scholarly journals Clinical Efficacy and Safety Study of Mifepristone with Misoprostol Treatment in Patients with Missed Abortion

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Xiaoying Zhao ◽  
Congyi Zhang ◽  
Haitao Lou ◽  
Chunfang Wu
Keyword(s):  
Research Group ◽  
Vaginal Bleeding ◽  
Bleeding Time ◽  
Drug Regimen ◽  
The Body ◽  
Treatment Modalities ◽  
Control Group ◽  
Missed Abortion ◽  
Intraoperative Bleeding ◽  
Β Hcg

Currently, medication abortion is widely used in clinical practice in China. The aim of this study was to investigate the effect of mifepristone with misoprostol treatment on the efficacy of patients with missed abortion (MA) and the safety of this drug regimen. 95 patients with MA treated in our hospital from February 2019 to April 2021 were collected as the subjects of this study, and the patients were divided into the control and the research groups according to different treatment modalities. Among them, 46 cases in the control group were treated by diethylstilbestrol combined with oxytocin and 49 cases in the research group were treated by mifepristone combined with misoprostol, and both groups underwent curettage after medication. The rates of complete abortion, time of embryo expulsion, time of operation, intraoperative bleeding, time of postoperative vaginal bleeding, amount of vaginal bleeding, rate of one-time curettage, the levels of serum estradiol (E2), progesterone (P), β-chorionic gonadotropin (β-hCG), and interleukin-18 (IL-18), and the incidence of adverse effects in the two groups were examined and compared. Alanine transaminase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), and serum creatinine (Scr) were used as indicators to evaluate the safety of the drug. The results showed that the rates of complete abortion and one-time curettage were significantly higher in the study group than in the control group, while the time of embryo expulsion, operation time, intraoperative bleeding, postoperative vaginal bleeding time, and vaginal bleeding were significantly lower than in the control group. The serum E2, P, and β-hCG levels before curettage in both groups were significantly higher, and IL-18 levels were significantly lower than those at the time of admission, with E2, P, and β-hCG levels increasing more and IL-18 levels decreasing more in the research group. After drug treatment, no abnormal changes in liver and kidney functions were observed in both groups, and the incidence of adverse reactions was at a similar and lower level in both groups. This shows that mifepristone with misoprostol is a safer and more effective drug regimen for the treatment of MA, which can regulate the levels of serum sex hormones and inflammatory factors in the body, promote the shedding of placental tissue, and create conditions for improving the rate of curettage.

scholarly journals The influence of a relaxing massage on stress levels in women

2021 ◽  
Vol 10 (1) ◽  
pp. 19-22
Author(s):  
Marta Majewska-Pulsakowska ◽  
◽  
Martyna Mączka ◽  
Keyword(s):  
Perceived Stress ◽  
Research Group ◽  
Research Method ◽  
Negative Symptoms ◽  
Subjective Assessment ◽  
The Body ◽  
Control Group ◽  
Stress Scale ◽  
Stress Levels ◽  
Lower Education

One of the factors that negatively affect the human body is susceptibility to stress. The inability to react to negative emotions and reduce tensions in the body causes many negative symptoms that affect people every day. A relaxing massage is one of the ways to reduce stress levels. The aim of the study was to attempt to assess the effect of a relaxing massage on the level of stress in women aged 25-45 years. The research group consisted of 60 women. The research group underwent a proprietary relaxing massage, while the control group used manicures or pedicures. As the research method an original questionnaire and the PSS-10 (Perceived Stress Scale) was used. The subjective assessment of the level of stress based on the proprietary survey and the PSS-10 questionnaire among the respondents after the relaxing massage was statistically signifi cantly lower. How ever, no statistically signifi cant differences in the decrease in stress levels were found between the two groups. On the other hand, a statistically signifi cant relationship between education and the level of stress was proved. Subjects with lower education were characterized by a higher level of stress.

scholarly journals The Clinical and Hematological changes in Rabbits exposed to Melia azedarach fruits under experimental conditions

2015 ◽  
Vol 1 (1) ◽  
pp. 12 ◽  
Author(s):  
AL- Zubaedi Raad Mahmood
Keyword(s):  
Body Weight ◽  
Body Temperature ◽  
Bleeding Time ◽  
Hematological Parameters ◽  
The Body ◽  
Melia Azedarach ◽  
Control Group ◽  
Clotting Time ◽  
Experimental Conditions ◽  
Hb Concentration

The study was conducted on 10 local breed rabbits, of 1-2 years age, of 1- 1.5 kg body weight. They were feed concentrated and green food, and left ad libitum for water, and kept in room of 20- 25 oC. The animals divided into two groups of 5 each. First as treated group received the plant in powder form mixed with the food at a dose rate of 5 g/ animal / day for three weeks , while the second left without exposure as a control group .The main dependent parameters in the study were , clinical parameters ( body temperature , heartbeat , respiratory rate, body weight , in addition to monitor any abnormal signs appear on the animals . While the main hematological parameters were included , RBC count , WBC count , Hb concentration,PCV percentage , Red cell indices , Bleeding time and Clotting time. The body temperature, respiratory rates, heart rate were increased .The body weight decreased .The bleeding time and clotting time were prolonged. The erythrocyte count, Hb concentration, and MCV values were decreased; PCV and MCHC did not showed any significant changes. The MCH increased. The total leucocytes count and the basophiles percentage did not showed any significant changes. The Heterophils and monocytes percentage increased .The lymphocytic and Eosinophil percentage were decreased during the study.

scholarly journals THE EFFECTIVENESS OF THE ELECTROMAGNETIC FIELD MATRIX TO THE WOUND HEALING PROCESS IN PARTIAL – THICKNESS BURNS

2020 ◽  
Vol 30 (6) ◽  
pp. 95-98
Author(s):  
Raminta Česnaitienė ◽  
Rytis Rimdeika
Keyword(s):  
Wound Healing ◽  
Treatment Period ◽  
Body Surface ◽  
Research Group ◽  
Standard Treatment ◽  
Healing Process ◽  
The Body ◽  
Control Group ◽  
Treatment Methods ◽  
Significant Difference

Burns are one of the most serious injuries, affecting around 11 million people a year worldwide. About 200/100000 inhabitants in Lithuania. Treatment is com­plex: the priorities of specialized facilities focus on sta­bilizing the patient, preventing infection, and optimizing functional recovery; and requires a lot of resources, both human and financial. Therefore, more and more effective treatments for burns are constantly being sought in order to accelerate the healing itself and thus reduce the du­ration of hospitalization. Number of recent reports sug­gests that EMF has a positive impact at different stages of healing. Processes impacted by EMF include, but are not limited to, cell migration and proliferation, expres­sion of growth factors, nitric oxide signaling, cytokine modulation, and more. Objectives and methods. The objective of this work was to study the effect of electromagnetic matrix on wound healing in burns. We evaluated medical records of 18 patients who underwent treatment in the department of plastic and reconstructive surgery from 2018.01.01 to 2019.12.30. All patients had IIA-IIB degree burns affec­ting less than 10% of the body surface and underwent the standard general treatment. They were divided into two groups: control group 55,6% (n=10) – treated only with the standard treatment and research group 44,4% (n=8) – to whom the EMF matrix were applied. Statistical data analysis was carried out using the SPSS 23.0 software. Results. Pain assessment, wound granulation area, and epithelialization were chosen to evaluate the burn healing process. These indicators were assessed on day 0-1; 3(±1) days and 7(±1) days after hospitalization. There was a statistically significant increase in wound granulation 5 days after the start of treatment in patients treated with the applicator (p = 0.019). Pain and epithelialization ra­tes between standard and applicator treatment methods did not differ statistically significantly over the treatment period. The partial nonparametric Spearman correlation coefficient, eliminating potentially influencing factors such as time after injury, the area of burn showed that the treatment method had a direct effect on the area of wound granulation (r = 0.625; p = 0.04). Conclusion. During the period from 2018.01.01 to 2019.12.31 patients had IIA-IIB degree burns affecting less than 10% of the body surface. 55,6 % of patients were treated only with the standard treatment and 44,4% with EMF matrix. The analysis showed that the average hospitalization time of the control group was 8.5 (0.898) days, while in the research group it was 7.88 (1.493) days, no statistically significant difference (p>0.05). There was a statistically significant increase in wound granulation 5 days after the start of treatment in patients treated with the applicator (p = 0.019). Pain and epitheli­alization rates between standard and applicator treatment methods did not differ statistically significantly over the treatment period.

scholarly journals Effects of Physical Exercise Program on Physical Mobility of Patients with Cranial Surgery

2021 ◽  
Vol 73 (10) ◽  
pp. 695-701
Author(s):  
Jittima Panyasarawut ◽  
Wallada Chanruangvanich ◽  
Prangtip Chayaput ◽  
Theerapol Witthiwej
Keyword(s):  
Physical Exercise ◽  
Research Group ◽  
Body Movement ◽  
Exercise Program ◽  
The Body ◽  
Control Group ◽  
Cranial Surgery ◽  
Physical Mobility ◽  
Movement Function ◽  
Experimental Group

Objective: This research aimed to study the effects of a physical exercise program on physical mobility in cranial surgery patients.Materials and Methods: The researcher used a quasi-experimental method of surveying 58 patients who had cranial surgery at Siriraj Hospital. The research group was divided into two groups: an experimental group (28 patients) participating in a physical exercise program of patients after cranial surgery, and a control group (30 patients) receiving routine nursing care only. The evaluation of the patients’ physical mobility was performed three days after the surgery.Results: Most patients in the research group had an intracranial tumor (86.2%). One day after the surgery, the experimental group had minor pain at the wound site while the control group had moderate pain. Both groups felt discomfort (64.2%) or had muscle stiffness in the neck and shoulder areas (63.3%). Three days after the surgery, at the end of the program, the body movement function of both groups was reduced compared with the preoperative data. However, the experimental group showed better body movement function scores than the control one as the scores of the former were reduced less than those of the latter at p < 0.05.Conclusion: Nurses who provide health care services to patients after cranial surgery should apply the physical exercise program to promote the recovery of the patients’ physical mobility.

scholarly journals The hematological and clinical changes in rabbits exposed to powder of dried leaves of (Lantana camara) under experimental conditions

2014 ◽  
Vol 13 (2) ◽  
pp. 44
Author(s):  
Nazar Jabbar Al-Khafaj
Keyword(s):  
Body Weight ◽  
Bleeding Time ◽  
Treated Group ◽  
Lantana Camara ◽  
The Body ◽  
Control Group ◽  
Experimental Conditions ◽  
Local Breed ◽  
Clinical Changes ◽  
Hb Concentration

The study was conducted on 10 local breed rabbits, 1-2 years of age, and 1- 1.5 kg body weight. Animals were divided into two equal groups. The first was the treated group which exposed to the dried powder of Lantana camara leaves mixed with the food at a dose rate of 5 g/ animal / day for three weeks, while the second group left without treatment as a control group. Clinically the study was revealed that the body temperature and body weight did not show any changes during the experiment, while the respiratory and heart rate were increased. Hematologically the bleeding time and clotting time were prolonged, the erythrocyte count, Hb concentration, and MCV values were decreased, and the MCH was increased, while the PCV, MCHC, total leucocytes count and the basophiles percentage did not showed any significant changes. The heterophiles and monocytes percentage were increased mean while the lymphocytic and eosinophil percentage were decreased during the study.

scholarly journals Pengaruh Ekstrak Kulit Buah Naga Merah (Hylocereus Polyrhizus) terhadap Waktu Perdarahan (Bleeding Time) Pada Mencit Strain Balb-C

2021 ◽  
Vol 18 (2) ◽  
pp. 61
Author(s):  
Dwi Mukti Kusumastuti ◽  
Zainul Cholid ◽  
Winny Adriatmoko
Keyword(s):  
Bleeding Time ◽  
The Body ◽  
Bleeding Complications ◽  
Control Group ◽  
Fruit Peel ◽  
Dragon Fruit ◽  
Whatman Paper ◽  
Natural Medicines ◽  
Peel Extract ◽  
Hylocereus Polyrhizus

Tooth extraction causes prolonged bleeding complications and the body will respond with hemostasis. Currently developing natural medicines to help the process of hemostasis. Red dragon fruit peel, which is generally a waste containing tannins, flavonoids, and saponins to stop bleeding. Purpose was to find out the effect of red dragon fruit peel extract on bleeding time in the tail of Balb-C strain mice. 16 mice samples were adapted for one week. Mice were divided into 2 groups subsquently fasted for 7 hours. The first group as a control (0.5% Na-CMC). The second group was given red dragon fruit peel extract which was divided into three sub-groups at a dose of 0.5 mg / g BW, mg / g BW, and 1.5 mg / g BW. All samples were waited for 45 minutes and cut along 2 cm from the tip of the tail. Blood is spilled on Whatman paper which has 30 seconds in each box. The number of blood spots on the box was calculated and multiplied by 30 seconds. The result showed that bleeding time in the group given red dragon fruit peel extract was significantly lower (p <0.05) than in the control group. The conclusion was red dragon fruit peel extract (Hylocereus Polyrhizus) has an effect on shortening the bleeding time in cutting the tail of bulb-c strain mice and the dose of red dragon fruit peel extract (Hylocereus Polyrhizus) which has the most significant effect is 1 mg / BB mice.

L-Ascorbic Acid Addition to Chitosan Reduces Body Weight in Overweight Women

2014 ◽  
Vol 84 (1-2) ◽  
pp. 5-11 ◽  
Author(s):  
Eun Y. Jung ◽  
Sung C. Jun ◽  
Un J. Chang ◽  
Hyung J. Suh
Keyword(s):  
Ascorbic Acid ◽  
Body Weight ◽  
Fat Body ◽  
Body Weight Gain ◽  
Skinfold Thickness ◽  
The Body ◽  
Control Group ◽  
Percentage Body Fat ◽  
Overweight Women ◽  
Body Weights

Previously, we have found that the addition of L-ascorbic acid to chitosan enhanced the reduction in body weight gain in guinea pigs fed a high-fat diet. We hypothesized that the addition of L-ascorbic acid to chitosan would accelerate the reduction of body weight in humans, similar to the animal model. Overweight subjects administered chitosan with or without L-ascorbic acid for 8 weeks, were assigned to three groups: Control group (N = 26, placebo, vehicle only), Chito group (N = 27, 3 g/day chitosan), and Chito-vita group (N = 27, 3 g/day chitosan plus 2 g/day L-ascorbic acid). The body weights and body mass index (BMI) of the Chito and Chito-vita groups decreased significantly (p < 0.05) compared to the Control group. The BMI of the Chito-vita group decreased significantly compared to the Chito group (Chito: -1.0 kg/m2 vs. Chito-vita: -1.6 kg/m2, p < 0.05). The results showed that the chitosan enhanced reduction of body weight and BMI was accentuated by the addition of L-ascorbic acid. The fat mass, percentage body fat, body circumference, and skinfold thickness in the Chito and Chito-vita groups decreased more than the Control group; however, these parameters were not significantly different between the three groups. Chitosan combined with L-ascorbic acid may be useful for controlling body weight.

Burnout of the Mind – Burnout of the Body?

2018 ◽  
Vol 32 (1) ◽  
pp. 30-42 ◽  
Author(s):  
Claudia Traunmüller ◽  
Kerstin Gaisbachgrabner ◽  
Helmut Karl Lackner ◽  
Andreas R. Schwerdtfeger
Keyword(s):  
Blood Pressure ◽  
Allostatic Load ◽  
Maslach Burnout Inventory ◽  
The Body ◽  
Lower Percentage ◽  
Control Group ◽  
Urinary Catecholamines ◽  
Morning Cortisol ◽  
The Mind ◽  
Cortisol Increase

Abstract. In the present paper we investigate whether patients with a clinical diagnosis of burnout show physiological signs of burden across multiple physiological systems referred to as allostatic load (AL). Measures of the sympathetic-adrenergic-medullary (SAM) axis and the hypothalamic-pituitary-adrenal (HPA) axis were assessed. We examined patients who had been diagnosed with burnout by their physicians (n = 32) and were also identified as burnout patients based on their score in the Maslach Burnout Inventory-General Survey (MBI-GS) and compared them with a nonclinical control group (n = 19) with regard to indicators of allostatic load (i.e., ambulatory ECG, nocturnal urinary catecholamines, salivary morning cortisol secretion, blood pressure, and waist-to-hip ratio [WHR]). Contrary to expectations, a higher AL index suggesting elevated load in several of the parameters of the HPA and SAM axes was found in the control group but not in the burnout group. The control group showed higher norepinephrine values, higher blood pressure, higher WHR, higher sympathovagal balance, and lower percentage of cortisol increase within the first hour after awakening as compared to the patient group. Burnout was not associated with AL. Results seem to indicate a discrepancy between self-reported burnout symptoms and psychobiological load.

Perbandingan Efek Suplementasi Tablet Tambah Darah Dengan Dan Tanpa Vitamin C Terhadap Kadar Hemoglobin Pada Ibu Hamil Dengan Usiakehamilan 16-32 Minggu Di Desa Keniten Kecamatan Mojo Kabupaten Kediri

2017 ◽  
Vol 3 (1) ◽  
pp. 76
Author(s):  
Siti Asiyah ◽  
Dwi Estuning Rahayu ◽  
Wiranti Dwi Novita Isnaeni
Keyword(s):  
Treatment Group ◽  
Vitamin C ◽  
Gestational Age ◽  
Group Treatment ◽  
Sampling Technique ◽  
Hemoglobin Level ◽  
The Body ◽  
Control Group ◽  
Fetal Organ ◽  
And Control

The needed of Iron Tablet in pregnancy was increase than mother who not pregnant.  That  cause of  high metabolism at the pregnancy for formed of  fetal organ and energy. One of effort for prevent anemia in mother pregnant with giving the Iron tablet and vitamin c. The reason of  this research in 4 June – 11 July 2014 is for compare the effect of  iron tablet suplementation with and without vitamin C toward Hemoglobin level in mother pregnant With Gestational Age Of 16-32 Weeks In Desa Keniten Kecamatan Mojo Kabupaten Kediri. This research method using comparative analytical.  Research design type of Quasy Eksperiment that have treatment group and control group. Treatment group will giving by Iron tablet and 100 mg vitamin C, and control group just giving by iron tablet during 21 days. Population in this research are all of mother pregnant with Gestational Age Of 16-32 Weeks with Sampling technique is  cluster random sampling is 29 mother pregnant. Comparison analysis of  iron tablet suplementation effect with and without vitamin C toward Hemoglobin level in mother pregnant With Gestational Age Of 16-32 Weeks, data analysis using Mann Whitney U-test and the calculated U value (44,5) less than U-table (51). So there was difference of iron tablet suplementation effect with and without vitamin C toward Hemoglobin level in mother pregnant With Gestational Age Of 16-32 Weeks Therefore, the addition of vitamin C on iron intake is needed to increase the uptake of iron tablets. When the amount of iron uptake increases, the reserves of iron in the body will also increase, so as to prevent anemia in pregnant women; Keywords : Iron Tablet (Fe), Vitamin C, Hemoglobin level, Mother Pregnant

Influence of DAFS-25+polizon composition on blood and functional state of liver of steers at fattening

2020 ◽  
pp. 15-18
Author(s):  
Inna R. Kilmetova ◽  
◽  
Igor A. Rodin ◽  
Nazira I. Khayrullina ◽  
Nikolay G. Fenchenko ◽  
...  
Keyword(s):  
Functional State ◽  
White Blood Cells ◽  
Live Weight ◽  
The Body ◽  
Farm Animals ◽  
Control Group ◽  
Standard Diet ◽  
The Impact ◽  
Experimental Group ◽  
Stimulation Of

Summary. The disbalanced feeding and the uneven distribution of micro- and macroelements in the environment leads to a trace element, in particular hypomelanosis. To accelerate the growth and preservation of young farm animals include in the diet of various biological additives and drugs, which include selenium. For stimulation of weight gain in the livestock industry, as well as for the prevention and treatment of pathological processes in addition to micro - and macrouse amino acids, primarily methionine. The aim of this work was to study the influence of composition of DAFS-25+Polizon on morpho-biochemical parameters of blood and functional state of the liver in fattening bulls of black-motley breed in the conditions of the Republic of Bashkortostan. Experiments using were conducted on bull-calves of black-motley breed of the properties in the properties age from 6 to 15 months. The first experimental group during the experiment was additionally given the composition of DAFS-25+Polizon at a dose of 2 mg/kg, the animals of the control group received a standard diet. To assess the impact of the composition DAFS-25+Polizon on metabolism cattle studied morphological and biochemical indicators of blood and conducted histological examination of the liver. It is established that the use of the composition of DAFS-25+Polizon at a dose of 2 mg/kg increases the number of erythrocytes and hemoglobin in the experimental group and reduces the amount of white blood cells. The serum content of total protein, phosphorus and calcium increases in the group of experimental animals. Microscopic examination of the liver revealed no changes in the structure of the organ and hepatocytes in the experimental group, whereas in the control group hemodynamic disorders and dystrophic changes in liver cells were observed. Thus, the use of the composition DAFS-25+Polizon at a dose of 2 mg/kg of live weight in fattening bulls black-and-white breed contributes to the increase of redox processes in the body, stimulation of metabolism, prevent the development of liver disorders of cellular mechanisms of metabolism, optimizes the structure of the liver, which generally provides higher productivity.

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