scholarly journals The Determination of Efficacy of CircuCare on Blood Circulation and Metabolism: An Animal Model Study

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Kai-Ting Chien ◽  
Ching-Chen Chen ◽  
Chien-Ming Chu ◽  
Ya-Lin Chan ◽  
Hsiu-Yun Chung ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Blood Circulation ◽  
Control Group ◽  
Sprague Dawley ◽  
Mineral Density ◽  
Endocrine Activity ◽  
Model Study ◽  
Before And After ◽  
Animal Model Study ◽  
Swimming Test

Objectives. To determine whether feeding CircuCare to rats improves blood circulation, metabolism, immune regulation, endocrine activity, and oxidative stress. Methods. 28 eight-week-old male Sprague-Dawley rats were evenly randomized into control and experimental groups. The control group was fed with ordinary drinking water, while the experimental group was fed with CircuCare at a daily dose of 93.75 mg per 300 g of body weight over eight weeks. Both groups were subjected to a swimming test, and blood samples were taken to observe any variations in various biochemical parameters before and after the test. Key Findings. The experimental group’s mean swimming exhaustion duration was 53.2% longer and had a significantly higher lactic acid removal ratio. Their mean prostaglandin E2 level and mean glucose, cortisol, and glutathione level (30 minutes after swimming test) were also significantly higher. No undesirable impacts from CircuCare relating to general blood biochemistry values and bone mineral density were reported. Conclusions. The present results show that CircuCare can be safely used to increase stamina and exercise capability, expedite the metabolism of lactic acid, accelerate muscle repair, and promote the antioxidant activity of cells in rats.

scholarly journals N-Acetylcysteine Added to Local Anesthesia Reduces Scar Area and Width in Early Wound Healing—An Animal Model Study

2021 ◽  
Vol 22 (14) ◽  
pp. 7549
Author(s):  
Wiktor Paskal ◽  
Adriana M. Paskal ◽  
Piotr Pietruski ◽  
Albert Stachura ◽  
Kacper Pełka ◽  
...  
Keyword(s):  
Wound Healing ◽  
Early Stage ◽  
Healing Process ◽  
Wound Healing Process ◽  
Sprague Dawley ◽  
Time Points ◽  
Model Study ◽  
Sprague Dawley Rats ◽  
Animal Model Study ◽  
Anesthetic Solution

The aim of the study was to evaluate if a pre-incisional N-acetylcysteine (NAC) treatment altered the process of wound healing in a rat model. The dorsal skin of 24 Sprague-Dawley rats was incised in six locations. Before the incisions were made, skin was injected either with lidocaine and epinephrine (one side) or with these agents supplemented with 0.015%, 0.03%, or 0.045% NAC (contralaterally). Photographic documentation of the wound healing process was made at 11 time points. Rats were sacrificed 3, 7, 14, or 60 days after incision to excise scars for histological analysis. They included: Abramov scale scoring, histomorphometry analysis, and collagen fiber arrangement assessment. Skin pretreated with 0.03% NAC produced the shortest scars at all analyzed time points, though this result was statistically insignificant. At this NAC concentration the scars had smaller areas on the third day and were narrower on the day 4 compared with all the other groups (p < 0.05). On day 7, at the same concentration of NAC, the scars had a higher superficial concentration index (p = 0.03) and larger dermal proliferation area (p = 0.04). NAC addition to pre-incisional anesthetic solution decreased wound size and width at an early stage of scar formation at all concentrations; however, with optimal results at 0.03% concentration.

scholarly journals The Use of Procalcitonin as a Sepsis Marker in a Community Hospital

2019 ◽  
Vol 3 (4) ◽  
pp. 545-552
Author(s):  
Nathalia De Oro ◽  
Maria E Gauthreaux ◽  
Julie Lamoureux ◽  
Joseph Scott
Keyword(s):  
Lactic Acid ◽  
Length Of Stay ◽  
Community Hospital ◽  
Unit Length ◽  
Hospital Setting ◽  
Control Group ◽  
Before And After ◽  
Quasi Experimental ◽  
Current Cutoff ◽  
The Impact

Abstract Background Procalcitonin (PCT) is a biomarker that shows good sensitivity and specificity in identifying septic patients. Methods This study investigated the diagnostic accuracy of PCT in a community hospital setting and how it compared to that of lactic acid. It explored the impact on patient care before and after PCT implementation regarding costs and length of stay. Two comparative groups were analyzed using an exploratory descriptive case–control study with data from a 19-month period after PCT implementation and a retrospective quasi-experimental study using a control group of emergency department patients diagnosed with sepsis using data before PCT implementation. Results Post-procalcitonin implementation samples included 165 cases and pre-procalcitonin implementation sample included 69 cases. From the 165 sepsis cases who had positive blood cultures, PCT had a sensitivity of 89.7%. In comparison, lactic acid's sensitivity at the current cutoff of 18.02 mg/dL (2.0 mmol/L) was 64.9%. There was a 32% decrease in median cost before and after PCT implementation, even with the length of stay remaining at 5 days in both time periods. Conclusions There was a significant decrease after the implementation of PCT in cost of hospitalization compared to costs before implementation. This cost is highly correlated with length of stay; neither the hospital nor the intensive care unit length of stay showed a difference with before and after implementation. There was a positive correlation between lactic acid and PCT values. PCT values had a higher predictive usefulness than the lactic acid values.

Effects of aerobic plus explosive power exercises on bone remodeling and bone mineral density in young men

2017 ◽  
Vol 43 (1) ◽  
pp. 40-48
Author(s):  
Veysi Çay ◽  
Gurbuz Buyukyazi ◽  
Cevval Ulman ◽  
Fatma Taneli ◽  
Yeliz Doğru ◽  
...  
Keyword(s):  
Maximal Oxygen Consumption ◽  
Exercise Program ◽  
Exercise Group ◽  
Risk Level ◽  
Control Group ◽  
Maximal Heart Rate ◽  
Mineral Density ◽  
Explosive Power ◽  
Before And After ◽  
And Control

AbstractObjectives:This study aims to examine effects of aerobic jogging and explosive power exercises on body composition, maximal oxygen consumption (MaxVOMaterials and methods:Thirty seven healthy males were divided into exercise group (EG, n=19) and control group (CG, n=18). EG completed 10 weeks of outdoor aerobic (jogging at 60–70% maximal heart rate reserve starting from 20 min steadily increasing up to 28 min) and explosive power exercises (in 2–3 sets, with maximum repetitions lasting 15 s), 3 times per week. All measurements were taken before and after the exercise program. BMD was measured via dual energy X-ray absorptiometry (DEXA).Results:Body mass index (p<0.001) significantly decreased; MaxVOConclusion:Performing our outdoor exercise program in spring months might have an important role in the significant increase (9 vs. 22 ng/mL) in mean vitamin D level, which reached above the fracture risk level of 20 ng/mL.

scholarly journals Amylase-Producing Maltooligosaccharide Provides Potential Relief in Rats with Loperamide-Induced Constipation

2020 ◽  
Vol 2020 ◽  
pp. 1-9 ◽  
Author(s):  
Eun Yeong Jang ◽  
Yejin Ahn ◽  
Hyung Joo Suh ◽  
Ki-Bae Hong ◽  
Kyungae Jo
Keyword(s):  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Positive Control ◽  
Lactobacillus Bulgaricus ◽  
Control Group ◽  
Sprague Dawley ◽  
Potential Relief ◽  
Bowel Movements ◽  
Mucosal Thickness

Constipation is a chronic disease caused by infrequent, inadequate, and difficult bowel movements. The present study aimed to evaluate the potential laxative effect of maltooligosaccharide (MOS) on loperamide-induced constipation in a rat model. In vitro experiments were conducted to evaluate the effect of MOS on the growth of lactic acid bacteria. Moreover, to examine the effect of MOS administration on Sprague-Dawley (SD) rats with loperamide-induced constipation, the drinking water for the rats was supplemented with 10% or 15% of MOS for 14 days, and, thereafter, the improvement in constipation was assessed. For this, the rats were divided into five groups: normal (Nor), loperamide-induced constipated (Con), positive control (15% of dual-oligosaccharide (DuO-15)), 10% MOS treated (MOS-10), and 15% MOS-treated (MOS-15). In an in vitro test, MOS treatment promoted the growth of lactic acid bacteria except Lactobacillus bulgaricus. Treatment with higher MOS dose relieved constipation in rats by improving the fecal pellet and water content. Furthermore, in the high MOS dose group, the cecal short-chain fatty acid levels significantly increased compared to those in the control group (P<0.001). MOS treatment also improved the mucosal thickness as well as mucin secretion and increased the area of intestinal Cajal cells compared to that in the control group (P<0.001). These findings suggest that MOS relieves constipation and has beneficial effect on the gastrointestinal tract, and, therefore, it can be used as an ingredient in functional foods for treating constipation or improving intestinal health.

scholarly journals Effect of 12 weeks of recreational soccer on bone mineral density and sarcopenia in the elderly: a randomized clinical trial

1989 ◽  
Author(s):  
Guilherme Henrique de Lima Matias ◽  
◽  
André dos Santos Costa ◽  
Romulo Maia Carlos Fonseca
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Repeated Measures ◽  
Intervention Group ◽  
The Elderly ◽  
Whole Body ◽  
Control Group ◽  
Mineral Density ◽  
Before And After ◽  
Post Hoc

Objective: To verify the effect of recreational soccer on bone mineral density and sarcopenia in the elderly. Methods: Fourteen elderly people aged 65.9 ± 3.4 years were selected. They were separated into two groups: the intervention group and the control group; the intervention group played recreational soccer for 12 weeks on two days of the week. Assessments were performed for bone mineral density and body muscle mass before and after the intervention. For statistical analysis, the repeated measures ANOVA with Bonferroni’s post hoc test was used. Results: After 12 weeks, there was a significant change in bone mineral density in the region of the total femur (p = 0.020). Analyzing the participants’ sarcopenia, no significant results were found after the intervention period. Conclusion: Playing recreational soccer causes a significant improvement in the total femur and maintains bone regions in the spine, whole body, and femoral neck. Also, it promotes a removal from the threshold for sarcopenia screening in the elderly.

Carvacrol attenuates amikacin-induced nephrotoxicity in the rat

2021 ◽  
Author(s):  
Atta Mohammad Dost ◽  
Mehmet Gunata ◽  
Onural Ozhan ◽  
Azibe Yildiz ◽  
Nigar Vardi ◽  
...  
Keyword(s):  
Inflammatory Cell ◽  
Kidney Tissue ◽  
Control Group ◽  
Histopathological Changes ◽  
Sprague Dawley ◽  
Tissue Samples ◽  
Sprague Dawley Rats ◽  
Before And After ◽  
Per Oral

Abstract Amikacin (AK) is frequently used in the treatment of gram-negative and some gram-positive infections. However, its use is limited due to nephrotoxicity due to the increase in reactive oxygen radicals. The aim of this study was to investigate the role of carvacrol (CAR) against AK-induced nephrotoxicity in rats. Thirty-two Sprague Dawley rats were randomly divided into four groups as control (Vehicle), AK (400 mg/kg), CAR + AK (80 mg/kg CAR + 400 mg/kg AK), and AK + CAR (400 mg/kg AK + 80 mg/kg CAR) groups. AK and CAR were administered via intramuscular and per-oral for 7 days, respectively. Blood and kidney tissue samples were taken at the end of the experiment. Renal function and histopathological changes were compared, and the relevant parameters of oxidative stress and inflammation were detected. Histopathological findings (necrotic changes and dilatation and inflammatory cell infiltration) significantly increased in the AK group compared to the control group. Also, the rats in the AK group lost weight significantly. It was found that CAR treatment before and after AK significantly improved nephrotoxicity histopathologically (p < 0.05). However, this improvement was not detected biochemically. These results show that CAR treatment before and after AK improves nephrotoxicity in the histopathological level.

The Effects of α-Viniferin on Adjuvant-Induced Arthritis in Rats

2004 ◽  
Vol 32 (04) ◽  
pp. 521-530 ◽  
Author(s):  
Jae Yeong Lee ◽  
Joong-Hyun Kim ◽  
Seong Soo Kang ◽  
Chun Sik Bae ◽  
Seok Hwa Choi
Keyword(s):  
Initial Point ◽  
Bone Destruction ◽  
Physiological Saline ◽  
Control Group ◽  
Sprague Dawley ◽  
Mineral Density ◽  
Entire Study ◽  
Adjuvant Induced Arthritis ◽  
Radiological Changes ◽  
The Right

This study was performed to assess the efficacy of α-viniferin (Carex humilis Leyss) on adjuvant-induced arthritis in rats. Adjuvant arthritis was induced by a single subcutaneous injection of 0.1 ml complete Freund's adjuvant (CFA) containing 7.5 mg Mycobacterium butyricum suspended in 1 ml sterile paraffin oil into the right hind paw. Forty female Sprague-Dawley rats were injected. Righting reflex was uniformly lost and considered to be the initial point of arthritis development on day 7 after CFA injection. Rats were divided into four groups, and upon development of arthritis, tested groups were orally administered 3 or 10 mg/kg α-viniferin or 10 mg/kg ketoprofen every day for 14 days. The control group was orally administered 2 ml of physiological saline solution. Bone mineral density (BMD), radiological changes and edematous volumes were measured for 35 days. α-viniferin suppressed the development of inflammatory edema, and inhibited the bone destruction, noted with a decrease in BMD ( p <0.05). Hind paw edema volume, BMD and radiological changes did not differ significantly in the ketoprofen and α-viniferin groups during the entire study period. In conclusion, α-viniferin suppressed arthritic inflammation and bony change in rats.

scholarly journals THE EFFECTS OF ETHANOL EXTRACTS OF Centella asiatica LEAF ON SERIAL SERUM BRAIN DERIVED NEUROTROPHIN FACTOR (BDNF) CONCENTRATION OF RATS (SPRAGUE DAWLEY) FOLLOWING CHRONIC STRESS

2015 ◽  
Vol 2 (1) ◽  
pp. 159 ◽  
Author(s):  
Dwi Cahyani Ratna Sari ◽  
Mawaddah Ar Rochmah
Keyword(s):  
Chronic Stress ◽  
Centella Asiatica ◽  
Male Rats ◽  
Control Group ◽  
Sprague Dawley ◽  
Electrical Stress ◽  
Significant Difference ◽  
Before And After ◽  
Ethanol Extracts ◽  
Serum Bdnf

<p>Centella asiatica is considered herbal plant for increasing memory performance. Brain-derived neurotrophin factor (BDNF) has a significant role in memory formation process, while stress causes memory impairment. Objective: This study aimed to investigate the effects of ethanol extracts of Centella asiatica leaf on serum BDNF concentration of rats that was taken serially before and after chronic electrical stress. Materials and Methods : Twenty male rats (Sprague Dawley) were divided into four groups: control/aquades group and groups treated with different doses (mg/kg) of Centella asiatica :150 (CA150), 300 (CA300) and 600 (CA600). Each rat underwent memory exercise for nine days before and after electrical stress and oral administration of ethanol extracts of Centella asiatica for twenty-eight days. Blood sampling was taken serially from rats’ tail for four times : (1) before memory exercise, (2) after memory exercise (before stress), (3) after chronic stress, and (4) after memory exercise (following chronic stress). Concentration of serum BDNF was assessed using ELISA. Results: There was no significant difference in serum BDNF concentration between groups in first and second serum sampling, which was prior to chronic stress and administration of different treatments. However, there was significant difference in third and fourth serum sampling between groups. Mean concentration of serum BDNF (ng/ml) in third and fourth sampling for control group, CA150, CA300, and CA600, respectively were 1.88+0.21 &amp;1.93+0.24; 2.29+0.13 &amp; 2.01+0.22; 2.29+0.08 &amp;1.86+0.11; 2.71+0.70 and 2.99+0.27 (p&lt;0.05). Conclusion: Ethanol extracts of Centella asiatica leaf increases serum BDNF concentration in rats after chronic stress. <br /><strong></strong></p><p><strong>Keywords</strong>: stress, memory, Centella asiatica, BDNF</p>

scholarly journals Analysis of Densitometric Indices of Osteotropic Therapy by the Method of F* (Fisher) in Case Of Knee Arthroplasty

2018 ◽  
Vol 11 (2) ◽  
pp. 1035-1038
Author(s):  
Mirhakim Zh. Azizov ◽  
Aziz P. Alimov ◽  
Umida M. Rustamova ◽  
Khurshid Kh. Shakirov ◽  
Nadezhda V. Stupina
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Main Group ◽  
Control Group ◽  
Mathematical Treatment ◽  
Treatment Schedule ◽  
Mineral Density ◽  
Before And After ◽  
And Control ◽  
Densitometric Data

Clinical and densitometric researches in patients with the terminal stage of gonarthrosis and decrease in bone mineral density allow determining the condition of knee joint endoprosthesis. In the process of research women took part; their average age made up 57 years (max. 84 years old, min. 52 years old – menopausal age). X-ray densitometry (dual energy absorptiometry) before and after surgery (in 12 months). Patients were divided into two (main and control) groups depending on further treatment schedule. Studying the treatment results was carried out using the method of criteria calculation – f* (Fisher) by the method of mathematical treatment. Densitometric data analysis before and after operation showed after operation in the main group of women, who took osteotropic drugs as compared to the indicators of control group, significant bone density increase. The growth in bone mineral density of the main group by the year end made up on the average 60%, in control group – 18,75%.

The acute supplementation of combination juice of yellow watermelon (citrullus lanatus thunb.) - plantain (musa paradisiacal var. Sapientum l.) suppress post-exercise blood lactic acid production in rats

2021 ◽  
Vol 9 (2) ◽  
pp. 73-79
Author(s):  
Farida Farida ◽  
Hesti Permata Sari ◽  
Afina Rachma Sulistyaning
Keyword(s):  
Lactic Acid ◽  
Acid Production ◽  
Citrullus Lanatus ◽  
Lactic Acid Production ◽  
Test Dose ◽  
Negative Control ◽  
Muscle Performance ◽  
Sprague Dawley ◽  
Significant Difference ◽  
Swimming Test

Background: Yellow watermelon contains citrulline, which can suppress lactic acid production, while plantains contain potassium which is important for muscle performance. The yellow watermelon and plantain combination juice potential to be a natural sports drink that delays muscle fatigue by suppressing lactic acid production after exercise.Objectives: To determine the effect of yellow watermelon-plantain juice on lactic acid in rats after swimming test.Materials and Methods: This true experimental study used a post-test-only with controlled group design. Thirty Sprague Dawley rats, eight-week-old, male, were divided into five groups, namely positive control (C+), negative control (C-), dose 1 (P1), dose 2 (P2), and dose 3 (P3). The C (+) group received no juice and was not tested swimming, the C (-) group received no juice but was tested swimming, P1 received combined juice up to 1.8 g and tested swimming, P2 received combined juice up to 3, 6 g and tested swimming, P3 received combined juice up to 1.8 g with the addition of 0.27 g granulated sugar and tested swimming. The juice is given 30 minutes before the test. The swim test was performed for three minutes; after that, the blood was taken to test the lactic acid levels. The data were analyzed using the one-way ANOVA and the advanced post-hoc with the least significant difference test.Results: The lactic acid levels in C (+), in C (-), P1, P2, and P3 groups after swimming test were 1.38 mMol / L; 7.14 mMol / L; 3.74 mMol / L; 1.66 mMol; and 2.91 mMol/L. There were differences in levels of lactic acid (p <0.05) in each group after the combination juice intervention was given.Conclusion: Combination juice of yellow watermelon-plantain has an effect on lactic acid levels after swimming test. Dose 2 (3.6 g) was the best because it produces the lowest lactic acid after the swimming test.

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