scholarly journals Pengaruh Ekstrak Kulit Buah Naga Merah (Hylocereus Polyrhizus) terhadap Waktu Perdarahan (Bleeding Time) Pada Mencit Strain Balb-C

2021 ◽  
Vol 18 (2) ◽  
pp. 61
Author(s):  
Dwi Mukti Kusumastuti ◽  
Zainul Cholid ◽  
Winny Adriatmoko
Keyword(s):  
Bleeding Time ◽  
The Body ◽  
Bleeding Complications ◽  
Control Group ◽  
Fruit Peel ◽  
Dragon Fruit ◽  
Whatman Paper ◽  
Natural Medicines ◽  
Peel Extract ◽  
Hylocereus Polyrhizus

Tooth extraction causes prolonged bleeding complications and the body will respond with hemostasis. Currently developing natural medicines to help the process of hemostasis. Red dragon fruit peel, which is generally a waste containing tannins, flavonoids, and saponins to stop bleeding. Purpose was to find out the effect of red dragon fruit peel extract on bleeding time in the tail of Balb-C strain mice. 16 mice samples were adapted for one week. Mice were divided into 2 groups subsquently fasted for 7 hours. The first group as a control (0.5% Na-CMC). The second group was given red dragon fruit peel extract which was divided into three sub-groups at a dose of 0.5 mg / g BW, mg / g BW, and 1.5 mg / g BW. All samples were waited for 45 minutes and cut along 2 cm from the tip of the tail. Blood is spilled on Whatman paper which has 30 seconds in each box. The number of blood spots on the box was calculated and multiplied by 30 seconds. The result showed that bleeding time in the group given red dragon fruit peel extract was significantly lower (p <0.05) than in the control group. The conclusion was red dragon fruit peel extract (Hylocereus Polyrhizus) has an effect on shortening the bleeding time in cutting the tail of bulb-c strain mice and the dose of red dragon fruit peel extract (Hylocereus Polyrhizus) which has the most significant effect is 1 mg / BB mice.

scholarly journals Formulation, Physical Quality Evaluation, and Antioxidant Activity of Body Butter of Ethanol Extract of Dragon Fruit (Hylocereus polyrhizus) Peel

2020 ◽  
Vol 25 (3) ◽  
Author(s):  
Agustina Nila Yuliawati ◽  
Kadek Duwi Cahyadi
Keyword(s):  
Antioxidant Activity ◽  
Quality Evaluation ◽  
Activity Index ◽  
Ethanol Extract ◽  
The Body ◽  
Fruit Peel ◽  
Physical Quality ◽  
Antioxidant Content ◽  
Dragon Fruit ◽  
Hylocereus Polyrhizus

Dragon fruit (Hylocereus polyrhizus) has polyphenols as an antioxidant. It has known that the antioxidant content of dragon fruit peels was more than in the flesh, so it can be used as a source of natural antioxidants to replace synthetic antioxidants. The use of dragon fruit (Hylocereus polyrhizus) peel, especially as topical preparations in the form of body butter, was still rarely done, whereas dragon fruit peel as an antioxidant can be used as an active ingredient of cosmetics. The purpose of this study was to obtain the body butter formula of ethanol extract of dragon fruit (Hylocereus polyrhizus) peel and its physical quality evaluation, to know the antioxidant activity of ethanol extract of dragon fruit (Hylocereus polyrhizus) peel and its body butter. This research was an experimental study with the stages of research consisting of determination of native plants, making ethanol extract of dragon fruit (Hylocereus polyrhizus) peel, ensuring its activity antioxidant, performing body butter formulation procedures, carrying out physical quality evaluation such as organoleptic, homogeneity, pH, spread, protection, and adhesion ability, then antioxidant activity of its body butter. The result of this research showed that the ethanol extract of dragon fruit (Hylocereus polyrhizus) peel has a moderate level of antioxidant (Antioxidant Activity Index / AAI = 0,88). Furthermore, body butter which has contains antioxidant content of ethanol extract of dragon fruit (Hylocereus polyrhizus) peel as much as 0.5% has the best physical quality evaluation during storage and the highest AAI (0,54) among other body butter formulas.

scholarly journals Dragon Fruit (Hylocereus polyrhizus) Increases Hemoglobin Levels in Young Women

2018 ◽  
pp. 197-203
Author(s):  
Halida Thamrin ◽  
Budu Budu ◽  
Werna Nontji ◽  
Suchi Avnalurini Sharief
Keyword(s):  
Young Women ◽  
Intervention Group ◽  
Female Students ◽  
The Body ◽  
Female Adolescent ◽  
Control Group ◽  
Increased Risk ◽  
Dragon Fruit ◽  
Significant Difference ◽  
Hylocereus Polyrhizus

Young women have a high risk of anemia, this is due to iron loss during menstruation. Female teenagers have an increased risk of anemia compared to young men because young women experience menstruation every month and the desire to reduce food so that the body lacks important nutrients such as iron. This study aims to determine the effect of dragon fruit (Hylocereus polyrhizus) on increasing hemoglobin levels in young women. This study used an experimental design with pretest-posttes with control group design. The sample in this research is student Prodi DIII Kebidanan. The total sample of 32 female students was divided into 2 groups, 16 female students were given dragon fruit (Hylocereus polyrhizus) as intervention group and 16 female students who were given nutrition education as control group. Measurements of hemoglobin levels were performed before and after treatment for 8 weeks, periodic measurements were performed every 2 weeks. Data analysis using Paired t-test. The results showed no effect but no significant difference of dragon fruit (Hylocereus polyrhizus) to increase hemoglobin level in female adolescent (P> 0,05).  

scholarly journals EFFECTS OF RED DRAGON FRUIT PEEL EXTRACT ADMINISTRATION ON NEUTROPHIL COUNTS FOLLOWING PERIAPICAL RADIOGRAPHY EXPOSURE

2021 ◽  
Vol 6 (2) ◽  
pp. 154
Author(s):  
Maydina Izzatul Yazidah ◽  
Didit Aspriyanto ◽  
Renie Kumala Dewi
Keyword(s):  
Free Radicals ◽  
Radiation Exposure ◽  
Cell Damage ◽  
Control Group ◽  
Fruit Peel ◽  
X Ray ◽  
Dragon Fruit ◽  
Significant Difference ◽  
Peel Extract ◽  
Periapical Radiography

Background: Radiation exposure from periapical imaging can cause cell damage in various tissues due to the formation of free radicals. Cell damage in the tissue can be observed from the number of neutrophils which are immune cells. Free radicals can be suppressed by administering exogenous antioxidants. One source of natural antioxidants is red dragon fruit, especially on its peel. Objective: To analyze the effect of periapical imaging x-ray radiation exposure after the administration of red dragon fruit peel extract on absolute neutrophil counts in mice. Method: This research was a true experimental study with a post-test only and control group design using 24 mice that were divided into 6 groups. The control group was not given any treatment while P1 to P5 group were given red dragon fruit peel extract at a dose of 100 mg/kg BW and exposed to radiation with different exposures. P1 group was exposed 1 time (0.63 mGy), P2 group was exposed 4 times (1.66 mGy), P3 group was exposed 8 times (4.37 mGy), P4 group was exposed 12 times (8.19 mGy), and group P5 was given no exposure. Results: There were changes in the number of neutrophils in all groups. The LSD Posthoc test results showed a significant difference between the control group (12.470 / mm3) and the P5 group (12.470 / mm3) compared to P3 group with 8 times exposure (40.348 / mm3). Conclusion: There is an effect of periapical radiographic x-ray radiation exposure by red dragon fruit peel extract on the absolute neutrophil count in mice. Keywords: Antioxidants, Neutrophils, Periapical Radiography, Radiation, Red Dragon Fruit Peel.

scholarly journals Pengaruh Penambahan Ekstrak Kulit Buah Naga (Hylocereus polyrhizus) terhadap Karakteristik Krim Kunyit dan Daun Asam

2020 ◽  
Vol 8 (4) ◽  
pp. 569
Author(s):  
Yohanes Wiliam Pagur ◽  
Sri Mulyani ◽  
Lutfi Suhendra
Keyword(s):  
Antioxidant Capacity ◽  
Water Extract ◽  
Fruit Peel ◽  
Color Test ◽  
Separation Ratio ◽  
Randomized Design ◽  
Dragon Fruit ◽  
Completely Randomized Design ◽  
Peel Extract ◽  
Hylocereus Polyrhizus

The purpose of this study was to determine the effect of dragon fruit peel extract (Hylocereus polyrhizus) on the characteristics of turmeric cream and tamarind leaves. The concentration of dragon fruit peel extract treatment consisted of 6 levels, namely 0, 5, 10, 15, 20 and 25%. Each treatment was repeated 3 times, so that 18 experimental units were obtained. The variables observed in turmeric cream and tamarind leaves were homogeneity, viscosity, pH, dispersibility, adhesion, and separation ratio, antioxidant capacity, LAB color test. Data were observed and analyzed using a completely randomized design. The results showed that the extract of dragon fruit peel did not affect homogeneous separation ratio, viscosity, spread power, pH and antioxidant capacity, while color testing affected the brightness level of the cream and the yellowish value b. All treatments adding water extract of dragon fruit peel produce turmeric cream and tamarind leaves that are homogeneous, there is no separation, viscosity 6766-6850cP, spread ability 5.9-6.27 cm, adhesion 54.67-72.33s, pH 5.37-5.57, nalia color test values L 38.72 – 46.08, values A 27.41-34.98 values B 31.56-44.65 and antioxidant capacity 91,67-112,17. Keywords: Dragon fruit, turmeric and tamarind leaves, cream characteristics.

scholarly journals Hylocereus polyrhizus Peel Extract Increase Testosteron Levels of Balb/C Mice (Mus musculus) Exposed Lead Acetate

2020 ◽  
Vol 1 (1) ◽  
pp. 1-6
Author(s):  
Reny I’tishom ◽  
Evy Wulandari ◽  
Sri Agus Sudjarwo
Keyword(s):  
Oxidative Stress ◽  
Mus Musculus ◽  
Lead Acetate ◽  
The Body ◽  
Control Group ◽  
Control Group Design ◽  
Post Test ◽  
Acetate Lead ◽  
Peel Extract ◽  
Hylocereus Polyrhizus

Lead is a heavy metal, the main polluting material in the environment, which comes from gasoline, batteries, paint, pipes, soil, cosmetics, household appliances, and decorations. Lead is a free radical causing oxidative stress. Lead can accumulate in the body due to its slow elimination process. Lead increases oxidative stress by forming reactive oxygen species (ROS) such as superoxide ion (O2-), hydroxil radical (OH-), and nitric oxide (NO), and direct suppression of antioxidant reserves such as Superoxide Dismutase (SOD), Catalase, and Glutathione Peroxide (GPx). Hylocereus polyrhizus peel is a natural antioxidant that can overcome the toxic effects of lead. The aim of this study was to analyze the treatment of Hylocereus polyrhizus peel extract orally once in a day for 40 days to increase testosteron levels of Balb/C mice (Mus musculus) exposed to lead acetate. The type of this study was true experimental study with Post Test Only Control Group design. Forty mice aged 8-10 weeks and the range of the body weight 30-40 grams were divided into 5 groups (each group of 8 mice). K- group was the control group without lead acetate and Hylocereus polyrhizus peel extract. K+, P1, P2 and P3 group was given 100 mg/kgBW lead acetate orally on the 1st day until day 14th. P1, P2 and P3 group was continued by giving Hylocereus polyrhizus peel extract orally on the 15th day until 39th day. P1 with dose 250 mg/KgBW, P2 with dose 500 mg/KgBW, and P3 with dose 1000 mg/KgBW. The results showed significant differences in testosterone levels between the K+ groups with P1 and P2. The conclusion of this study is Hylocereus polyrhizus peel extract can increase the testosteron levels of mice exposed to acetate lead.

scholarly journals Therapy Effect of Red Dragon Fruit (Hylocereus polyrhizus) Peel Extract to Increase the Number of Sertoli Cells On BALB/c Mice (Mus musculus) Exposed to Lead Acetate

2020 ◽  
Vol 56 (2) ◽  
pp. 108
Author(s):  
Evy Wulandari ◽  
Reny I'tishom ◽  
Sri Agus Sudjarwo
Keyword(s):  
Free Radicals ◽  
Mus Musculus ◽  
Sertoli Cells ◽  
Lead Acetate ◽  
Fruit Peel ◽  
Dragon Fruit ◽  
Therapy Effect ◽  
Significant Difference ◽  
Peel Extract ◽  
Hylocereus Polyrhizus

Lead is the free radicals and heavy metals of major pollutants in the environment. Lead is toxic and cumulative. Red dragon fruit (Hylocereus polyrhizus) peel extract is a natural antioxidant. Red dragon fruit peel extract can be used to stabilize free radicals by supplementing electron deficiencies and inhibiting chain reactions. This study aimed to analyze therapy effect of red dragon fruit peel extract to increase the number of Sertoli cells on BALB/c mice (Mus musculus) exposed to lead acetate. Fourty mice were divided into 5 groups (each group consisted of 8 mice). K- group was the control group without lead acetate and dragon fruit peel extract administration, K + group was given 100 mg/KgBW lead acetate orally on the 1st day until day 14th.. P1, P2, and P3 group were continued with red dragon extract orally on the 15th day until 39th day. P1 with dose 250 mg/KgBW, P2 with dose 500 mg/KgBW, and P3 with dose 1000 mg/KgBW. The result showed significant difference (P<0.05) in the number of Sertoli cells between K+ and P1, P2, P3 group. In conclusion, dose 500 mg/kgBW of red dragon fruit peel extract can be used as the most effective therapy to increase the number of Sertoli cells on mice exposed to acetate lead.

scholarly journals Uji Aktivitas Antioksidan Body Butter Ekstrak Etanol Kulit Buah Naga Merah dengan Metode DPPH

2021 ◽  
Vol 6 (2) ◽  
pp. 178-184
Author(s):  
Repining Tiyas Sawiji ◽  
Elisabeth Oriana Jawa La
Keyword(s):  
Antioxidant Activity ◽  
Cell Damage ◽  
Pharmaceutical Preparation ◽  
Ethanol Extract ◽  
The Body ◽  
Fruit Peel ◽  
Activity Test ◽  
Dragon Fruit ◽  
Ic50 Values ◽  
Hylocereus Polyrhizus

Red dragon fruit peels (Hylocereus polyrhizus) are considered important by the community. While the red dragon fruit peel contains flavonoids, betacyanin, anthocyanin, and vitamin C which have antioxidant activity so that it can ward off free radiation and prevent cell damage. Antioxidants are molecules that can prevent the oxidation of other molecules. Antioxidants can protect the skin from various free radical cell damage. The body butter is a pharmaceutical preparation in the cosmetic field that can be used for skin health care. This study aims to determine the percentage of antioxidant activity and IC50 values in the body butter ethanol extract of red dragon fruit peels. Red dragon fruit peels were extracted first using the maceration method with 96% ethanol solvent. The antioxidant activity test was measured using UV-Vis spectrophotometry. The results showed that the antioxidant activity value of formula I obtained IC50 values (56.17 μg / mL), formula II IC50 values (88.26 μg / mL), and formula III IC50 values (146.05 μg / mL). From the results obtained, the body butter formula which has the greatest activity is the formula I (AAI = 0.7). Antioxidant activity in body butter preparations is included in the group of moderate antioxidants.

scholarly journals 2. Antibacterial Test of Red Dragon Fruit Extract Peel (Hylocereus polyrhizus) Against Bacteria Salmonella pullorum

2018 ◽  
Vol 12 (1) ◽  
pp. 9-14
Author(s):  
Ichsan Maulana ◽  
Abdul Harris ◽  
Fakhrurrazi Fakhrurrazi ◽  
Maryulia Dewi ◽  
Safika Safika ◽  
...  
Keyword(s):  
Inhibition Zone ◽  
Fruit Peel ◽  
Mueller Hinton ◽  
Dragon Fruit ◽  
Salmonella Pullorum ◽  
Mueller Hinton Agar ◽  
Veterinary Faculty ◽  
Peel Extract ◽  
Hylocereus Polyrhizus ◽  
Positive Controls

The purpose of this study is to determine the effect of the red dragon fruit peels (Hylocereus polyrhizus) extract on the growth of Salmonella pullorum. This research was conducted at the Laboratory of Microbiology, Veterinary Faculty, University of Syiah Kuala, Banda Aceh. Red dragon fruit peels that used in this study is obtained from  ripe fruit and Salmonella pullorum cultures is  obtained from  Microbiology Laboratory of Veterinary Faculty Unsyiah. Salmonella pullorum culture added evenly on the surface of Mueller Hinton Agar, the number of the bacteria have been standarized using Mc Farland'1 method. Discs soaked in the red dragon fruit peels extracts at different concentrations (20 mg/ml, 40 mg/mL, and 60 mg/ml). Ampicillin is used as positive controls and DMSO (dimethyl sulfoxide) was placed on the surface of Mueller Hinton Agar. The parameters in this study is the inhibition zone diameter. Data were analyzed descriptively. The results showed that the red dragon fruit peel extract is able to inhibit the growth of Salmonella  pullorum and the average of  inhibition diameter zone at a concentration 60 mg / ml is 9.6 mm, 40 mg / ml is 9.4 mm and 20 mg / ml is 9.3 mm

scholarly journals PENGARUH EKSTRAK KULIT BUAH NAGA MERAH (HYLOCEREUS POLYRHIZUS) TERHADAP OVARIUM MENCIT MODEL ENDOMETRIOSIS

EMBRIO ◽  
2017 ◽  
Vol 9 ◽  
pp. 10-15
Author(s):  
Sagita candra Puspitasari
Keyword(s):  
Treatment Group ◽  
Granulosa Cell ◽  
Cell Apoptosis ◽  
Ovarian Follicle ◽  
The Body ◽  
Control Group ◽  
Mice Model ◽  
Fruit Peel ◽  
Dragon Fruit ◽  
Significant Difference

Endometriosis occurs when one of the normal tissues grows ectopically on the organs of the body other than the uterus. One of the mechanisms of infertility associated with endometriosis is a change in immune system function that affects the ovarian follicle which causes an increase in granulosa cells in the ovarian follicle endometriosis patients. The red dragon fruit is one of the plants capable of inhibiting NF-κB secretion of cytotine from endometriosis. This study aims to study the effect of red dragon fruit extract on the ovaries of mice of endometriosis model. 12 samples of female mice divided into 2 groups consisting of positive control group and treatment group used as endometriosis for 14 days, then the next 14 days positive group is given solution Na-CMC 0,5%, while treatment group given dose 0,25 mg / gram BB. This research type is true experimental by using randomized post test only control experimental group design. The results of this study indicate that there is a significant difference in the number of granulosa cell apoptosis between groups. Provision of extract dragon fruit peel in mice model of endometriosis can decrease the number of granulosa cell apoptosis with significant result P <0,05. Keywords : extract of hylocereus polyrhizuspeel, endometriosis, granulose cell apoptotic

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