scholarly journals Factors Influencing Atopic Dermatitis Incidence in Offspring

2019 ◽  
Author(s):  
Siqi Ye ◽  
Xiumei Mo ◽  
Junfeng Liu ◽  
Fenggen Yan ◽  
Dacan Chen
Keyword(s):  
Atopic Dermatitis ◽  
Atopic Disease ◽  
Skin Condition ◽  
Breastfeeding Duration ◽  
Protective Effects ◽  
Short Period ◽  
History Of ◽  
Fundamental Research ◽  
Genetic And Environmental Factors

Atopic dermatitis (AD) is a chronic, recurrent skin condition resulting from both genetic and environmental factors. In recent decades, the prevalence of AD has increased considerably in some countries. However, given that the role of genetics is unlikely to have changed over this short period, the increased prevalence is more likely to be explained by changes in environmental and maternal factors. The aim of this review is to comprehensively summarize the various factors impacting AD incidence in offspring and provide guidance for primary prevention. Recent research has demonstrated that environmental and climate factors, maternal history of allergies, gestational diabetes, and stress play essential roles in increasing the risk of AD in infants. Some factors have protective effects against the incidence of AD, including probiotic supplementation, fish intake, and moisturizers. This review also considers fundamental research into AD prevalence and factors that in the past were mistakenly thought to affect that prevalence, such as caesarean section and antigen avoidance. The potential influence of these factors on infant AD incidence remains inconclusive and needs further study. Furthermore, infants with a family history of atopic disease may benefit from early weaning or reduced breastfeeding duration.

scholarly journals Atopic Dermatitis and Psoriasis as Overlapping Syndromes

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
A. Bozek ◽  
M. Zajac ◽  
M. Krupka
Keyword(s):  
Atopic Dermatitis ◽  
Family History ◽  
Atopic Disease ◽  
Skin Lesions ◽  
The Body ◽  
T Helper 17 ◽  
Tnf Α ◽  
History Of

Background/Objectives. Cooccurrence of atopic dermatitis (AD) and psoriasis (PS) is not common. However, both diseases are still of interest because of their comprehensive and diverse mechanisms. This study aimed to present the clinical and immunological profiles of patients with concomitant AD and PS and compare them with those of patients with only one of the diseases. Methods. In this observational study, 38 children with concomitant AD and PS with a mean age of 6.5 ± 3.2  yrs were compared with 41 similar patients with AD only ( 5.3 ± 5.1  yrs) and 28 patients with PS only ( 6.4 ± 4.3  yrs). All patients underwent dermatological examinations, including determination of SCORAD and PASI scores. TNF-α, IFN-γ, IL-2, IL-4, IL-5, IL-6, IL-8, IL-12, IL-17, IL-18, IL-22, I:-33, and TARC/CCL17 were measured by ELISA according to the manufacturer’s instructions. Results. Patients with concomitant AD and PS were frequently boys and overweight and had skin lesions equally distributed throughout the body. Children with concomitant AD and PS were more likely to report a family history of atopic disease than children with only AD or PS, and those with AD were more likely to report a family history of atopic disease than those with PS. Significant differences were observed in the concentration of IL-17 between patients with AD and PS and those with only AD or PS: 9.1 ± 3.7  pg/ml vs. 4.8 ± 2.9  pg/ml; and 9.1 ± 3.7  pg/ml vs. 5.2 ± 3.9  pg/ml, respectively (PD vs. AD, p = 0.01 ; PD vs. PS, p = 0.03 ). Conclusions. AD and PS can coexist. The role of T helper 17 cells may be more essential than believed.

scholarly journals Atopic dermatitis and psoriasis as overlapping syndromes.

2020 ◽  
Author(s):  
Andrzej Bozek ◽  
Magdalena Zając ◽  
Magdalena Krupka
Keyword(s):  
Atopic Dermatitis ◽  
Positive Family History ◽  
Atopic Disease ◽  
Skin Lesions ◽  
T Helper 17 ◽  
Dermatological Examination ◽  
Area Distribution ◽  
Tnf Α ◽  
History Of

Abstract Background: Concomitant atopic dermatitis (AD) and psoriasis (PS) are not common. However, both diseases are still of interest because of their comprehensive and diverse mechanism. The aim of the study was to present the clinical and immunological profile of patients with concomitant AD and PS coexist in comparison to patients with one of these diseases.Methods: In this observational study, 38 children with concomitant AD and PS with a mean age of 6.5 ± 3.2 yrs. were compared with similar 41 patients with only AD (5.3± 5.1 yrs) and with 28 with PS (6.4± 4.3 yrs). All patients underwent the dermatological examination including SCORAD and PASI questionnaire. TNF-α, IFN-γ, Il-2, Il-4, Il-5, Il-6, Il-8, Il-12, I-17, Il-18, Il-22, Il-33, TARC/CCL17 were measured by the use ELISA method and according manufacturer (ThermoFischer Scientific, US).Results: Patients with concomitant AD and PS were frequently boys or with overweight and with a proportional area distribution of skin lesions. A positive family history of atopic disease was more frequently reported by children with concomitant AD and PS, and with AD vs. PS. Significant differences were observed in the concentration of Il-17 in patients with AD and PS compared with that in AD or PS patients as follows: 9.1±3.7 pg/ml vs. 4.8±2.9 pg/ml and 5.2±3.9 pg/ml (PD vs. AD, p = 0.01; PD vs. PS, p = 0.03).Conclusion: AD and PS might coexist as overlapping disease. The role of T-helper 17 may be more meaningful than it appeared.

scholarly journals A longitudinal study of suicide and suicide attempt in northwest of Iran: incidence, predictors, and socioeconomic status and the role of sociocultural status

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ali Fakhari ◽  
Mostafa Farahbakhsh ◽  
Elham Davtalab Esmaeili ◽  
Hosein Azizi
Keyword(s):  
Socioeconomic Status ◽  
Longitudinal Study ◽  
Religious Commitment ◽  
Incidence Rates ◽  
Demographic Characteristics ◽  
Protective Effects ◽  
Wide Range ◽  
Multiple Variable ◽  
History Of

Abstract Background A detailed community-level understanding of socioeconomic status (SES) and sociocultural status (SCS) of suicides and suicide attempters (SAs) in a prospective design could have significant implications for policymakers at the local prevention and treatment levels. The effect of SCS and SES on SAs is poorly understood and investigated in Iran. The present study aimed to investigate the incidence, trend, and role of SES and SCS on suicide and SAs. Methods A longitudinal study was conducted based on the registry for SAs in Malekan County, Iran, from 2015 to 2018. Demographic characteristics, SES, SCS, incidence rates, and predictors of suicidal behaviors were measured via structured instruments. Simple and multiple logistic regressions were used to estimate crude and adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Results A total of 853 SAs (32 suicides and 821 attempts) were identified during the study. Trend analysis revealed that the suicide rate significantly decreased from 2014 (10.28) to 2018 (1.75) per 100,000. In the final multiple variable models, age (26–40), male sex, unemployment, antisocial activities, history of SA, hanging method, and season (spring) increased the suicide risk while religious commitment had protective effects on suicide. Conclusions Our findings indicated that demographic characteristics, low SES, and SCS are associated with suicide. In this county, trend of suicide and SA were decreased from 2014 to 2018. This study findings highlight the need to consider a wide range of contextual variables, socio-demographic, SES, and SCS in suicide prevention strategies. Improving inter-sectoral collaborations and policymakers’ attitudes are imperative for SA reduction.

History of Activities of the Akmola District Union of Cooperatives (1917–1922)

2021 ◽  
pp. 113-121
Author(s):  
Galya A. Alpyspaeva ◽  
Keyword(s):  
Transport Infrastructure ◽  
Educational Work ◽  
Russian Market ◽  
Economic Relations ◽  
Cooperative Movement ◽  
Short Period ◽  
History Of ◽  
National Cooperative ◽  
Cooperation System

Based on the analysis of the previously unused archival sources and research works on the history of Russian cooperation, the main areas of the activities of the Akmola District Union of Cooperatives in 1917–1922 are studied and generalized. In terms of methodology, the study is based on the works of ideologists of Russian cooperation (M.I. Tugan-Baranovsky, V.F. Totomianets, A.V. Chayanov, and others) and the original concepts they developed. The article analyzes the activities of the Union of Cooperatives of a particular micro-region: the number of employees, organizational structure and management, organization of industrial production, financial and social policies, cultural and educational activities. The author substantiates the role of the District Union of Cooperatives in the development of economic relations in the region and in the district peasant farms’ entry into the all-Russian market. Despite the difficult political circumstances and the relatively short period of existence (from August 1917 to the end of 1922), the Akmola District Union of Cooperatives became an economic and organizational center, contributed to the establishment and development of the consumer cooperation system not only in the district, but also in the region: it initiated the establishment of the regional Union of Steppe Cooperatives. In the conditions of the territorial remoteness from industrial centers and the underdeveloped transport infrastructure, the District Union of Cooperatives significantly facilitated and promoted the production activities of the peasants of the region connecting them with the market, expedited the involvement of Kazakh farms in the regional economy. The Union carried out an active social policy and diversified cultural and educational work, allocated significant amounts from its profits to the development of education in the district. According to the author, the activities of the Akmola District Union of Cooperatives can be considered as an integral part of the national cooperative movement, and its success was due to the application of the allRussian experience during the heyday of cooperation in the country.

Badania przesiewowe w profilaktyce raka jelita grubego

2018 ◽  
Vol 21 (3) ◽  
Author(s):  
Marta Musińska ◽  
Marta Minkiewicz ◽  
Justyna Wasielica-Berger ◽  
Krystian Kidrycki ◽  
Krzysztof Kurek
Keyword(s):  
Colorectal Cancer ◽  
Screening Program ◽  
Single Step ◽  
Preventive Action ◽  
Asymptomatic Patients ◽  
Oncological Diseases ◽  
History Of ◽  
Genetic And Environmental Factors ◽  
Therapeutic Tools

Colorectal cancer is the second most frequently diagnosed cancer in Poland as well as in the world. In addition, this cancer is the second cause of death among oncological diseases. Genetic and environmental factors with a documented impact on the development and progression of colorectal cancer have been thoroughly investigated. Every case of colorectal cancer begins with the stage of a nonmalignant polyp, whose progression to invasive malignant tumor lasts about 10 years. This period is long enough to implement appropriate preventive action that allow early detection and treatment of pre-cancerous lesions. Colorectal cancer screening is the process of detecting polypoid lesions in asymptomatic patients with no history of cancers. Colonoscopy has the benefit of diagnostic and therapeutic tools, which allows to detect and remove of premalignant polyps in a single step approach. The aim of this work is to present the role of a screening program in the prevention of colorectal cancer.

scholarly journals Prevalence of atopic dermatitis, asthma and rhinitis from infancy through adulthood in rural Bangladesh: a population-based, cross-sectional survey

BMJ Open ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. e042380
Author(s):  
Courtney J Pedersen ◽  
Mohammad J Uddin ◽  
Samir K Saha ◽  
Gary L Darmstadt
Keyword(s):  
Atopic Dermatitis ◽  
Medical Diagnosis ◽  
Severe Disease ◽  
Age Groups ◽  
Working Party ◽  
Atopic Disease ◽  
Secondary Outcome ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
History Of

ObjectiveDescribe the pattern of atopic disease prevalence from infancy to adulthood.DesignCross-sectional household survey.SettingCommunity-based demographic surveillance site, Mirzapur, Bangladesh.Participants7275 individuals in randomly selected clusters within 156 villages.Primary and secondary outcome measuresThe 12-month prevalence of atopic dermatitis (by UK Working Party Criteria (UK criteria) and International Study of Asthma and Allergies in Childhood (ISAAC)), asthma and rhinitis (by ISAAC); disease severity (by ISAAC); history of ever receiving a medical diagnosis.ResultsChildren aged 2 years had the highest prevalence of atopic dermatitis—18.8% (95% CI 15.2% to 22.4%) by UK criteria and 14.9% (95% CI 11.6% to 18.1%) by ISAAC— and asthma (20.1%, 95% CI 16.4% to 23.8%). Prevalence of rhinitis was highest among 25–29 year olds (6.0%, (95% CI% 4.5 to 7.4%). History of a medical diagnosis was lowest for atopic dermatitis (4.0%) and highest for rhinitis (27.3%) and was significantly associated with severe disease compared with those without severe disease for all three conditions (atopic dermatitis: 30.0% vs 11.7%, p=0.015; asthma; 85.0% vs 60.4%, p<0.001; rhinitis: 34.2% vs 7.3%, p<0.001) and having a higher asset-based wealth score for asthma (29.7% (highest quintile) vs 7.5% (lowest quintile), p<0.001) and rhinitis (39.8% vs 12.5%, p=0.003). Prevalence of having >1 condition was highest (36.2%) at 2 years and decreased with age. Having atopic dermatitis (ISAAC) was associated with significantly increased odds ratios (OR) for comorbid asthma (OR 5.56 (95% CI 4.26 to 7.26)] and rhinitis (3.68 (95% CI 2.73 to 4.96)). Asthma and rhinitis were also strongly associated with each other (OR 8.39 (95% CI 6.48 to 10.86)).ConclusionsAtopic disease burden was high in this rural Bangladeshi population. Having one atopic condition was significantly associated with the presence of another. Low incidence of ever obtaining a medical diagnosis highlights an important opportunity to increase availability of affordable diagnosis and treatment options for all age groups.

scholarly journals How does parental history of atopic disease predict the risk of atopic dermatitis in a child? A systematic review and meta-analysis

2020 ◽  
Vol 145 (4) ◽  
pp. 1182-1193 ◽  
Author(s):  
Nina H. Ravn ◽  
Anne-Sofie Halling ◽  
Aviva G. Berkowitz ◽  
Maria R. Rinnov ◽  
Jonathan I. Silverberg ◽  
...  
Keyword(s):  
Systematic Review ◽  
Atopic Dermatitis ◽  
Meta Analysis ◽  
Atopic Disease ◽  
Parental History ◽  
History Of

scholarly journals Lviv printings general professional assosiation of mutual assistance in 1856-1867. Analysis of activity

2018 ◽  
Vol 21 (11) ◽  
pp. 6-13 ◽  
Author(s):  
I. R. Berest
Keyword(s):  
Trade Union ◽  
Trade Unions ◽  
Trade Union Movement ◽  
Mutual Assistance ◽  
Union Movement ◽  
Self Defense ◽  
Short Period ◽  
History Of ◽  
The Creation

The attempt to analyze and show the important role of Lviv printers and to describe their role in the development of Galician society has been made in the article. This attempt has been made on the basis of documents, the principle of historicism, scientific and objective approach. The importance and problematic of the comprehensive study of the oldest history of the creation, formation and development of Lviv printers’ professional co-operation of mutual assistance has been highlighted, and the history and activities of this organization in stages have been described. In general, trade unions emerged as an independent united self-defense organizations and they were formed in the form of workers’ associations and mutual assistance funds. During the first half of the nineteenth century the crystallization of the activities of trade unions happened under the influence of various measures, hold by the administrations, the police and the authorities. This contributed to the further unification of labor and the creation of all-city union of printers in Lviv. It is quite logical that the basis of their actions was their desire to achieve and get the working solidarity, mutual support and assistance. The activities of the trade union were regulated by the statutes. First of all, the purpose of the establishment and operation of the organization was socio-economic, cultural and educational ones. Those purposes were approved by the relevant state authorities and, thus, prevented trade unions from participating in political life.The short period of the 1860-1880s can be considered to be a separate stage in the process of the formation of the mass trade union movement in Galicia. Together with the trade unions of printers, settlers, brokers, masons, carpenters, builders, tanneries, metal workers, doctors, pharmacists, tradesmen, postmen, civil servants, lawyers and many others united and became active partners of the region.The problem, which has been investigated in the article, has a valuable scientific significance as it allows to solve one of the most important issues: to get the historical understanding of activities of Lviv trade union organizations, which have not been thoroughly studied yet.

scholarly journals The Role of Allergens in Atopic Dermatitis

2020 ◽  
Author(s):  
Suna Asilsoy ◽  
Serdar Al
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Allergic Diseases ◽  
Skin Lesions ◽  
Atopic Diseases ◽  
Chronic Skin ◽  
Genetic And Environmental Factors ◽  
Inhalant Allergens ◽  
Chronic Skin Disease

Atopic dermatitis (AD) is a chronic skin disease caused by genetic and environmental factors. Often it begins in early childhood. It is located at the first step of the process we refer to as atopic march. This feature is a precursor of the development of other allergic diseases such as asthma and allergic rhinitis. Especially in patients with atopy of food and inhalant allergens, the occurrence of other atopic diseases is more common. Although the role of these sensitivities in AD is controversial, it has been determined that some patients may trigger eczematous skin lesions. In this report, the role of allergens in atopic dermatitis are reviewed in the light of current literature.

scholarly journals The Natural History of Food Sensitization in Children With Atopic Dermatitis and the Prognostic Role of Specific Serum IgE

2013 ◽  
Vol 7 (1) ◽  
pp. 22-28
Author(s):  
Arianna Giannetti ◽  
Giampaolo Ricci ◽  
Arianna Dondi ◽  
Valentina Piccinno ◽  
Federica Bellini ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Natural History ◽  
School Age ◽  
Food Tolerance ◽  
Serum Ige ◽  
Specific Serum ◽  
Hen’S Egg ◽  
History Of ◽  
Before School

Background: The natural history and the prognostic factors for food tolerance in childhood atopic dermatitis(AD) are poorly understood. Objective: We aimed at investigating the natural course of egg and milk allergy in children affected by AD and food allergy and identifying if the persistence of allergy is associated with high specific serum IgE(sIgE). Methods: The retrospective study included 58 patients affected by AD, aged 9-16 months, with a first clinical examination between 1993 and 2002. Results: Patients with AD and allergy to hen’s egg(N=58) or cow’s milk(N=44) were studied. In most patients milk and egg tolerance was reached before school age, but it was achieved later in children with severe AD and high egg sIgE. Conclusions: The food tolerance is normally reached before school age and, at the time of diagnosis, levels of sIgE>5kU/L for hen’s egg are risk factors for a later tolerance achievement.

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