scholarly journals Evaluation of a random access analyser: BM/Hitachi 911

1995 ◽  
Vol 17 (6) ◽  
pp. 213-218
Author(s):  
Taweesook Kanluan ◽  
Surapon Tangvarasittichai ◽  
Orathai Tangvarasittichai

The performance of Boehringer Mannheim's BM/Hitachi 911 was evaluated for three months. The mean coeffcient of variation (CV) of the within-run and between-run imprecision of the 16 analytes were less than 1.16% (range 0.47-2.38%) and 1.35% (range 0.62-2.93,%), respectively. A linearity study for the various assays covered clinically important levels. No relevant drift was observed during an eight-hour assay nor was any sample-related carry-over detected. In all cases, the regression analyses (slopes) of the results obtainedfrom BM/Hitachi 911 and 717 were between the extreme values of 0.94 and 1.05. During the three months of operation, no major problem was encountered. The BM/Hitachi 911 was found to be easily operated, to require minimal attention and simple daily maintenance during operation.

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Md. Saiful Islam ◽  
Md. Asad Ullah ◽  
Ummay Soumayia Islam ◽  
Sahadat Hossain ◽  
Yusha Araf ◽  
...  

Abstract Background Countrywide lockdown or stay-at-home order has been implemented to slow down the transmission of emergent coronavirus. However, the influence on attitudes and lifestyle due to lockdown amidst the coronavirus disease 2019 (COVID-19) pandemic has been poorly understood. The present study aimed to investigate the influence on attitudes and lifestyle due to lockdown amidst the COVID-19 pandemic among Bangladeshi residents. Methods A cross-sectional survey carried out involving 1635 community dwellers across eight divisions in Bangladesh conducted from April 15, 2020 to May 10, 2020. A structured questionnaire incorporating socio-demographic, attitudes towards lockdown and adverse lifestyle amidst lockdown measures was employed to collect data using the Google Forms. Multiple regression analyses were executed to determine the associated factors of positive attitudes towards lockdown and adverse lifestyle. Results The mean scores of attitudes towards lockdown were 67.9 (SD = 8.4) out of 85 with an overall correct rate (positive attitudes) of 79.9%; whereas the mean scores of adverse lifestyle amidst lockdown were 16.1 (SD = 4.8) out of 34 with an overall rate of 47.4%. The factors associated with more positive attitudes towards lockdown included being female, divorced, higher educated, and students. Conversely, being male, having no formal education, and rural residence were associated factors of adverse lifestyle amidst the COVID-19 pandemic. Conclusions The findings reflect how the COVID-19 lockdown has preciously impacted the attitudes, and lifestyle of Bangladeshi citizens, which will contribute to promoting appropriate measures during a subsequent zonal or complete lockdown.


1984 ◽  
Vol 39 (1) ◽  
pp. 51-57 ◽  
Author(s):  
C. A. Morris

ABSTRACTThe calving dates of spring-calving cows in New Zealand Angus and Hereford herds, taken from 350 and 240 herd-years respectively, and the intercalving intervals (CI) of cows in 95 Angus and 73 Hereford herds have been summarized. The relationships of each CI with the calving date which initiated it were also analysed. Results for each breed were analysed taking account of district, herd, year and cow age (in years), a total of 35 890 Angus and 22 397 Hereford records being used. The first-calving date (FCD) was identified for each herd-year, and 0·82 of Angus and 0·75 of Hereford cows were recorded as calving within 60 days of the FCD. On a herd basis, proportionately only 0·27 of Angus and 0·15 of Hereford herds had calving spreads of 80 days or less (defined as the time from the FCD to the last calving date). With barren years ignored, the CIs of cows averaged 370 days (Angus) and 368 days (Hereford). Two-year-old cows had on average a CI of 12 (Angus) or 7 days (Hereford) longer in 1974-75 than older cows, and the differences were both 12 days in 1975-76. Regression analyses showed that, on average, the later the calving date within a herd-year and age group, the shorter the subsequent CI. For cows calving early in the first year, the CI increased by 7 days for Angus and 5·4 days for Herefords for each 10 days before the mean calving date for the breed. There were significant effects of district and cow age on the regression estimates. The overall regressions were not consistent with those derived from British beef industry data.


2010 ◽  
Vol 14 (5) ◽  
pp. 778-784 ◽  
Author(s):  
Eva Balcells ◽  
Mario Delgado-Noguera ◽  
Ricardo Pardo-Lozano ◽  
Taïs Roig-González ◽  
Anna Renom ◽  
...  

AbstractObjectivesEvidence of the effects of soft drinks consumption on BMI and lifestyle in adult populations is mixed and quite limited. The aim of the present study was to determine the association of soft drinks consumption with BMI and lifestyle in a representative Mediterranean population.DesignTwo independent, population-based, cross-sectional (2000 and 2005) studies. Dietary intake was assessed using a validated FFQ. Weight and height were measured.SettingGirona, Spain.SubjectsRandom sample of the 35- to 74-year-old population (3910 men and 4285 women).ResultsLess than half (41·7 %) of the population consumed soft drinks; the mean consumption was 36·2 ml/d. The prevalence of sedentary lifestyle increased with the frequency of soft drinks consumption (P = 0·025). Daily soft drinks consumption significantly increased the risk of low adherence to the Mediterranean diet (OR = 0·57, 95 % CI 0·44, 0·74 v. top tertile of Mediterranean diet score). Multiple linear regression analyses, controlled for potential confounders, revealed that an increment in soft drinks consumption of 100 ml was associated with a 0·21 kg/m2 increase in BMI (P = 0·001). Only implausibly low reports of energy consumption showed a null association between soft drinks consumption and BMI.ConclusionsSoft drinks consumption was not embedded in a healthy diet context and was positively associated with BMI and sedentary lifestyle in this Mediterranean population.


1985 ◽  
Vol 77 (1) ◽  
pp. 255-262
Author(s):  
A. Robaglia ◽  
R. Seite

A stereological and ultrastructural study was performed on the nucleoli of the adrenal medulla chromaffin cells of rats exposed to a standardized 12 h light/12 h dark cycle with free access to food and water. The animals were killed three at a time, every 4 h during the 24-h span and fixed by intracardiac perfusion. In these reticulated nucleoli, the stereological analysis over a 24-h period showed a variation dependent on the time of killing for the two parameters investigated, the mean nucleolar volume, Vnu, and the mean volume of the fibrillar centres, Vfc(nu). The minimal value occurred at 0300 h (dark span) and the maximal one at 0700 h (at the onset of the light span). Between these two extreme values, Vnu increased 1.8-fold and Vfc(nu) 5.3-fold. These data are compared with a previous description from our laboratory of circadian rhythm in nucleoli of sympathetic neurons of superior cervical ganglion in the same animals. Analogies and differences are pointed out, but apart from these considerations the present study provides a new example of temporal organization at the cellular level in the organelle involved in ribosomal RNA synthesis and ribosome assembly.


2011 ◽  
Vol 48 (No. 7) ◽  
pp. 293-297
Author(s):  
V. Hosnedl ◽  
H. Honsová

Barley seed sensitivity to water and anoxia was tested. Standard germination, mean time of germination (MTG), germination in sand wetted by water to 100% water capacity (anoxia) or by hydrogen peroxide (wet conditions without anoxia), germination in 0.75% hydrogen peroxide and laboratory emergence (15 and 20&deg;C) were evaluated. Barley seed responds sensitively to stress conditions during germination. Significant germination decrease was found in abundance of water. Percentage of reduction depends on the variety and on the year of seed production. Extreme values of water sensitivity are in interval 4&ndash;90%. At wetted sand by 0.75%, solution of H<sub>2</sub>O<sub>2</sub> the germination was significantly less reduced. That means that barley seed is very sensitive to oxygen deficiency above all and is less injured by quick imbibition. Heterogeneity in seed vigour was demonstrated in laboratory emergence tests. Quick test of germination in 0.75% hydrogen peroxide deserves attention for its high correlation coefficient with the seed laboratory emergence. The results significantly demonstrate a&nbsp;higher sensitivity of deteriorated seed to germination in abiotic stresses conditions. Variability in speed of germination is increasing, which unfavourably extends the mean time of germination.


2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Junho Park ◽  
Chang-Hun Lee ◽  
Youngjin Choi ◽  
Il-Han Joo ◽  
Kwang-Hyun Lee ◽  
...  

Our purpose was to compare the contributions of these two systems to assess PIP joint extension in fresh cadaver models. Nine middle fingers of fresh cadavers were used. The PIP joint angle was measured while an extension load was applied on the extensor tendons. Specimens on which extension load was applied on the extrinsic extensors were classified as the extrinsic group, and those on which extension load was applied on the intrinsic extensors were classified as the intrinsic group. Linear regression analyses were performed to obtain regression equation and the extension load-PIP joint angle curve. The mean of slope of the curve was compared between the two groups using paired t-test. The same experiments were done for the metacarpophalangeal (MP) joint in 0° and 60° flexion to evaluate the effect of MP joint flexion on PIP joint extension. The mean slope of the extension load-PIP joint angle curve of the extrinsic group was significantly greater than that of the intrinsic group. With the MP joint in 0° flexion, the mean slope of the extrinsic and intrinsic groups was -0.148 and -0.117, respectively (greater absolute value means greater slope, p=0.01). With the MP joint in 60° flexion, the mean slopes were -0.147 and -0.104, respectively (p=0.015). The contribution of the intrinsic extensor for PIP joint extension shows decreasing trends with MP joint flexion. The extrinsic extensors have greater contribution for PIP joint extension compared with the intrinsic extensors.


2007 ◽  
Vol 90 (3) ◽  
pp. 715-719 ◽  
Author(s):  
Maria InÊs Rocha Miritello Santoro ◽  
Tatiana Tatit Fazio ◽  
Anil Kumar Singh ◽  
Erica Rosa Maria Kedor-Hackmann

Abstract Lamivudine (3TC) and zidovudine (AZT) are systemic antiviral substances extensively used in human immunodeficiency virus (HIV) infected patients. Nowadays, 3TC, AZT, and several other pharmacologically potent pharmaceuticals are manufactured in the same production area. To assure quality of drug products and patient safety, properly validated cleaning methodology is necessary. A carefully designed cleaning validation and its evaluation can ensure that residues of 3TC and AZT will not carry over and cross contaminate the subsequent product. The aim of this study was to validate a simple analytical method for verification of residual 3TC and AZT in equipment used in the production area and to confirm the efficiency of the cleaning procedure. The liquid chromatography method was validated using a Nova-Pak&lt;sup/&gt; C18 column (3.9 150 mm, 4 m particle size) and methanolwater (20 + 80, v/v) as the mobile phase at a flow rate of 1.0 mL/min. Ultraviolet detection was made at 266 nm. The calibration curve was linear over a concentration range of 2.022.0 g/mL with a correlation coefficient of 0.9998. The detection and quantitation limits were 0.36 and 1.21 g/mL, respectively. The intra-day and interday precision expressed as relative standard deviation were below 2.0%. The mean recovery of the method was 99.19%. The mean extraction recovery from manufacturing equipment was 83.5%.


1997 ◽  
Vol 19 (5) ◽  
pp. 169-173 ◽  
Author(s):  
D. M. Obzansky ◽  
E. G. Gorman ◽  
S. P. Kramer ◽  
I. S. Masulli ◽  
E. A. Nuzzaci ◽  
...  

A fully automated, random access method for the determination of cannabinoids (UTHC) was developed for the Dimension AR and XL clinical chemistry systems. The method utilizes Abuscreen ONLINE reagents and a multianalyte liquid calibrator containing 11-nor-Δ9-THC-9-carboxylic acid. Within-run and total reproducibility, determined using NCCLS protocol EP5- T2, was less than 0.6% and 1.6% CV, respectively, at all concentrations. Calibration stability was retained for at least 30 days. An extensive evaluation of non-structurally related drugs and various physiological substances indicated lack of interference in the method. No sample carry-over was observed following a specimen containing 1886 ng/ml 11-nor-Δ9-THC-9-carboxylic acid. A 99.1% agreement (N = 445 samples) was found between an EMIT based method on the aca discrete clinical analyser and the Dimension UTHC method.Dimension clinical chemistry system and aca discrete clinical analyser are registered trademarks of Dade International.


1970 ◽  
Vol 10 (46) ◽  
pp. 544 ◽  
Author(s):  
PD Mullaney ◽  
ID Sanderson

The economic weights of various quality traits of both Merino and crossbred wool types hive been estimated. Australian averages of clean wool prices for Australian Wool Board wool types, into which mid-side samples of fleece were classified, have been used.For each of fifteen seasons, 1953-54 to 1967-68, the mean clean wool price for each wool type was expressed as a percentage of the mean wool price for all types in that season. Rank correlations for price-type means were high between seasons, varying between 0.91 and 0.98. Further analyses were therefore performed using prices averaged for the 15 seasons. Multiple regression analyses were carried out, the dependent variable being the mean price for each fleece type, expressed as a percentage of the average price of all types for al) seasons and the independent variables being the measurement of fibre diameter, crimps per inch and length, and the subjective gradings of colour, handle, character, and quality number. For both Merino and crossbred wool types, the major determinants of price were quality number, colour, and handle, with quality number being of overwhelming importance. The remaining variables were not important as joint determinants of price, and were deleted from the analyses. Quality number, colour, and handle controlled about 81 and 86 per cent of the variation in price for Merino and crossbred wool types. It is likely that most progress in selection for wool production would be made by incorporating these findings into a selection index.


2019 ◽  
Vol 20 (4) ◽  
pp. 595-611 ◽  
Author(s):  
Rajib Maity ◽  
Mayank Suman ◽  
Patrick Laux ◽  
Harald Kunstmann

Abstract Changes in extreme precipitation due to climate change often require the application of methods to bias correct simulated atmospheric fields, including extremes. Most existing bias correction techniques (i) only focus on the bias in the mean value or on the extreme values separately, and (ii) exclude zero values from analysis, even though their presence is significant in daily precipitation. We developed a copula-based bias correction scheme that is suitable for zero-inflated daily precipitation data to correct the bias in mean as well as in extreme precipitation at any specific statistical quantile. In considering the whole of Germany as a test bed, the proposed scheme is found to work well across the entire study area, including the German Alpine regions. The joint distribution between observed and regional climate model (RCM)-derived precipitation is developed through copulas. In particular, the joint distribution is modified to make it discrete at zero in order to account for zero values. The benefit of considering zero precipitation values is revealed through the improved performance of bias correction both in the mean and extreme values. Second, the quantile that best captures the bias (whether in the mean or any extreme value) is determined for a specific location and varies spatially and seasonally. This relaxation in selecting the location-specific optimal quantile renders the proposed methodology spatially transferable. By acknowledging possible changes in extreme precipitation due to climate change, the proposed scheme is expected to be suitable for climate change impact assessments for extreme events worldwide.


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