scholarly journals The Antioxidant Supplementation with Filipendula ulmaria Extract Attenuates the Systemic Adverse Effects of Nanosized Calcium Phosphates in Rats

2021 ◽  
Vol 2021 ◽  
pp. 1-16
Author(s):  
Radomir Scepanovic ◽  
Dragica Selakovic ◽  
Jelena S. Katanic Stankovic ◽  
Natalija Arsenijevic ◽  
Marija Andjelkovic ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Oral Surgery ◽  
Calcium Phosphates ◽  
Serum Levels ◽  
Antioxidant Supplementation ◽  
Histological Changes ◽  
Filipendula Ulmaria ◽  
Stress Markers ◽  
Metallic Compounds ◽  
Tbars Values

The aim of this study was to investigate and compare the systemic toxicity of three nanosized calcium phosphates (CaPs): hydroxyapatite (HA), tricalcium phosphate (TCP), and amorphous calcium phosphate (ACP) in rats. Since those metallic compounds are widely used as bone replacement materials, including their use in oral surgery, CaPs were applied (per os) equimollary (17.8 mg/kg, 11 mg/kg, and 9.65 mg/kg b.w., respectively) for 30 days in order to mimic the previously described release rate from dental composites. Also, we employed antioxidant supplementation with Filipendula ulmaria (FU) extract. All the applied CaPs significantly increased serum calcium, triglycerides, LDL, and LDH, while serum levels of testosterone and LH declined, with no alterations in the liver enzymes. The evaluation of oxidative stress markers (in the liver, kidney, and testicle) showed an increase in TBARS values, while SOD and CAT activities and GSH levels were significantly reduced. The relative gene expression of Bax and Bcl-2 was shifted to proapoptotic action, accompanied by intense characteristic histological changes in architecture in all investigated organs. The toxic effects were most prominent in groups treated by ACP. FU administration attenuated the majority of nanosized CaP-induced adverse effects, thus recommending this therapeutic approach to minimize nano-CaP systemic toxicities.

Oxidative Stress Markers and Metal Ions are Correlated With Cognitive Function in Alzheimer’s Disease

2017 ◽  
Vol 32 (6) ◽  
pp. 353-359 ◽  
Author(s):  
Zhengping Pu ◽  
Wenjie Xu ◽  
Yong Lin ◽  
Jincai He ◽  
Manli Huang
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Metal Ions ◽  
Serum Levels ◽  
Zinc Level ◽  
Copper Level ◽  
Iron Level ◽  
Oxidative Stress Markers ◽  
Stress Markers

We investigated oxidative stress markers and metal ions in patients with Alzheimer’s disease (AD). The serum levels of ceruloplasmin (CER), C-reactive protein (CRP), uric acid (UA), homocysteine (Hcy), copper, iron, and zinc were determined in 125 patients with AD (mild, n = 2 8; moderate, n = 42; and severe, n = 55) and 40 healthy control (HC) participants. Compared to HC, CER and UA levels were significantly lower in moderate and severe AD groups, whereas CRP and Hcy levels were significantly higher in the severe AD group. Copper level was significantly higher in moderate and severe AD groups than the other groups. Compared to HC, iron level was significantly higher in patients with AD, whereas zinc level was significantly lower in patients with AD. In patients with AD, the severity of cognitive impairment was positively correlated with CER, UA, and zinc levels, whereas it was negatively correlated with copper level. Taken together, our findings provide a novel approach to assess AD progression.

Glyphosate effects on the female reproductive systems: a systematic review

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Sakineh Kaboli Kafshgiri ◽  
Tahereh Farkhondeh ◽  
Ebrahim Miri-Moghaddam
Keyword(s):  
Systematic Review ◽  
Reproductive System ◽  
English Language ◽  
Interstitial Fibrosis ◽  
Serum Levels ◽  
Female Reproductive Tract ◽  
Publication Date ◽  
Female Reproductive System ◽  
Reproductive Systems ◽  
Histological Changes

Abstract Glyphosate-based herbicides (GBHs) are organophosphate pesticides, which interrupt the chemicals involved in the endocrine system and cause lifelong disorders in women's reproductive system. The current study was designed to systematically evaluate the association between GBH exposure and the female reproductive tract. According to PRISMA Guidelines, the systematic review was performed, searching online databases, including Google Scholar, Web of Science, PubMed, and Scopus, throughout April 2020. Studies with Rodent, lamb, and fish or exposed to GBH to affect the female reproductive system were selected. All studies were in the English language. Two investigators independently assessed the articles. The first author's name, publication date, animal model, age, sample size, gender, dose, duration, and route of exposure and outcomes were extracted from each publication. The present review summarizes 14 publications on uterus alterations and oocytes, histological changes ovary, and assessed mRNA expression, protein expression, serum levels progesterone, and estrogen and intracellular Reaction Oxygen Species (ROS) in rodents, fish, and lamb exposed to GHB exposure. Most of the studies reported histological changes in ovarian and uterus tissue, alterations in serum levels, and increased oxidative stress level following exposure to GBH. Additionally, due to alterations in the reproductive systems (e.g., histomorphological changes, reduction of the mature follicles, higher atretic follicles, and interstitial fibrosis), it seems the GBH-induced female these alterations are both dose- and time-dependent. The present findings support an association between GBH exposure and female reproductive system diseases. However, more studies are needed to identify the mechanisms disrupting the effects of GBH and their underlying mechanisms. Considering the current literature, it is recommended that further investigations be focused on the possible effects of various pesticides on the human reproductive system.

scholarly journals Study of Adverse Effect Profile of Zoledronic Acid Infusion Among Patients with Cancer: A Retrospective Analysis

2020 ◽  
Vol 13 (10) ◽  
Author(s):  
Lina Elsalem ◽  
Haneen A. Basheer ◽  
Ayat Alshoh ◽  
Abdullah Abu-Aqoulah ◽  
Hussein Alsa'di ◽  
...  
Keyword(s):  
Zoledronic Acid ◽  
Adverse Effects ◽  
Biochemical Parameters ◽  
Symptomatic Treatment ◽  
Serum Levels ◽  
Mean Values ◽  
Protein Levels ◽  
Patients With Cancer ◽  
Significant Difference ◽  
Pre Treatment

Background: Zoledronic acid (ZA) is widely used in the management of cancer-related bone events. It, however, might be associated with serious adverse effects. Objectives: To evaluate ZA adverse effects and changes in biochemical parameters related to ZA toxicities among patients with cancer. Methods: Ninety-eight oncology patients, who were prescribed ZA intravenous (IV) infusion, were interviewed to assess whether they experienced ZA related symptoms, including acute events and serious adverse effects. ZA’s effects on the serum levels of different biochemical parameters were retrospectively assessed by checking patients’ electronic medical records. Results: The most commonly reported adverse effects were: myalgia (48%), bone pain (36.7%), influenza-like symptoms (34.7%), headache (31.6%), and pyrexia (22.45%) with decreasing frequency of such adverse effects upon repeated infusions. Serious side effects including jaw osteonecrosis, cardiac, and renal problems were not reported. A small, but statistically significant reduction in serum calcium, creatinine, and total protein levels was observed upon comparing levels before and after the first IV infusion of ZA (P ≤ 0.031). No significant change was recorded with other serum electrolytes including phosphorus, sodium, potassium, and magnesium as well as urea levels (P ≥ 0.271). No significant difference was determined in terms of final serum levels of all parameters in comparison to pre-treatment (P ≥ 0.059), except for potassium, where a significant reduction was observed (P = 0.003). Notably, the mean values of all parameters were within the normal range. Conclusions: ZA acute events resolved with symptomatic treatment and reduced with repeated IV infusions. ZA appears as a safe treatment modality for skeletal-related events among patients with cancer and the reported adverse effects should not affect patients’ compliance.

scholarly journals Oxidative stress and outcome of antioxidant supplementation in patients with polycystic ovarian syndrome (PCOS)

2018 ◽  
Vol 7 (5) ◽  
pp. 1667 ◽  
Author(s):  
Abubakar A. Panti ◽  
Constance E. Shehu ◽  
Yusuf Saidu ◽  
Karima A. Tunau ◽  
Emmanuel I. Nwobodo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Enzymes ◽  
Serum Levels ◽  
Clinical Pregnancy ◽  
Oxidative Stress Marker ◽  
Randomised Control Trial ◽  
Antioxidant Supplementation ◽  
Control Groups ◽  
Stress Marker ◽  
And Control

Background: PCOS is a condition with significant decrease in antioxidant with an increased risk of oxidative stress. Antioxidant supplementation has been shown to improve insulin sensitivity in PCOS and may improve outcome of management of PCOS. Objectives of this study were to determine the oxidative stress level of PCOS patients, to assess the effect of antioxidant supplementation on the outcome of management of PCOS and to compare with a control group.Methods: The study was a single blind randomised control trial involving 200 patients with PCOS. The study was conducted at Usmanu Danfodiyo University Teaching Hospital Sokoto. They were randomly divided into intervention and control groups and base line serum levels of oxidative stress marker, antioxidant enzymes, vitamins and minerals were determined. Antioxidant supplementation and placebo were given to the intervention and control groups respectively. All the patients had ovulation induction with clomiphene citrate and were followed up for 6 months. Outcome measures were clinical pregnancy or menstrual regularisation. Level of significance was <0.05.Results: There was statistical significance in the serum levels of oxidative stress marker, antioxidant enzymes, vitamins and minerals between the two groups (post intervention). Glutathione peroxidase (p = 0.001), superoxide dismutase (p = 0.0001), catalase (p= 0.0369), melondialdehyde (p= 0.007), Vitamin A, Vitamin C, Vitamin E (p = 0.0001), zinc and copper (p = 0.0001). The clinical pregnancy outcomes were 22 (22%) versus 2 (2%); live births 18 (18%) versus 2 (2%) and menstrual regularisation 48 (48%) versus 46 (46%) in the intervention and control groups respectively.Conclusions: Antioxidant supplementation in this study significantly affected pregnancy rate in patients with PCOS. Larger studies are suggested to revisit the conclusion of the Cochrane review that antioxidants supplementation had no significant role in female infertility.

Recommendations for Monitoring Lithium Therapy

1983 ◽  
Vol 17 (5) ◽  
pp. 346-350 ◽  
Author(s):  
Ronald B. Salem
Keyword(s):  
Side Effects ◽  
Adverse Effects ◽  
Serum Levels ◽  
Normal Serum ◽  
Lithium Therapy ◽  
Organ Systems

The literature concerning side effects of normal serum levels of lithium on various organ systems is reviewed. Suggestions for monitoring and managing these adverse effects are discussed. A table is presented that provides recommendations for evaluation prior to initiation and during follow-up of therapy.

Mood Stabilizer Loading Versus Titration in Acute Mania: Audit of Clinical Practice

2008 ◽  
Vol 42 (11) ◽  
pp. 955-962 ◽  
Author(s):  
Amanda Wheeler ◽  
Gail Robinson ◽  
Allen Fraser
Keyword(s):  
Intensive Care ◽  
Length Of Stay ◽  
Adverse Effects ◽  
Legal Status ◽  
Clinical Decision Making ◽  
Average Length ◽  
Mood Stabilizer ◽  
Serum Levels ◽  
High Serum ◽  
Routine Practice

Objective: The aim of the present study was to investigate whether the use of a loading strategy with lithium or valproate followed recommended practice and second, whether this had any impact on indicators of outcome in acutely manic inpatients. Method: A 12 month retrospective review of admissions to two adult psychiatric units in Auckland, New Zealand, was conducted. Demographic, legal status, psychiatric admissions, outcome indicators (length of stay, intensive care and seclusion use) and medication data were collected for all patients with a diagnosis of acute bipolar mania who started mood stabilizer treatment within 3 days of admission (n=93). Serum levels and adverse effects were also recorded. Results: In 46.2% of admissions a loading strategy was prescribed, and lithium was the treatment choice in two-thirds of admissions. Serum levels were taken inconsistently, particularly for valproate. No difference was found between loading and titrating for the assessed outcomes in routine practice; average length of stay was 30.2 days; most patients (71.0%) spent time in intensive care (average 8.4 days) and 33.3% spent time in seclusion. More adverse effects occurred with loading (51.2%) compared to titrating (36.0%), particularly with lithium. Conclusion: The literature supports a strong link between rapidly attained high serum levels and positive outcomes. The present study found inconsistent and infrequent measurement of levels, which was not in accord with recommended practice. Frequent monitoring of serum levels to support dosing decisions is important to inform better clinical decision making, especially when a loading strategy is used. This may explain the less than optimal outcomes (with respect to rapid resolution of mania and hospital discharge) that were found, irrespective of dosing strategy.

scholarly journals Serum Levels of Oxidative Stress Markers in Patients with Type 2 Diabetes Mellitus and Non-alcoholic Steatohepatitis

2016 ◽  
Vol 54 (4) ◽  
pp. 228-236 ◽  
Author(s):  
F. Casoinic ◽  
D. Sampelean ◽  
Anca D. Buzoianu ◽  
N. Hancu ◽  
Dorina Baston
Keyword(s):  
Oxidative Stress ◽  
Fatty Liver Disease ◽  
Serum Levels ◽  
Protein Carbonyls ◽  
Oxidative Stress Markers ◽  
Multivariate Logistic Regression ◽  
Alcoholic Fatty Liver ◽  
Stress Markers ◽  
Alcoholic Fatty Liver Disease

Abstract Introduction. Oxidative stress is one of the key mechanisms responsible for disease progression in non-alcoholic fatty liver disease. The aim of this study was to evaluate the serum levels of oxidative stress markers in patients with type 2 diabetes mellitus (DMT2) and non-alcoholic steatohepatitis (NASH) and test their relationships with clinical and biochemical patient characteristics, compared to patients with DMT2 without non-alcoholic fatty liver disease (NAFLD), and controls. Materials and methods. In all, 60 consecutive patients with DMT2 and NASH, 55 with DMT2 without NAFLD, and 50 age-and-gender-matched healthy subjects participated in the study. The serum levels of protein carbonyls and 8-isoprostane were determined by ELISA methods, while the serum levels of malondialdehyde (MDA) were detected by means of the spectrophotometric method. Clinical, demographic, and laboratory parameters were examined for all the subjects included in the study. Multivariate logistic regression was used to test the independent predictive factors in the relationships investigated here. Results. Patients with DMT2 and NASH displayed significantly higher serum levels of protein carbonyls (1.112 ± 0.42 nmol/dL), MDA (6.181 ± 1.81 ng/mL), and 8-isoprostane (338.6 ± 98.5 pg/mL) compared to patients with DMT2 without NAFLD, and controls. Results of multivariate logistic regression analyses indicate that in patients with DMT2 and NASH, the serum levels of oxidative stress markers were independently and positively associated with: HbA1c, duration of diabetes, the UKPDS cardiovascular risk score (for protein carbonyls); age, LDL-cholesterol (for 8-isoprostane); and triglycerides serum levels (for MDA). Conclusions. Our findings indicate that the process of oxidative stress tends to increase in patients with DMT2 and NASH, compared to patients with DMT2 without NAFLD, and controls. This evidence suggests that an antioxidant therapy might prove useful in the treatment of patients with DMT2 and NASH.

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