scholarly journals The Vista of Application of Specific Anaphylaxis Accurate Diagnosis Based on DNA Single-Nucleotide Methylation Sites

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Xiangjie Guo ◽  
Yaqin Bai ◽  
Hualin Guo ◽  
Peng Wu ◽  
Hao Li ◽  
...  
Keyword(s):  
Machine Learning ◽  
Dna Methylation ◽  
Pollen Season ◽  
Accurate Diagnosis ◽  
The Other ◽  
Single Nucleotide ◽  
Machine Learning Classification ◽  
The World ◽  
On Line ◽  
The Difference

Anaphylaxis has rapidly spread around the world in the last several decades. Environmental factors seem to play a major role, and epigenetic marks, especially DNA methylation, get more attention. We discussed several GEO opening data classifications with TOP 100 specific methylation region values (normalized M-values on line) by machine learning, which are remarkable to classify specific anaphylaxis after monoallergen exposure. Then, we sequenced the whole-genome DNA methylation of six people (3 wormwood monoallergen atopic rhinitis patients and 3 normal-immune people) during the pollen season and analyzed the difference of the single nucleotide and DNA region. The results’ divergences were obvious (the differential single nucleotides were mostly distributed in nongene regions but the differential DNA regions of GWAS, on the other hand), which may have caused most single nucleotides to be concealed in the regions’ sequences. Therefore, we suggest that we should conduct more “pragmatic” and directly find special single-nucleotide changes after exposure to atopic allergens instead of complex correlativity. It is possible to try to use DNA methylation marks to accurately diagnose anaphylaxis and form a machine learning classification based on the single methylated CpGs.

Distinction between Dolus and Culpa with reference to Arson in Zakon Sudnyj LJudem, the Vinodol Law and the Statute of Senj

De Jure ◽  
2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Daniel Haman ◽  
◽  
◽  
Keyword(s):  
Criminal Law ◽  
The Other ◽  
Legal Documents ◽  
The Third ◽  
Other Hand ◽  
Criminal Offenses ◽  
The World ◽  
The Difference ◽  
Different Levels ◽  
Better Than

The difference between intent (dolus) and negligence (culpa) was rarely emphasized in codified medieval laws and regulations. When compared to the legal statements related to intent, negligence was mentioned even more rarely. However, there are some laws that distinguished between the two concepts in terms of some specific crimes, such as arson. This paper draws attention to three medieval Slavic legal documents – the Zakon Sudnyj LJudem (ZSLJ), the Vinodol Law and the Statute of Senj. They are compared with reference to regulations regarding arson, with the focus being on arson as a crime committed intentionally or out of negligence. The ZSLJ as the oldest known Slavic law in the world shows some similarities with other medieval Slavic legal codes, especially in the field of criminal law, since most of the ZSLJ’s articles are related to criminal law. On the other hand, the Vinodol Law is the oldest preserved Croatian law and it is among the oldest Slavic codes in the world. It was written in 1288 in the Croatian Glagolitic script and in the Croatian Chakavian dialect. The third document – the Statute of Senj – regulated legal matters in the Croatian littoral town of Senj. It was written in 1388 – exactly a century after the Vinodol Law was proclaimed. When comparing the Vinodol Law and the Statute of Senj with the Zakon Sudnyj LJudem, there are clear differences and similarities, particularly in the field of criminal law. Within the framework of criminal offenses, the act of arson is important for making a distinction between intent and negligence. While the ZSLJ regulates different levels of guilt, the Vinodol Law makes no difference between dolus and culpa. On the other hand, the Statute of Senj strictly refers to negligence as a punishable crime. Even though the ZSLJ is almost half a millennium older than the Statute of Senj and around 400 years older than the Vinodol Law, this paper proves that the ZSLJ defines the guilt and the punishment for arson much better than the other two laws.

The Apocalyptic Image of the Beast in William Blake’s ‘The Tyger’ and W.B. Yeats’ ‘The Second Coming’

2021 ◽  
Vol 33 (3-4) ◽  
pp. 47-61
Author(s):  
Yasser K. R. Aman
Keyword(s):  
William Blake ◽  
The Other ◽  
Modern World ◽  
Christian Religion ◽  
The World ◽  
The Difference ◽  
Second Coming

The monstrous image created by William Blake in ‘The Tyger’ left the world wrapped in an apocalyptic vision that creates an epiphany of unknown Romantic potentials symbolised in ‘The Tyger’. The apocalyptic vision, deeply rooted in Christian religion, develops into an ominous harbinger of the destruction of the modern world portrayed in W.B. Yeats’ ‘The Second Coming’. The image of the beast marks the difference between two ages, one with strong potentials and the other with fear and resident evil unexplained. I argue that the apocalyptic theory in Christianity has an impact on the development of the image of the beast in both poems, an impact that highlights man’s retreat from Nature into the modern world which may fall apart because of beastly practices.

scholarly journals Image-to-Image Translation with Multi-Path Consistency Regularization

2019 ◽  
Author(s):  
Jianxin Lin ◽  
Yingce Xia ◽  
Yijun Wang ◽  
Tao Qin ◽  
Zhibo Chen
Keyword(s):  
Machine Learning ◽  
Computer Vision ◽  
The Other ◽  
Natural Images ◽  
Original Image ◽  
Target Domain ◽  
Source Domain ◽  
Face To Face ◽  
Image Translation ◽  
The Difference

Image translation across different domains has attracted much attention in both machine learning and computer vision communities. Taking the translation from a source domain to a target domain as an example, existing algorithms mainly rely on two kinds of loss for training: One is the discrimination loss, which is used to differentiate images generated by the models and natural images; the other is the reconstruction loss, which measures the difference between an original image and the reconstructed version. In this work, we introduce a new kind of loss, multi-path consistency loss, which evaluates the differences between direct translation from source domain to target domain and indirect translation from source domain to an auxiliary domain to target domain, to regularize training. For multi-domain translation (at least, three) which focuses on building translation models between any two domains, at each training iteration, we randomly select three domains, set them respectively as the source, auxiliary and target domains, build the multi-path consistency loss and optimize the network. For two-domain translation, we need to introduce an additional auxiliary domain and construct the multi-path consistency loss. We conduct various experiments to demonstrate the effectiveness of our proposed methods, including face-to-face translation, paint-to-photo translation, and de-raining/de-noising translation.

Introduction

2017 ◽  
Author(s):  
David M. Kaplan
Keyword(s):  
Climate Change ◽  
Environmental Impacts ◽  
Philosophy Of Technology ◽  
Environmental Issues ◽  
Environmental Philosophy ◽  
The Other ◽  
Natural Environments ◽  
The World ◽  
The Difference ◽  
Two Sides

Environmental philosophy and philosophy of technology have a lot in common. Both fields explore the positive and negative aspects of human modifications of the world. Both question the limits of technology in relation to natural environments, animals, plants, and food. Both examine if human making and doing is compatible with nature or wholly different from it. And both examine the difference between what is considered to be natural and artificial. Technology and the environment further intersect in a number of issues, such as climate change, sustainability, geo-engineering, and agriculture. The reason for the overlap is fundamental: Environmental issues inevitably involve technology, and technologies inevitably have environmental impacts. Technology and the environment are like two sides of the same coin: Each is fully understood only in relation to the other. Yet, despite the ample overlap of questions concerning technology and the environment, the two philosophical fields have developed in relative isolation from each other. Even when philosophers in each field address themselves to similar concerns, the research tends to be parallel rather than intersecting, and the literatures remain foreign to one another. These divergent paths are unfortunate. Philosophers from each field have a lot to contribute to the other....

Can Theological Language Have Hidden Meaning?

1983 ◽  
Vol 19 (1) ◽  
pp. 43-56
Author(s):  
John Morreall
Keyword(s):  
The Other ◽  
Time And Space ◽  
Other Hand ◽  
The World ◽  
Spatio Temporal ◽  
The Difference ◽  
Theological Language

Any reflective account of theological language acknowledges very early that words drawn from our experience with creatures have special meanings when applied to God. Because God transcends the created world, we cannot take predicates which apply to creatures and apply them to God without modification. And the more transcendent God is understood to be, the more modified will our language taken from creatures have to be when it is used in theology. A primitive theism which thinks of God simply as a very powerful person will view the difference between God and creatures as merely a matter of degree and not of kind. In such a view God transcends things in the world only in that he has a greater degree of the properties we find in creatures, so that predicates taken from creatures, ‘wise’ and ‘strong’, for example, can be applied to God in almost a straightforward way. The only change in meaning is that God is moreknowing and stronger. In a more sophisticated theism such as Judaism or Christianity, on the other hand, God' transcendence is seen not simply as a difference in degrees of properties, but as a difference in kind. The being God is is radically other than the kinds of beings we find in the created world. Indeed, it is sometimes claimed that God is not even ‘a being’, a thing which exists; rather God is ‘being itself’, ‘pure existence’. Aquinas, for instance, held that God does not haveproperties. God is absolutely simple, and so if we can talk about properties at all in talking about God, we have to say that God is identical to God' properties. God, too, differs radically from creatures in that he is not in time and space, nor is he dependent on anything else. But our language used with creatures is full of explicit or implicit references to time and space and to dependence, so that we cannot take our ordinary terms derived from our experience with spatio-temporal, dependent creatures and apply them straightforwardly to God.

scholarly journals Aquella Carta a una profesora (aquí maestra) cumple 50 años

2017 ◽  
Vol 21 (4) ◽  
pp. 39-55
Author(s):  
José Luís Corzo
Keyword(s):  
Educational System ◽  
Personal Development ◽  
The Other ◽  
The World ◽  
The Difference ◽  
Spanish Educational System

Resumen:El artículo insiste en el enorme valor pedagógico de aquella carta escrita colectivamente por chicos de montaña con su maestro Lorenzo Milani. Tiene tres apartados: el primero, contextualiza adecuadamente la lectura de la Carta y da cuenta de sus destinatarios y autores reales, del porqué se tradujo a una maestra y no a una profesora, de las dificultades de su traducción y de su recepción en Italia y España. El segundo, señala los rasgos más característicos de la pedagogía de don Milani, con un énfasis especial en la distinción entre la instrucción/aprendizaje y la educación como desarrollo personal. Así como en la relevancia de las relaciones – y el amor - con el mundo, con los otros y el Otro. Finalmente, se exponen de forma sintética algunas de las principales aportaciones de la pedagogía milaniana y de la Carta a una maestra al sistema educativo español actual. Abstract:This paper proclaims the great pedagogical value of that letter collectively written by a few boys from the mountains with their teacher, Lorenzo Milani. The article has three sections: the first one, where the Letter is properly contextualized and its authors as well as whose main audience is clarified. It also explains the reasons behind the translation of the title into Spanish, and how it was received in both Italy and Spain. The second section focuses on the main features of the pedagogy of Mr. Milani, emphasizing particularly the difference between instruction/learning and education as personal development. It also deals with the relevance of relations -love- with the world, with the others and with the Other. The article concludes by sintetizing some of the main contributions of the milanian pedagogy and of the „Letter to a Teacher‟ to the current Spanish educational system.

scholarly journals Looking for the Lost Sibling

2021 ◽  
Vol 14 (1) ◽  
pp. 63-74
Author(s):  
Ronny Jaffè
Keyword(s):  
The Other ◽  
Foreign Object ◽  
Internal Representations ◽  
Object A ◽  
The Uncanny ◽  
The World ◽  
The Difference ◽  
Different Levels

Abstract The author addresses the siblings theme not only by considering it part of the bonds of a concrete and real family but by relating it to more phantasmal analogies in order to give voice to the world of internal representations. This paper is inspired by some fundamental considerations formulated by René Kaes in the book “The fraternal complex” (Le complexe fraternal, 2008): n the fraternal complex two different levels can be identified: 1) an archaic level characterized by a pre-Oedipal climate in which confusion and undifferentiatedness prevail and where the brother or sister assumes the uncanny dimension of a foreign object, a non-recognized, encrypted and encysted double or lookalike. 2) a level of Oedipal nature in which the otherness, the difference and the recognition of the other can be structured; this level makes it possible to open up towards a dimension of separation and identification. These two different levels will be illustrated trough some clinical situations.

scholarly journals Analysis of the TP53 Deleterious Single Nucleotide Polymorphisms Impact on Estrogen Receptor Alpha-p53 Interaction: A Machine Learning Approach

2019 ◽  
Vol 20 (12) ◽  
pp. 2962 ◽  
Author(s):  
Kumaraswamy Naidu Chitrala ◽  
Mitzi Nagarkatti ◽  
Prakash Nagarkatti ◽  
Suneetha Yeguvapalli
Keyword(s):  
Breast Cancer ◽  
Machine Learning ◽  
Risk Factors ◽  
Estrogen Receptor ◽  
Estrogen Receptor Alpha ◽  
Large Deviation ◽  
The Other ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
The Impact

Breast cancer is a leading cancer type and one of the major health issues faced by women around the world. Some of its major risk factors include body mass index, hormone replacement therapy, family history and germline mutations. Of these risk factors, estrogen levels play a crucial role. Among the estrogen receptors, estrogen receptor alpha (ERα) is known to interact with tumor suppressor protein p53 directly thereby repressing its function. Previously, we have studied the impact of deleterious breast cancer-associated non-synonymous single nucleotide polymorphisms (nsnps) rs11540654 (R110P), rs17849781 (P278A) and rs28934874 (P151T) in TP53 gene on the p53 DNA-binding core domain. In the present study, we aimed to analyze the impact of these mutations on p53–ERα interaction. To this end, we, have modelled the full-length structure of human p53 and validated its quality using PROCHECK and subjected it to energy minimization using NOMAD-Ref web server. Three-dimensional structure of ERα activation function-2 (AF-2) domain was downloaded from the protein data bank. Interactions between the modelled native and mutant (R110P, P278A, P151T) p53 with ERα was studied using ZDOCK. Machine learning predictions on the interactions were performed using Weka software. Results from the protein–protein docking showed that the atoms, residues and solvent accessibility surface area (SASA) at the interface was increased in both p53 and ERα for R110P mutation compared to the native complexes indicating that the mutation R110P has more impact on the p53–ERα interaction compared to the other two mutants. Mutations P151T and P278A, on the other hand, showed a large deviation from the native p53-ERα complex in atoms and residues at the surface. Further, results from artificial neural network analysis showed that these structural features are important for predicting the impact of these three mutations on p53–ERα interaction. Overall, these three mutations showed a large deviation in total SASA in both p53 and ERα. In conclusion, results from our study will be crucial in making the decisions for hormone-based therapies against breast cancer.

Social Indicators: A Comparison Among Selected Countries

2019 ◽  
Vol 4 (2) ◽  
pp. 123-144
Author(s):  
Badar Alam Iqbal ◽  
Mohd Nayyer Rahman ◽  
Munir Hasan
Keyword(s):  
World Bank ◽  
Growth And Development ◽  
Social Indicators ◽  
High Growth ◽  
The Other ◽  
Lower Income ◽  
The Social ◽  
The World ◽  
The Difference ◽  
The One

The difference between growth and development is not subtle but substantially huge and the gap is ever increasing. The dividing line is social indicators. Countries witnessing high growth rates for decades are not equal performers in development when social indicators are observed. India is an emerging economy on the one hand and a developing on the other hand but a lower income country as per World Bank statistic. While India holds economic indicators that appears to be promising to the world and investors that is not the case with social indicators. The present study is an attempt to critically review the social indicators for India and to trace the trajectory of fall or growth in such indicators while comparing with selected countries.

The Influence of Early Twentieth-Century Technology

Jazz in China ◽  
2018 ◽  
pp. 21-31
Author(s):  
Eugene Marlow
Keyword(s):  
Twentieth Century ◽  
The Other ◽  
Early Twentieth Century ◽  
Communications Technologies ◽  
The World ◽  
The Difference ◽  
Music For Dance ◽  
Opium Wars

The superior war-making technology of the Western colonial powers—the steam-driven warship and cannon—made the difference between China prevailing and its defeat during the Opium Wars. It resulted in the colonial powers controlling Shanghai, tantamount to controlling China. In turn, the colonial powers brought their culture with them to Shanghai, which included jazz in the first quarter of the twentieth century. Within a couple of decades, jazz became not only the music of Shanghai but was global. This chapter asks how jazz traveled halfway around the world to China (and in the other direction, to Europe) so quickly? And how did the non-American musicians in Shanghai (Russians, Filipinos, and Chinese) learn to play the music for dance hall purposes? Transportation and communications technologies of the early twentieth century—the steamship, the locomotive, the gramophone, and early film—also were major influences in bringing jazz to China's shores.

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