scholarly journals Changes of Serum Zinc-α2-Glycoprotein Level and Analysis of Its Related Factors in Gestational Diabetes Mellitus

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Dongmei Xu ◽  
Jie You ◽  
Guixia Chen ◽  
Hongli Su ◽  
Li Zhang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pearson Correlation ◽  
Serum Zinc ◽  
Normal Subjects ◽  
Control Group ◽  
Case Group ◽  
Newly Diagnosed ◽  
Related Factors

Previous studies have discovered that zinc-α2-glycoprotein (ZAG) is related to insulin resistance and lipid metabolism. The aim of the study is to explore the change of serum ZAG and its related factors in gestational diabetes mellitus (GDM). Eighty newly diagnosed GDM patients were enrolled in the case group, and 80 normal pregnant women were selected as the control group. The differences of baseline data between the two groups were compared, and the change of serum ZAG level and its relationship with related indexes was analyzed. Compared to the control group, the level of serum ZAG in GDM women decreased ( P < 0.001 ). What is more, the serum ZAG level of overweight and normal subjects in two groups was also found to have statistical differences. The Pearson correlation (or Spearman correlation) analysis showed that serum ZAG level was negatively correlated with FPG, FINS, HOMA-IR, and TG (all P < 0.05 ) and positively correlated with HDL ( P < 0.05 ). Multiple linear regression showed that HDL and HOMA-IR were independent factors of serum ZAG ( P < 0.05 ). The level of serum ZAG in patients with gestational diabetes mellitus decreased, and HDL and HOMA-IR are the influencing factors in the case group.

scholarly journals Changes of serum zinc-α2-glycoprotein level and analysis of its related factors in gestational diabetes mellitus:a cross-sectional study

2020 ◽  
Author(s):  
Caiying Feng ◽  
Jie You ◽  
Guixia Chen ◽  
Hongli Su ◽  
Li Zhang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Serum Zinc ◽  
Cross Sectional Study ◽  
Control Group ◽  
Study Group ◽  
Clinical Trial Registry ◽  
Related Factors ◽  
Cross Sectional

Abstract Background Previous studies have discovered that zinc-α2-glycoprotein is related to insulin resistance and lipid metabolism. The aim of the study is to explore the change of serum zinc-α2-glycoprotein(ZAG) and its related factors in gestational diabetes mellitus(GDM). Methods Eighty newly diagnosed GDM patients were enrolled in study group, and 80 normal pregnant women were selected as control group. The differences of baseline data between the two groups were compared, and the change of serum ZAG level and its relationship with related indexes was analyzed. Results Compared to control group, the level of serum ZAG in the study group decreased [(43.94 ± 14.51)mg/L vs. (62.57 ± 19.05)mg/L, P < 0.001]. Pearson correlation (or Spearman correlation) analysis showed that serum ZAG level was negatively correlated with FPG, FINS, HOMA-IR and TG (P < 0.05) and positively correlated with HDL(P < 0.05). Multiple linear regression showed that HDL, FINS, HOMA-IR were independent factors of serum ZAG(P < 0.001). Conclusion The level of serum ZAG in patients with gestational diabetes mellitus decreased, and HDL, FINS and HOMA-IR are the influencing factors in study group. Trial registration: The study registered in the Chinese Clinical Trial Registry(Chi CTR2000028811).

scholarly journals Serum Zinc and Copper Levels in Gestational Diabetes Mellitus in a Tertiary Care Hospital of Bangladesh

2017 ◽  
Vol 8 (1) ◽  
pp. 52-55 ◽  
Author(s):  
Farzana Akonjee Mishu ◽  
MA Muttalib ◽  
Bilkis Sultana
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Serum Zinc ◽  
Control Group ◽  
Case Group ◽  
Third Trimester ◽  
Group I ◽  
Significant Difference

Background: The term gestational diabetes mellitus (GDM) is becoming a major health problem in developing countries undergoing rapid changes in lifestyle, dietary habits and body mass index. GDM is associated with an increased incidence of congenital abnormalities which is also aggravated by mother’s zinc and copper deficiency. Zinc and copper are essential trace elements for normal embryogenesis and fetal growth and their deficiency increase mortality and morbidity of mothers, embryos and neonates. This study was designed to evaluate the association of serum zinc and copper with GDM in second and third trimester.Methods: It was a case-control study. This study was conducted in Mymensingh Medical College Hospital during the period from July 2013 to June 2014 to evaluate the association of zinc and copper levels of pregnant women with GDM. A total induded of 172 subjects were participated in this study; among them 86 women diagnosed with GDM were selected as case (Group-I) and 86 healthy pregnant women were control (Group- II).The case group was again subdivided as Group Ia and Ib according to second and third trimester respectively. Control group was also subdivided as Group IIa and IIb according to second and third trimester respectively. Student’s unpaired ‘t’ test was used to analyse the data between groups. For analytical purpose 95% confidence limit (p<0.05) was taken as level of significance.Results: There was significant difference in serum zinc and copper levels in cases compared to control group. Highly significant difference (p<0.001) was found when serum zinc was compared between women with GDM and normoglycemic pregnant women in second and third trimester. Serum copper level was significantly increased in cases compared to control group in second trimester and the difference was found highly significant (p<0.001) and significant difference (p<0.01) was found in GDM compared to normoglycemic pregnant women in third trimester.Birdem Med J 2018; 8(1): 52-55

scholarly journals Folic acid deficiency related to hyperhomocystinemia has less correlation with Gestational Diabetes Mellitus (GDM)

2016 ◽  
Vol 6 (1) ◽  
pp. 1-7
Author(s):  
Shamim Ara Begum ◽  
Ibrahim Khalil ◽  
Chanchal Kumar Mandal ◽  
Md Moynul Hasan ◽  
Mohammad Ali Kawsar
Keyword(s):  
Diabetes Mellitus ◽  
Folic Acid ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Metabolic Enzyme ◽  
Control Group ◽  
Case Group ◽  
Folic Acid Deficiency ◽  
Acid Deficiency ◽  
The Mean

Gestational diabetes mellitus (GDM) is a different degree of the glucose intolerance that begins during pregnancy. GDM affects maternal and child health and is associated with a potential for preeclampsia, caesarean delivery due to macrosomic baby and type 2 diabetes in the mother, and with higher rates of perinatal mortally and many abnormalities in the infant. Homocysteine is a naturally occurring amino acid. Hyperhomocysteinemia(Hcy) is increased homocysteine levels which are associated folic acid deficiency. Hcy is regulated by several factors including genetically determined metabolic enzyme alteration, nutritional status, underlying disease, certain medication, age and pregnancy. A total of (40 case+40control) 80 patients are included in this study, it was observed that majority 21(52.5%) patients were age belonged to 31-35 years in case group and 17(42.5%) patients were age belonged to 31-35 years in control group. The mean age was found 30.5±4.2 years in case group and 29.05±4.2 years in control group. Majority 19(47.5%) patients had 3rd gravida in case group and 20(50.0%) patients had 3rd gravida in control group. Majority patients BMI belonged to 25-29.9 kg/m2 (over weight) in both groups which was 21(52.5%) in case and 32(80.0%) in control group. The mean BMI was found 28.9±3.4 kg/m2 in case and 28.53±2.9 kg/m2 in control group. The difference was not statistically significant (p>0.05) between two groups. Studies have shown that folate deficiency is associated with increased homocysteine levels in blood.Update Dent. Coll. j: 2016; 6 (1): 01-07

scholarly journals Prospective of study of gestational diabetes mellitus risk in relation to maternal recreation physical activity before and after pregnancy

2018 ◽  
Vol 6 (8) ◽  
pp. 2785
Author(s):  
Sukesh R. S. ◽  
Laxmy Rajmohan
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Challenge Test ◽  
Control Group ◽  
Case Group ◽  
Oral Glucose ◽  
Family History Of Diabetes ◽  
Pregnant Females

Background: Gestational diabetes mellitus is common complications of pregnancy. Physical activity is associated with a lower risk of type 2 diabetes mellitus. The present study aimed to know association between physical activity and gestational diabetes mellitus in the first 20 weeks of their pregnancy.Methods: In the current case-control study, 50 pregnant females with gestational diabetes mellitus as the case group and 50 pregnant females as control group were selected. To diagnose gestational diabetes mellitus using diagnostic criteria. Females with abnormal oral glucose challenge test (>140mg/dL) were asked to perform the three-hour 100 g oral glucose tolerance test. The details of physical activity were collected by pregnancy physical activity questionnaire. Anthropometric and other data were recorded for all of the participants.Results: Females with low total physical activity at early pregnancy were at a significantly higher risk of developing gestational diabetes mellitus compared to the ones with higher levels of physical activity. After adjusting for age, body mass index (BMI), gravidity and a family history of diabetes, females with low physical activity during 20 weeks of pregnancy were at a significantly higher risk of developing gestational diabetes mellitus. Females with the low intensity of sedentary, light and moderate physical activity are at a higher risk of developing gestational diabetes mellitus compared to females with a higher intensity of sedentary, light and moderate physical activity.Conclusions: Females should be encouraged to do regular daily physical activity during pregnancy, if there is no specific contraindication to it. 

scholarly journals QT Dispersion and Electrocardiographic Changes in Women With Gestational Diabetes Mellitus

2012 ◽  
pp. S49-S55 ◽  
Author(s):  
E. MEDOVÁ ◽  
E. FIALOVÁ ◽  
M. MLČEK ◽  
J. SLAVÍČEK ◽  
A. DOHNALOVÁ ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Qt Dispersion ◽  
Normal Subjects ◽  
Control Group ◽  
Body Surface Potential ◽  
Heart Field ◽  
Electrocardiographic Changes

Gestational diabetes mellitus (GDM) represents additional risks to both mother and infant. Moreover it increases a woman's risk of cardiovascular disease in the postpartum. The aim of our study was therefore to detect changes of both the QT dispersion and the electrical heart field that could be typical for GDM. Body surface potential maps were obtained using the Cardiac 112.2 device from 26 young women with GDM and 54 young healthy pregnant women in the 36th week of pregnancy. The same recordings were obtained from 18 healthy women in the same age (19-36 years). The average QT dispersion (±SD) in women suffering from GDM was significantly higher (107±25 ms) both than in those with physiological pregnancy (73±18 ms) and than in the normal subjects (34±12 ms) (P<0.001). Moreover we have found in GDM patients shorter QRS complex 82.0±6.8 ms vs. 89.5±8.2 ms in healthy pregnant women and 90.8±7.9 ms in the control group (p=0.011), more horizontal electrical heart axis [16.4±20.1° vs. 42.4±28.7° and 74.6±39.2° respectively (P<0.05)] and lower some depolarization and repolarization amplitudes on isopotential and isointegral maps. According to these results we suppose that described electrocardiographic changes reflect a deterioration of the complete process of ventricular depolarization and repolarization in GDM.

scholarly journals Correlation of serum 25-hydroxyvitamin-D3, hs-CRP, and homocysteine in women with gestational diabetes mellitus

2021 ◽  
Author(s):  
Li Zhang ◽  
Huani Yi ◽  
Jie Li ◽  
Juan Dong
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Correlation Analysis ◽  
Glucose Tolerance ◽  
Gestational Diabetes Mellitus ◽  
Pearson Correlation ◽  
Control Group ◽  
Model Assessment ◽  
Pearson Correlation Analysis ◽  
Hs Crp

IntroductionTo explore the changes and correlation of serum 25-hydroxyvitamin-D3, high-sensitivity C-reactive protein (hs-CRP), and homocysteine (Hcy) in patients with gestational diabetes mellitus (GDM).Material and methodsA total of 110 GDM patients from September 2019 to September 2020 were consisted of in the GDM group, and 100 pregnant women with normal 75g oral glucose tolerance test (OGTT) throughout the same duration were consisted of in the control group. General information of the patients was collected: maternal age, BMI, gravidity, parity, and the gestational week at the time of glucose tolerance screening. Serum levels of 25-(OH)2-VitD3, hs-CRP, Hcy were compared between the two groups. Pearson correlation analysis was used to evaluate the correlation between 25-(OH)2-VitD3, hs-CRP, Hcy, and homeostasis model assessment of insulin resistance index (HOMA-IRI) in GDM patients.ResultsSerum 25-(OH)2-VitD3 levels in the GDM group and Control group were 19.64±4.32 and 16.86±4.49 ng/ml, hs-CRP levels were 2.35±1.10 and 3.15±1.49 mg/L, and serum Hcy levels were 17.96±6.41 and 9.83±3.65 µmol/L. Serum 25-(OH)2-VitD3 levels in the GDM group were substantially lower than those in the control group, while hs-CRP, Hcy, and HOMA-IRI in the GDM group were significantly higher than those in the control group (P<0.05). Pearson correlation analysis demonstrated that serum 25-(OH)2-VitD3 levels in the GDM group were negatively correlated with HOMA-IRI. In contrast, hs-CRP and Hcy levels were substantially positively correlated with HOMA-IRI (P <0.01).ConclusionsBlood levels of 25-(OH)2-VitD3, hs-CRP, and Hcy levels can be a potential indicator of GDM.

Thyroid Dysfunction in Pregnant Women with Gestational Diabetes Mellitus

2020 ◽  
Vol 16 (8) ◽  
pp. 895-899 ◽  
Author(s):  
Shahin Safian ◽  
Farzaneh Esna-Ashari ◽  
Shiva Borzouei
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Thyroid Dysfunction ◽  
Control Group ◽  
Thyroid Peroxidase ◽  
Free T4 ◽  
Significant Difference ◽  
Experimental Group

Aims: Investigation thyroid dysfunction and autoimmunity in pregnant women with gestational diabetes mellitus. Background: This article was written to evaluate the thyroid function and anti-thyroid peroxidase (anti- TPO) antibodies in pregnant women with gestational diabetes mellitus (GDM). Method: A total of 252 women with GDM and 252 healthy pregnant women were enrolled. Thyroid tests, including TSH, FreeT3, Free T4, and anti-TPO were performed for all women at 24–28 weeks of gestation. Data analysis was then carried out using SPSS ver. 22. Result: There was a significant difference between the experimental group (38.4%) and the control group (14.06%) in terms of the prevalence of subclinical hypothyroidism (p= 0.016). The frequency of anti-TPO was higher in the experimental group than the control group and positive anti-TPO was observed in 18.6% of women with GDM and 10.3% of healthy pregnant women (P= 0.008). Conclusion: Thyroid disorders are observed in pregnant women with GDM more frequently than healthy individuals and it may be thus reasonable to perform thyroid tests routinely.

scholarly journals Associations between gestational diabetes mellitus and the neurodevelopment of offspring from 1 month to 72 months: study protocol for a cohort study

BMJ Open ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. e040305
Author(s):  
Chao Li ◽  
Ping Zhou ◽  
Yixi Cai ◽  
Bin Peng ◽  
Yongfang Liu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Cohort Study ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Public Health Problem ◽  
Multiple Linear Regression Model ◽  
Preschool Age ◽  
Control Group ◽  
Global Public Health ◽  
Open Access Journals

IntroductionGestational diabetes mellitus (GDM) is a common gestational disease and an important global public health problem. GDM may affect the short-term and long-term health of offspring, but the associations between GDM and the neurodevelopment of offspring of mothers with GDM (OGDM) are still unclear, and studies based on the Chinese population are lacking. We aim to determine the associations between GDM and the neurodevelopment of OGDM by studying a cohort of OGDM and offspring of non-GDM mothers.Methods and analysisThe single-centre prospective cohort study is being conducted in China over 7 years. A total of 490 OGDM (GDM group) and 490 fromof healthy mothers (control group) will be enrolled during the same period. Baseline characteristics, neuropsychological development scores and clinical data at specific time points (at 0, 1, 3, 6, 12, 24, 36, 48, 60 and 72 months old) will be collected from the children in both groups until the age of 6 years. The associations between GDM and the neurodevelopment of OGDM from infancy to preschool age will be analysed using a multiple linear regression model adjusted for confounders. In addition, we will compare longitudinal data to further assess the effects of GDM on neurodevelopmental trajectories.Ethics and disseminationThe study has been approved by the Ethics Committee of the Children’s Hospital of Chongqing Medical University (Approval Number: (2019) Institutional Review Board (IRB) (STUDY) No. 85). The findings of this study will be disseminated through open access journals, peer-reviewed journals and scientific meetings.Trial registration numberNCT03997396.

scholarly journals Management of postprandial hyperglycaemia and weight gain in women with gestational diabetes mellitus using a novel telemonitoring system

2018 ◽  
Vol 47 (2) ◽  
pp. 754-764 ◽  
Author(s):  
Ebtisam A. Al-ofi ◽  
Hala H. Mosli ◽  
Kholoud A. Ghamri ◽  
Sarah M. Ghazali
Keyword(s):  
Diabetes Mellitus ◽  
Weight Gain ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Dietary Advice ◽  
Control Group ◽  
Close Monitoring ◽  
Pregnancy Weight Gain ◽  
Glucose Levels ◽  
Pregnancy Weight

Objectives The purpose of this study was to investigate the effect of remotely delivered telemedicine dietary advice on monitoring of blood glucose levels and weight gain of women with gestational diabetes mellitus (GDM). Methods Women with GDM were recruited and randomly allocated into two groups: a Tele-GDM group that received a telemonitoring device, and a control group that was followed-up traditionally. A telemonitoring service calculated the ratio of reaching or exceeding the pregnancy weight gain target (according to pre-pregnancy weight), following Institute of Medicine guidelines for healthy pregnancy weight gain. Results The sample comprised 27 women in the Tele-GDM group and 30 in the control group. At the end of pregnancy, the Tele-GDM group showed significantly lower 2-hour postprandial glucose levels than the control group. Most women in the Tele-GDM group reached their recommended range of weight gain at the end of pregnancy. Additionally, the Tele-GDM group showed significantly lower weight gain than the control group. Conclusions Telemonitoring can facilitate close monitoring of women with GDM and motivate patients to adopt a healthy lifestyle.

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