scholarly journals Determination of Electrospinning Parameters’ Strength in Poly(D,L)-lactide-co-glycolide Micro/Nanofiber Diameter Tailoring

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Yi-Pin Chen ◽  
Hsin-Yi Liu ◽  
Yen-Wei Liu ◽  
Tzung-Yan Lee ◽  
Shih-Jung Liu
Keyword(s):  
Applied Voltage ◽  
Electrospinning Process ◽  
Wound Dressings ◽  
Diameter Distribution ◽  
Sem Images ◽  
Nanofiber Diameter ◽  
Fiber Size ◽  
Multiple Field ◽  
Matrix Design

Electrospinning has received increasing interest and attention in recent years for fabricating micro/nanofibers of various materials; this is due to its versatility and capability of multiple field applications, including filtration, biosensors, tissue engineering, wound dressings, drug delivery, and composites. Nonetheless, the optimization of the electrospinning process is based on a time-consuming trial-and-error procedure. An empirical study, in conformity with the Taguchi orthogonal matrix design, was carried out to investigate the influence of various processing variables on the electrospinning of resorbable poly(D,L)-lactide-co-glycolide (PLGA). Three different solvents, hexafluoro-2-propanol (HFIP), dichloromethane (DCM), and trichloromethane (TCM), were employed. Five variables were selected for evaluation, including PLGA concentration, the solution’s flow rate from the nozzle, the distance between the nozzle and ground collection, the voltage, and the type of solvents. After electrospinning, we performed a morphological analysis of nanofibers by scanning electron microscopy (SEM) and measured the fiber size by the evaluation of SEM images. Among the variables selected, the type of solvent and the applied voltage were found to be the principal variables influencing the diameter distribution of electrospun PLGA fibers. Nanofibers with the smallest fiber size (466.25±158.38 nm) could be obtained with HFIP solvent and an applied voltage of 15 kV.

scholarly journals A Sulfur Copolymers (SDIB)/Polybenzoxazines (PBz) Polymer Blend for Electrospinning of Nanofibers

Nanomaterials ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 1526 ◽  
Author(s):  
Ronaldo P. Parreño ◽  
Ying-Ling Liu ◽  
Arnel B. Beltran
Keyword(s):  
Polymer Blend ◽  
Single Phase ◽  
Fiber Diameter ◽  
Electrospinning Process ◽  
Diameter Distribution ◽  
Sem Images ◽  
Water Contact ◽  
Fixed Concentration ◽  
New Material ◽  
Nanofiber Mats

This study demonstrated the processability of sulfur copolymers (SDIB) into polymer blend with polybenzoxazines (PBz) and their compatibility with the electrospinning process. Synthesis of SDIB was conducted via inverse vulcanization using elemental sulfur (S8). Polymer blends produced by simply mixing with varying concentration of SDIB (5 and 10 wt%) and fixed concentration of PBz (10 wt%) exhibited homogeneity and a single-phase structure capable of forming nanofibers. Nanofiber mats were characterized to determine the blending effect on the microstructure and final properties. Fiber diameter increased and exhibited non-uniform, broader fiber diameter distribution with increased SDIB. Microstructures of mats based on SEM images showed the occurrence of partial aggregation and conglutination with each fiber. Incorporation of SDIB were confirmed from EDX which was in agreement with the amount of SDIB relative to the sulfur peak in the spectra. Spectroscopy further confirmed that SDIB did not affect the chemistry of PBz but the presence of special interaction benefited miscibility. Two distinct glass transition temperatures of 97 °C and 280 °C indicated that new material was produced from the blend while the water contact angle of the fibers was reduced from 130° to 82° which became quite hydrophilic. Blending of SDIB with component polymer proved that its processability can be further explored for optimal spinnability of nanofibers for desired applications.

Research on Electrospinning Process of Pullulan Nanofibers

2012 ◽  
Vol 268-270 ◽  
pp. 198-201 ◽  
Author(s):  
Xiao Bin Sun ◽  
D. Jia ◽  
Wei Min Kang ◽  
Bo Wen Cheng ◽  
Ya Bin Li
Keyword(s):  
Flow Rate ◽  
Applied Voltage ◽  
Great Influence ◽  
Solution Concentration ◽  
Electrospinning Process ◽  
Diameter Distribution ◽  
Optimal Parameters ◽  
Redistilled Water ◽  
Water As Solvent

A kind of pullulan biopolymer nanofibers with diameter of 100～700nm were obtained using redistilled water as solvent through electrospinning technology in this paper. The effects of the spinning solution concentration, applied voltage, flow rate and capillary–screen distance on morphology and diameter distribution of pullulan nanofiber were studied by SEM. The results show that, different parameters had great influence on nanofibers’ morphology and diameter. The optimal parameters of pullulan nanofibers electrospinning were: 22wt.% spinning solution concentration, 31 kV voltage, 20 cm capillary–screen distance and 0.5ml/h flow rate.

Effect of Electrospinning Parameters Setting towards Fiber Diameter

2013 ◽  
Vol 845 ◽  
pp. 985-988 ◽  
Author(s):  
N.H.A. Ngadiman ◽  
M.Y. Noordin ◽  
Ani Idris ◽  
Denni Kurniawan
Keyword(s):  
Flow Rate ◽  
Applied Voltage ◽  
Fiber Diameter ◽  
Volume Flow Rate ◽  
Electrospinning Process ◽  
Volume Flow ◽  
Fiber Volume ◽  
Nanofiber Diameter ◽  
New Process

Fabrication of nanofibers using electrospinning has recently attracted much attention for various applications due to its simplicity. Electrospinning has the ability to produce nanofibers within 100-500 nm. Some applications require certain fiber diameter. As a relatively new process, there are many electrospinning parameters that are believed to influence the nanofibers diameter. The purpose of this review is to identify and discuss the effect of some of those parameters, i.e. concentration, spinning distance, and applied voltage, and volume flow rate, to the nanofiber diameter during electrospinning process. It was concluded that fiber volume flow rate is proportional to fiber diameter while there is no agreement in reports on other parameters.

Preparation of Chitosan based Nanofibers: Optimization and Modeling

2016 ◽  
Vol 14 (1) ◽  
pp. 283-288 ◽  
Author(s):  
K. Thirugnanasambandham ◽  
V. Sivakumar
Keyword(s):  
Polymer Solution ◽  
Response Surface ◽  
Applied Voltage ◽  
Solution Concentration ◽  
Electrospinning Process ◽  
Interactive Effects ◽  
Optimum Process ◽  
Process Conditions ◽  
Good Correspondence ◽  
Nanofiber Diameter

AbstractThe main objective of the present study is to prepare a chitosan based nanofiber and model the electrospinning process using response surface methodology (RSM). The electrospinning parameters such as collector distance, polymer solution concentration and applied voltage were optimized by using three-variable-three-level Box–Behnken design (BBD). Based on RSM analysis, second order polynomial equation was formed and it indicated good correspondence between experimental and predicted values. 3D response surface plots were used to study the individual and interactive effects of process variables on chitosan based nanofiber diameter. The optimum process conditions for the minimum chitosan based nanofiber diameter (0.3 µm) were found to be collector distance of 12 cm, polymer solution concentration of 25% and applied voltage of 6 kV.

Using Orthogonal Design in Optimizing Parameters for Bubble Electrospinning of Polyvinyl Alcohol (PVA) Nanofibers

2010 ◽  
Vol 29-32 ◽  
pp. 1943-1947 ◽  
Author(s):  
Liang Dong ◽  
Wan Shou ◽  
Yong Liu ◽  
Rui Wang ◽  
Ru Dong Chen
Keyword(s):  
Polyvinyl Alcohol ◽  
Process Parameters ◽  
Applied Voltage ◽  
Orthogonal Design ◽  
Solution Concentration ◽  
Electrospinning Process ◽  
Electrospinning Technique ◽  
Array Design ◽  
Nanofiber Diameter ◽  
Lower Medium

The present work was aimed at studying the effects of process parameters on morphologies of Polyvinyl alcohol (PVA) nanofibers in a novel electrospinning technique, bubble electrospinning. The process was optimized by constructing L 9(34) orthogonal experimental array design. Three factors were investigated and nine tests were run under lower, medium and higher levels of these factors. The results showed that PVA solution concentration plays an important role in affecting the morphologies of PVA nanofibers in bubble electrospinning process. With the increase of the concentration of PVA solution, the morphologies of fibers were changed from beaded fibers to uniform cylinder fibers and the average nanofiber diameter also increased. The optimization process was 12w% for PVA solution, 30kV for applied voltage and 10cm for spinning distance.

A Study of Sericin-Thunbergia Laurifolia Electrospun Fibre for Wound Healing Applications

2019 ◽  
Vol 798 ◽  
pp. 53-58
Author(s):  
Pattarinee White ◽  
Sirinat Chooprajong ◽  
Piyapong Pankaew
Keyword(s):  
Wound Healing ◽  
Bombyx Mori ◽  
Applied Voltage ◽  
Antimicrobial Properties ◽  
Average Diameter ◽  
Electrospinning Process ◽  
Potential Candidate ◽  
Sem Images ◽  
Electrospinning Technique ◽  
Thunbergia Laurifolia

Thunbergia laurifolia is a Thai herb that possesses outstanding wound healing properties. In addition, Sericin, obtained from the Bombyx mori silkworm, is also a potential candidate for wound healing applications. This is due to its moisture content and hydrophilic and antimicrobial properties. In this research, an electrospinning technique using Sericin and Thunbergia laurifolia was studied for wound healing purposes. Sericin solution was prepared by boiling Bombyx mori silkworm at 80 °C and Thunbergia laurifolia solution was prepared by boiling Thunbergia laurifolia leaves in distilled water at 100°C. The Sericin-Thunbergia laurifolia (STL) solution was mixed at the ratios of 1:9, 2:8, 3:7, 4:6, 5:5, 6:4, 7:3, 8:2 and 9:1 respectively. After mixing the solution of STL at the various ratios, all STL solutions were blended with 9 wt% PVA for the electrospinning process. The ratios of Sericin and Thunbergia laurifolia, the applied voltage and the distance between the needle tip to the target and the size of the needle were all optimized in this study. The fibre morphology was examined through SEM images. The electrospun PVA–STL fibre was found to have an average diameter in the range of 100-530 nm. The result from the SEM images showed the optimum ratio of Sericin and Thunbergia laurifolia to be 5:5. A suitable applied voltage, the distance between the needle tip to target and the size of the needle were 15 kV, 10 cm and an 18 gauge needle, respectively.

scholarly journals Effects of Chitosan Alkali Pretreatment on the Preparation of Electrospun PCL/Chitosan Blend Nanofibrous Scaffolds for Tissue Engineering Application

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Fatemeh Roozbahani ◽  
Naznin Sultana ◽  
Ahmad Fauzi Ismail ◽  
Hamed Nouparvar
Keyword(s):  
Tissue Engineering ◽  
Molecular Weight ◽  
Treatment Time ◽  
Engineering Application ◽  
Electrospinning Process ◽  
Wound Dressings ◽  
Tissue Engineering Application ◽  
Sem Images ◽  
Nanofibrous Scaffolds ◽  
3D Network

Recently, nanofibrous scaffolds have been used in the field of biomedical engineering as wound dressings, tissue engineering scaffolds, and drug delivery applications. The electrospun nanofibrous scaffolds can be used as carriers for several types of drugs, genes, and growth factors. PCL is one of the most commonly applied synthetic polymers for medical use because of its biocompatibility and slow biodegradability. PCL is hydrophobic and has no cell recognition sites on its structure. Electrospinning of chitosan and PCL blend was investigated in formic acid/acetic acid as the solvent with different PCL/chitosan ratios. High viscosity of chitosan solutions makes difficulties in the electrospinning process. Strong hydrogen bonds in a 3D network in acidic condition prevent the movement of polymeric chains exposed to the electrical field. Consequently, the amount of chitosan in PCL/chitosan blend was limited and more challenging when the concentration of PCL increases. The treatment of chitosan in alkali condition under high temperature reduced its molecular weight. Longer treatment time further decreased the molecular weight of chitosan and hence its viscosity. Electrospinning of PCL/chitosan blend was possible at higher chitosan ratio, and SEM images showed a decrease in fiber diameter and narrower distribution with increase in the chitosan ratio.

scholarly journals Biohybrid Fibro-Porous Vascular Scaffolds: Effect of Crosslinking on Properties

2015 ◽  
Vol 1718 ◽  
pp. 79-84 ◽  
Author(s):  
Vinoy Thomas ◽  
Danna Nozik ◽  
Harsh Patel ◽  
Raj K. Singh ◽  
Yogesh K. Vohra
Keyword(s):  
Mechanical Properties ◽  
Extracellular Matrix ◽  
Diameter Distribution ◽  
Sem Images ◽  
Cell Matrix ◽  
Matrix Interactions ◽  
Fiber Size ◽  
Vascular Scaffolds ◽  
Cell Matrix Interactions ◽  
Crosslinking Agents

ABSTRACTTubular grafts were fabricated from blends of polycaprolactone (PCL) and poly(glycolide-co-caprolactone) (PGC) polymers and coated with an extracellular matrix containing collagens, laminin, and proteoglycans, but not growth factors (HuBiogel™). Multifunctional scaffolds from polymer blends and membrane proteins provide the necessary biomechanics and biological functions for tissue regeneration. Two crosslinking agents, a natural crosslinker namely genipin (Gp) and a carbodiimide reagent namely 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC), were used for further stabilizing the protein matrix and the effect of crosslinking was evaluated for structural, morphological, mechanical properties using SEM, DSC and DMA. SEM images and fiber diameter distribution showed fiber-size between 0.2 μm to 1 μm with the majority of fiber diameters being under 500 nm, indicating upper range of protein fiber-sizes (for example, collagen fibers in extracellular matrix are in 50 to 500 nm diameter range). HB coating did not affect the mechanical properties, but increased its hydrophilicity of the graft. Overall data showed that PCL/PGC blends with 3:1 mass ratio exhibited mechanical properties comparable to those of human native arteries (tensile strength of 1-2 MPa and Young’s modulus of <10 MPa). Additionally, the effect of crosslinking on coating stability was investigated to assure the retention of proteins on scaffold for effective cell-matrix interactions.

Design of Experiment Approach for Fabrication Process of Electrospun Shellac Nanofibers Using Factorial Designs

2017 ◽  
Vol 757 ◽  
pp. 120-124 ◽  
Author(s):  
Nawinda Chinatangkul ◽  
Sirikarn Pengon ◽  
Chutima Limmatvapirat ◽  
Sontaya Limmatvapirat
Keyword(s):  
Applied Voltage ◽  
Feed Rate ◽  
Diameter Distribution ◽  
Optimum Conditions ◽  
Protective Properties ◽  
Response Surface Plot ◽  
Surface Plot ◽  
Nanofiber Diameter ◽  
Full Factorial ◽  
Negative Relationships

Electrospun shellac nanofibers might be potentially used for wound dressing application due to its natural origin and excellent protective properties. In this study, a full factorial design with three replicated center points was performed in order to investigate the main and interaction effects of shellac content (35-40% w/w), applied voltage (9-27 kV) and flow rate (0.4-1.2 mL/hr) on the morphology of shellac nanofibers. A total of 11 experiments were conducted. The response variables were the diameter of nanofibers, the distribution of diameter and the amount of beads. The results showed that the concentration of shellac was the most significant impact on shellac nanofiber diameter, while applied voltage, interaction between shellac content and voltage, and feed rate were minor factors, respectively. Shellac content and applied voltage had negative relationships with bead amount. When reducing the concentration of shellac and voltage, the amount of beads was increased. However, the influence of these parameters on diameter distribution seemed to be not significant. Based on response surface plot, nanofibers with thinner diameter (~493 nm) and less number of beads (~0.47) could be obtained at the optimum conditions; the shellac content of 38.5% w/w, the voltage of 21 kV and the feed rate of 0.4 mL/hr.

scholarly journals Electrospun Janus Beads-On-A-String Structures for Different Types of Controlled Release Profiles of Double Drugs

Biomolecules ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 635
Author(s):  
Ding Li ◽  
Menglong Wang ◽  
Wen-Liang Song ◽  
Deng-Guang Yu ◽  
Sim Wan Annie Bligh
Keyword(s):  
Controlled Release ◽  
Combined Therapy ◽  
Diffusion Mechanism ◽  
Amorphous State ◽  
Electrospinning Process ◽  
Fickian Diffusion ◽  
In Vitro Dissolution ◽  
Sem Images ◽  
Release Profiles

A side-by-side electrospinning process characterized by a home-made eccentric spinneret was established to produce the Janus beads-on-a-string products. In this study, ketoprofen (KET) and methylene blue (MB) were used as model drugs, which loaded in Janus beads-on-a-string products, in which polyvinylpyrrolidone K90 (PVP K90) and ethyl cellulose (EC) were exploited as the polymer matrices. From SEM images, distinct nanofibers and microparticles in the Janus beads-on-a-string structures could be observed clearly. X-ray diffraction demonstrated that all crystalline drugs loaded in Janus beads-on-a-string products were transferred into the amorphous state. ATR-FTIR revealed that the components of prepared Janus nanostructures were compatibility. In vitro dissolution tests showed that Janus beads-on-a-string products could provide typical double drugs controlled-release profiles, which provided a faster immediate release of MB and a slower sustained release of KET than the electrospun Janus nanofibers. Drug releases from the Janus beads-on-a-string products were controlled through a combination of erosion mechanism (linear MB-PVP sides) and a typical Fickian diffusion mechanism (bead KET-EC sides). This work developed a brand-new approach for the preparation of the Janus beads-on-a-string nanostructures using side-by-side electrospinning, and also provided a fresh idea for double drugs controlled release and the potential combined therapy.

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