scholarly journals Influence of Abdominal Obesity on the Lipid-Lipoprotein Profile in Apoprotein E2/4 Carriers: The Effect of an Apparent Duality

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Sylvia Villeneuve ◽  
Diane Brisson ◽  
Daniel Gaudet
Keyword(s):  
Lipid Profile ◽  
Abdominal Obesity ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Low Density ◽  
Vldl Cholesterol ◽  
Apo E ◽  
Apoe Genotypes ◽  
The Impact

Background. Apolipoprotein (Apo) E plays a key role in the handling of lipoprotein particles with ApoE2 and ApoE4 frequently having opposite effects compared to ApoE3. Some individuals simultaneously carry both E2 and E4 alleles. The impact of the ApoE2/4 genotype on lipid concentrations and its consequences on health remain poorly documented.Objective. This study compared the lipid profile between ApoE2/4 carriers and other ApoE genotypes in relation to the waist circumference.Methods. Cholesterol, triglyceride (TG), and ApoB concentrations were measured among 2,680 Caucasians. Multivariate logistic regression models were used to estimate the contribution of ApoE2/4 to various dyslipidemic profiles associated with abdominal obesity.Results. In presence of abdominal obesity, the lipid profile was as deteriorated in ApoE2/4 carriers as in carriers of other ApoE genotypes. There was a more pronounced effect on TG-rich lipoproteins, particularly in ApoE2/2 (a feature of type III dysbetalipoproteinemia), and non-high-density lipoprotein (HDL) cholesterol in ApoE4/4. Compared to ApoE2/2, ApoE2/4 carriers presented lower very-low-density lipoprotein (VLDL) cholesterol concentrations and VLDL-cholesterol/TG ratios, with or without obesity, and higher low-density lipoprotein (LDL) cholesterol concentrations.Conclusion. In presence of abdominal obesity, the influence of the ApoE2 allele could be less pronounced than that of ApoE4 among ApoE2/4 individuals.

scholarly journals Longitudinal Trend in Lipid Profile of Incident Peritoneal Dialysis Patients is Not Influenced by the Use of Biocompatible Solutions

2015 ◽  
Vol 36 (2) ◽  
pp. 146-153 ◽  
Author(s):  
Yeoungjee Cho ◽  
Janine Büchel ◽  
Sonja Steppan ◽  
Jutta Passlick-Deetjen ◽  
Carmel M. Hawley ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Low Density ◽  
Lipid Parameter ◽  
Time Period ◽  
Multilevel Linear Regression ◽  
The Impact ◽  
Lipid Parameters

Background The longitudinal trends of lipid parameters and the impact of biocompatible peritoneal dialysis (PD) solutions on these levels remain to be fully defined. The present study aimed to a) evaluate the influence of neutral pH, low glucose degradation product (GDP) PD solutions on serum lipid parameters, and b) explore the capacity of lipid parameters (total cholesterol [TC], triglyceride [TG], high density lipoprotein [HDL], TC/HDL, low density lipoprotein [LDL], very low density lipoprotein [VLDL]) to predict cardiovascular events (CVE) and mortality in PD patients. Methods The study included 175 incident participants from the balANZ trial with at least 1 stored serum sample. A composite CVE score was used as a primary clinical outcome measure. Multilevel linear regression and Poisson regression models were fitted to describe the trend of lipid parameters over time and its ability to predict composite CVE, respectively. Results Small but statistically significant increases in serum TG (coefficient 0.006, p < 0.001), TC/HDL (coefficient 0.004, p = 0.001), and VLDL cholesterol (coefficient 0.005, p = 0.001) levels and a decrease in the serum HDL cholesterol levels (coefficient -0.004, p = 0.009) were observed with longer time on PD, whilst the type of PD solution (biocompatible vs standard) received had no significant effect on these levels. Peritoneal dialysis glucose exposure was significantly associated with trends in TG, TC/HDL, HDL and VLDL levels. Baseline lipid parameter levels were not predictive of composite CVEs or all-cause mortality. Conclusion Serum TG, TC/HDL, and VLDL levels increased and the serum HDL levels decreased with increasing PD duration. None of the lipid parameters were significantly modified by biocompatible PD solution use over the time period studied or predictive of composite CVE or mortality.

scholarly journals Adiponectin levels, lipid profile and glucose metabolism in patients with abdomi-nal obesity

2009 ◽  
Vol 15 (3) ◽  
pp. 309-313 ◽  
Author(s):  
O. Belyaeva ◽  
E. A. Bazhenova ◽  
A. V. Berezina ◽  
O. O. Bolsha-Kova ◽  
E. A. Chubenko ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Lipid Profile ◽  
Abdominal Obesity ◽  
Adiponectin Level ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Resistance Index ◽  
Hdl Cholesterol ◽  
Insulin Level ◽  
Model Assessment

Adiponectin levels, lipid profile and parameters of glucose metabolism were evaluated in patients with abdominal obesity. It was found that adiponectin level negatively correlated with body mass index (BMI). The significant correlations were found between levels of adiponectin, triglycerides, and high-density lipoprotein (HDL) cholesterol in patients with abdominal obesity. Patients with abdominal obesity and arterial hypertension had higher levels of total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides comparing to non-hypertensive patients with abdominal obesity. BMI increase positively correlated with insulin level and insulin resistance index estimated by homeostasis model assessment (HOMA-IR). Positive correlations were also determined between HOMA-IR and waist circumference, BMI, and adiponectin level.

scholarly journals The effect of cholecystectomy on the lipid profile of patients with gallstone disease: a prospective study

2019 ◽  
Vol 6 (11) ◽  
pp. 4112
Author(s):  
Jose V. Francisco Menezes ◽  
Rewanth R. Katamreddy
Keyword(s):  
Prospective Study ◽  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Gallstone Disease ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Lipid Profiles ◽  
Favourable Effect ◽  
Low Density ◽  
Post Surgery

Background: Gallstones are a common cause for abdominal pain and discomfort. Laparoscopic cholecystectomy is the ‘gold standard’ for the treatment of gallstone disease. The association of gallstones in patients with altered lipid profiles is well documented. Recent studies have shown that there is an improvement in the lipid profile following cholecystectomy. The aim of the study was to study the effect of cholecystectomy on lipid profile and to study the relation between lipid profile and the nature of gallstones.Methods: Prospective study involving 100 patients admitted to the surgery department for cholecystectomy at Kempegowda Institute of Medical Sciences (KIMS) hospital, Bangalore. Study period was on between October 2016 to July 2018. The pre-operative lipid profile was compared to the post-operative lipid profile done 6 months after cholecystectomy. Gallstone analysis was done with the extracted specimen.Results: There was a significant improvement in the lipid profiles of study subjects post cholecystectomy. The total cholesterol, low density lipoprotein (LDL) cholesterol, very low density lipoprotein (VLDL) cholesterol and triglycerides decreased significantly (p<0.001) post cholecystectomy. Simultaneously, there was a significant increase (p<0.001) in the high density lipoprotein (HDL) cholesterol levels post-surgery. Majority of the stones were cholesterol stones (51%) followed by pigment stones (6%) and mixed stones (43%).Conclusions: Cholecystectomy has a favourable effect on the lipid profile of patients. However, we found no correlation between lipid profile and nature of gallstones.

Standard short-term diet ameliorates the lipid profile altered by a fructose-rich diet in rats

2015 ◽  
Vol 6 (4) ◽  
pp. 335-341 ◽  
Author(s):  
L. T. Cambri ◽  
A. C. Ghezzi ◽  
G. Arsa ◽  
J. D. Botezelli ◽  
M. A. R. de Mello
Keyword(s):  
Lipid Profile ◽  
Neonatal Period ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Experimental Period ◽  
Standard Diet ◽  
Low Density ◽  
Short Term ◽  
Cholesterol Levels ◽  
Vldl Cholesterol

Markers of metabolic abnormalities are commonly found in rodents fed a fructose-rich diet. The purpose of this study was to determine whether the administration of a short-term standard diet to rats is able to improve the lipid profile altered by a fructose-rich diet. The male pups, immediately after birth, were divided in three groups according to the diet for 90 days. Standard diet: a standard diet for the whole experimental period; fructose (60% fructose-rich diet): fructose-rich diet during the entire experimental period; fructose/standard (FS): fructose-rich diet from the neonatal period up to 60 days of age and standard diet from 60 to 90 days of age. A fructose-rich diet from the neonatal period to 60 days reduced weight gain (P<0.05), as well as the weight of adipose tissues in all the regions analyzed (epididymal, mesenteric, retroperitoneal and posterior subcutaneous), and it altered the lipid profile (elevation of triglycerides, total cholesterol, low density lipoprotein (LDL) cholesterol and very low density lipoprotein (VLDL) cholesterol;P<0.05). When a standard diet was administered after the fructose-rich diet, it was able to partially reverse changes to the lipid profile, as total cholesterol levels were significantly different in all the groups (P<0.05), and triglyceride and VLDL cholesterol levels were similar between the control and FS group. In summary, a fructose-rich diet altered the lipid profile, and a standard diet can partially reverse the changed parameters in short term.

scholarly journals A study of lipid profile Levels of Type II Diabetes Mellitus

2016 ◽  
Vol 5 (2) ◽  
Author(s):  
Murwan Khalid Sabahelkhier ◽  
Mohammed Ali Awadllah ◽  
Atif Saeed Mohammed Idrees ◽  
Ali Abdel-Ghaffar Abel Rahheem Mohammed ◽  
Mohammed Abdel Rahman Idris
Keyword(s):  
Blood Glucose ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Diabetic Patients ◽  
Low Density ◽  
Type Ii

This study consists of two parts; the Part one is to evaluate the level of Blood glucose and lipid profile  among diabetic patients(121 patients) which are compared with non-diabetic subjects (60 persons)  and  part two is to correlate lipid profile with cardiovascular abnormalities among type II diabetic patients. The diabetic patients were collected from Jabir Aboeleiz Center for Diabetes (51.9±11.22 years). Sixty healthy non-diabetic subjects were chosen as controls (52.44±10.76years). Blood glucose, total cholesterol (TC), triglycerides (TG) and high density lipoprotein (HDL) were measured by enzymatic colorimetric methods in both groups, and low density lipoprotein cholesterol (LDL) was calculated for each sample. Among diabetic patients, there is high glucose level, serum total cholesterol, triglycerides and LDL cholesterol (p<0.5), while low level of HDL cholesterol was observed when compared to non-diabetic subjects. No statistically variation was found in the level of glucose and lipid profile between male and female diabetic patients. In our study, we have found that serum lipid - cholesterol, triglycerides and low-density lipoprotein - levels were significantly (p < 0.05) correlated to cardiovascular abnormalities, while HDL had shown a statistically non-significant correlation (p>0.05). The study concluded that higher level of cholesterol, triglyceride and LDL-cholesterol in diabetic patients compared to non-diabetic subjects with lower level of serum HDL-cholesterol in diabetic patient compared to non- diabetic subjects.Keywords: Diabetic, Insulin, Mellitus and lipid.

scholarly journals Anthropometric Measureme nts, Dietary Intake and Lipid Profile of Hypertensive Young Adults (25-35 years): A Comparison Between Vegetarians and Non Vegetarians

2014 ◽  
Vol 2 (3) ◽  
pp. 122-130
Author(s):  
Prajakta Nande
Keyword(s):  
Blood Pressure ◽  
Body Weight ◽  
Young Adult ◽  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
The Impact

Increasing prevalence of hypertension is a major health concern.Dietary habits and food choices play an important role in maintaining lipid levels.The aim of this study was to investigate the impact of dietary habits on lipid profile of young adult hypertensive males. Two hundred vegetarians (V) and two hundred non vegetarians (NV) stage I hypertensive young adult men from age group 25-35 yrs. Anthropometric indices like weight, height, waist circumference (WC), hip circumference (HC) and mid-upper-arm circumference (MUAC) were measured. Body mass index (BMI) and waist hip ratio (WHR) were computed using standard equations. 24 hour’s food intake data for each subject was collected for consecutive 3 days and energy and energy yielding nutrients were computed. Total cholesterol (T-C), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and triglyceride (TG) levels were estimated. Very low density lipoprotein cholesterol (VLDL-C) was computed using standard equation.Insignificant difference was noticed between V and NV for BMI, WC and HC. In contrast, MUAC of NV was found to be significantly higher than V. NV had higher mean daily intake of energy, protein and fat but low mean daily consumption of carbohydrate as compared to V.NV had higher mean values of systolic blood pressure (SBP) (p>0.05) and diastolic blood pressure (DBP) (0.01<p<0.05) than V. 30% NV were obese grade II. TC and LDL-C of NV were greater than V but HDL-C and TG of V were greater than NV (p>0.05). TC, LDL-C and VLDL-C among NV correlated positively (p<0.01) with body weight (r 0.5340, 0.4841 and 0.5921, respectively). Stronger relationships existed between HDL-C and body weight among both groups. BP, BMI and MUAC were more among NV than V. V showed better lipid profile than NV. This could be attributed to higher intake of energy and fat among NV.

scholarly journals Lipid profile of pediatric patients with chronic rheumatic diseases - a retrospective analysis

2020 ◽  
Vol 66 (8) ◽  
pp. 1093-1099
Author(s):  
Wellington Douglas Rocha Rodrigues ◽  
Roseli Oselka Saccardo Sarni ◽  
Thais Tobaruela Ortiz Abad ◽  
Simone Guerra Lopes da Silva ◽  
Fabiola Isabel Suano de Souza ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Children And Adolescents ◽  
Rheumatic Diseases ◽  
Lupus Erythematosus ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Low Density ◽  
Cross Sectional

SUMMARY AIM To describe the prevalence of dyslipidemia in children and adolescents with autoimmune rheumatic diseases (ARDs), particularly juvenile idiopathic arthritis (JIA), juvenile systemic lupus erythematosus (jSLE), and juvenile dermatomyositis (JDM). METHODS Retrospective cross-sectional study conducted in the pediatric rheumatology outpatient clinic. We evaluated 186 children and adolescents between the ages of 5 and 19 years. The medical records were reviewed for the following data: demographic and clinical features, disease activity, and lipid profile (triglycerides (TG), total cholesterol (TC), low density lipoprotein (LDL-C), high density lipoprotein (HDL-C) and very low density lipoprotein (VLDL-C)). In addition, non-HDL cholesterol was calculated as TC minus HDL-C. The cut-off points proposed by the American Academy of Pediatrics were used to classify the lipid profile. RESULTS Dyslipidemia was observed in 128 patients (68.8%), the most common being decreased HDL-C (74 patients, 39.8%). In the JIA group there was an association between the systemic subtype and altered LDL-C and NHDL-C, which demonstrated a more atherogenic profile in this subtype (p=0.027 and p=0.017, respectively). Among patients with jSLE, the cumulative corticosteroid dose was associated with an increase in LDL-C (p=0.013) and with a decrease in HDL-C (p=0.022). CONCLUSION Dyslipidemia is common in children and adolescents with ARDs, especially JIA, jSLE, and JDM, and the main alteration in the lipid profile of these patients was decreased HDL-C.

scholarly journals Analisis Profil Lipid Ikan Gelodok (Periophthalmodon schlosseri) di Desa Tanipah dan Desa Kuala Lupak Kalimantan Selatan

2020 ◽  
Vol 7 (2) ◽  
pp. 89
Author(s):  
Gusti Maharani ◽  
Hidayaturrahmah Hidayaturrahmah
Keyword(s):  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
High Density ◽  
The Body ◽  
Low Density ◽  
Purposive Sampling

Lipid adalah kelompok molekul alami yang berperan penting sebagai bahan bakar metabolisme, stabilitas membran sel dan komponen penting pada struktur sel didalam tubuh. Penelitian profil lipid ikan gelodok dilakukan dengan pemeriksaan kolesterol total, trigliserida, High Density Lipoprotein (HDL), dan Low Density Lipoprotein (LDL). Penelitian ini bertujuan untuk mengetahui dan menganalisa profil lipid yang ada pada ikan gelodok (Periothalmodon schlosseri) di perairan desa Kuala Lupak dan desa Tanipah, Kalimantan Selatan. Rancangan penelitian dilakukan secara eksploratif dengan menentukan lokasi pengambilan sampel. Teknik pengambilan sampel yang dilakukan adalah purposive sampling atau pengambilan sampel secara isidental berdasarkan pertimbangan heterogenitas lokasi sampel. Pemeriksaan profil lipid dilakukan dengan metode enzimatik. Hasil yang diperoleh pada penelitian ini yaitu profil lipid ikan timpakul pada perairan desa Tanipah mengandung kolesterol total sebanyak 101.17±36.06 mg/dL, HDL Kolesterol 26.5±7.06 mg/dL, LDL Kolesterol 50±26.9 mg/dL dan trigliserida sebanyak 134.8±146.07 mg/dL, sedangkan hasil profil lipid pada desa Kuala Lupak mengandung kolesterol total sebanyak 76.09±25.7 mg/dL, HDL Kolesterol 24±11.3 mg/dL, LDL Kolesterol 27.8±16.2 mg/dL, dan trigliserida 97.3±90.2 mg/dL, berdasarkan hasil yang didapatkan mengindikasikan bahwa kadar profil lipid pada ikan gelodok memiliki nilai yang lebih rendah dibandingkan dengan nilai kadar normal ikan pada umumnya.Lipids are a group of natural molecules that important role as fuel metabolism, cell membrane stability and important components of cell structure in the body. The research of lipid fish lipid profiles was carried out by examining total cholesterol, triglycerides, High Density Lipoprotein (HDL), and Low Density Lipoprotein (LDL). This research aims to determine and analyze the existing lipid profile in the gelodok (Periothalmodon schlosseri) in the waters of Kuala Lupak and Tanipah villages, South Kalimantan. The research design was carried out exploratively by determining the location of sampling. The sampling technique used was purposive sampling based on consideration of heterogeneity of sample locations. Lipid profile examination was carried out using an enzymatic method. The results obtained in this study are the lipid profile of the lead fish in the waters of Tanipah village containing total cholesterol as much as 101.17 ± 36.06 mg / dL, HDL Cholesterol 26.5 ± 7.06 mg / dL, LDL Cholesterol 50 ± 26.9 mg / dL and triglycerides as much as 134.8 ± 146.07 mg / dL, while the results of the lipid profile in Kuala Lupak village contained 76.09 ± 25.7 mg / dL total cholesterol, HDL Cholesterol 24 ± 11.3 mg / dL, Cholesterol LDL 27.8 ± 16.2 mg / dL, and triglycerides 97.3 ± 90.2 mg / dL, based on the results obtained indicate that the lipid profile level in the mackerel fish has a lower value than the normal value of fish in general.Keywords: lipid, Perithalmodon schlosseri, total cholesterol, Lipoprotein, Triglycerides

Platelet Aggregation and Plasma Lipoproteins in Alcoholics During Alcohol Withdrawal

1986 ◽  
Vol 55 (02) ◽  
pp. 173-177 ◽  
Author(s):  
K Desai ◽  
J S Owen ◽  
D T Wilson ◽  
R A Hutton
Keyword(s):  
Platelet Aggregation ◽  
Alcohol Withdrawal ◽  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Plasma Lipoprotein ◽  
Cholesterol Concentration ◽  
Arachidonic Acid Content ◽  
Low Density

SummaryPlatelet aggregation, platelet lipid composition and plasma lipoprotein concentrations were measured each week in a group of seventeen alcoholics, without overt liver disease, for one month, following acute, total alcohol withdrawal. The platelets were initially hypoaggregable but, within 1-2 weeks of cessation of drinking, they became hyperaggregable and then gradually returned towards normal values. Hyperaggregability could not be explained by increases in either the cholesterol or the arachidonic acid content of the platelets. Plasma very-low-density lipoprotein cholesterol levels remained high throughout the study, but the initially raised levels of high-density lipoprotein (HDL) cholesterol fell by 26%. Low-density lipoprotein (LDL) cholesterol concentration rose by 10% after two weeks of withdrawal but then returned to about the starting level. The resulting changes in the plasma LDL-cholesterol: HDL-cholesterol ratio, which had increased by more than 50% after two weeks of abstinence, essentially paralleled the time course of enhanced platelet reactivity in all but four of the alcoholics. These findings suggest that alterations in plasma lipoprotein concentrations during acute alcohol withdrawal may be a contributory factor to the haemostatic disorders present in such patients.

Effect of Turmeric and Ginger on Lipid Profile in Male Rats Exposed to Oxidative Stress

2019 ◽  
Vol 10 (01) ◽  
Author(s):  
Eman A. Al-Rekabi ◽  
Dheyaa K. Alomer ◽  
Rana Talib Al-Muswie ◽  
Khalid G. Al-Fartosi
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Drinking Water ◽  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Male Rats ◽  
Control Group ◽  
Very Low Density Lipoprotein ◽  
Low Density

The present study aimed to investigate the effect of turmeric and ginger on lipid profile of male rats exposed to oxidative stress induced by hydrogen peroxide H2O2 at a concentration of 1% given with consumed drinking water to male rats. Methods: 200 mg/kg from turmeric and ginger were used, and the animals were treatment for 30 days. Results: the results showed a significant increase in cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipoprotein (VLDL), whereas it explained a significant decrease in high density lipoprotein (HDL) of male rats exposed to oxidative stress when compared with control group. the results showed a significant decrease in cholesterol, triglycerides, (LDL), (VLDL), whereas it explained a significant increase in (HDL) of rats treated with turmeric and ginger at dose 200 mg/kg when compared with male rats exposed to oxidative stress.

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