D43TW006589. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.


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