scholarly journals The Effects ofPunica granatumFlower Extract on Skin Injuries Induced by Burn in Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Ebrahim Nasiri ◽  
Seyed Jalal Hosseinimehr ◽  
Jafar Akbari ◽  
Mohammad Azadbakht ◽  
Soheil Azizi
Keyword(s):  
Wound Healing ◽  
Punica Granatum ◽  
Healing Time ◽  
Burn Injuries ◽  
Thermal Burn ◽  
Wound Area ◽  
Collagen Formation ◽  
Flower Extract ◽  
Complete Wound Healing ◽  
Average Size

Background. We compared the efficacy ofP. granatum(P) flower extract with that of silver sulfadiazine (SSD) for treating thermal burn injuries in rats.Methods. Ten Wistar rats in each group were topically given base cream, normal saline, cream containing 1% SSD, or creams containing 5% or 10%Punica granatumflower extract. The treatments were administered once daily until complete wound healing was observed. The wound area and healing time were assessed. In addition, percentage wound contraction and histopathological characteristics such as neovascularization and collagen formation were determined. The tannin content inP. granatumextract was determined.Results. The decrease in the average size of wounds on day 15 of the treatment was higher in rats treated with creams containingP. granatumextract than in rats treated with cream containing SSD (2.8±0.9 cm2versus8.4±3.2 cm2). The wounds completely healed on day 25 of the treatment in rats treated with creams containingP. granatumflower extract compared with those in rats treated with the other agents.Conclusion. These results indicated thatP. granatumflower extract promoted wound healing in rats and could be used for managing burn injuries.

Application of paste-type acellular dermal matrix in hard-to-heal wounds

2021 ◽  
Vol 30 (5) ◽  
pp. 414-418
Author(s):  
Sang Wha Kim ◽  
Hyung Sup Shim ◽  
Jihye Lee ◽  
Youn Hwan Kim
Keyword(s):  
Wound Healing ◽  
Adverse Events ◽  
Acellular Dermal Matrix ◽  
Complete Healing ◽  
Dermal Matrix ◽  
Wound Area ◽  
Number Of Patients ◽  
Complete Wound Healing ◽  
Zero Baseline ◽  
Acellular Dermal

Objective: The extracellular matrix (ECM) is one of the most important elements in wound healing. Absence or dysfunction of the ECM may impair wound healing. The application of acellular dermal matrix (ADM) as a substitute for ECM has been suggested. This study investigated the clinical application and wound healing effects of a paste-type ADM in patients presenting with hard-to-heal wounds due to various causes. Method: Patients with a hard-to-heal wound for >1 month, from September 2017 to February 2019, were included in this study. After debridement, the paste-type ADM was applied, at zero (baseline), two and four weeks. After application of the paste-type ADM, a conventional dressing was applied using polyurethane foam. Wound size, the formation of granulation tissue, re-epithelialisation, complete healing and adverse events were recorded at zero (baseline), one, two, four, eight and 12 weeks after the initial treatment. Results: A total of 18 patients took part (eight male, 10 female, mean age of 56±16.16 years). The mean wound area decreased from 17.42±10.04cm2 to 12.73±7.60cm2 by week one (p<0.05), to 10.16±7.00 by week two (p<0.0005), to 5.56±5.25 by week four (p<0.0001), to 2.77±5.15 by week eight (p<0.0001) and to 2.07±4.78 by week 12 (p<0.0001). The number of patients with >75% re-epithelialisation increased from two (11.1%) at two weeks to five (27.8%) at four weeks, to 11 (61.1%) at eight weeks and to 13 (72.2%) at 12 weeks. The number of patients showing complete wound healing was two (11.1%) at four weeks, nine (50.0%) at eight weeks and 12 (66.7%) at 12 weeks. No adverse events were reported during treatment. Conclusion: The paste-type ADM used in this study is a viable option for facilitating wound healing; it can shorten hospitalisation, and promote a faster recovery and return to normal life activities.

scholarly journals The Use of Stem Cells in Burn Wound Healing: A Review

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Fadi Ghieh ◽  
Rosalyn Jurjus ◽  
Amir Ibrahim ◽  
Alice Gerges Geagea ◽  
Hisham Daouk ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Therapeutic Effect ◽  
Healing Time ◽  
Burn Injuries ◽  
Burn Wound ◽  
Burn Wounds ◽  
Complex Processes ◽  
Burn Wound Healing

Burn wound healing involves a series of complex processes which are subject to intensive investigations to improve the outcomes, in particular, the healing time and the quality of the scar. Burn injuries, especially severe ones, are proving to have devastating effects on the affected patients. Stem cells have been recently applied in the field to promote superior healing of the wounds. Not only have stem cells been shown to promote better and faster healing of the burn wounds, but also they have decreased the inflammation levels with less scar progression and fibrosis. This review aims to highlight the beneficial therapeutic effect of stem cells in burn wound healing and to discuss the involved pathways and signaling molecules. The review covers various types of burn wound healing like skin and corneal burns, along with the alternative recent therapies being studied in the field of burn wound healing. The current reflection of the attitudes of people regarding the use of stem cells in burn wound healing is also stated.

scholarly journals PENGARUH PENGGUNAAN ASI PADA PERAWATAN LUKA PERINIEM DENGAN LAMA WAKTU PENYEMBUHAN LUKA PERINIUM

2019 ◽  
Vol 7 (2) ◽  
pp. 67-73
Author(s):  
Annisa Ul Mutmainnah ◽  
Siti Noorbaya
Keyword(s):  
Wound Healing ◽  
Data Analysis ◽  
Random Sampling ◽  
Wound Care ◽  
Healing Time ◽  
Natural Process ◽  
Control Group ◽  
P Value ◽  
Research Subjects ◽  
Wound Area

Childbirth is a natural process, but sometimes labor can also cause birth canaltrauma, especially in the aluminum region, this trauma can be injuries to the periniumarea, the cause can be intentional biases such as episiotomy or unintentional actions such as spontaneous tears in the process of removing the baby. Injury to the perineum if not treated properly can cause postpartum infection because the wound area will be a medium for developing germs. The purpose of this study was to analyze the effect of the use of breast milk in the treatment of periniem wounds with the duration of perinium wound healing at the Ramlah Parjib Clinic in Samarinda. The method used in this study was Posttest Only Control Group Desigen research subjects were postpartum motherswith a sample of 60 respondents taken by random sampling and grouped based on treatment using ASI. Data analysis using ANOVA test. The results showed that the use of ASI had a significant effect on the treatment of periniem wounds with a healing time seen from the P value of 0,000. Conclusion: Periniuem wound care techniques are factors that influence the duration of perinieum wound healing

scholarly journals Surgical treatment of chronic hidradenitis suppurativa in the gluteal and perianal regions

2012 ◽  
Vol 59 (2) ◽  
pp. 91-95 ◽  
Author(s):  
Sokol Bilali ◽  
Vangjel Todi ◽  
Ali Lila ◽  
Valbona Bilali ◽  
Julian Habibaj
Keyword(s):  
Wound Healing ◽  
Successful Treatment ◽  
Hidradenitis Suppurativa ◽  
Surgical Excision ◽  
Healing Time ◽  
Complete Healing ◽  
Sweat Glands ◽  
Apocrine Glands ◽  
Treatment Methods ◽  
Complete Wound Healing

Introduction: Verneuil disease, or perianal hidradenitis suppurativa (HS), is a chronic suppurative disease with a tendency to develop sinus formation, fibrosis, and sclerosis, having a great impact on quality of life. HS affect the apocrine sweat glands or sebaceous glands and may arise in each of the regions where the apocrine glands are prominent: the axilla, breast aureole, umbilicus, perineum, groin, and buttocks. We present here moderate and extensive HS cases, with their respective treatment methods and outcomes. Methods: A retrospective re-view of 6 patients? medical records from January 2001 to December 2010. Results: The 6 patients underwent treatment for HS in the gluteal and perianal regions with surgical excision. Five of the patients were male (83%). The median age was 42.5 years. We performed a total of 8 operations on these patients. In 3 patients, the wound was left open for secondary healing, and the mean time for complete wound healing was 11.3 weeks (range: 9.5-19 weeks). Delayed skin grafting was used for 2 patients in whom the wounds had been left open after the first operation. In this group, complete wound healing took 2 months in total. One patient underwent primary wound closure using rotation flaps, with a complete healing time of 2 weeks. Successful treatment without recurrence was accomplished in 5 (83.3%) of the patients. Conclusion: The conservative treatment methods had little effect, particularly on gluteal and perianal/perineal HS. The only successful treatment was wide surgical excision. Management of the wound after wide excision should be tailored to the individual patient.

scholarly journals Using tilapia skin (Oreochromis niloticus) as an occlusive biological curative in equine wounds:

2020 ◽  
Vol 56 (4) ◽  
pp. e154079 ◽  
Author(s):  
Sofia Cicolo da Silva ◽  
Vívian Fratti Penna Ríspoli ◽  
Cesar Graner ◽  
Lilian Rose Marques de Sá ◽  
Carla Bargi Belli ◽  
...  
Keyword(s):  
Wound Healing ◽  
Chronic Wound ◽  
Healing Process ◽  
Biological Factor ◽  
Histopathological Analysis ◽  
Environment Pollution ◽  
Wound Area ◽  
Area Reduction ◽  
Speed Up ◽  
Complete Wound Healing

Tilapia skin is being already use in humans and wild animals present burning wounds and showed a great result. The objective is to evaluate if tilapia skin used as an occlusive curative improves equine wound healing in two horses present chronic wound. Both animals are males, adults, both of breed Mangalarga Marchador South America. Every seven days wound we measured, photographed, biopsied for histopathological analysis, cleaned and tilapia curative was changed. Image J software was used to measure wound area. Tilapia skin as an occlusive biological factor seemed to improve healing process, wounds present an area reduction and clinical improvement during 35 days treatment, even though is still waiting for complete wound healing. In equine tilapia skin curative seemed to speed up healing process and allowed reduced curative change from every two days to once a week. This implies in decrease animal´s stress, less pain and treatment cost reduction since we used less bandage amount. Beside that tilapia skin industrial waste. Furthermore, it allowed avoid using antibiotics, which reduces environment pollution and there´s no antibiotic resistance issues.

scholarly journals Development of a Novel Polymer-Based mRNA Coating for Surgical Suture to Enhance Wound Healing

Coatings ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. 374
Author(s):  
Antonia Link ◽  
Hanna Haag ◽  
Tatjana Michel ◽  
Markus Denzinger ◽  
Hans Peter Wendel ◽  
...  
Keyword(s):  
Wound Healing ◽  
Population Aging ◽  
Keratinocyte Growth Factor ◽  
Functional Protein ◽  
Wound Area ◽  
Surgical Suture ◽  
Surgical Sutures ◽  
Rising Incidence ◽  
Complete Wound Healing

A therapeutic strategy to improve wound healing has become an increasingly important medical task due to the rising incidence of adiposity and type II diabetes as well as the proceeding population aging. In order to cope with the resulting burdens, new strategies to achieve rapid and complete wound healing must now be developed. Accordingly, the development of a bioactive wound dressing in the form of a messengerRNA (mRNA)-bearing poly(lactide-co-glycolide acid) (PLGA) coating on surgical suture is being pushed further with this study. Furthermore, the evaluation of the polymer-based transfection reagent Viromer RED has shown that it can be used for the transfection of eukaryotic cells: The mRNA gets properly complexed and translated into a functional protein. In addition, the mRNA-PLGA coating triggered the expression of the keratinocyte growth factor (KGF) in HaCat cells although KGF is not expressed under physiological conditions. Moreover, transfection via surgical sutures coated with mRNA does not affect the cell viability and a proinflammatory reaction in the transfected cells is not induced. These properties make the mRNA-PLGA coating very attractive for the in vivo application. For the future, this could mean that through the use of mRNA-coated sutures in surgical wound closure, cells in the wound area can be transfected directly, thus accelerating and improving wound healing.

scholarly journals Healing the third degree thermal burn in mice by Dielectric Barrier Discharge Plasma (DBD plasma): Comparison and evaluation of area, burn wound healing time, burn skin temperature

10.29007/fmkc ◽  
2020 ◽  
Author(s):  
Thi Minh Hien Ngo ◽  
Tuyet Nhi Do ◽  
Quoc Duy Nam Nguyen ◽  
Duy Phuong Nguyen ◽  
Nguyen Ngan Ha Lam ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Time ◽  
Diagnostic Methods ◽  
Invasive Treatment ◽  
Burn Wound ◽  
Dbd Plasma ◽  
Thermal Burn ◽  
Non Invasive ◽  
Burn Wound Healing ◽  
Wound Healing Time

Burns are one of the most devastating conditions encountered in medicine. This injury is in skin or other tissues, caused by heat-cold, electricity or chemicals [1,2]. There are lots of methods to treat burns and each method has its own advantages, such as medicine, dressing, low-level laser, plasma, skin graft surgery... [3].This study experimented with the 3rd degree burn model in mice by heat, treating by DBD plasma, is a non-invasive treatment and using clinical diagnostic methods by (1) normal image, (2) thermal image, (3) HE staining. Aim of this research is evaluation and comparison the area, temperature and wound healing time of non-invasive treatment with DBD plasma and nontreatment. After 3-week experiment, using diagnostic methods and analysis tools have demonstrated that the 3rd thermal burn wound healing of plasma treatment recovers faster than non-treatment about: (1) Burn wound surface shrinkage rate is higher: ~ 5%; (2) Healing time is faster: 2-3 days; (3) The average temperature of the burn wound is lower: 1-2oC. Therefore, DBD plasma is a potential treatment in burns wound and wound healing in the future. Keywords: DBD plasma, burn wound, healing wound

Efficacy of Maggot Debridement Therapy on Refractory Atypical Diabetic Foot Ulcers: An Open-Label Study

2020 ◽  
pp. 153473462092040
Author(s):  
Mansour Siavash ◽  
Ali Najjarnezhad ◽  
Nader Mohseni ◽  
Seyed Mohammad Abtahi ◽  
Azadeh Karimy ◽  
...  
Keyword(s):  
Wound Healing ◽  
Diabetic Foot ◽  
Bacterial Infections ◽  
Healing Time ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Open Label ◽  
Major Health Problem ◽  
Maggot Debridement Therapy ◽  
Complete Wound Healing

Atypical or refractory diabetic foot ulcers (DFUs) are still a major health problem. Maggot debridement therapy (MDT) by larva of Lucilia sericata is an ancient and a modern option for wound healing. It works by debridement, stimulation of wound healing, and disinfection. In this study, we aimed to evaluate the efficacy of MDT for healing atypical and refractory DFUs. Patients with atypical DFUs were selected and further evaluated for some predefined differential diagnoses like atypical fungal, parasitic, or bacterial infections, malignancy, trauma, and so on. Multiple MDT sessions were carried out. Ulcer size was measured before every MDT session. Complete wound healing, time to heal, and adverse effects were recorded as well. Forty-two DFU patients (26 men, 16 women) with 42 nonhealing atypical ulcers participated in this study. Complete wound healing was achieved in 35 patients (83.3%) by MDT. Complete debridement and then healing of the wounds happened in less than 1.79 ± 0.8 months. Four ulcers persisted, and 3 (7.1%) were eventually amputated. MDT may be considered as an effective treatment for atypical DFUs, which are unresponsive to conventional therapies.

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