Prevalence of Multiple Sclerosis in the Republic of Moldova

2016 ◽  
Vol 46 (3) ◽  
pp. 166-172 ◽  
Author(s):  
Cristina Marcoci ◽  
Vitalie Lisnic ◽  
Mihail Gavriliuc ◽  
Olesea Odainic ◽  
Marina Sangheli ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Disease Burden ◽  
Nationwide Survey ◽  
Epidemiological Data ◽  
Age Group ◽  
Disease Modifying Drugs ◽  
Republic Of Moldova ◽  
Mcdonald Criteria ◽  
The Republic ◽  
Crude Prevalence

Background: The occurrence of multiple sclerosis (MS) increases in populations featuring both high and low disease burden, and variations across regions at the same latitude are reported. MS epidemiological data in Eastern Europe are scarce and out of date. We report on sex- and age-specific prevalence of MS in the Republic of Moldova. Methods: Benefitting from a nationwide survey aimed to quantify the MS burden in Moldovans (3,559,541 population in 2012), multiple epidemiological sources were scrutinized. Results: On prevalence day, December 31, 2012, 747 MS patients (McDonald criteria) resided in the study area, yielding a crude prevalence of 20.9 per 100,000 (95% CI 14.7-27.1), 25.7 (95% CI 20.5-30.5) in women and 15.8 (95% CI 12.2-19.3) in men (F:M ratio of 1.63), and standardized estimates of 20.2, 24.3 and 15.5 per 100,000, respectively. Prevalence was highest in the age group 40-49 years (43.9 per 100,000) and higher in rural (72.6%) than in urban (27.4%) areas. Conclusions: This is the first report on sex- and age-specific prevalence of MS in the Republic of Moldova, which was lower than in Europe on average, but consistent with that of neighboring countries, Romania and Ukraine. Moldovans represent a population wherein MS natural history is not yet influenced by use of disease-modifying drugs.

scholarly journals Pertussis Outbreak Analysis in Republic of Moldova

2017 ◽  
Vol 16 (3) ◽  
pp. 96-100 ◽  
Author(s):  
V. . Bukova ◽  
A. . Melnik ◽  
L. . Tsurcan ◽  
A. . Cheban ◽  
V. . Gutsu
Keyword(s):  
Urban Areas ◽  
Whooping Cough ◽  
Laboratory Data ◽  
Epidemiological Data ◽  
School Age Children ◽  
School Age ◽  
Age Group ◽  
Republic Of Moldova ◽  
Igm Antibodies ◽  
One Year

There are analyzed the incidence of whooping cough for the period of 1993 - 2016 in Republic of Moldova in this article. 210 from 280 cases of pertussis reported in 2016 and. Specific IgM antibodies of 174 patients were investigated. The epidemic process of pertussis is cyclical, with a period of 3 - 4 years, with a higher incidence in urban areas and in children up to two years, with a tendency to increase the proportion among the patients of school-age children and adults. The decrease in vaccination coverage from 95.4% in 2008 to 89.7% in 2015 led to an increased incidence. From total number of cases, 68.1% were children aged from 0 to 6 years old. The age structure of registered cases in 2016 included: 22.4% under one year old; 44.3% between 1 - 2 years, 27.1% school age children between 7 -17 years and 4.8% adults. A later uptake of medical care was registered, with an average of 10.5 days after onset of the disease, but in age group of children under one year it was 9.6 days. The bases of the diagnosis of whooping cough in 10.7% of cases were clinical data, in 16.2% were clinical - epidemiological data and in 73.1% were laboratory data. Specific IgM antibodies were detected in 77.0 ± 6.4% of patients. Among patients under one year old, 14.9% were under the age of vaccination, 34.0% received from 1 to 3 doses of vaccine, 19.1% are not vaccinated by false contraindications and 27.6% due to refusal. Among patients from the age group of 3-6 years, 56.0% received 3 - 4 doses of vaccine, 18.0% were not vaccinated because of false contraindications and 40.0% due to the failure of the vaccination. From children patients who received a full course of vaccination against pertussis, 25.0% had been vaccinated 1 - 2 years ago and other 25.0% became ill after three or four years after immunization.

scholarly journals Nontuberculous mycobacteria and bronchiectasis

2021 ◽  
Vol 69 (1) ◽  
Author(s):  
Oxana Munteanu ◽  
◽  
Victor Botnaru ◽  
Keyword(s):  
Pulmonary Disease ◽  
Patient Management ◽  
Nontuberculous Mycobacteria ◽  
Epidemiological Data ◽  
Republic Of Moldova ◽  
Diagnosis And Management ◽  
Radiological Features ◽  
The Republic ◽  
Optimal Patient Management

Nontuberculous mycobacterial pulmonary disease is an emerging multidisciplinary problem during the last decades, despite the lack of epidemiological data in most countries, including the Republic of Moldova. An increasing interest has been observed in evaluating nontuberculous mycobacteria (NTM) in patients with bronchiectasis, although the dilemma of which of these diseases comes first remains unresolved. This paper reviews several aspects of the correlations between NTM and bronchiectasis including pathogenesis, radiological features, diagnosis and management, emphasizing the necessity for clinicians to have sufficient familiarity of the mycobacteria types to provide optimal patient management.

Prevalence of smear-positive tuberculosis in persons aged ⩾15 years in Bangladesh: results from a national survey, 2007–2009

2011 ◽  
Vol 140 (6) ◽  
pp. 1018-1027 ◽  
Author(s):  
K. ZAMAN ◽  
S. HOSSAIN ◽  
S. BANU ◽  
M. A. QUAIYUM ◽  
P. C. BARUA ◽  
...  
Keyword(s):  
Fluorescence Microscopy ◽  
Rural Areas ◽  
Participation Rate ◽  
Nationwide Survey ◽  
Age Group ◽  
Prevalence Rates ◽  
Standard Methods ◽  
Multi Stage ◽  
Study Participants ◽  
Crude Prevalence

SUMMARYThe aim of this study was to determine the nationwide prevalence of smear-positive tuberculosis (TB) in Bangladesh. A multi-stage cluster survey of a random sample of persons aged ⩾15 years was included in 40 clusters (20 urban, 20 rural). Two sputum samples were collected from study participants and tested initially by fluorescence microscopy and confirmed by the Ziehl–Neelsen method. The crude and adjusted prevalence rates and 95% confidence intervals (CIs) were calculated using standard methods. A total of 33 new smear-positive TB cases were detected among 52 098 individuals who participated in the study. The average participation rate was over 80%. The overall crude prevalence of new smear-positive TB in persons aged ⩾15 years was estimated as 63·3/100 000 (95% CI 43·6–88·9) and the adjusted prevalence was 79·4/100 000 (95% CI 47·1–133·8). TB prevalence was higher in males (n=24) and in rural areas (n=20). The prevalence was highest in the 55–64 years age group (201/100 000) and lowest in 15–24 years age group (43·0/100 000). The prevalence was higher in persons with no education (138·6/100 000, 95% CI 78·4–245·0). The overall prevalence of smear-positive TB was significantly lower than the prevalence estimate of the previous nationwide survey in Bangladesh in 1987–1988 (870/100 000).

Time to diagnosis in multiple sclerosis: Epidemiological data from the German Multiple Sclerosis Registry

2021 ◽  
pp. 135245852110397
Author(s):  
Stefan J Blaschke ◽  
David Ellenberger ◽  
Peter Flachenecker ◽  
Kerstin Hellwig ◽  
Friedemann Paul ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Epidemiological Data ◽  
Primary Analysis ◽  
Younger Adults ◽  
Mcdonald Criteria ◽  
Time To Diagnosis ◽  
The Mean ◽  
Magnetic Resonance Imaging Mri ◽  
Disease Modifying Treatment ◽  
Mean Time

Objective: To investigate the time to diagnosis in multiple sclerosis (MS) in Germany. Methods: Analysis of real-world registry data from the German Multiple Sclerosis Registry (GMSR) and performing a primary analysis in patients where month-specific registration of the dates of onset and diagnosis was available. Results: As of January 2020, data of a total of 28,658 patients with MS were extracted from the GMSR, with 9836 patients included in the primary analysis. The mean time to diagnosis was shorter following the introduction of the first magnetic resonance imaging (MRI)-based McDonald criteria in 2001. This effect was most pronounced in younger adults below the age of 40 years with relapsing onset multiple sclerosis (ROMS), with a decrease from 1.9 years in 2010 to 0.9 years in 2020, while unchanged in patients aged 40–50 years (1.4 years in 2010 and 1.3 years in 2020). In the limited number of paediatric onset MS patients, the time to diagnosis was longer and did not change (2.9 years). Conclusion: The current sensitive MRI-based diagnostic criteria have likely contributed to an earlier diagnosis of MS in Germany in younger adults aged 18–39 years with ROMS. Whether this translated to earlier initiation of disease-modifying treatment or had a beneficial effect on patient outcomes remains to be demonstrated.

scholarly journals Metabolic syndrome and other comorbidities in the structure of COVID-19 mortality in the Republic of Moldova (March-December 2020)

2021 ◽  
Vol 70 (2) ◽  
Author(s):  
Ion Mereuta ◽  
◽  
Vasile Fedas ◽  
Anastasia Tomsa ◽  
Anghela Cebotari ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Syndrome ◽  
Malignant Tumors ◽  
Age Groups ◽  
Circulatory System ◽  
Age Group ◽  
Rural Sector ◽  
Urban Sector ◽  
Republic Of Moldova ◽  
The Republic

Metabolic syndrome and other co-morbidities in the structure of COVID-19 mortality in the Republic of Moldova (March-December 2020) The mortality of the population of the Republic of Moldova through COVID-19 in March-December 2020 made up 2846 (100%) people confirmed with SARS CoV-2 (women –1362/2846 (47,8%), men — 1484/2846 (52,2%). In the urban sector it is 1649/2846 (58,0%), including Chisinau — 1034/2846 (36,3%), Balti — 158/2846 (5,6%), in the rural sector — 1197/2846 (42%). Mortality in the age groups constituted for the age group of 30-70 years (men — 862/2846 (30,3%), women — 805/2846 (28,2%). The share of comorbidity was 1905/2846 (66,9%), the structure of the main diseases being: diseases of the cardiovascular system – 966/1905 (33,9%); diabetes mellitus – 523/1905 (27,5%); malignant tumors – 91/1905 (4,8%). In the age groups — 30-70 years: diseases of the circulatory system – 485/1905 (25.4%), diabetes – 335/1905 (17.6%), cancer – 62/1905 (3.3%).

Prospective 20-year clinical-genetic study of multiple sclerosis in the Republic of Bashkortostan

2020 ◽  
Vol 18 (5) ◽  
pp. 58-64
Author(s):  
T. R. GALIULLIN ◽  
◽  
K. Z. BAKHTIYAROVA ◽  
O. V. ZAPLAKHOVA ◽  
N. F. UTYAGULOVA ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Genetic Study ◽  
Venous Blood ◽  
Clinical Genetic ◽  
Study Objective ◽  
Disease Modifying Drugs ◽  
Republic Of Bashkortostan ◽  
Rate Of Progression ◽  
The Republic

The study objective was to analyze the results of 20 years of clinical follow-up and genetic study of 247 patients with multiple sclerosis (MS) registered at the Republican MS Centre. Material and methods. The study comprised unrelated patients with a verified diagnosis of MS included in the register of the Republican MS Center, and age-, gender-, and ethnicity-matched controls. DNA was isolated from whole venous blood by phenol-chloroform extraction. Genotyping was performed by PCR and PCR-RFLP methods. Quantitative variables were assessed using the non-parametric Mann — Whitney test (U-test); the exact two-sided Fisher’s test was applied to compare the distribution of genotypes and alleles frequencies in the groups of patients and controls. Differences were considered statistically significant at p < 0,05. Results. The group of 247 patients enrolled in the clinical genetic study in 2000 included 123 (49,8%) Russians, 98 (39,7%) Tatars, and 26 (10,5%) Bashkirs. The ratio of women to men was 2:1 (166:81). A polysymptomatic debut with a predominance of motor disorders was more often observed in the Bashkir group compared with others. At the time of inclusion in the study, the rate of progression in the Bashkir group was statistically significantly higher than in the Russian group, and non-significantly higher than in the Tatars group. Over a 20-year follow-up period, the rate of progression slowed in all groups. With the advent of magnetic resonance imaging in the region, the time to establish a verified diagnosis of MS has significantly decreased (p = 0,001). An increase in disability was not recorded during the observation period in 46 patients, 43 of them were taking disease modifying drugs. In a clinical genetic study, ethnospecific associations between MS and the polymorphismsin TNF and IL1B genes was revealed. Conclusion. The findings of the study emphasize the need for the continued follow-up and more in-depth investigation of the regional characteristics of MS, course variants and risk factors for the development of the disease.

Pediatric multiple sclerosis in Bashkortostan Republic

2020 ◽  
Vol 18 (5) ◽  
pp. 76-78
Author(s):  
N. F. UTYAGULOVA ◽  
◽  
T. R. GALIULLIN ◽  
O. V. LYUTOV ◽  
K. Z. BAKHTIYAROVA ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Pediatric Patients ◽  
Careful Monitoring ◽  
Childhood Onset ◽  
Global Trends ◽  
Clinical Hospital ◽  
Pediatric Multiple Sclerosis ◽  
Mcdonald Criteria ◽  
Republic Of Bashkortostan ◽  
The Republic

The purpose — to explore prevalence and clinical particularities of the pediatric multiple sclerosis in Bashkortostan Republic. Material and methods. The data of 21 children with multiple sclerosis were analyzed. The data were provided by the Republican Centre of the multiple sclerosis (Ufa) and outpatient records of the Kuvatov’s Republican Clinical Hospital (Ufa). All children were examined out patiently at the Neurology Department at the Republican Children’s Clinical Hospital (Ufa) and the polyclinics of the Republican Clinical Hospital (Ufa). Diagnosis «multiple sclerosis» (MS) was issued by McDonald criteria (2017). Results. MS affects female children more often. City residents are hit much more frequently. The onset occurs among senior schoolchildren in most cases. Most of the patients have remitting course of MS. Conclusion. The main epidemiological indicators of childhood onset MS in the Republic of Bashkortostan are comparable to those in neighboring regions of Russia, and the observed changes reflect the global trends. The study confirmed the findings of other authors on the main characteristics of childhood MS. Pediatric patients require a specialized approach to the diagnosis and careful monitoring of neurological symptoms in order to timely identify multiple sclerosis.

Multiple sclerosis in the Republic of San Marino: a prevalence and incidence study

2008 ◽  
Vol 14 (3) ◽  
pp. 325-329 ◽  
Author(s):  
E. Granieri ◽  
C. Monaldini ◽  
R. De Gennaro ◽  
S. Guttmann ◽  
M. Volpini ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Temporal Trend ◽  
Prevalence Ratio ◽  
Diagnostic Procedures ◽  
Italian Peninsula ◽  
The Past ◽  
The Republic ◽  
Descriptive Survey ◽  
Crude Prevalence

Studies on the distribution of multiple sclerosis (MS) carried out in Southern Europe in the last years have shown a significant increase in the frequency of the disease. A previous descriptive survey in the Republic of San Marino, northern Italian peninsula, published in 1984 established that this area is at high risk for MS. We updated the frequency estimates of the disease by adopting a complete enumeration approach. On 31 December 2005, 50 MS patients (36 women and 14 men) yieldeda crude prevalence rate of 166.7 per 100 000 (95% CI 123.7—220), 235.3 (95% CI 165—327.4) for women and 95.2 (95% CI 52—160) for men. The average incidence from 1990 to 2005 was 7.9 (95% CI 5.3—11.1) per 100 000, 11.7 (95% CI 7.6—17.3) for women and 3.9 (95% CI 1.7—7.7) for men. We did not detect any significant temporal trend over the study period. These results confirm that in San Marino the disease occurs more frequently than that suggested in the past and support the data on MS frequency in continental Italy. The marked increase in MS prevalence ratio is partly due to the increasing survival of patients and the accumulation of new incidence cases owing to the reduction in diagnostic latency for better quality of neurological diagnostic procedures. However, an increased incidence of the disease could be considered. Multiple Sclerosis 2008; 14: 325—329. http://msj.sagepub.com

scholarly journals First report of canine ocular thelaziosis in the Republic of Moldova

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Mirabela Oana Dumitrache ◽  
Angela Monica Ionică ◽  
Eugeniu Voinițchi ◽  
Nicolai Chavdar ◽  
Gianluca D’Amico
Keyword(s):  
Epidemiological Data ◽  
Emerging Pathogens ◽  
Intact Male ◽  
Public Health Perspective ◽  
Veterinary Clinic ◽  
First Report ◽  
Transmission Cycle ◽  
Republic Of Moldova ◽  
History Of ◽  
The Republic

Abstract Background Countries of eastern Europe are considered, due to several risk factors, more vulnerable to infections with newly (re)emerging pathogens. During the last decade, in several European countries, reports of autochthonous cases of ocular thelaziosis due to Thelazia callipaeda have been published, posing a great concern from both veterinary and public health perspective. However, in the Republic of Moldova only limited epidemiological data are available regarding zoonotic vector-borne pathogens and, until now, no data exist on the zoonotic nematode T. callipaeda. Methods In September 2018, an 11-year-old dog, mixed-breed, intact male was referred to a private veterinary clinic from Chișinău, Republic of Moldova, with a history of 2 weeks of an ocular condition affecting the right eye. The ophthalmological exam revealed the presence of nematode parasites in the conjunctival sac and under the third eyelid. The collected parasites were identified by morphological techniques and molecular analysis. Results A total of 7 nematodes were collected, and 5 females and 2 males of T. callipaeda were identified morphologically. The BLAST analysis confirmed the low genetic variability of this parasite in Europe. The travel history of the patient allowed us to confirm the autochthonous character of the case. Conclusions To the best of our knowledge, this is the first report of thelaziosis in dogs from the Republic of Moldova, which confirms the spreading trend of T. callipaeda and the existence of an autochthonous transmission cycle of this zoonotic parasite in the country.

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