Role of Histamine in Modulating the Immune Response and Inflammation

Inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, and leukotrienes, impact the immune system, usually as proinflammatory factors. Other mediators act as regulatory components to establish homeostasis after injury or prevent the inflammatory process. Histamine, a biogenic vasoactive amine, causes symptoms such as allergies and has a pleiotropic effect that is dependent on its interaction with its four histamine receptors. In this review, we discuss the dualistic effects of histamine: how histamine affects inflammation of the immune system through the activation of intracellular pathways that induce the production of inflammatory mediators and cytokines in different immune cells and how histamine exerts regulatory functions in innate and adaptive immune responses. We also evaluate the interactions between these effects.

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Organization of the Skin Immune System and Compartmentalized Immune Responses in Infectious Diseases

Clinical Microbiology Reviews ◽

10.1128/cmr.00034-18 ◽

2019 ◽

Vol 32 (4) ◽

Cited By ~ 12

Author(s):

Juarez Antonio Simões Quaresma

Keyword(s):

Immune System ◽

Infectious Diseases ◽

Immune Responses ◽

Immune Cells ◽

Adaptive Immune Responses ◽

Adaptive Immune ◽

Skin Immune System ◽

Host Pathogen ◽

Cellular Mediators ◽

And Control

SUMMARY The skin is an organ harboring several types of immune cells that participate in innate and adaptive immune responses. The immune system of the skin comprises both skin cells and professional immune cells that together constitute what is designated skin-associated lymphoid tissue (SALT). In this review, I extensively discuss the organization of SALT and the mechanisms involved in its responses to infectious diseases of the skin and mucosa. The nature of these SALT responses, and the cellular mediators involved, often determines the clinical course of such infections. I list and describe the components of innate immunity, such as the roles of the keratinocyte barrier and of inflammatory and natural killer cells. I also examine the mechanisms involved in adaptive immune responses, with emphasis on new cytokine profiles, and the role of cell death phenomena in host-pathogen interactions and control of the immune responses to infectious agents. Finally, I highlight the importance of studying SALT in order to better understand host-pathogen relationships involving the skin and detail future directions in the immunological investigation of this organ, especially in light of recent findings regarding the skin immune system.

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The Role of Creatine in the Development and Activation of Immune Responses

Nutrients ◽

10.3390/nu13030751 ◽

2021 ◽

Vol 13 (3) ◽

pp. 751

Author(s):

Eric C. Bredahl ◽

Joan M. Eckerson ◽

Steven M. Tracy ◽

Thomas L. McDonald ◽

Kristen M. Drescher

Keyword(s):

Immune System ◽

Immune Responses ◽

Health Care Professionals ◽

Elite Athletes ◽

Nutritional Supplements ◽

The Elderly ◽

Adaptive Immune Responses ◽

Adaptive Immune ◽

The Past

The use of dietary supplements has become increasingly common over the past 20 years. Whereas supplements were formerly used mainly by elite athletes, age and fitness status no longer dictates who uses these substances. Indeed, many nutritional supplements are recommended by health care professionals to their patients. Creatine (CR) is a widely used dietary supplement that has been well-studied for its effects on performance and health. CR also aids in recovery from strenuous bouts of exercise by reducing inflammation. Although CR is considered to be very safe in recommended doses, a caveat is that a preponderance of the studies have focused upon young athletic individuals; thus there is limited knowledge regarding the effects of CR on children or the elderly. In this review, we examine the potential of CR to impact the host outside of the musculoskeletal system, specifically, the immune system, and discuss the available data demonstrating that CR can impact both innate and adaptive immune responses, together with how the effects on the immune system might be exploited to enhance human health.

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The role of platelets in inflammation

Thrombosis and Haemostasis ◽

10.1160/th14-12-1067 ◽

2015 ◽

Vol 114 (09) ◽

pp. 449-458 ◽

Cited By ~ 155

Author(s):

Robert Storey ◽

Mark Thomas

Keyword(s):

Immune Responses ◽

Inflammatory Mediators ◽

Clinical Relevance ◽

Critical Role ◽

Adaptive Immune Responses ◽

Adaptive Immune ◽

Inflammatory Stimuli

SummaryThere is growing recognition of the critical role of platelets in inflammation and immune responses. Recent studies have indicated that antiplatelet medications may reduce mortality from infections and sepsis, which suggests possible clinical relevance of modifying platelet responses to inflammation. Platelets release numerous inflammatory mediators that have no known role in haemostasis. Many of these mediators modify leukocyte and endothelial responses to a range of different inflammatory stimuli. Additionally, platelets form aggregates with leukocytes and form bridges between leukocytes and endothelium, largely mediated by platelet P-selectin. Through their interactions with monocytes, neutrophils, lymphocytes and the endothelium, platelets are therefore important coordinators of inflammation and both innate and adaptive immune responses.

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The Role of Myeloid Cells in Acute Kidney Injury and Kidney Repair

Kidney360 ◽

10.34067/kid.0000672021 ◽

2021 ◽

Vol 2 (11) ◽

pp. 1852-1864

Author(s):

Leyuan Xu

Keyword(s):

Acute Kidney Injury ◽

Immune Responses ◽

Immune Cells ◽

Experimental Studies ◽

Myeloid Cells ◽

Kidney Injury ◽

Adaptive Immune Responses ◽

Injury Repair ◽

Adaptive Immune

AKI remains highly prevalent, yet no optimal therapy is available to prevent it or promote recovery after initial insult. Experimental studies have demonstrated that both innate and adaptive immune responses play a central role during AKI. In response to injury, myeloid cells are first recruited and activated on the basis of specific signals from the damaged microenvironment. The subsequent recruitment and activation state of the immune cells depends on the stage of injury and recovery, reflecting a dynamic and diverse spectrum of immunophenotypes. In this review, we highlight our current understanding of the mechanisms by which myeloid cells contribute to injury, repair, and fibrosis after AKI.

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Neutrophil-Mediated Regulation of Innate and Adaptive Immunity: The Role of Myeloperoxidase

Journal of Immunology Research ◽

10.1155/2016/2349817 ◽

2016 ◽

Vol 2016 ◽

pp. 1-11 ◽

Cited By ~ 63

Author(s):

Dragana Odobasic ◽

A. Richard Kitching ◽

Stephen R. Holdsworth

Keyword(s):

Immune Responses ◽

Autoimmune Diseases ◽

Adaptive Immunity ◽

Inflammatory Mediators ◽

First Responders ◽

Adaptive Immune Responses ◽

Innate And Adaptive Immunity ◽

Adaptive Immune ◽

Granule Protein

Neutrophils are no longer seen as leukocytes with a sole function of being the essential first responders in the removal of pathogens at sites of infection. Being armed with numerous pro- and anti-inflammatory mediators, these phagocytes can also contribute to the development of various autoimmune diseases and can positively or negatively regulate the generation of adaptive immune responses. In this review, we will discuss how myeloperoxidase, the most abundant neutrophil granule protein, plays a key role in the various functions of neutrophils in innate and adaptive immunity.

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ATP Induces IL-1βSecretion inNeisseria gonorrhoeae-Infected Human Macrophages by a Mechanism Not Related to the NLRP3/ASC/Caspase-1 Axis

Mediators of Inflammation ◽

10.1155/2016/1258504 ◽

2016 ◽

Vol 2016 ◽

pp. 1-10 ◽

Cited By ~ 3

Author(s):

Killen García ◽

Gisselle Escobar ◽

Pablo Mendoza ◽

Caroll Beltran ◽

Claudio Perez ◽

...

Keyword(s):

Immune Responses ◽

Immune Evasion ◽

Transcriptional Activation ◽

Pore Formation ◽

Human Monocyte ◽

Positive Staining ◽

Adaptive Immune Responses ◽

Adaptive Immune ◽

Caspase 1

Neisseria gonorrhoeae(Ngo) has developed multiple immune evasion mechanisms involving the innate and adaptive immune responses. Recent findings have reported that Ngo reduces the IL-1βsecretion of infected human monocyte-derived macrophages (MDM). Here, we investigate the role of adenosine triphosphate (ATP) in production and release of IL-1βin Ngo-infected MDM. We found that the exposure of Ngo-infected MDM to ATP increases IL-1βlevels about ten times compared with unexposed Ngo-infected MDM (P<0.01). However, we did not observe any changes in inflammasome transcriptional activation of speck-like protein containing a caspase recruitment domain (CARD) (ASC,P>0.05) and caspase-1 (CASP1,P>0.05). In addition, ATP was not able to modify caspase-1 activity in Ngo-infected MDM but was able to increase pyroptosis (P>0.01). Notably ATP treatment defined an increase of positive staining for IL-1βwith a distinctive intracellular pattern of distribution. Collectively, these data demonstrate that ATP induces IL-1βsecretion by a mechanism not related to the NLRP3/ASC/caspase-1 axis and likely is acting at the level of vesicle trafficking or pore formation.

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Role of DAP12 in Innate and Adaptive Immune Responses

Current Pharmaceutical Design ◽

10.2174/1381612033392503 ◽

2003 ◽

Vol 9 (1) ◽

pp. 7-10 ◽

Cited By ~ 21

Author(s):

Naoko Aoki ◽

Shoji Kimura ◽

Zhou Xing

Keyword(s):

Immune Responses ◽

Adaptive Immune Responses ◽

Adaptive Immune

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Adipocytes, Innate Immunity and Obesity: A Mini-Review

Frontiers in Immunology ◽

10.3389/fimmu.2021.650768 ◽

2021 ◽

Vol 12 ◽

Author(s):

Alecia M. Blaszczak ◽

Anahita Jalilvand ◽

Willa A. Hsueh

Keyword(s):

Adipose Tissue ◽

Immune System ◽

Immune Cells ◽

Adaptive Immune System ◽

Innate Immune ◽

Lymphoid Cells ◽

Innate Immune Cells ◽

Adaptive Immune

The role of adipose tissue (AT) inflammation in obesity and its multiple related-complications is a rapidly expanding area of scientific interest. Within the last 30 years, the role of the adipocyte as an endocrine and immunologic cell has been progressively established. Like the macrophage, the adipocyte is capable of linking the innate and adaptive immune system through the secretion of adipokines and cytokines; exosome release of lipids, hormones, and microRNAs; and contact interaction with other immune cells. Key innate immune cells in AT include adipocytes, macrophages, neutrophils, and innate lymphoid cells type 2 (ILC2s). The role of the innate immune system in promoting adipose tissue inflammation in obesity will be highlighted in this review. T cells and B cells also play important roles in contributing to AT inflammation and are discussed in this series in the chapter on adaptive immunity.

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Innate immunity and the pneumococcus

Microbiology ◽

10.1099/mic.0.28551-0 ◽

2006 ◽

Vol 152 (2) ◽

pp. 285-293 ◽

Cited By ~ 52

Author(s):

Gavin K. Paterson ◽

Tim J. Mitchell

Keyword(s):

Innate Immunity ◽

Immune System ◽

Streptococcus Pneumoniae ◽

Immune Responses ◽

Innate Immune System ◽

Innate Immune ◽

First Line ◽

Adaptive Immune Responses ◽

Adaptive Immune ◽

Made In

The innate immune system provides a non-specific first line of defence against microbes and is crucial both in the development and effector stages of subsequent adaptive immune responses. Consistent with its importance, study of the innate immune system is a broad and fast-moving field. Here we provide an overview of the recent key advances made in this area with relation to the important pathogen Streptococcus pneumoniae (the pneumococcus).

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Regulatory Immune Cells in Idiopathic Pulmonary Fibrosis: Friends or Foes?

Frontiers in Immunology ◽

10.3389/fimmu.2021.663203 ◽

2021 ◽

Vol 12 ◽

Author(s):

Chiel van Geffen ◽

Astrid Deißler ◽

Markus Quante ◽

Harald Renz ◽

Dominik Hartl ◽

...

Keyword(s):

Immune System ◽

Idiopathic Pulmonary Fibrosis ◽

Pulmonary Fibrosis ◽

Immune Responses ◽

Immune Cells ◽

Current Knowledge ◽

Suppressor Cells ◽

Interstitial Lung Diseases ◽

Stromal Stem Cells

The immune system is receiving increasing attention for interstitial lung diseases, as knowledge on its role in fibrosis development and response to therapies is expanding. Uncontrolled immune responses and unbalanced injury-inflammation-repair processes drive the initiation and progression of idiopathic pulmonary fibrosis. The regulatory immune system plays important roles in controlling pathogenic immune responses, regulating inflammation and modulating the transition of inflammation to fibrosis. This review aims to summarize and critically discuss the current knowledge on the potential role of regulatory immune cells, including mesenchymal stromal/stem cells, regulatory T cells, regulatory B cells, macrophages, dendritic cells and myeloid-derived suppressor cells in idiopathic pulmonary fibrosis. Furthermore, we review the emerging role of regulatory immune cells in anti-fibrotic therapy and lung transplantation. A comprehensive understanding of immune regulation could pave the way towards new therapeutic or preventive approaches in idiopathic pulmonary fibrosis.

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