scholarly journals Terpenoids and Their Biological Activities from Cinnamomum: A Review

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Meiting Wu ◽  
Lin Ni ◽  
Haixiao Lu ◽  
Huiyou Xu ◽  
Shuangquan Zou ◽  
...  
Keyword(s):  
Biological Activities ◽  
Biological Effects ◽  
Pharmacological Effects ◽  
Bioactive Components ◽  
Anticancer Activities ◽  
Chemical Structures ◽  
The Family ◽  
Beneficial Uses ◽  
The Future ◽  
Depth Study

Cinnamomum is a genus of the family Lauraceae, which has been recognized worldwide as an important genus due to its beneficial uses. A great deal of research on its phytochemistry and pharmacological effects has been conducted. It is noteworthy that terpenoids are the characteristic of Cinnamomum due to the peculiar structures and significant biological effects. For a more in-depth study and the better use of Cinnamomum plants in the future, the chemical structures and biological effects of terpenoids obtained from Cinnamomum were summarized in the present study. To date, a total of 181 terpenoids with various skeletons have been isolated from Cinnamomum. These compounds have been demonstrated to play an important role in immunomodulatory, anti-inflammatory, antimicrobial, antioxidant, and anticancer activities. However, studies on the bioactive components from Cinnamomum plants have only focused on a dozen species. Hence, further studies on the potential pharmacological effects need to be conducted in the future.

Current Advances in the Biological Activity of Polysaccharides in Dendrobium with Intriguing Therapeutic Potential

2018 ◽  
Vol 25 (14) ◽  
pp. 1663-1681 ◽  
Author(s):  
Chun-Ting Lee ◽  
Heng-Chun Kuo ◽  
Yung-Hsiang Chen ◽  
Ming-Yen Tsai
Keyword(s):  
Biological Activity ◽  
Therapeutic Potential ◽  
Biological Activities ◽  
Biological Effects ◽  
Herbal Medicines ◽  
Research Field ◽  
Protective Effects ◽  
Pharmacological Effects ◽  
The Family ◽  
Anti Tumor Activity

The polysaccharides in many plants are attracting worldwide attention because of their biological activities and medical properties, such as anti-viral, anti-oxidative, antichronic inflammation, anti-hypertensive, immunomodulation, and neuron-protective effects, as well as anti-tumor activity. Denodrobium species, a genus of the family orchidaceae, have been used as herbal medicines for hundreds of years in China due to their pharmacological effects. These effects include nourishing the Yin, supplementing the stomach, increasing body fluids, and clearing heat. Recently, numerous researchers have investigated possible active compounds in Denodrobium species, such as lectins, phenanthrenes, alkaloids, trigonopol A, and polysaccharides. Unlike those of other plants, the biological effects of polysaccharides in Dendrobium are a novel research field. In this review, we focus on these novel findings to give readers an overall picture of the intriguing therapeutic potential of polysaccharides in Dendrobium, especially those of the four commonly-used Denodrobium species: D. huoshanense, D. offininale, D. nobile, and D. chrysotoxum.

scholarly journals Alkaloids Produced by Endophytic Fungi: A Review

2012 ◽  
Vol 7 (7) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Yanyan Zhang ◽  
Ting Han ◽  
Qianliang Ming ◽  
Lingshang Wu ◽  
Khalid Rahman ◽  
...  
Keyword(s):  
Endophytic Fungi ◽  
Host Plants ◽  
Biological Activities ◽  
Biological Properties ◽  
Research Progress ◽  
Indole Derivatives ◽  
Anticancer Activities ◽  
Action Mechanisms ◽  
The Future ◽  
Potential Applications

In recent years, a number of alkaloids have been discovered from endophytic fungi in plants, which exhibited excellent biological properties such as antimicrobial, insecticidal, cytotoxic, and anticancer activities. This review mainly deals with the research progress on endophytic fungi for producing bioactive alkaloids such as quinoline and isoquinoline, amines and amides, indole derivatives, pyridines, and quinazolines. The biological activities and action mechanisms of these alkaloids from endophytic fungi are also introduced. Furthermore, the relationships between alkaloid-producing endophytes and their host plants, as well as their potential applications in the future are discussed.

scholarly journals Erythrina suberosa: Ethnopharmacology, Phytochemistry and Biological Activities

Medicines ◽  
2019 ◽  
Vol 6 (4) ◽  
pp. 105 ◽  
Author(s):  
Felicia Patti ◽  
Yasaman Taheri ◽  
Javad Sharifi-Rad ◽  
Miquel Martorell ◽  
William C. Cho ◽  
...  
Keyword(s):  
Southeast Asia ◽  
Pharmacological Activity ◽  
Biological Activities ◽  
Deciduous Tree ◽  
Pharmacological Properties ◽  
Bioactive Components ◽  
Food Energy ◽  
Ornamental Tree ◽  
The Family ◽  
Coral Tree

Plants are a great and irreplaceable source of medicines, fuel, food, energy and even cosmetics. Since prehistory, humans have learned to use plants for survival, growth and proliferation and still today it relies on natural and cultivated vegetables for food and the source of novel compounds with pharmacological activity. Not only herbs and flowers, but also trees are used. Indeed, Erythrina suberosa Roxb. is a deciduous tree of the family Fabaceae, common in Southeast Asia. In India, E. suberosa is called the “corky coral tree” or simply the “Indian coral tree”, given its peculiar red-orange flowers that can flower throughout the year and its corky irregular bark covered by prickles. It is a plant commonly used as an ornamental tree, but it also holds ethnopharmacological and socioeconomic uses. This article explored phytobiological features of E. suberosa, analysing its taxonomy, examining its traditional and common uses and investigating its bioactive components and pharmacological properties.

scholarly journals Anticancer Activity of 2-O-caffeoyl Alphitolic Acid Extracted from the Lichen, Usnea barbata 2017-KL-10

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3937
Author(s):  
Hae-Jung Chae ◽  
Geum-Jin Kim ◽  
Barsha Deshar ◽  
Hyun-Jin Kim ◽  
Min-Ji Shin ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Biological Activities ◽  
Biological Effects ◽  
Cancer Cell Line ◽  
Colorectal Cancer Cell Line ◽  
Migration And Invasion ◽  
Dependent Manner ◽  
Anticancer Activities ◽  
Concentration Dependent Manner ◽  
Mortality And Morbidity

Colorectal cancer is one of the life-threatening ailments causing high mortality and morbidity worldwide. Despite the innovation in medical genetics, the prognosis for metastatic colorectal cancer in patients remains unsatisfactory. Recently, lichens have attracted the attention of researchers in the search for targets to fight against cancer. Lichens are considered mines of thousands of metabolites. Researchers have reported that lichen-derived metabolites demonstrated biological effects, such as anticancer, antiviral, anti-inflammatory, antibacterial, analgesic, antipyretic, antiproliferative, and cytotoxic, on various cell lines. However, the exploration of the biological activities of lichens’ metabolites is limited. Thus, the main objective of our study was to evaluate the anticancer effect of secondary metabolites isolated from lichen (Usnea barbata 2017-KL-10) on the human colorectal cancer cell line HCT116. In this study, 2OCAA exhibited concentration-dependent anticancer activities by suppressing antiapoptotic genes, such as MCL-1, and inducing apoptotic genes, such as BAX, TP53, and CDKN1A(p21). Moreover, 2OCAA inhibited the migration and invasion of colorectal cancer cells in a concentration-dependent manner. Taken together, these data suggest that 2OCAA is a better therapeutic candidate for colorectal cancer.

scholarly journals Bulbous Plants Drimia: “A Thin Line between Poisonous and Healing Compounds” with Biological Activities

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1385
Author(s):  
Madira Coutlyne Manganyi ◽  
Gothusaone Simon Tlatsana ◽  
Given Thato Mokoroane ◽  
Keamogetswe Prudence Senna ◽  
John Frederick Mohaswa ◽  
...  
Keyword(s):  
South Africa ◽  
Medicinal Plants ◽  
Biological Activities ◽  
Biological Properties ◽  
Google Scholar ◽  
Therapeutic Effects ◽  
Anticancer Activities ◽  
Poisonous Plants ◽  
Thin Line ◽  
The Family

Drimia (synonym Urginea) plants are bulbous plants belonging to the family Asparagaceae (formerly the family Hyacinthaceae) and are distinctive, powerful medicinal plants. Just some species are indigenous to South Africa and have been traditionally utilized for centuries to cure various diseases and/or ailments. They have been recognized among the most famous and used medicinal plants in South Africa. Traditionally, the plants are used for various illnesses such as dropsy, respiratory disease, bone and joint complications, skin disorders, epilepsy and cancer. A number of studies have reported biological properties such as antiviral, antibacterial, antioxidant and anti-inflammatory, immunomodulatory, and anticancer activities. Their bulbs are a popular treatment for colds, measles, pneumonia, coughs, fever and headaches. However, some plant species are regarded as one of the six most common poisonous plants in Southern Africa that are toxic to livestock and humans. Due to the therapeutic effects of the Drimia plant bulb, research has focused on the phytochemicals of Drimia species. The principal constituents isolated from this genus are cardiac glycosides. In addition, phenolic compounds, phytosterols and other phytochemical constituents were identified. This study constitutes a critical review of Drimia species’ bioactive compounds, toxicology, biological properties and phytochemistry, advocating it as an important source for effective therapeutic medicine. For this purpose, various scientific electronic databases such as ScienceDirect, Scopus, Google Scholar, PubMed and Web of Science were researched and reviewed to conduct this study. Despite well-studied biological investigations, there is limited research on the toxic properties and the toxic compounds of certain Drimia species. Searching from 2017 to 2021, Google Scholar search tools retrieved 462 publications; however, only 3 investigated the toxicity and safety aspects of Drimia. The aim was to identify the current scientific research gap on Drimia species, hence highlighting a thin line between poisonous and healing compounds, dotted across numerous publications, in this review paper.

scholarly journals A review on Active Constituents and Pharmacological Effects of Eriobotrya Japonica Lindl. (Loquat)

2021 ◽  
Vol 30 (1) ◽  
pp. 41-55
Author(s):  
Ruaa M. Ibrahim
Keyword(s):  
Inflammatory Diseases ◽  
Biological Effects ◽  
Fruit Tree ◽  
Eriobotrya Japonica ◽  
Pharmacological Effects ◽  
Active Constituents ◽  
The Family ◽  
Medical Plant ◽  
Subtropical Fruit ◽  
Japan And China

Eriobotrya japonica Lindl., named as loquat, is a subtropical fruit tree of the family Rosaceae which is well known medical plant originated in  Japan and China. Loquat portions, like leaves, peels and fruits have been shown to possess various health usefulnesses.  In Chinese classical medicine, it is vastly utilized in many illnesses, like gastroenteric disorders, diabetes mellitus, pulmonary inflammatory diseases and chronic bronchitis. Loquat plant contain many active constituents, such as flavonoids, carotenoids, vitamins, polyphenolic compounds, other that have many biological effects like anti-tumor, anti-diabetic, anti-inflammatory, anti-mutagenic, antioxidant, antiviral, antitussive, hepatoprotective and hypolipidemic activity.

scholarly journals Pinocembrin: A Novel Natural Compound with Versatile Pharmacological and Biological Activities

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Azhar Rasul ◽  
Faya Martin Millimouno ◽  
Wafa Ali Eltayb ◽  
Muhammad Ali ◽  
Jiang Li ◽  
...  
Keyword(s):  
Time Window ◽  
Biological Activities ◽  
New Drugs ◽  
Pharmacological Effects ◽  
Anticancer Activities ◽  
Anti Inflammatory ◽  
Cerebral Ischemic ◽  
Sites Of Action ◽  
Almost All ◽  
Apoptotic Effects

Pinocembrin (5,7-dihydroxyflavanone) is one of the primary flavonoids isolated from the variety of plants, mainly fromPinusheartwood,Eucalyptus, Populus, Euphorbia, andSparattosperma leucanthum, in the diverse flora and purified by various chromatographic techniques. Pinocembrin is a major flavonoid molecule incorporated as multifunctional in the pharmaceutical industry. Its vast range of pharmacological activities has been well researched including antimicrobial, anti-inflammatory, antioxidant, and anticancer activities. In addition, pinocembrin can be used as neuroprotective against cerebral ischemic injury with a wide therapeutic time window, which may be attributed to its antiexcitotoxic effects. Pinocembrin exhibits pharmacological effects on almost all systems, and our aim is to review the pharmacological and therapeutic applications of pinocembrin with specific emphasis on mechanisms of actions. The design of new drugs based on the pharmacological effects of pinocembrin could be beneficial. This review suggests that pinocembrin is a potentially promising pharmacological candidate, but additional studies and clinical trials are required to determine its specific intracellular sites of action and derivative targets in order to fully understand the mechanism of its anti-inflammatory, anticancer, and apoptotic effects to further validate its medical applications.

scholarly journals A Review: Halogenated Compounds from Marine Actinomycetes

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2754
Author(s):  
Cong Wang ◽  
Weisheng Du ◽  
Huanyun Lu ◽  
Jianzhou Lan ◽  
Kailin Liang ◽  
...  
Keyword(s):  
Metabolic Pathways ◽  
Biological Activities ◽  
Biological Properties ◽  
Marine Actinomycetes ◽  
Halogenated Compounds ◽  
Anticancer Activities ◽  
Streptomyces Species ◽  
Chemical Structures ◽  
Review Reports ◽  
Nitrogen Containing Compounds

Marine actinomycetes, Streptomyces species, produce a variety of halogenated compounds with diverse structures and a range of biological activities owing to their unique metabolic pathways. These halogenated compounds could be classified as polyketides, alkaloids (nitrogen-containing compounds) and terpenoids. Halogenated compounds from marine actinomycetes possess important biological properties such as antibacterial and anticancer activities. This review reports the sources, chemical structures and biological activities of 127 new halogenated compounds originated mainly from Streptomyces reported from 1992 to 2020.

scholarly journals Phytochemistry and Biological Activities of Poria

2021 ◽  
Vol 2021 ◽  
pp. 1-20
Author(s):  
Jie Lu ◽  
Jing Tian ◽  
Li Zhou ◽  
Lijun Meng ◽  
Sitan Chen ◽  
...  
Keyword(s):  
Biological Activities ◽  
Hepatoprotective Activity ◽  
Pharmacological Effects ◽  
Immunomodulatory Effects ◽  
Main Compound ◽  
Material Basis ◽  
Pharmacological Studies ◽  
Great Progress ◽  
Depth Study ◽  
Antioxidant Effects

Poria is a common Traditional Chinese Medicine in clinic. In recent years, the chemical and pharmacological studies of Poria have made great progress, triterpenes and polysaccharides have been isolated, and various types of compounds containing lipids, octanoic acids, fatty acids, and trace elements have been found. In this paper, we reviewed the literature, summarized the main compound types, and reviewed in detail their pharmacological effects in antitumor, immunomodulatory, effects on kidney, hepatoprotective activity, effects on blood sugar, antioxidant effects, anti-inflammatory effects, effects on the gut, antidepressant, and so on, and also categorized the compounds with the same or similar pharmacological effects to provide a reference for the in-depth study of the material basis of the pharmacological effect, quality standards, and pharmacological activity of Poria.

scholarly journals Design of New Chlorochalcone Derivatives as Potential Breast Anticancer Compound Based on QSAR Analysis and Molecular Docking Study

2021 ◽  
Vol 20 (3) ◽  
Author(s):  
Anita Dwi Puspitasari ◽  
Harno Dwi Pranowo ◽  
Endang Astuti ◽  
Tutik Dwi Wahyuningsih
Keyword(s):  
Molecular Docking ◽  
Correlation Coefficient ◽  
Biological Activities ◽  
Basis Set ◽  
Log P ◽  
Anticancer Activities ◽  
Mcf7 Cells ◽  
Molecular Docking Study ◽  
Chemical Structures ◽  
Cox 2

Quantitative structure-activity relationships (QSAR) proposes a model that relates the biological activities of drugs to their chemical structures, and the interaction between the drug and its target enzyme is revealed by molecular docking research. These studies were conducted on chalcone to produce a model that could design highly potent breast anticancer MCF7 cells. The compounds were optimized using ab initio using a basis set 6-31G, then their descriptors calculated using this method. Genetic Function Algorithm (GFA) was used to select descriptors and build the model. One of the six models generated was found to be the best with internal and external squared correlation coefficient (R2) of 0.743 and 0.744, respectively, adjusted squared correlation coefficient (adjusted R2) of 0.700, Standard estimate of error (SEE) of 0.198, Fcalc/Ftable of 6.423, and Predicted residual sum of squares (PRESS) of 1.177. The QSAR equation is pIC50 = 3.869 + (1.427 x qC1) + (4. 027 x qC10) + (0.856 x qC15) - (35.900 x ELUMO) + (0.208 x Log P). Hence, it can predict the breast anticancer activities of new chlorochalcones A-F. The compound with the best prediction was chlorochalcone A with pIC50 2.65 and IC50 value of 2.26 μM. The chlorochalcones A-F were able to bind to the main amino acid residues, namely Arg120 and Tyr355, on the active site of the COX-2 enzyme. These results could serve as a model for designing novel chlorochalcone as inhibitors of COX-2 with higher breast anticancer activities. Keywords: Chlorochalcone, COX-2, QSAR, MCF-7, Molecular docking

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