scholarly journals Comparison between the Hypolipidemic Activity of Parsley and Carob in Hypercholesterolemic Male Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Haddad A. El Rabey ◽  
Madeha N. Al-Seeni ◽  
Habibah B. Al-Ghamdi
Keyword(s):  
Methanol Extract ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Male Rats ◽  
High Density Lipoproteins ◽  
Control Group ◽  
Albino Rats ◽  
Low Density ◽  
Creatine Kinase Mb ◽  
Liver Tissues

Hypercholesterolemia is commonly associated with obesity that leads to heart diseases and diabetes. The hepatocardioprotective activity of parsley and carob methanol extract was tested in hypercholesterolemic male rats. Twenty-four male albino rats were divided into four groups (n=6). Group 1 was the negative control group fed with fat rich diet, group 2 (G2) was hypercholesterolemic rats fed with fat rich diet with 2% cholesterol, and group 3 and group 4 (G3 and G4) were hypercholesterolemic rats supplemented with 2% cholesterol and cotreated with 20% w/w parsley seed methanol extract and 20% w/w carob legume methanol extract, respectively. The experiment was conducted for eight weeks. The positive hypercholesterolemic rats showed significant increase in serum levels of total cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipoprotein (VLDL), lactate dehydrogenase (LDH), creatine kinase-mb, liver function enzymes, and decrease in the high density lipoproteins (HDL). Moreover, heart and liver tissues were ameliorated and nearly restored their normal appearance. It could be concluded that both parsley and carob extracts supplementations have a protective effect against hyperlipidemia and improved the histological alteration in heart and liver tissues. The methanol extract of parsley appeared to be more efficient than that of carob in lowering hypercholesterolemia.

Effect of Turmeric and Ginger on Lipid Profile in Male Rats Exposed to Oxidative Stress

2019 ◽  
Vol 10 (01) ◽  
Author(s):  
Eman A. Al-Rekabi ◽  
Dheyaa K. Alomer ◽  
Rana Talib Al-Muswie ◽  
Khalid G. Al-Fartosi
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Drinking Water ◽  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Male Rats ◽  
Control Group ◽  
Very Low Density Lipoprotein ◽  
Low Density

The present study aimed to investigate the effect of turmeric and ginger on lipid profile of male rats exposed to oxidative stress induced by hydrogen peroxide H2O2 at a concentration of 1% given with consumed drinking water to male rats. Methods: 200 mg/kg from turmeric and ginger were used, and the animals were treatment for 30 days. Results: the results showed a significant increase in cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipoprotein (VLDL), whereas it explained a significant decrease in high density lipoprotein (HDL) of male rats exposed to oxidative stress when compared with control group. the results showed a significant decrease in cholesterol, triglycerides, (LDL), (VLDL), whereas it explained a significant increase in (HDL) of rats treated with turmeric and ginger at dose 200 mg/kg when compared with male rats exposed to oxidative stress.

scholarly journals Effect of Some Strains of Lactic Acid Bacteria and Their Mixture on the Level of Fats and Cholesterol in Albino Rats (Rattus norvegicus) Male with Hypothyroidism Induced Using Carbimazole

2021 ◽  
Vol 34 (1) ◽  
pp. 139-146
Author(s):  
Elham K. Nasser ◽  
Kithar R. Majeed ◽  
Hayder I. Ali
Keyword(s):  
High Density Lipoprotein ◽  
Low Density Lipoprotein ◽  
Control Sample ◽  
Density Lipoprotein ◽  
High Density ◽  
Control Group ◽  
Albino Rats ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Fortified Milk

Fortified milk containing Lactobacillus plantarum, L. casei, and L. acidophilus isolates and their mixture were used in dosing the male albino rats at an age of 9-12 weeks at an average of 23 g with induced hypothyroidism at a concentration of 0.6 g.kg-1 of carbimazole. Total cholesterol, triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very-low-density lipoprotein (VLDL) were estimated. The results showed a significant increase in the level of triglycerides (TG), cholesterol and triglycerides. Low-density lipoprotein (LDL) and very-low-density lipoprotein (VLDL), with a significant decrease in the level of high-density lipoprotein (HDL) in infected male mice, compared to the control sample, and upon dosing with liquid milk fortified, it returned to its normal level without significant differences from the control group.

scholarly journals Effect of Hyper and Hypothyroidism on Lipid Profile and Liver Function of Male Rats

2011 ◽  
Vol 8 (4) ◽  
pp. 926-933
Author(s):  
Baghdad Science Journal
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Physiological Saline ◽  
Serum Levels ◽  
Lipoprotein Cholesterol ◽  
Male Rats ◽  
Control Group ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Significant Difference

This study was designed to investigate the effect of thyroid hormone disturbance on lipids profiles and liver functions. Eighteen mature male rats Rattus norvegicus were divided into three groups. The first and the second groups were injected subcutaneously with thyroxine (T4) and carbimazol (both at 600 µg/kg BW) respectively on alternate days, to produce recurrent periods of hyper and hypothyroidism .The control group which is the third group was injected with physiological saline. The process continued 4 weeks, after that, injection, blood specimens were collected to estimate serum levels of T3 and T4, Total cholesterol (TC), Triglycerides (TG), High density lipoprotein cholesterol (HDL-C), Low density lipoprotein cholesterol (LDL-C) and Very low density lipoprotein cholesterol (VLDL-C) were determined in the serum. In addition to that, we measure GOT, GPT and CPK enzymes activity. The results showed no significant difference in body weight and a significant increase (P

scholarly journals PREPARATION OF SALVIA OFFICINALIS L. EXTRACT AND STUDY OF ITS EFFECT ON SOME PHYSIOLOGICAL VARIABLES IN ALBINO RATS

2021 ◽  
Vol 12 (01) ◽  
Author(s):  
Wijdan I.A. Abd- Alwahab ◽  
Wijdan I.A. Abd- Alwahab ◽  
Wijdan I.A. Abd- Alwahab
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Salvia Officinalis ◽  
Male Rats ◽  
Control Group ◽  
Phytochemical Analysis ◽  
Low Density ◽  
Physiological Variables ◽  
White Rats ◽  
Salvia Officinalis L

Salvia officinalis is one of the most valued herbs because of its high amount of essential oil and its many components. It has many health-related uses such as improving cognition, as well as reducing the amount of nursing mother's milk during weaning, also recommended for the gargling of the infectious throat, and to treat cardiovascular diseases and nervous disturbance, depression, cerebral ischemia and acts as an antiseptic for wounds. This study aim was to prepare the plant extract of Salvia officinalis L. from the Iraq local areas, determine its chemical properties and study its effect on some physiological and immunological variables in white rats. The plant leave Extract was Prepared and its effects were assessed on several physiological parameters using 20 male rats. The rats were divided into four groups. the control group(G1) received standard food and water; the negative control group (G2) received fat rich diet; G3 rats were given Salvia officinalis with a concentration of 100 mg\ kg\day. G4: rats were given Salvia officinalis 100mg/kg body weight and received fat rich diet. Roche/Hitachi, cobas c 501/502 were used to evaluate the levels of aminotransferase Enzymes, Aspartate transaminase (AST), Alanine aminotransferase (ALT), alkaline phosphatase enzyme (ALP), serum creatinine, serum urea, total protein, albumin, cholesterol, triglyceride, and high-density lipoprotein (HDL). While Globulin concentration, very Low-Density Lipoprotein (VLDL), and Low-Density Lipoprotein (LDL) were calculated according to some referred equations. The phytochemical analysis showed that the compounds identified in the sample were found to be alkaloids, phenols, tannins, coumarins glycosides, flavonoids, quinines, Carbohydrates and steroids. The results showed a significant increase (P <0.01) in the level of liver enzymes ALT, AST and ALP, in the G2 treated with the high fat diet compared with a control group and showed a significant increase (P <0.01) in the level of urea an

scholarly journals Cardio-protective properties of Momordica charantia in Albino Rats

2013 ◽  
Vol 12 (3) ◽  
pp. 291-297
Author(s):  
Ojulari Lekan Sheriff ◽  
FA Yusuf
Keyword(s):  
Plant Extract ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Momordica Charantia ◽  
Blood Cholesterol ◽  
Control Group ◽  
Albino Rats ◽  
Low Density ◽  
Protective Properties ◽  
Experimental Group

Momordica charantia, commonly known as bitter gourd, is used as a vegetable by the Asian community in Africa. It is frequently used as an anti-diabetic herb for the management of disease in the Ayurvedic system of Medicine. This present study was aimed at evaluating possible cardio-protective properties of M. charantia by determining its effect on blood cholesterol levels in albino rats. The study involved 25 rats and they were divided into 5 groups each comprising of 5 rats. The aqueous extract of M. Charantia was administered orally with syringes and cannula to 4 groups at different doses (80mg/kg, 100mg/kg, 120mg/kg and 140mg/kg body weights per day, respectively) and the last group served as the control and were given drug vehicle (normal saline) only. After two weeks of administration, the 25 rats were sacrificed and blood samples were collected and assayed for total blood cholesterol, triglyceride, highdensity lipoprotein and low-density lipoprotein levels. Results indicated that M. charantia plant extract increased significantly (P<0.05) the low density lipoprotein levels in the experimental group B (100mg/kg), and significantly reduced low density lipoprotein levels (P<0.05) in the experimental group A (80mg/kg), when compared to the control group. This study showed that M. charantia plant extract has cardio-protective properties by its dose-dependent effects on blood cholesterol. Bangladesh Journal of Medical Science Vol. 12 No. 03 July ’13 Page 291-297 DOI: http://dx.doi.org/10.3329/bjms.v12i3.15428

scholarly journals Aqueous extract of Azadirachta indica leaves favorably alters the course of streptozotocin-induced diabetes in rats: A comparative prospective cohort study

2020 ◽  
Vol 7 (7) ◽  
pp. 3877-3889
Author(s):  
Obiajulu C. Ezeigwe ◽  
Francis C. Ezeonu ◽  
Chukwudi O. Okani ◽  
Daniel N. Onwusulu ◽  
Maryclare E. Onuegbu
Keyword(s):  
Aqueous Extract ◽  
Azadirachta Indica ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Organ System ◽  
Lipoprotein Cholesterol ◽  
Male Rats ◽  
Albino Rats ◽  
Low Density ◽  
The Mean

Introduction: Azadirachta indica (neem) is one of the plants commonly used in African traditional medicine for the treatment and management of diabetes mellitus. The present study was undertaken to evaluate the effect of aqueous extract of A. indica leaves on hematology, lipid profile and organ-system function of streptozotocin-induced diabetic male rats. Methods: Thirty albino rats of Wistar strain, weighing between 120 and 150 g, were randomly divided into 6 groups (A-F) and used for the study. Group A was used as a healthy normal control. Groups B-F were induced with diabetes using 50 mg/kg bodyweight (bw.) of streptozotocin. Group B was diabetic untreated; Group C was treated with 100 mg/kg bw. metformin; Groups D to F were treated with 100, 200 and 400 mg/kg bw. of the aqueous extract, respectively. The treatment was carried out daily for a period of 28 days. At the end of the experimental period, the hematological parameters were analyzed using auto haematology analyser. Lipid profiles and histopathological investigations were performed using standard methods. Results: The results obtained showed that aqueous extract of A. indica significantly (p < 0.05) increased the hemoglobin concentration, packed cell volume, red blood cell count, and platelet count of the streptozotocin-induced diabetic rats compared with those of the diabetic-untreated rats. The mean hemoglobin concentrations for groups A, B, C, D, E and F were 11.78, 8.200, 15.18, 13.88, 14.03 and 14.93, respectively. Treatment with the graded doses of the aqueous extract of A. indica significantly (p < 0.05) reduced the total cholesterol, low-density lipoprotein cholesterol, triglycerides and very-low-density lipoprotein, compared with those of the diabetic-untreated control. Treatment also significantly (p < 0.05) increased the high-density lipoprotein cholesterol (HDL-c), compared with that of the control. The mean HDL-c concentration for groups A, B, C, D, E and F were 49.58, 29.79, 40.89, 38.53, 40.40 and 46.54, respectively. The histopathological studies showed regeneration of the pancreas, liver, kidney, heart, brain and lungs for the groups treated with the extract, compared with the diabetic-untreated animals that revealed severe damage to the organ-system functions. Conclusion: These results suggest that the aqueous extract of A. indica can be considered as an excellent remedy for diabetes and a substitute for drugs to reduce complications associated with diabetic conditions.

scholarly journals Hypoglycemic and Hypolipidemic effects of Watermelon (Citrullus vulgaris) Seed Kernels on Male Albino Rats

2017 ◽  
Vol 5 (3) ◽  
pp. 368-373 ◽  
Author(s):  
Reetapa Biswas ◽  
Alok Chattopadhyay ◽  
Santa Datta De
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Treated Group ◽  
Atherogenic Index ◽  
Control Group ◽  
Albino Rats ◽  
Seed Kernel ◽  
Low Density ◽  
Stock Diet ◽  
Modified Diet

The current investigation was planned to assess the hypoglycemic and hypolipidemic efficiency of watermelon seeds on male albino rats. Eight male albino rats weighing between 105-150g were randomly selected for the present experiment and were placed into two equal groups (n=4) designated as control and treated group. The control group received normal stock diet (20% protein, 5 % fat, 60 % carbohydrate). The treated group received a modified diet (90g Stock diet excluding groundnut oil + 9g watermelon seed kernel + 1g sugar). Percentages of protein, fat and carbohydrate in the modified diet were kept same as that of the stock diet. All animals were given water ad libitum. Rats were weighed at weekly intervals. After 28 days rats were anesthetized using chloroform anesthesia and blood samples were collected via cardiac puncture and serum was obtained for evaluation of some biochemical parameters. Result showed that serum glucose, triglyceride (TG) and very low density lipoprotein (VLDL) of the treated group were decreased significantly (p < 0.01, p < 0.05 and p < 0.05 respectively) compared to that of the control group. Liver glycogen, serum total cholesterol, low density lipoprotein (LDL) and AI (Atherogenic Index) were decreased (non-significant) whereas high density lipoprotein (HDL) increased (non-significant) in the treated group.

scholarly journals Effect of Whole Quail (Coturnix japonica) Egg Consumption on some Reproductive Parameters and Lipid Profile of Male Albino Rat (Rattus norvegicus)

2017 ◽  
Vol 9 (3) ◽  
pp. 315-320 ◽  
Author(s):  
Chidozie N. OKOYE ◽  
Samuel O. EKERE ◽  
Onyinyechukwu A. AGINA ◽  
Ikechukwu J. UDEANI ◽  
Chukwunonso K. EZEASOR
Keyword(s):  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Control Group ◽  
Low Density ◽  
Epididymal Sperm ◽  
Treatment Groups ◽  
Egg Consumption ◽  
Group A ◽  
The Mean

The present study evaluated the effect of whole egg consumption on the liver, testes, cauda epididymal sperm reserve and lipid profile of male rats. These evaluations were carried out on adult twenty (20) male albino rats, which were randomly selected into four groups of 5 rats each, designated groups A, B, C and D. Group A was the control group and received only equivalent volume of distilled water, while groups B, C and D received 0.25mg/kg, 0.5mg/kg; and 1.0mg/kg body weight of the quail egg respectively. Standard procedures were carried out in the tissue processing, cauda epididymal sperm reserve and in lipid profile determinations. On days 35 and 49, the mean serum total cholesterol value of group D was significantly lower than that of the control group. On day 35, the mean serum low density lipoprotein and high density lipoprotein (LDL and HDL cholesterol) values of all the treatment groups were significantly lower and higher than that of the control group, respectively. However, on days 49 and 63, the mean serum very low density lipoprotein (VLDL cholesterol) and triglyceride values of all the treatment groups were significantly higher than that of the control group. A significant increase in cadual epididymal sperm count (CESR) was recorded on day 63 at the mid and high doses. No obvious pathological lesions were observed in the histomorphology of the testes and liver when compared to the control. Therefore, whole quail egg consumption caused an increase in serum triglyceride and very low density lipoprotein concentration, and also improved fertility. In other words, prolonged consumption of quail egg should be done with caution as it may predispose one to cardiovascular disease.

scholarly journals Study the Effects of Methotrexate with and without Vitamin A on Some Biochemical and Histological Parameters in Male Rabbits

2017 ◽  
Vol 11 (1) ◽  
pp. 45-53
Author(s):  
Makarim Q. Al-Lami ◽  
Asmaa I. Sail ◽  
Salah M. Al-Chalabi ◽  
Ferial A. Al-Mahdawi
Keyword(s):  
Vitamin A ◽  
Histological Examination ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Treated Group ◽  
Control Group ◽  
Low Density ◽  
Typical Structure ◽  
Histological Changes ◽  
Sinusoidal Dilatation

The present study aims to evaluate the effects of methotrexate (MTX) with and without vitamin A (Vit. A) on some biochemical parameters and histological structure in male rabbits liver. Twenty male rabbits weighing 1250-1480 gm were divided into four equal number groups. The first group was given 2 ml distilled water as control group. The second group was given MTX (20 mg/kg), the third group was given Vit. A (5000 IU), while the fourth group was given MTX (20 mg/kg) +Vit. A (5000 IU) in alternative days. Following four weeks of treatment, lipid profile total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), [low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL)]; in addition to thyroid hormones triiodothyronine (T3) and thyroxin (T4)] and liver enzymes [glutamic pyruvic transaminase (GPT) and glutamic oxaloacetic transaminase (GOT)] were determined in the serum. Also, the histological examination of liver of all the experimental groups were carried out. The results were revealed that the treatment with MTX caused a significant P≤0.05 increases in TC, HDL, LDL, T4, and GPT when compared with the control group. The treatment with Vit. A did not cause any significant P≥0.05 differences in all the studied parameters. The MTX+Vit. A treated group showed a significant P≤0.05 increases only in GPT compared with the control group; while a significant P≤0.05 decreases was found in TC, HDL, T3, T4, and GOT when compared with the MTX treated group. The histological examination of the liver sections showed that MTX administration caused major histological changes in comparison with the control such as inflammatory cell infiltrations, vascular congestion, sinusoidal dilatation and granular degeneration of hepatocytes. Treatment with Vit. A showed a typical structure in liver tissue. While in MTX+Vit. A group, the histological changes were less severe than those in the MTX treated group; these changes were granular degeneration of hepatocytes and sinusoidal dilatation at low levels. The overall results of this study confirmed that administration of Vit. A decreased the side effects of MTX; this protective effect of Vit. A may have clinical applications in chemotherapy.

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