scholarly journals Evaluation of Objective Signs and Subjective Symptoms of Dry Eye Disease in Patients with Inflammatory Bowel Disease

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Zsolt Barta ◽  
Levente Czompa ◽  
Aniko Rentka ◽  
Eva Zold ◽  
Judit Remenyik ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Dry Eye ◽  
Bowel Disease ◽  
Clinical Signs ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Subjective Symptoms ◽  
Ocular Surface Disease Index ◽  
Inflammatory Bowel

Aim. To evaluate tear film parameters and relationship of objective clinical signs and subjective symptoms of dry eye disease (DED) in inflammatory bowel disease (IBD) subgroups. Methods. 39 patients with Crohn’s disease (CD), 26 patients with ulcerative colitis (UC), and 39 control persons with no ocular symptoms or surface disorders were included in this prospective, case-control, and cross-sectional study. The ocular surface disease index (OSDI) questionnaire was applied to evaluate dry eye symptoms, and objective tests of DED were performed on both eyes of each subject. Results. The average of OSDI scores was 30.59 (±16.68) in CD patients, 24.67 (±23.48) in UC patients, and 11.19 (±5.8) in controls. Except for tear film breakup time (tBUT) and Schirmer-I values other objective parameters were better in UC patients, than in CD patients. CD patients rather than UC patients tend to develop DED. This was associated with immunosuppressant and TNF-α inhibitor use. Conclusions. Clinicians must be aware of the spectrum of DED involvement in IBD and suggest using artificial tears in order to decrease severity of ocular complications.

scholarly journals Lactoferrin and Its Detection Methods: A Review

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2492
Author(s):  
Yingqi Zhang ◽  
Chao Lu ◽  
Jin Zhang
Keyword(s):  
Inflammatory Bowel Disease ◽  
Human Health ◽  
Dry Eye ◽  
Human Body ◽  
Bowel Disease ◽  
Dry Eye Disease ◽  
Detection Methods ◽  
Eye Disease ◽  
Sensing Systems ◽  
Inflammatory Bowel

Lactoferrin (LF) is one of the major functional proteins in maintaining human health due to its antioxidant, antibacterial, antiviral, and anti-inflammatory activities. Abnormal levels of LF in the human body are related to some serious diseases, such as inflammatory bowel disease, Alzheimer’s disease and dry eye disease. Recent studies indicate that LF can be used as a biomarker for diagnosis of these diseases. Many methods have been developed to detect the level of LF. In this review, the biofunctions of LF and its potential to work as a biomarker are introduced. In addition, the current methods of detecting lactoferrin have been presented and discussed. We hope that this review will inspire efforts in the development of new sensing systems for LF detection.

scholarly journals Effects of Cyclosporine 0.05% ophthalmic solution on diagnostic parameters of dry eye disease

2017 ◽  
Vol 5 (10) ◽  
pp. 4289
Author(s):  
Maneesha Sethi ◽  
Amarjeet Singh Bali ◽  
P. Sadhotra
Keyword(s):  
Dry Eye ◽  
Tear Film ◽  
Ophthalmic Solution ◽  
Dry Eye Disease ◽  
Diagnostic Tools ◽  
Eye Disease ◽  
Inclusion Criteria ◽  
Ocular Surface Disease Index ◽  
Diagnostic Parameters ◽  
A Prospective Study

Background: Dry eye is a multifactorial disease particularly prevalent in Asia for which there are several treatments. Among anti-inflammatory treatment, cyclosporine 0.05% is preferred therapy. Our study evaluated effects of cyclosporine 0.05% ophthalmic solution on the diagnostic tools of dry eye.Material & Methods: A prospective study was carried out in ophthalmological outpatient department of ASCOMS and Hospital. Total 60 patients of dry eye disease who fulfilled the inclusion criteria were treated with cyclosporine 0.05% ophthalmic solution twice a day. The diagnostic parameters of dry eye were assessed at baseline, at month 1 and 3. Patients underwent Ocular Surface Disease Index (OSDI) score, Schirmer’s test, Tear film break up time (TBUT) .Results: After three months, mean OSDI score was significantly improved (p < 0.001). There was significant improvement in mean Schirmer score (p < 0.001). Baseline TBUT also increased significantly (p < 0.001). Conclusion: Cyclosporine 0.05% ophthalmic solution has significant effect on diagnostic parameters of dry eye disease.  

scholarly journals Tear Metabolomics in Dry Eye Disease: A Review

2019 ◽  
Vol 20 (15) ◽  
pp. 3755 ◽  
Author(s):  
Mazyar Yazdani ◽  
Katja Benedikte Prestø Elgstøen ◽  
Helge Rootwelt ◽  
Aboulghassem Shahdadfar ◽  
Øygunn Aass Utheim ◽  
...  
Keyword(s):  
Dry Eye ◽  
Early Stage ◽  
Clinical Signs ◽  
Tear Film ◽  
Current Method ◽  
Signs And Symptoms ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Health And Disease ◽  
Clinical Signs And Symptoms

Dry eye disease (DED) is a multifactorial syndrome that can be caused by alteration in the quality or quantity of the precorneal tear film. It is considered one of the most common ocular conditions leading patients to seek eye care. The current method for diagnostic evaluations and follow-up examinations of DED is a combination of clinical signs and symptoms determined by clinical tests and questionnaires, respectively. The application of powerful omics technologies has opened new avenues toward analysis of subjects in health and disease. Metabolomics is a new emerging and complementary research discipline to all modern omics in the comprehensive analysis of biological systems. The identification of distinct metabolites and integrated metabolic profiles in patients can potentially inform clinicians at an early stage or during monitoring of disease progression, enhancing diagnosis, prognosis, and the choice of therapy. In ophthalmology, metabolomics has gained considerable attention over the past decade but very limited such studies have been reported on DED. This paper aims to review the application of tear metabolomics in DED.

scholarly journals Comparative of meibomian gland morphology in patients with evaporative dry eye disease versus non-dry eye disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ricaurte Ramiro Crespo-Treviño ◽  
Anna Karen Salinas-Sánchez ◽  
Francisco Amparo ◽  
Manuel Garza-Leon
Keyword(s):  
Dry Eye ◽  
Healthy Subjects ◽  
Morphological Changes ◽  
Tear Film ◽  
Meibomian Gland ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Ocular Surface Disease Index ◽  
Evaporative Dry Eye ◽  
The Impact

AbstractMany recent studies have showed that morphological changes are one of the key signs of meibomian gland disease (MGD). These changes can be seen even before symptom onset, potentially underestimating the prevalence of MGD; however, until now, there is no conclusive information about the impact of meibomian gland (MG) morphology in tear film physiology and disease. This study aimed to investigate the prevalence of anatomical and morphological MG alterations between patients with evaporative dry eye disease (DED) and healthy controls. Retrospective chart review of seventy-five patients with evaporative DED and healthy individuals who had dry eye assessments included Ocular Surface Disease Index questionnaire, meibum quality, meibum expressibility, lid margin abnormality, ocular staining, non-invasive tear film break-up time, and meibography. We did not find significant differences in MG alterations in the upper lid between healthy and DED subjects. Patients with evaporative DED presented MG alterations in the lower lid more frequently than healthy subjects (54.8 vs. 30.3%; p = 0.03). The presence of shortened glands was the only MG alteration that was more prevalent in the lower lid in dry-eye patients than in healthy subjects (p < 0.05). Subjects with evaporative DED presented more alterations in the lower lid than healthy subjects.

scholarly journals Effect of dry eye diseases on the level of Protein and Lipids in Tears of Postmenopausal Women.

2021 ◽  
Vol 46 (1) ◽  
Author(s):  
A.O. Shuaibu ◽  
G. A. Akinlabi
Keyword(s):  
Postmenopausal Women ◽  
Dry Eye ◽  
Total Protein ◽  
Clinical Signs ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Ocular Surface Disease Index ◽  
Significant Difference ◽  
Eye Symptoms ◽  
Breakup Time

The study is aimed at investigating the effect of dry eye disease on the level of protein and lipids in tears of postmenopausal women. The study was carried out on 33 postmenopausal women with dry eye symptoms and 22 postmenopausal women that were asymptomatic. The ocular surface disease index (OSDI) questionnaire classified participants as being symptomatic or asymptomatic of dry eye. Tear stability and tear volume were assessed with Fluorescein Tear Break up Time (FBUT) and Schirmer’s test respectively. Tears were analysed for protein (total protein, albumin, and globulin) and lipid (cholesterol and triglycerides). The mean total protein for Dry Eye (DE) was higher than that for Non-dry eye (NDE). Albumin and globulin were also higher for the DE group when compared to the NDE group. These were however, not statistically significant (p > 0.05). There was also no significant difference in triglycerides and cholesterol between DE and NDE. There was no significant correlation between clinical signs (tear volume and tear breakup time) and total protein, albumin, globulin cholesterol and triglycerides in the NDE and DE eye groups. The study shows that proteins and lipids do not change in postmenopausal women irrespective of the presences of dry eye disease.

scholarly journals Dry eye disease in students with myopia during COVID-19 pandemic

2021 ◽  
Vol 9 (3) ◽  
pp. 34-37
Author(s):  
M.V. Panchenko ◽  
P.A. Bezditko
Keyword(s):  
Distance Learning ◽  
Dry Eye ◽  
Contact Lenses ◽  
Tear Film ◽  
Face Mask ◽  
Corneal Topography ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Eye Drops ◽  
Ocular Surface Disease Index

Background. Today, the urgent problem is coronavirus disease 2019 pandemic in the whole world. Safety measures such as the use of masks, distance learning have been implemented. However, ophthalmologists, as well as the general population, should know that a face mask together with prolonged use of digital devices leads to an increase in the number of dry eye cases in many patients. The purpose was to study the frequency of dry eye disease in students with myopia. Materials and methods. The study involved 96 medical students diagnosed with myopia taken by random sampling, who were examined by an ophthalmologist. Apart from the standard ophthalmologic examination, all patients underwent the evaluation of the stability of the precorneal tear film by means of corneal topography, and Norn test (tear break-up time (TBUT)). There was also used a standard questionnaire designed to assess the severity of dry eye disease symptoms (Ocular Surface Disease Index). Results. The corneal topography of the 47 patients did not demonstrate any reduction in TBUT. The average time of the concentric ring remained stable for 20.2 ± 3.0 seconds. But 49 individuals exhibited signs of tear film instability over time compared to 47 patients without TBUT impairment. In 47 people without impairments, corneal topography demonstrated that this indicator in Norn test varied from 25 to 18 seconds, i.e. was within the age norm (21.5 ± 3.5 seconds on average). In 3 patients with a minimum TBUT on keratotopography, its value during the Norn test was 9 seconds. In 36 patients with reduced TBUT according to both methods, there was a weak degree of dry eyes, in 10 — moderate, in 3 — severe. The most common complaints were a sandy, gritty sensation in the eyes, visual discomfort when working at a computer and in windy weather, and with prolonged use of a protective mask. Conclusions. Among students who were on distance learning, 51.04 % of individuals have objectively confirmed dry eye disease. People wearing contact lenses have a more pronounced degree of dry eye, so it is mandatory for ophthalmologists to prescribe lubricating eye drops.

scholarly journals The HYLAN M Study: Efficacy of 0.15% High Molecular Weight Hyaluronan Fluid in the Treatment of Severe Dry Eye Disease in a Multicenter Randomized Trial

2020 ◽  
Vol 9 (11) ◽  
pp. 3536 ◽  
Author(s):  
Gysbert-Botho van Setten ◽  
Christophe Baudouin ◽  
Jutta Horwath-Winter ◽  
Daniel Böhringer ◽  
Oliver Stachs ◽  
...  
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Dry Eye ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Control Group ◽  
Eye Drops ◽  
Artificial Tears ◽  
Ocular Surface Disease Index

The aim of the HYLAN M study was to investigate if symptoms and/or signs of patients suffering from severe dry eye disease (DED) can be improved by substituting individually optimized artificial tear therapy by high molecular weight hyaluronan (HMWHA) eye drops. In this international, multicenter study, patients with symptoms of at least ocular surface disease index (OSDI) 33 and corneal fluorescein staining (CFS) of at least Oxford grade 3 were included. A total of 84 per-protocol patients were randomized in two study arms. The control group continued to use their individual optimum artificial tears over the study period of eight weeks; in the verum group, the artificial tears were substituted by eye drops containing 0.15% HMWHA. At the week 8 visit, the average OSDI of the verum group had improved by 13.5 as compared to the control group (p = 0.001). The best corrected visual acuity (BCVA) had improved by 0.04 logMAR (p = 0.033). CFS, tear film break-up time (TBUT), Schirmer I, lid wiper epitheliopathy (LWE), mucocutaneous junction (Yamaguchi score), and tear osmolarity were not significantly different between the verum and control groups (p > 0.050). We conclude that for most patients with severe DED, 0.15% HMWHA eye drops provide excellent improvement of symptoms without impairment of dry eye signs.

Diagnostic Possibilities of Interferometry in Detection and Monitoring of Dry Eye Disease Development

2020 ◽  
pp. 41-48
Author(s):  
Dong Fang Hui ◽  
I Bezkorovayna ◽  
H Pavlovska
Keyword(s):  
Dry Eye ◽  
Tear Film ◽  
Time Estimation ◽  
Scientific Data ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Lipid Layer ◽  
Ocular Surface Disease Index ◽  
Film Rupture ◽  
Surface Examination

The work is dedicated to the features of the eye surface examination, and clinical and functional disruptions in the tear film in 112 (224 eyes) young people aged 18 to 30 years. Based on the analysis of the common objective methods results, such as determination of the Ocular Surface Disease Index, conducting the Shirmer II test, the LIPCOF test, the tear meniscus and tear film rupture time estimation, we have refined scientific data on indicators that characterize dry eye disease. Interferometric studies using the SBM ICP Tearscope (Italy) and iPad Pro (USA) showed a decrease in the thickness of the tear film lipid layer below 80 nm in 64% of the surveyed. The interferometry data well associated with known eye surface methods, demonstrating the highest level of sensitivity. The thinning of the lipid layer below 30 nm, detected in 33% of the subjects, was characteristic for the eyes with dry eye disease.

Biomarkers In Dry Eye Disease

2012 ◽  
Vol 06 (03) ◽  
pp. 157 ◽  
Author(s):  
Michael A Lemp ◽  
Benjamin D Sullivan ◽  
Leslie A Crews ◽  
◽  
◽  
...  
Keyword(s):  
Dry Eye ◽  
Clinical Signs ◽  
Tear Film ◽  
Signs And Symptoms ◽  
Critical Issue ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Chronic Disorder ◽  
Clinical Signs And Symptoms

Dry eye disease is a multifactorial chronic disorder of the ocular surface that affects up to 100 million people worldwide. During the pathogenesis of dry eye, impaired function of the lacrimal and meibomian glands results in hyposecretion of aqueous tear fluid, coupled with increased evaporation and instability of the tear film, which becomes increasingly hyperosmolar in character at more severe stages of disease. One critical issue in the field is that the commonly used clinical signs and symptoms for the diagnosis or classification of dry eye often do not correlate with one another. This underscores the need to systematically evaluate current tests and highlights the importance of developing new markers of disease progression for use as endpoints in clinical trials of diagnostic devices and potential therapeutics. In this review, we examine the utility and limitations of commonly used signs and symptoms of dry eye disease and comment on newer biomarkers and analytical devices that show promise for future diagnostic and therapeutic use.

scholarly journals Comparison of Clinical Use of Ocular-surface Disease Index Questionnaire, Tear Film Break-up time, and Schirmer Tests in Diagnosing Dry-eye

2019 ◽  
pp. 1-7
Author(s):  
Suwarna Suman ◽  
Prachi Goyal
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Disease Index ◽  
Ocular Surface Disease ◽  
Eye Disease ◽  
Ocular Surface Disease Index ◽  
Schirmer’S Test ◽  
The Mean

Aims:  To evaluate and compare the diagnostic values and clinical utility of the Ocular Surface Disease Index (OSDI) questionnaire, the tear film break-up time test (TBUT), and the Schirmer’s test in diagnosing dry eye disease in patients presenting with dry eye symptoms. Study Design: A prospective observational study. Place and Duration of Study: Department of Ophthalmology, AIIMS Jodhpur, Rajasthan, India. Two-month period between July 2016 and September 2016. Methodology: We have included 100 patients aged >20 years having foreign body sensations, burning sensations, pain, dryness, blurred vision, photophobia, redness in the study. Routine ophthalmological examination was performed after OSDI questionnaire, followed by TBUT and Schirmer’s test and outcomes were evaluated. Results: The mean age of 100 participants was 43 ± 15.97years (range 20–78 years). The mean OSDI, TBUT, and Schirmer’s test scores were 58.67± 12.12 (range 30.0–88.9), 5.77 ± 3.49 seconds (range 0–17 seconds), and 09.78 ± 7.93 mm (range 0–32.5 mm), respectively. There was a statistically highly significant inverse correlation between the OSDI and TBUT (r = −0.597, P = <0.0001), statistically significant correlation between TBUT and Schirmer test (r= -0.227, p= 0.023), whereas no significant correlation noted between the OSDI and Schirmer’s test (r= -0.142, p= 0.158).  Conclusion: The prevalence of dry eye disease (DED) is increasing these days. For early recognition and treatment, we need rapid, reliable and less invasive diagnostic test in daily practice. The OSDI together with the TBUT is less time consuming, easy to perform and can be useful in diagnosis of DED.

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