scholarly journals From Traditional Usage to Pharmacological Evidence: Systematic Review ofGunnera perpensaL.

2016 ◽  
Vol 2016 ◽  
pp. 1-14 ◽  
Author(s):  
Alfred Maroyi
Keyword(s):  
Biological Activities ◽  
Pharmaceutical Products ◽  
Future Research ◽  
Pharmacological Activities ◽  
Sexually Transmitted ◽  
Animal Diseases ◽  
Wide Range ◽  
Medicinal Properties ◽  
Human And Animal Diseases

Gunnera perpensais the only species of the genusGunnerathat has been recorded in Africa. Its leaves, rhizomes, roots, and stems are reported to possess diverse medicinal properties and used to treat or manage various human and animal diseases and ailments.Gunnera perpensais an ingredient in many herbal concoctions and prescriptions which have been used to induce or augment labour, postnatal medication, to treat parasitic diseases, urinary complaints, kidney problems, general body pains, sexually transmitted infections, and many other diseases. Several classes of phytochemicals including alkaloids, benzoquinones, ellagic acids, flavonoids, phenols, proanthocyanidins, tannins, and minerals have been isolated fromG. perpensa. Scientific studies onG. perpensaindicate that it has a wide range of pharmacological activities including acetylcholinesterase, anthelmintic, antibacterial, antifungal, antinociceptive, anti-inflammatory, antioxidant, antitumour, lactogenic, and uterotonic.Gunnera perpensahas a lot of potential as a possible source of pharmaceutical products for the treatment of a wide range of both human and animal diseases and ailments. Some of the chemical compounds isolated fromG. perpensahave demonstrated various biological activities when investigated inin vitroassays. Future research should focus on the mechanisms of action of the isolated compounds, their efficacy, toxicity, and clinical relevance.

scholarly journals URARIA PICTA (JACQ.): A REVIEW ON ETHNOMEDICAL USES, PHYTOCHEMISTRY, AND BIOLOGICAL ACTIVITIES

2021 ◽  
pp. 40-44
Author(s):  
JAYKUMAR MANE ◽  
DHEERAJ NAGORE ◽  
SOHAN CHITLANGE
Keyword(s):  
Biological Activities ◽  
Future Research ◽  
Phytochemical Analysis ◽  
Pharmacological Activities ◽  
Technological Potential ◽  
Depth Study ◽  
Toxicological Research ◽  
Commercial Research

The aim of this systematic review is to provide an in-depth study of ethnological uses, phyto-chemistry, pharmacological activities, and toxicological research in Uraria picta (Jacq.), to identify remaining gaps, and to provide a basis for future research. By searching for the words “U. picta” and “Prishnaparni” in electronic databases such as SciFinder, Web of Science, PubMed, and Google Scholar, information on common uses, phytochemistry, and pharmacological activities was systematically collected. Phytochemical analysis of U. picta shows various components such as alkaloids, flavonoids, steroids, terpenoids, phenols, and saponins. The extracts and their isolated components showed numerous in vitro and in vivo pharmacological effects, including urinary tract diseases, tumors, edema, smoking, and dyspnea. On the other hand, searches of patent databases found almost seven applications, highlighting the differences between a large number of published scientific articles and non-existent patent applications. This event demonstrates the technological potential of undiscovered species. Ethnographic research shows that U. picta, an important Asian medicinal plant, is used to treat many diseases. In this review, the ethnobotanical, phytochemical, pharmacological, and ethnological properties of various morphological parts of the U. picta plant are highlighted. Future research has provided information for commercial research and has shown that this herb has tremendous potential for pharmaceutical and nutritional applications.

Vitex Diterpenoids: Structural Diversity and Pharmacological Activity

2020 ◽  
Vol 26 (1) ◽  
pp. 138-159 ◽  
Author(s):  
Yanfei Ban ◽  
Tianshuang Xia ◽  
Rui Jing ◽  
Yaoli Guo ◽  
Yiya Geng ◽  
...  
Keyword(s):  
Pharmacological Activity ◽  
Hormone Level ◽  
Biological Activities ◽  
Folk Medicine ◽  
Structural Diversity ◽  
Pharmacological Activities ◽  
Structure Activity ◽  
Wide Range ◽  
Potential Applications

Plants of the genus Vitex (Verbenaceae) are mainly distributed throughout tropical and temperate regions, and many Vitex plants have been traditionally used in folk medicine. Plants of this genus are a rich source of diterpenoids, which not only displayed versatile structural diversity with potential chemotaxonomical significance but also exhibited a wide range of biological activities, mainly including in vitro cytotoxic, antiinflammatory, antimicrobial, hormone level-regulating and antiangiogenic activities. Recently, a series of bioactive diterpenoids, with interesting carbon skeletons, have been reported and gathered considerable interest. This article systematically reviewed diterpenoids isolated from the genus Vitex that appeared in the literature up to December 2018, critically highlighting their structural diversity and pharmacological activities. Up to now, a total of 154 diterpenoids with diverse structures have been isolated and identified from Vitex plants. The authors also summarized the reported structure-activity relationships of those well explored Vitex diterpenoids. Finally, the authors discussed the challenges and potential applications of these diterpenoids in the future.

Phytochemical Constituents of Guggul and their Biological Qualities

2020 ◽  
Vol 17 (3) ◽  
pp. 277-288 ◽  
Author(s):  
Vijay Kumar ◽  
Simranjeet Singh ◽  
Ravindra Singh
Keyword(s):  
Pharmacological Activities ◽  
Commiphora Wightii ◽  
Toxicological Studies ◽  
Wide Range ◽  
Commiphora Mukul ◽  
Medicinal Properties ◽  
Phytochemical Constituents ◽  
Herbal Formulations

: In the herbal drug pharmaceutical industry, guggul is enjoying emergent consumer acceptance around the world. In the Indian market, more than fifty formulations of guggul have been introduced by well-known brands including Himalaya, Patanjali and Baidyanath Pharmaceuticals. Basically, guggul is the gum resin from Commiphora wightii (syn. Commiphora Mukul). It has been used to treat various ailments including obesity, osteoarthritis, arthritis, constipation, liver disorders, inflammation, anemia, diabetes, etc. Including medicinal properties, it is used as a good binding agent and mixed in various herbal formulations. To review the major phytochemical, medicinal properties and analytical methods involved in the detection of guggul by using the exhaustive bibliographic research by means of various scientific engines and databases. Guggul contained approximately 66 phytochemical including gallic acid, quercetin, and guggulsterones E and Z. These phytochemicals have a wide range of pharmacological activities such as antioxidant, antibacterial, antimutagenic, antivenom and antitumor. It has been noticed that the mode of action of guggulsterone has not been fully explored. Pharmacology and toxicological studies are very few. These works have shown huge literature gap, which is to be fulfilled through the detailed in-vivo and in-vitro studies.

scholarly journals Ethnopharmacological Uses, Phytochemistry, and Pharmacological Properties of Croton macrostachyus Hochst. Ex Delile: A Comprehensive Review

2017 ◽  
Vol 2017 ◽  
pp. 1-17 ◽  
Author(s):  
Alfred Maroyi
Keyword(s):  
Herbal Medicine ◽  
Herbal Medicines ◽  
Pharmaceutical Products ◽  
Extensive Literature ◽  
Pharmacological Properties ◽  
Ethnoveterinary Medicine ◽  
Animal Diseases ◽  
Wide Range ◽  
Croton Macrostachyus ◽  
Human And Animal Diseases

Croton macrostachyus is widely used as herbal medicine by the indigenous people of tropical Africa. The potential of C. macrostachyus as herbal medicine, the phytochemistry, and pharmacological properties of its parts used as herbal medicines are reviewed. The extensive literature survey revealed that C. macrostachyus is traditionally used to treat or manage at least 81 human and animal diseases and ailments. The species is used as herbal medicine for diseases and ailments such as abdominal pains, cancer, gastrointestinal disorders, malaria, pneumonia, sexually transmitted infections, skin infections, typhoid, and wounds and as ethnoveterinary medicine. Multiple classes of phytochemicals such as alkaloids, amino acids, anthraquinones, carbohydrates, cardiac glycosides, coumarins, essential oil, fatty acids, flavonoids, phenolic compounds, phlobatannins, polyphenols, phytosteroides, saponins, sterols, tannins, terpenoids, unsaturated sterol, vitamin C, and withanoides have been isolated from the species. Pharmacological studies on C. macrostachyus indicate that it has a wide range of pharmacological activities such as anthelmintic, antibacterial, antimycobacterial, antidiarrhoeal, antifungal, anticonvulsant and sedative, antidiabetic, anti-inflammatory, antileishmanial, antioxidant, antiplasmodial, and larvicidal effects. Croton macrostachyus has potential as a possible source of a wide range of pharmaceutical products for the treatment of a wide range of both human and animal diseases and ailments.

scholarly journals Review of phytochemistry, biological activities and therapeutic potential of Cleistochlamys kirkii

2020 ◽  
Vol 11 (4) ◽  
pp. 5596-5602
Author(s):  
Alfred Maroyi
Keyword(s):  
Therapeutic Potential ◽  
Biological Activities ◽  
Central Africa ◽  
Indole Alkaloid ◽  
Pharmaceutical Products ◽  
Future Research ◽  
Pharmacological Properties ◽  
Scientific Publications ◽  
Medicinal Uses

Cleistochlamys kirkii (Benth.) Oliv is a shrub or small tree widely used as a traditional medicine in the east and central Africa. Cleistochlamys kirkii is indigenous to Malawi, Mozambique, Tanzania, Zambia and Zimbabwe. This study is aimed at evaluating the phytochemistry, biological activities and therapeutic potential of C. kirkii. Results of the current study are based on data derived from several online databases such as Scopus, Google Scholar, PubMed and Science Direct, and pre-electronic sources such as scientific publications, books, dissertations, book chapters and journal articles. This study revealed that the leaf and root infusion, maceration and decoction of C. kirkii are mainly used as traditional medicines for haemorrhoid wounds, rheumatism and tuberculosis. Phytochemical compounds identified from the species include α,β-unsaturated lactone, acetogenin, benzyl benzoate derivatives, c-benzylated flavanone, heptanolide, an indole alkaloid, phenolics, polyoxygenated cyclohexene and derivatives, sesquiterpene and tetracyclic triterpenes. In vitro studies have confirmed the biological activities of C. kirkii crude extracts and compounds isolated from the species which include antibacterial, antifungal, antiplasmodial and cytotoxicity. Documentation of the medicinal uses, phytochemistry and pharmacological properties of C. kirkii is essential as this information provides baseline data required for future research and development of health-promoting and pharmaceutical products. Cleistochlamys kirkii should be subjected to detailed ethnopharmacological and toxicological evaluations aimed at correlating its medicinal uses with its phytochemistry and pharmacological properties.

scholarly journals Chemical Compounds and Pharmacological Activities of Mangosteen (Garcinia mangostana L.) – Updated Review

2021 ◽  
Vol 12 (2) ◽  
pp. 2503-2516
Keyword(s):  
Research Field ◽  
In Vivo Studies ◽  
Future Research ◽  
Drug Candidate ◽  
Garcinia Mangostana ◽  
Pharmacological Activities ◽  
Tropical Fruit ◽  
Wide Range

Mangosteen (Garcinia mangostana L.) is a tropical fruit belonging to Guttiferae (syn. Clusiaceae) family. Research on mangosteen has been widely conducted. Also, numerous in vitro and in vivo studies related to mangosteen have been published, indicating its significance and potential usefulness in the research field. This review was constructed by collecting and analyzing more than 50 research articles to explore the phytochemical contents and the medicinal benefits of mangosteen. A significant level of xanthones greatly contributes to the extensive pharmacological activities of mangosteen. Apart from xanthones, mangosteen also contained benzophenones, flavonoids, and anthocyanins. Mangosteen had a wide range of pharmacological effects, including antioxidant, anti-acne, anti-aging, anti-hyperpigmentation, antibacterial, antidiabetic, anti-obesity, anti-inflammatory, antimalarial, antiparasitic, and antitumor. Additionally, mangosteen has shown an advantageous activity toward pathological conditions such as Alzheimer's, bipolar disorder, schizophrenia, neuropathic pain, and pulmonary fibrosis. This literature review indicated that xanthone in mangosteen had potential and promising to be developed as a drug candidate. More extensive explorations, especially in pharmacokinetic, pharmacodynamic, and xanthone targeting effects, are widely open to be carried out for future research.

scholarly journals A synthesis and review of medicinal uses, phytochemistry and biological activities of Markhamia zanzibarica

2020 ◽  
Vol 11 (4) ◽  
pp. 5985-5993
Author(s):  
Alfred Maroyi
Keyword(s):  
Respiratory Infections ◽  
Biological Activities ◽  
Clinical Effectiveness ◽  
Pharmaceutical Products ◽  
Future Research ◽  
Extensive Literature ◽  
Medicinal Uses ◽  
In Vivo Experiments

Markhamia zanzibarica (Bojer ex DC.) K. Schum.has been used in herbal medicine in tropical Africa since ancient times. Markhamia zanzibarica is indigenous to central, eastern and southern Africa. This extensive literature review synthesizes the information currently available on the medicinal uses, phytochemistry and biological activities of M. zanzibarica. The University library and electronic search engines Google Scholar, Scopus, Web of Science, ScienceDirect and PubMed were searched for pertinent information on the medicinal uses, phytochemistry and biological activities of M. zanzibarica. Traditionally, the species has been used as anthelmintic, and traditional medicine for backache, female reproductive problems, sexually transmitted infections, respiratory infections and gastro-intestinal problems. In vitro studies have confirmed the biological activities of M. zanzibarica which include antibacterial, antimycobacterial, antioxidant and cytotoxicity. Various phytochemicals such as alkaloids, anthraquinones, fatty acids, flavonoids, glycosides, phenolics, saponins, sterols, tannins and triterpenes have been isolated from M. zanzibarica. Documentation of the medicinal uses, phytochemistry and pharmacological properties of M. zanzibarica is essential as this information provides baseline data required for future research and development of health-promoting and pharmaceutical products. However, further pharmacological studies including phytochemical, toxicological, in vitro and in vivo experiments are needed to provide evidence for the clinical effectiveness of remedies prepared from the species.

scholarly journals Bioactivities and Structure–Activity Relationships of Fusidic Acid Derivatives: A Review

2021 ◽  
Vol 12 ◽  
Author(s):  
Junjun Long ◽  
Wentao Ji ◽  
Doudou Zhang ◽  
Yifei Zhu ◽  
Yi Bi
Keyword(s):  
Fusidic Acid ◽  
Structural Modification ◽  
Biological Activities ◽  
Pharmacological Activities ◽  
Structure Activity ◽  
Wide Range ◽  
Resistance Reversal ◽  
Anti Inflammation

Fusidic acid (FA) is a natural tetracyclic triterpene isolated from fungi, which is clinically used for systemic and local staphylococcal infections, including methicillin-resistant Staphylococcus aureus and coagulase-negative staphylococci infections. FA and its derivatives have been shown to possess a wide range of pharmacological activities, including antibacterial, antimalarial, antituberculosis, anticancer, tumor multidrug resistance reversal, anti-inflammation, antifungal, and antiviral activity in vivo and in vitro. The semisynthesis, structural modification and biological activities of FA derivatives have been extensively studied in recent years. This review summarized the biological activities and structure–activity relationship (SAR) of FA in the last two decades. This summary can prove useful information for drug exploration of FA derivatives.

scholarly journals Evaluation of medicinal uses, phytochemistry and pharmacological properties of Bersama lucens (Hochst.) Szyszyl.

2020 ◽  
Vol 11 (4) ◽  
pp. 5855-5859
Author(s):  
Alfred Maroyi
Keyword(s):  
Biological Activities ◽  
Pharmaceutical Products ◽  
In Vivo Studies ◽  
Future Research ◽  
Pharmacological Properties ◽  
Scientific Publications ◽  
Medicinal Uses ◽  
Sexually Transmitted ◽  
Phytochemical Compounds

Bersama lucens (Hochst.) Szyszyl is a shrub or small tree with its different parts used traditionally to treat various diseases. Bersama lucens has been recorded in Eswatini, Mozambique and South Africa. The main aim of this review is to provide an overview and critical analysis of the medicinal uses, phytochemistry and biological activities of B. lucens. The information presented in this study was gathered using various databases such as PubMed, Taylor and Francis imprints, Springer, NCBI, Google scholar and Science direct, and review of books, journal articles and other scientific publications kept in the University library. The bark and root infusion or decoction of B. lucens are mainly used as a blood purifier, lice repellent and protective charm, and traditional medicine for stomach problems, leprosy, stroke, sexually transmitted infections, headache, infertility, nervous disorders, impotence and menstrual pain. The biological activities exhibited by B. lucens extracts include antibacterial, antifungal and anti-inflammatory activities. Documentation of the medicinal uses, phytochemistry and pharmacological properties of B. lucens is vital as this information provides baseline data required for future research and development of health-promoting and pharmaceutical products. Future research should focus on detailed phytochemical, pharmacological and toxicological screening, in vivo studies and clinical trials involving the crude extracts and phytochemical compounds isolated from the species.

Ethnomedicinal uses, Phytochemistry and Pharmacological Aspects of the Genus Berberis Linn: A Comprehensive Review

2020 ◽  
Vol 23 ◽  
Author(s):  
Roohi Mohi-ud-din ◽  
Reyaz Hassan Mir ◽  
Prince Ahad Mir ◽  
Saeema Farooq ◽  
Syed Naiem Raza ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Pharmacological Activities ◽  
Traditional Use ◽  
Comprehensive Review ◽  
Wide Range ◽  
Anti Cancer ◽  
Comprehensive Survey ◽  
Ethnomedicinal Uses

Background: Genus Berberis (family Berberidaceae), which contains about 650 species and 17 genera worldwide, has been used in folklore and various traditional medicine systems. Berberis Linn. is the most established group among genera with around 450-500 species across the world. This comprehensive review will not only help researchers for further evaluation but also provide substantial information for future exploitation of species to develop novel herbal formulations. Objective: The present review is focussed to summarize and collect the updated review of information of Genus Berberis species reported to date regarding their ethnomedicinal information, chemical constituents, traditional/folklore use, and reported pharmacological activities on more than 40 species of Berberis. Conclusion: A comprehensive survey of the literature reveals that various species of the genus possess various phytoconstituents mainly alkaloids, flavonoid based compounds isolated from different parts of a plant with a wide range of pharmacological activities. So far, many pharmacological activities like anti-cancer, anti-hyperlipidemic, hepatoprotective, immunomodulatory, anti-inflammatory both in vitro & in vivo and clinical study of different extracts/isolated compounds of different species of Berberis have been reported, proving their importance as a medicinal plant and claiming their traditional use.

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