scholarly journals Oral Syphilis: A Reemerging Infection Prompting Clinicians’ Alertness

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Sebastian Dybeck Udd ◽  
Bodil Lund
Keyword(s):  
Infectious Diseases ◽  
Standard Treatment ◽  
Correct Diagnosis ◽  
Diagnostic Delay ◽  
Oral Lesions ◽  
Oral Manifestations ◽  
Medical Doctors ◽  
Proper Treatment ◽  
Severity Of Disease ◽  
Oral And Maxillofacial Surgeon

Syphilis is a rare but increasing disease. Due to changing sexual habits, presentation of oral manifestations may rise. Since syphilis may mimic other oral manifestations, diagnoses can be difficult. Clinicians need to be aware that ambiguous oral manifestations may in fact be caused by oral syphilis. Here, we present a case of extended diagnostic delay highlighting the importance of consulting an expert in infectious diseases in case of obscure oral lesions not responding to standard treatment. Despite seven visits to six different medical doctors, a patient who presented with oral syphilis was continuously misdiagnosed. After 6 months of increasing complaints and deteriorating severity of disease, the patient was referred to an oral and maxillofacial surgeon where the correct diagnosis was determined and proper treatment initiated.

scholarly journals HIV/AIDS-RELATED ORAL LESIONS STATISTICS IN GEORGIA 2013-2015

2019 ◽  
Author(s):  
Eter Bukhnikashvili ◽  
Mariam Tsintsadze ◽  
Nana Abashidze ◽  
Lia Jashi
Keyword(s):  
Herpes Virus ◽  
Oral Candidiasis ◽  
Correct Diagnosis ◽  
Oral Lesions ◽  
Oral Manifestations ◽  
Aids Patients ◽  
Herpès Virus ◽  
Hiv Aids

The aim of our research was to detect the frequency of oral manifestations among the new revealed HIV-infected persons in 2013-2015. For this we studied the data from the center of AIDS, according to the testimony we studied those patients who needed stationary treatment and we got these results: In 2013 out of 490 new cases the presence of specific oral manifestations was found in 253(51.63 0.796%) patients. From whom we investigated 69 (27.270.61%) people. 45(65. 220. 45%) of them had oral candidiasis and 34(49.270.45%) disorders were caused by herpes-virus. In 2014 were revealed 564 new cases and the number of different concurrent intraoral lesions were found in 295(52.300.82%) patients. We investigated from them 146(49.490.66%) people and the result was next: 98 (67.120.32%) were different kinds of oral candidiasis and 54 (36.990.32%) diseases - caused by herpes-virus. In 2015 out of 717 new cases the HIV-associated oral manifestations were found in 381(53.130.86%) patients. We investigated 184(48.290.73%) people and as a result - 118 (64.130.46%) cases of them were oral candidiasis and 67(36.410.32%) were diseases caused by herpes-virus. According to the study it is obvious, that HIV-associated oral manifestations are met quite often among the HIV/ AIDS patients. It is very important to know specifications of these disorders, to make some right investigations and correct diagnosis in all situations, especially when it takes place HIV-associated oral lesions. Dentists should take in account the importance of instant diagnostic of oral manifestations in HIV/AIDS patients.

scholarly journals Prevalence of Oral Lesions in Hospitalized Patients with Infectious Diseases in Northern Brazil

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Karina Gemaque ◽  
Gustavo Giacomelli Nascimento ◽  
José Luiz Cintra Junqueira ◽  
Vera Cavalcanti de Araújo ◽  
Cristiane Furuse
Keyword(s):  
Infectious Diseases ◽  
Periodontal Diseases ◽  
Total Sample ◽  
Hospitalized Patients ◽  
University Hospital ◽  
Oral Lesions ◽  
Oral Manifestations ◽  
Oral Manifestation ◽  
Northern Brazil ◽  
The University

The aim of this study was to assess the prevalence of oral lesions in infectious-contagious diseases patients being treated in the University Hospital of the Federal University of Pará, northern Brazil. One hundred seven patients with infectious diseases were clinically investigated for oral lesions at the University Hospital of Pará, northern Brazil. From total sample, most patients were men (65.7%) with a mean age of 45.4 years. About prevalence of systemic diseases, tuberculosis was the most frequent illness, followed by AIDS, hepatitis types B and C, leishmaniasis, and meningitis. Analyzing oral manifestations, periodontal diseases and candidiasis were the most prevalent diseases in both genders, followed by recurrent aphthous ulcers, saburral tongue, simplex herpes, and squamous cell carcinoma. Of all 107 patients, only 10 males and 6 females did not present any oral manifestation. There was no statistical difference between genders with any systemic condition (P>0.05). The great prevalence of oral manifestations in hospitalized patients with systemic disorder emphasizes the need of integral dental care in this context, aiming at a multidisciplinary approach of patients. Therefore, presence of some oral conditions, such as candidiasis, should be an alert to different systemic conditions, once in assistance with physicians; dentists can influence the early diagnosis and treatment.

scholarly journals Oral Manifestations of Systemic Alterations in Early Childhood

2013 ◽  
Vol 14 (2) ◽  
pp. 327-331 ◽  
Author(s):  
Maria Cristina Ramos Lima Padovani ◽  
Patricia Silva Barbosa ◽  
Fernando Baeder ◽  
Giselle Rodrigues de Sant'Anna ◽  
Maria Teresa Botti Rodrigues Santos ◽  
...  
Keyword(s):  
Early Childhood ◽  
Case Report ◽  
Correct Diagnosis ◽  
Oral Lesions ◽  
Oral Manifestations ◽  
Age Group ◽  
The Third ◽  
Pediatric Dentist ◽  
Related Approach ◽  
Herpetic Gingivostomatitis

ABSTRACT Aim This study aimed to describe certain common oral manifestations during early childhood that should be known by the pediatric dental surgeon. Background The correct diagnosis and treatment of oral manifestations during early childhood is important for children's development. The pediatric dentist is responsible for maintaining oral health in children, since they change constantly during their development and growth. Case report Four cases of oral lesions are described, in which the diagnosis and related approach for each one is reported. The first was an acute primary herpetic gingivostomatitis, the second, pseudomembranous candidiasis, the third, chickenpox and the last was molluscum. Conclusion Professionals who treat children in this age group must be able to diagnose and treat common oral manifestations when necessary and should refer the child to a pediatrician for effective treatment if the presence of any systemic alteration is suspected. Clinical significance Pathognomonic signs of the most common oral manifestations in early childhood should be known by dentists to improve early diagnosis and proper management. How to cite this article Padovani MCRL, Barbosa PS, Baeder F, de Sant'Anna GR, Santos MTBR, Guaré RO. Oral Manifestations of Systemic Alterations in Early Childhood. J Contemp Dent Pract 2013;14(2):327-331.

scholarly journals POS1137 IDENTIFYING ADULT HYPOPHOSPHATASIA IN THE RHEUMATOLOGY UNIT

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 848.1-848
Author(s):  
J. Feurstein ◽  
M. Behanova ◽  
J. Haschka ◽  
K. Roetzer ◽  
G. Uyanik ◽  
...  
Keyword(s):  
Burden Of Illness ◽  
Trabecular Bone Score ◽  
Correct Diagnosis ◽  
Diagnostic Delay ◽  
Official Journal ◽  
Mineral Density ◽  
Mineral Research ◽  
Clinical Factor ◽  
Logistic Regression Models ◽  
Rheumatology Unit

Background:The most frequent manifestation in adult Hypophosphatasia (HPP) is musculoskeletal pain.1,2 The unspecific nature of its clinical presentation may prevent correct diagnosis.3Objectives:Identifying adult hypophosphatasia in the rheumatology unit.Methods:Over a period of 10 years 9,522 patients were screened in a rheumatological outpatient unit. Serum ALP levels ≤ 40 U/l were found in 524 patients. After screening for secondary causes, 73 patients were invited for clinical evaluation. Genetic testing was performed in 23 patients with suspected HPP. Logistic regression models were used to estimate the association of each clinical factor with HPP.Results:Mutations in the ALPL gene were observed in 57% of genetically screened patients. Arthralgia, fractures and pain were the leading symptoms in HPP patients. Chondrocalcinosis (OR 29.12; 95% CI 2.02-1593.52) and dental disease (OR 8.33; 95% CI 0.93-143.40) were associated with HPP independent of BMI. Onset of symptoms in HPP was at 35.1 (14.3) years, with a mean duration from symptoms to diagnosis of 14.4 (8.1) years. Bone mineral density (BMD) and trabecular bone score (TBS) as well as bone turnover markers were not indicative for HPP.Conclusion:HPP can mimic joint diseases.4 Thus, in patients with uncertain rheumatologic complaints and low ALP, HPP should be considered as potential diagnosis.References:[1]Durrough C, Colazo JM, Simmons J, et al. Characterization of physical, functional, and cognitive performance in 15 adults with hypophosphatasia. Bone 2021;142:115695.[2]Seefried L, Kishnani PS, Moseley S, et al. Pharmacodynamics of asfotase alfa in adults with pediatric-onset hypophosphatasia. Bone 2021;142:115664.[3]Högler W, Langman C, Gomes da Silva H, et al. Diagnostic delay is common among patients with hypophosphatasia: initial findings from a longitudinal, prospective, global registry. BMC musculoskeletal disorders 2019;20(1):80.[4]Seefried L, Dahir K, Petryk A, et al. Burden of Illness in Adults With Hypophosphatasia: Data From the Global Hypophosphatasia Patient Registry. Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research 2020;35(11):2171-78.Disclosure of Interests:None declared.

scholarly journals COVID-19: Oral Manifestations-A Dentist's Perspective

2021 ◽  
Vol 5 (2) ◽  
pp. RV1-RV5
Author(s):  
Ruhee Sangha ◽  
Sumanjit ◽  
Ramandeep Sandhu ◽  
Mohit Bansal ◽  
Simran
Keyword(s):  
Health Care ◽  
Early Diagnosis ◽  
Inflammatory Response ◽  
Oral Hygiene ◽  
Acute Respiratory Infection ◽  
Facial Pain ◽  
Opportunistic Infections ◽  
Oral Lesions ◽  
Oral Manifestations ◽  
Global Pandemic

Covid-19 is a global pandemic disease which has crippled health care system and economics worldwide. According to WHO, an acute respiratory infection, fever and cough are the most valid diagnostic clinical features. Some common orofacial manifestations of this viral infection may contribute to early diagnosis of covid-19 infection. Oral manifestations include olfactory and gustatory disturbances, dry mouth, facial pain, vesicobullous lesions such as erosion, pustule, macule, papule, plaque, pigmentation and depapilliated tongue with whitish areas, hemorrhagic crust, necrosis, swelling and  erythema. The most common sites of involvement in descending order are tongue (38%), labial mucosa (26%), and palate (22%).  Oral lesions are symptomatic in 68% of the cases who test positive for SARS Co-V. Lack of oral hygiene, opportunistic infections, stress, immunosuppression, vasculitis, and hyper-inflammatory response secondary to COVID-19 are the most important predisposing factors for onset of oral lesions in COVID-19 patients.

Oral Manifestations of Pediatric Human Immunodeficiency Virus Infection: A Review of the Literature

PEDIATRICS ◽  
1996 ◽  
Vol 97 (3) ◽  
pp. 380-388
Author(s):  
Mark W. Kline
Keyword(s):  
Disease Status ◽  
Oral Lesions ◽  
Oral Manifestations ◽  
Hiv Disease ◽  
Continuous Assessment ◽  
Immunodeficiency Virus ◽  
History Of ◽  
Adults And Children ◽  
Available Information ◽  
Distinguishing Features

Oral lesions are the source of substantial HIV-associated morbidity in both adults and children. In addition, certain oral lesions are markers for progressive immunologic dysfunction and HIV disease progression. For these reasons, careful and continuous assessment of oral health is an integral part of comprehensive HIV disease treatment. Available information suggests that HIV-infected children have many of the same oral manifestations observed in HIV-infected adults, but distinguishing features have been noted. Prospective pediatric studies are needed to determine the prevalence and natural history of oral lesions, to examine the relationships between immunologic and virologic markers of HIV disease status and the occurrence of oral manifestations, to evaluate changes in the oral microbial flora of HIV-infected children over time, and to assess the causative nature of oral lesions comprehensively.

scholarly journals Oral Manifestations in HIV/AIDSInfected Children

2011 ◽  
Vol 05 (03) ◽  
pp. 291-298 ◽  
Author(s):  
Charles Mugisha Rwenyonyi ◽  
Annet Kutesa ◽  
Louis Muwazi ◽  
Isaac Okullo ◽  
Arabat Kasangaki ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Dental Caries ◽  
Highly Active Antiretroviral Therapy ◽  
Dietary Habits ◽  
Oral Candidiasis ◽  
Cervical Lymphadenopathy ◽  
World Health ◽  
Mulago Hospital ◽  
Oral Lesions ◽  
Oral Manifestations

ABSTRACTObjectives: To assess factors influencing the distribution of oral manifestations in HIV/AIDS-infected children attending the Paediatric Infectious Disease Clinic in Mulago Hospital, Kampala. Methods: This was a cross-sectional study comprising 237 children (males/females: 113/124) aged 1 to 12 years. The parents/guardians were interviewed to obtain demographic information, oral hygiene practices, dietary habits and health seeking behaviours as well as any medications taken. The children were clinically examined for oral lesions based on World Health Organization criteria with modifications. Results: About 71.7% of the children cleaned their teeth. About 16.9% of the children had visited a dentist since birth, mainly for emergency care. One or more oral lesions were recorded in 73% of the children of whom 19.0% experienced discomfort during oral functions. Cervical lymphadenopathy, oral candidiasis and gingivitis were the most common soft tissue oral lesions: 60.8%, 28.3% and 19.0%, respectively. Except for dental caries, the overall frequency distribution of soft tissue oral lesions was significantly lower in children on highly active antiretroviral therapy (HAART) as compared to their counterparts not on HAART. The prevalence of dental caries in deciduous and permanent dentitions was 42.2% and 11.0%, respectively. Tooth brushing and previous visits to the dentist were indirectly and significantly associated with dental caries. About 5.9% (n=14) of the children had <200 CD3 + CD4 T-lymphocyte cells per μl of blood. Conclusions: The majority of the children had one or more oral lesions, particularly in the group not on HAART. Some of the lesions were associated with discomfort during oral functions. (Eur J Dent 2011;5:291-298)

Chronobiology differs between men and women with cluster headache, clinical phenotype does not

Neurology ◽  
2017 ◽  
Vol 88 (11) ◽  
pp. 1069-1076 ◽  
Author(s):  
Nunu Lund ◽  
Mads Barloese ◽  
Anja Petersen ◽  
Bryan Haddock ◽  
Rigmor Jensen
Keyword(s):  
Cluster Headache ◽  
Clinical Characteristics ◽  
Clinical Phenotype ◽  
Correct Diagnosis ◽  
Diagnostic Delay ◽  
Headache Disorders ◽  
Structured Interviews ◽  
Secondary Sector ◽  
Headache Center

Objective:To describe differences between the sexes in the phenotype of cluster headache (CH) in a large, well-characterized clinical CH population.Methods:Patients from the Danish CH survey aged 18–65 years, diagnosed with CH according to International Classification of Headache Disorders, second edition, completed questionnaires and structured interviews.Results:A total of 351 patients with CH participated, with a male:female ratio of 2:1. The diurnal variation of attacks showed moments of peak prominence in men’s attack cycle to be advanced by 1 hour compared to women’s, despite no difference in self-reported bedtime or chronotype (p = 0.31). The onset of CH decreased with increasing age for both sexes. Diagnostic delay was numerically longer for men vs women (6.56 vs 5.50 years, p = 0.21); however, more women had previously been misdiagnosed (61.1% vs 45.5%, p < 0.01) and received the correct diagnosis at a tertiary headache center (38.8% vs 20.9%, p < 0.001). Only minor sex differences in clinical characteristics were found but chronic CH was more prevalent in women compared to men (44.0% vs 31.9%, p < 0.05).Conclusions:Despite a similar clinical phenotype, diurnal attack cycle is advanced by 1 hour in men with CH compared to women. Rhythmicity is a defining characteristic of CH and these findings suggest differences in the hypothalamus’ influence on attack occurrence between the sexes. In addition, women were more often misdiagnosed and diagnosis in the primary or secondary sector more often failed. Furthermore, women had chronic CH more frequently than men. A long diagnostic delay and frequent misdiagnosis emphasize the need for increased awareness of CH in both sexes.

scholarly journals Molecular Application of Aptamers in the Diagnosis and Treatment of Cancer and Communicable Diseases

2018 ◽  
Vol 11 (4) ◽  
pp. 93 ◽  
Author(s):  
Philisiwe Molefe ◽  
Priscilla Masamba ◽  
Babatunji Oyinloye ◽  
Londiwe Mbatha ◽  
Mervin Meyer ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Diagnostic Delay ◽  
Drug Carriers ◽  
Diagnostic Tools ◽  
Rna Molecules ◽  
Diagnostic Agents ◽  
Target Molecules ◽  
Diagnostic Delays ◽  
Huge Challenge

Cancer and infectious diseases such as Ebola, HIV, tuberculosis, Zika, hepatitis, measles and human schistosomiasis are serious global health hazards. The increasing annual morbidities and mortalities of these diseases have been blamed on drug resistance and the inefficacy of available diagnostic tools, particularly those which are immunologically-based. Antibody-based tools rely solely on antibody production for diagnosis and for this reason they are the major cause of diagnostic delays. Unfortunately, the control of these diseases depends on early detection and administration of effective treatment therefore any diagnostic delay is a huge challenge to curbing these diseases. Hence, there is a need for alternative diagnostic tools, discovery and development of novel therapeutic agents. Studies have demonstrated that aptamers could potentially offer one of the best solutions to these problems. Aptamers are short sequences of either DNA or RNA molecules, which are identified in vitro through a SELEX process. They are sensitive and bind specifically to target molecules. Their promising features suggest they may serve as better diagnostic agents and can be used as drug carriers for therapeutic purposes. In this article, we review the applications of aptamers in the theranostics of cancer and some infectious diseases.

scholarly journals Pitfalls associated with the diagnosis of herpes simplex encephalitis

2013 ◽  
Vol 04 (02) ◽  
pp. 176-179 ◽  
Author(s):  
Ivana Vachalová ◽  
Leila Kyavar ◽  
Josef G Heckmann
Keyword(s):  
Herpes Simplex ◽  
Lumbar Puncture ◽  
Herpes Simplex Encephalitis ◽  
Correct Diagnosis ◽  
Diagnostic Delay ◽  
Cranial Computed Tomography ◽  
Diabetic Woman ◽  
High Morbidity ◽  
Posttraumatic Epilepsy ◽  
Atypical Presentations

ABSTRACTHerpes simplex encephalitis (HSE) still remains a serious illness with high morbidity and mortality. The characteristic presentation of HSE usually consists of fever, headache, and altered mental function. We present three patients with atypical features of HSE. First, a 48‑year‑old man with symptomatic posttraumatic epilepsy, who developed a gastrointestinal infection, seizures, and fever. After significant clinical improvement, the patient had fever again and developed a status epilepticus, which led to the diagnosis of HSE. Second, an 84‑year‑old woman with hyperactive delirium after levofloxacin intake. Cranial computed tomography (CCT) revealed hypodense temporal changes, prompting lumbar puncture and diagnosis of HSE. Third, a 51‑year‑old diabetic woman presented with fever and acute confusion. As CCT and cell count of cerebrospinal fluid (CSF) were normal, infection and hyperglycemia as initial diagnoses were postulated. Due to aphasic symptoms, the differential diagnosis of a stroke was taken into account. Thus a second lumbar puncture led to the correct diagnosis of HSE. These atypical presentations need a high grade of suspicion and a high willingness to reconsider the initial working diagnosis, in order to prevent a diagnostic delay.

Sign in / Sign up

Export Citation Format

Share Document