Abstract 4181: Awareness of human papillomavirus (HPV) infection among men and women with oral cancer

Background. Human papillomavirus (HPV) infection has been recognized as an important risk factor in cancer. The purpose of this systematic review and meta-analysis was to determine the prevalence and effect size of association between salivary HPV DNA and the risk of developing oral and oropharyngeal cancer. Methods. A systematic literature search of PubMed, EMBASE, Web of Science, LILACS, Scopus and the Cochrane Library was performed, without language restrictions or specified start date. Pooled data were analyzed by calculating odds ratios (ORs) and 95% confidence intervals (CIs). Quality assessment was performed using the Newcastle–Ottawa Scale (NOS). Results. A total of 1672 studies were screened and 14 met inclusion criteria for the meta-analysis. The overall prevalence of salivary HPV DNA for oral and oropharyngeal carcinoma was 43.2%, and the prevalence of salivary HPV16 genotype was 27.5%. Pooled results showed a significant association between salivary HPV and oral and oropharyngeal cancer (OR = 4.94; 2.82−8.67), oral cancer (OR = 2.58; 1.67−3.99) and oropharyngeal cancer (OR = 17.71; 6.42−48.84). Significant associations were also found between salivary HPV16 and oral and oropharyngeal cancer (OR = 10.07; 3.65−27.82), oral cancer (OR = 2.95; 1.23−7.08) and oropharyngeal cancer (OR = 38.50; 22.43−66.07). Conclusions. Our meta-analysis demonstrated the association between salivary HPV infection and the incidence of oral and oropharyngeal cancer indicating its value as a predictive indicator.

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Exploring lay public and dental professional knowledge around HPV transmission via oral sex and oral cancer development

BMC Public Health ◽

10.1186/s12889-019-7923-6 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 1

Author(s):

Mario A. Brondani ◽

Adriana B. Siqueira ◽

Claudia Maria Coelho Alves

Keyword(s):

Human Papillomavirus ◽

Oral Cancer ◽

Health Care Professionals ◽

Oropharyngeal Cancer ◽

Hpv Infection ◽

Cancer Development ◽

Oral Sex ◽

Sexual Activities ◽

Lay Public ◽

Dental Professionals

Abstract Background Human papillomavirus (HPV) has been associated with certain types of oropharyngeal cancers and yet, the level of knowledge that dental professionals and the lay public have in terms of HPV transmission, oral sexual activities, and oral cancer development needs exploration. The aim of this study was to assess the knowledge held by practicing dental professionals as well as the lay public regarding Human Papillomavirus (HPV) transmission through oral sex and subsequent oropharyngeal cancer development. Methods Textual data were collected from a public forum with dental professionals in. Vancouver, who discussed the HPV-oral sex-oral cancer triad, and from survey data gathered from 212 lay public participants (also in Vancouver) who answered a 13-item questionnaire on the perceived risks of oral sex in terms of HPV infection and oropharyngeal cancer development. The data were analyzed statistically by age group, gender, and sexual orientation using descriptive statistics, while an ANOVA test was used to compare variation in the responses to the survey (p-value = 0.05). Results The forum engaged 46 health care professionals, many of whom were aware of the potential risks for head and neck cancer development due to HPV infection, while also questioning “how to effectively talk about HPV with patients.” The survey revealed that 34.5% of the participants believed that oral sex is an activity with no or low risk for the transmission of HPV, while 84% of participants believed the same sexual practices were of low or no-risk for HIV (Human Immunodeficiency Virus) transmission. Most participants (82%) never discussed oral sexual activities with their physicians or dentists/dental hygienists. Conclusions The general public remains mostly unaware of the potential links between HPV infection and oropharyngeal cancer. Physicians and dental providers should discuss oral sexual practice with their patients to raise awareness.

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Oral sex and oral cancer in the context of human papillomavirus infection: lay public understanding

Oncology Reviews ◽

10.4081/oncol.2010.171 ◽

2011 ◽

Vol 4 (3) ◽

pp. 171

Author(s):

Mario A. Brondani ◽

Mario A. Cruz-Cabrera ◽

Cheryle Colombe

Keyword(s):

Human Papillomavirus ◽

Sexual Orientation ◽

Oral Cancer ◽

Small Sample Size ◽

Hpv Infection ◽

Small Sample ◽

Public Understanding ◽

Sexual Practices ◽

Cancer Development ◽

Oral Sex

Human papillomavirus (HPV) is a risk factor for ano-genital and cervical cancers and has been associated with head and neck malignancies in the context of oral sex for the transmission of the virus. However, the level of knowledge that lay people have in terms of HPV transmission through oral sex and oral cancer development remains unknown. A pilot sample of 150 questionnaires was distributed at specific non-profit health organizations in Vancouver, Canada. Questions included perceived risks for oral sex in terms of HPV infection and oral cancer development, and the frequency with which respondents were asked about oral sexual practices by physicians and dentists. Data were analysed statistically by age group (19– 30, 31–50, 50\), gender (male, female), and sexual orientation (queer, straight). 110 questionnaires were returned fully completed. For the transmission of HPV, 58% of the participants believed that oral sex is an activity of no or low risk, whereas 72% considered the same activity to be of no risk for the development of oral cancer. There was no statistical difference between gender and sexual orientation. Participants never discussed related health risks in regard to oral sex with their physicians or dentists. In conclusion, although recent attention has been given to the potential links between HPV infection and oral cancer, such links remain mostly unknown by the public. Physicians and dentists could discuss oral sex practices to raise awareness with their patients. This is a small sample size study and the results should be interpreted with caution.

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Anal canal Human papillomavirus (HPV) infection in men and women undergoing colonoscopy: prevalence and risk factors, high burden in Crohn’s disease patients.

10.26226/morressier.59a6b34bd462b80290b55934 ◽

2017 ◽

Author(s):

Lucine Vuitton

Keyword(s):

Risk Factors ◽

Crohn’S Disease ◽

Human Papillomavirus ◽

Crohn's Disease ◽

Anal Canal ◽

Hpv Infection ◽

Men And Women ◽

High Burden

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Cloning, Expression, and Purification of the rE2 Protein Human Papillomavirus type 16

Protein Research & Bioinformatics ◽

10.24966/prb-1545/100012 ◽

2020 ◽

pp. 1-5

Author(s):

Saucedo Mendiola María Leticia ◽

Keyword(s):

Human Papillomavirus ◽

Sexually Transmitted Disease ◽

Reliable Method ◽

Uterine Cancer ◽

Transmitted Disease ◽

Hpv Infection ◽

Expression And Purification ◽

Men And Women ◽

Sexually Transmitted ◽

Human Papillomavirus Type 16

Human papillomavirus (HPV) infection is the most common sexually transmitted disease, both in men and women, and the persistence of this infection is the main causative agent of cervical-uterine cancer. HPV 16 protein E2 is important in viral replication and transcription. For this reason, it is of utmost importance to have a reliable method of expression and purification of recombinant E2 (rE2) proteins to carry out experiments focused on the development of drugs against HPV.

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Detection of Human Papillomavirus Infection in Oral Cancers reported at Dental Facility: Assessing the Utility of FFPE tissues

10.21203/rs.3.rs-767234/v1 ◽

2021 ◽

Author(s):

Gaurav Verma ◽

Nikita Aggarwal ◽

Abhishek Tyagi ◽

Kanchan Vishnoi ◽

Mohit Jadli ◽

...

Keyword(s):

Human Papillomavirus ◽

Oral Cancer ◽

Epidemiological Data ◽

Hpv Infection ◽

Oral Cancers ◽

Dental Hospital ◽

Formalin Fixed Paraffin Embedded ◽

Ffpe Tissues ◽

Oral Malignancies ◽

Protocol Standardization

Abstract Incidence of human papillomavirus (HPV)–associated oral cancers is on the rise. However, epidemiological data of this subset of cancers is limited. Dental hospital pose a unique advantage in detection of HPV-positive oral malignancies. We assessed the utility of formalin-fixed, paraffin-embedded (FFPE) tissues, which are readily available, for evaluation of high-risk HPV infection in oral cancer. For protocol standardization, we used 20 prospectively-collected, paired FFPE and fresh tissues of histopathologically-confirmed oral cancer cases reported in Oral Medicine department of a dental hospital for comparative study. Only short-PCRs (~200bp) of DNA isolated using a modified xylene-free method displayed a concordant HPV result. For HPV analysis, we used additional 30 retrospectively-collected FFPE tissues. DNA isolated from these specimens showed an overall 23.4% (11/47) HPV positivity with detection of HPV18. Comparison of HPV positivity from dental hospital FFPE-specimens with overall HPV positivity of freshly-collected oral cancer specimens (n-55) from three cancer care hospitals of the same region showed notable difference (12.7%; 7/55). Further, cancer hospital specimens showed HPV16 positivity and displayed a characteristic difference in reported sub-sites and patient spectrum. Overall, using a xylene-free FFPE-DNA isolation method clubbed with short amplicon PCR, we showed detection of HPV-positive oral cancer in dental hospitals.

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Association between Human papillomavirus and oral cancer in Iranian clinical samples: a meta- analysis review

10.21203/rs.3.rs-307575/v1 ◽

2021 ◽

Author(s):

Tahoora Mousavi ◽

Mahmood Mosazadeh ◽

Saeid Taghiloo ◽

Reza Valadan ◽

Sogol Sattari ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Human Papillomavirus ◽

Oral Cancer ◽

Cell Carcinoma ◽

Squamous Cell ◽

Meta Analysis ◽

Hpv Infection ◽

Clinical Samples ◽

Oral Diseases ◽

Iranian Patients

Abstract Background: Oral squamous cell carcinoma (OSCC) is one of the most common malignancies and is a serious problem worldwide. The role of HPV in oral cavity squamous cell carcinoma has beenstudied in several researches. Objective: The aim of the present review and meta-analysis was to investigate the relation between human papillomavirus (HPV) and oral cancer. Study design: Relevant studies were found using online international databases and suitable studies were selected and assessed by two independent researchers. The quality of all papers were determined by a checklist. Heterogeneity assay among the primary studies was evaluated by Cochran's Q test and I2 index. The statistical analyses were done using Stata SE, V.11 software. Trim and Fill method was applied to confirm the validity of the results.Results: This meta- analysis consists of 8 primary studies on the incidence of HPV infection in Iranian patients with oral diseases. The odds ratio between HPV infection and risk of oral cancer was 4.00 (95%CI: 2.31, 6.93).Conclusion: This meta- analysis showed associations between prevalence of HPV infection and oral cancer among Iranian patients. The chance of developing oral cancer among HPV positive patients was higher than that in HPV negative patients.

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Sex Differences in the Incidence and Clearance of Anogenital Human Papillomavirus Infection in Liuzhou, China: An Observational Cohort Study

Clinical Infectious Diseases ◽

10.1093/cid/ciz168 ◽

2019 ◽

Vol 70 (1) ◽

pp. 82-89 ◽

Cited By ~ 3

Author(s):

Feixue Wei ◽

Meng Guo ◽

Shoujie Huang ◽

Mingqiang Li ◽

Xuelian Cui ◽

...

Keyword(s):

Sex Differences ◽

Cohort Study ◽

Human Papillomavirus ◽

Natural History ◽

Hpv Infection ◽

Observational Cohort Study ◽

Men And Women ◽

History Of ◽

Observational Cohort ◽

Oncogenic Hpv

Abstract Background Human papillomavirus (HPV) causes anogenital warts and cancers in men and women. However, little is known about sex differences regarding the natural history of anogenital HPV infection. Methods Starting in May 2014, an observational cohort study including 2309 men and 2378 women aged 18–55 years was conducted in Liuzhou, China. Samples from anogenital sites were tested for HPV genotypes by multicolor real-time polymerase chain reaction and melting curve analysis biannually for ~1 year. Results The incidence of oncogenic HPV infection was similar in men and women (10.3 and 11.5/1000 person-months; P = .275), whereas the incidence of HPV-6/11 infection was higher in men than in women (2.0 vs 1.1; P = .018). The incidence of both oncogenic HPV and HPV-6/11 infections was significantly higher in women in the 18- to 25-year age group than in the older age groups (P = .006 and .011, respectively), whereas it did not vary by age among men (P = .552 and .425, respectively). Additionally, men were more likely than women to clear oncogenic infections (101.5 vs 58.6/1000 person-months; P < .001), but no significant difference was found in the clearance of HPV-6/11 by sex (111.7 vs 84.8; P = .266). The median time to clearance of oncogenic type and type 6/11 infections was not age dependent for either sex (all P > .05). Conclusions The natural history of oncogenic and nononcogenic HPV infection differs by sex, which implies that sex-specific vaccination strategies should be considered for oncogenic and nononcogenic HPV. Clinical Trials Registration NCT02188004.

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Human Papillomavirus Infection and Vaccination: Knowledge, Attitude and Perception among Undergraduate Men and Women Healthcare University Students in Switzerland

Vaccines ◽

10.3390/vaccines7040130 ◽

2019 ◽

Vol 7 (4) ◽

pp. 130 ◽

Cited By ~ 3

Author(s):

Jeannot ◽

Viviano ◽

Follonier ◽

Kaech ◽

Oberhauser ◽

...

Keyword(s):

Women Students ◽

Human Papillomavirus ◽

Undergraduate Students ◽

Hpv Vaccine ◽

Hpv Infection ◽

Basic Knowledge ◽

Transmitted Infection ◽

Men And Women ◽

Knowledge And Beliefs ◽

Mode Of Transmission

Abstract: Background: Human Papillomavirus is a common sexually transmitted infection, representing the main cause of genital warts and cervical cancer. The objective of this study was to evaluate basic knowledge and beliefs regarding HPV infection and HPV vaccine among undergraduate healthcare men and women students, as well as their attitudes towards HPV vaccine. Methods: Undergraduate women and men (nursing and midwifery curses) attending three Schools of Health Sciences located in Switzerland. A total of 427 women and 223 men have completed the web questionnaire, which included questions on their socio-demographic background and about basic knowledge and attitudes toward the HPV infection and vaccination. Results: Women undergraduate students have a better knowledge of HPV infection than their men counterparts, although there was a significant gap in knowledge of the disease’s mode of transmission and prevention. Among women, 72.6% of respondents reported having received at least one dose of HPV vaccines versus 31.4% for men respondents. Conclusion: The results of this study revealed a poor understanding among undergraduate healthcare men and women students about the HPV infection, its mode of transmission and its prevention. Our findings highlight the need to improve education on HPV for undergraduate healthcare students in order to increase the awareness of the disease.

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