MMP20 rs1784418 Protects Certain Populations against Caries

This work aimed to further evaluate the association of MMP20 rs1784418 C>T and dental caries experience with the hypothesis that MMP20 rs1784418 C>T is a risk factor for dental caries. 184 children 4-7 years of age had their caries experience determined and buccal cheek swabs collected for DNA extraction to test for association with the MMP20 rs1784418 C>T using standard statistical approaches. A meta-analytic approach was also implemented to compile previous discrepant reports of the same association. We found an association between MMP20 rs1784418 C>T and dental caries experience in primary dentition (p = 0.01). The meta-analysis showed that this association appears to favor individuals born in Brazil and not Turkey. MMP20 rs1784418 C>T appears to protect against dental caries, but its effects are likely to be more marked in certain populations.

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Does non-institutionalized elders have a better oral health status compared to institutionalized ones? A systematic review and meta-analysis

Ciência & Saúde Coletiva ◽

10.1590/1413-81232020256.18252018 ◽

2020 ◽

Vol 25 (6) ◽

pp. 2177-2192 ◽

Cited By ~ 3

Author(s):

Ilky Pollansky Silva e Farias ◽

Simone Alves de Sousa ◽

Leopoldina de Fátima Dantas de Almeida ◽

Bianca Marques Santiago ◽

Antonio Carlos Pereira ◽

...

Keyword(s):

Systematic Review ◽

Health Status ◽

Oral Health ◽

Dental Caries ◽

Meta Analysis ◽

Oral Health Status ◽

Cochrane Library ◽

Caries Experience ◽

Institutionalized Elderly ◽

Periodontal Status

Abstract This systematic review compared the oral health status between institutionalized and non-institutionalized elders. The following electronic databases were searched: PubMed (Medline), Scopus, Web of Science, Lilacs and Cochrane Library, in a comprehensive and unrestricted manner. Electronic searches retrieved 1687 articles, which were analyzed with regards to respective eligibility criteria. After reading titles and abstracts, five studies were included and analyzed with respect their methodological quality. Oral status of institutionalized and non-institutionalized elderly was compared through meta-analysis. Included articles involved a cross-sectional design, which investigated 1936 individuals aged 60 years and over, being 999 Institutionalized and 937 non-institutionalized elders. Studies have investigated the prevalence of edentulous individuals, the dental caries experience and the periodontal status. Meta-analysis revealed that institutionalized elderly have greater prevalence of edentulous (OR = 2.28, 95%CI = 1.68-3.07) and higher number of decayed teeth (MD = 0.88, 95%CI = 0.71-1.05) and missed teeth (MD = 4.58, 95%CI = 1.89-7.27). Poor periodontal status did not differ significantly between groups. Compared to non-institutionalized, institutionalized elders have worse dental caries experience.

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Redefining the Phenotype of Dental Caries

Caries Research ◽

10.1159/000481414 ◽

2018 ◽

Vol 52 (4) ◽

pp. 263-271 ◽

Cited By ~ 13

Author(s):

Megan Weber ◽

Jenny Bogstad Søvik ◽

Aida Mulic ◽

Kathleen Deeley ◽

Anne B. Tveit ◽

...

Keyword(s):

Dental Caries ◽

Genetic Variants ◽

Public Health Problem ◽

Recessive Model ◽

Primary Dentition ◽

Caries Experience ◽

Major Public Health Problem ◽

Cross Sectional ◽

Vast Number ◽

Kallikrein 4

Dental caries is a multifactorial infectious disease and a major public health problem estimated to affect 60-90% of school children as well as a vast number of adults. The aim of this work was to define patterns of progression of the disease based on longitudinal data in contrast to using a cross-sectional assessment. dmft/DMFT scores were collected at ages 5, 12, 14, 16, 17, and 18 from 876 individuals. We tested our newly defined phenotypes for association with genetic variants in genes shown to be associated with caries. We generated genotyping data using Taqman chemistry in markers of genes involved in processes such as enamel formation and salivary contributions. Kallikrein 4 (KLK4) was found to show a significant association with the created phenotypes (p = 0.0008 in a recessive model for low caries experience in the primary dentition vs. high caries experience in the primary dentition, and p = 0.0004 in a recessive model for caries free primary dentition vs. high caries experience in the primary dentition).

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Dental caries experience, care index and restorative index in children with learning disabilities and children without learning disabilities: a systematic review and meta-analysis

Evidence-Based Dentistry ◽

10.1038/s41432-020-0075-9 ◽

2020 ◽

Vol 21 (1) ◽

pp. 16-17

Author(s):

James Bird ◽

Zoe Marshman

Keyword(s):

Systematic Review ◽

Learning Disabilities ◽

Dental Caries ◽

Meta Analysis ◽

Caries Experience ◽

Care Index

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Dental Caries Experience in 6-13 Years Old School Children of Dharan Sub-Metropolitan City, Nepal: A Cross-Sectional Study

Journal of Nepalese Association of Pediatric Dentistry ◽

10.3126/jnapd.v2i1.41559 ◽

2021 ◽

Vol 2 (1) ◽

pp. 12-18

Author(s):

Bhawana Sigdel Bastola ◽

Bandana Koirala ◽

Mamta Dali ◽

Sneha Shrestha ◽

Dharanidhar Baral

Keyword(s):

Risk Factors ◽

Oral Health ◽

Dental Caries ◽

School Children ◽

Cross Sectional Study ◽

Primary Dentition ◽

Caries Experience ◽

Sectional Study ◽

Cross Sectional ◽

Associated Risk Factors

Introduction: Dental caries though preventable oral health problem is affecting school children worldwide and around 50% of Nepalese children are suffering from it. Baseline data with good understanding of dental caries and associated risk factors are necessary to form preventive strategies for setting and achieving oral health goals. Objective: This study was conducted to determine dental caries experience and associated risk factors among school-going children of 6-13 years old in Dharan sub-metropolitan city, Nepal. Methods: A cross-sectional study was conducted from 5th Jan 2018 to 4th Jan 2019 among 680 school children selected by multistage cluster sampling method. Pretested, standardized, closed-ended questionnaire answered by the parents was used to gather information regarding the associated risk factors. Dental caries experience was obtained from deft/DMFT (WHO modification 1997). Comparison of categorical data was done using Chi-square test. Multivariable binary logistic regressions were used for the statistical analysis. Results: The overall caries prevalence was 61.6%, in primary dentition it was 48.25% and in permanent dentition it was 34.4%. Dental caries experience was with mean deft 4.67 (±2.7) in primary dentition and mean DMFT 1.72 (±1.05).in permanent dentition. Multivariate analysis showed significant association between dental caries experience and grade three and grade four school children had experienced greater caries (p<0.05, OR =2.7). Dental caries was associated with eating sweets at night (p<0.001, OR=2.5) and snacking in-between meals (p<0.001, OR=2.5). Conclusions: Dental caries among school-children in Dharan showed a significant burden especially within the primary dentition. It was significantly associated with factors like feeding habits -eating sweets in a day, eating sweets at night and snaking in between meals

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Developmental defects of enamel and dental caries in the primary dentition: A systematic review and meta-analysis

Journal of Dentistry ◽

10.1016/j.jdent.2017.03.006 ◽

2017 ◽

Vol 60 ◽

pp. 1-7 ◽

Cited By ~ 21

Author(s):

Francine S. Costa ◽

Ethieli R. Silveira ◽

Gabriela S. Pinto ◽

Gustavo G. Nascimento ◽

William Murray Thomson ◽

...

Keyword(s):

Systematic Review ◽

Dental Caries ◽

Meta Analysis ◽

Primary Dentition ◽

Developmental Defects ◽

Developmental Defects Of Enamel

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A systematic review and meta-analysis of the effects of fluoride toothpastes on the prevention of dental caries in the primary dentition of preschool children

Community Dentistry And Oral Epidemiology ◽

10.1111/j.1600-0528.2012.00708.x ◽

2012 ◽

Vol 41 (1) ◽

pp. 1-12 ◽

Cited By ~ 55

Author(s):

Ana Paula Pires dos Santos ◽

Paulo Nadanovsky ◽

Branca Heloisa de Oliveira

Keyword(s):

Systematic Review ◽

Preschool Children ◽

Dental Caries ◽

Meta Analysis ◽

Primary Dentition

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Genetic Association ofMMP10,MMP14, andMMP16with Dental Caries

International Journal of Dentistry ◽

10.1155/2017/8465125 ◽

2017 ◽

Vol 2017 ◽

pp. 1-7 ◽

Cited By ~ 5

Author(s):

D. D. Lewis ◽

J. R. Shaffer ◽

E. Feingold ◽

M. Cooper ◽

M. M. Vanyukov ◽

...

Keyword(s):

Dental Caries ◽

Genome Wide Association Study ◽

Meta Analysis ◽

Extracellular Proteins ◽

Caries Experience ◽

Caries Risk ◽

Physiological Processes ◽

Genome Wide ◽

A Genome ◽

White Adults

Matrix metalloproteinases (MMPs), which degrade extracellular proteins as part of a variety of physiological processes, and their inhibitors have been implicated in the dental caries process. Here we investigated 28 genetic variants spanning theMMP10,MMP14, andMMP16genes to detect association with dental caries experience in 13 age- and race-stratified (n=3,587) samples from 6 parent studies. Analyses were performed separately for each sample, and results were combined across samples by meta-analysis. Two SNPs (rs2046315 and rs10429371) upstream ofMMP16were significantly associated with caries in an individual sample of white adults and via meta-analysis across 8 adult samples after gene-wise adjustment for multiple comparisons. Noteworthy is SNP rs2046315 (p=8.14×10-8) association with caries in white adults. This SNP was originally nominated in a genome-wide-association study (GWAS) of dental caries in a sample of white adults and yielded associations in a subsequent GWAS of surface level caries in white adults as well. Therefore, in our study, we were able to recapture the association between rs2046315 and dental caries in white adults. Although we did not strengthen evidence thatMMPs 10,14, and16influence caries risk,MMP16is still a likely candidate gene to pursue.

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Dental Caries, Developmental Defects of Enamel and Enamel Microhardness Associated with Genetic Polymorphisms in the RANK/RANKL/OPG System

Journal of Clinical Pediatric Dentistry ◽

10.17796/1053-4625-44.1.6 ◽

2020 ◽

Vol 44 (1) ◽

pp. 35-40

Author(s):

E Calvano Küchler ◽

C Maschietto Pucinelli ◽

K Carpio Horta ◽

R Assed Bezerra da Silva ◽

M de Castro Costa ◽

...

Keyword(s):

Dental Caries ◽

Genetic Polymorphisms ◽

Primary Dentition ◽

Caries Experience ◽

Chi Square ◽

Developmental Defects ◽

Allele Distribution ◽

Chain Reactions ◽

Significant Difference ◽

Developmental Defects Of Enamel

Purpose: Recent studies have suggested that disruptions in the RANKL/RANK/OPG system might be involved in enamel conditions. The aim of this study was to test whether genetic polymorphisms in RANK, RANKL and OPG are associated with dental caries, developmental defects of enamel (DDE) and enamel microhardness. Study design: Saliva samples were collected from two subsets for the purpose of genomic DNA extraction. In the first subset, composed of 248 children, dental caries and DDE were evaluated during their clinical examination. In the second subset, composed of 72 children, enamel samples from the buccal surface of primary teeth were used for enamel microhardness analysis. Genetic polymorphisms in RANK, RANKL and OPG were genotyped by real-time polymerase chain reactions in all samples from both populations. The chi-square test was used for dental caries and DDE analysis while, one-way ANOVA with Tukey's post-test was used for microhardness analysis. Hardy-Weinberg equilibrium was also calculated. The established alpha was 5%. Results: Caries experience analysis demonstrated a statistically-significant difference for OPG allele distribution in primary dentition (p=0.033). The studied polymorphisms in RANK, RANKL and OPG were not associated with DDE or enamel microhardness (p>0.05). Conclusion: The genetic polymorphism rs2073618 in OPG is associated with dental caries experience in primary dentition.

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Do Patients with Extrinsic Black Tooth Stains Have a Lower Dental Caries Experience? A Systematic Review and Meta-Analysis

Caries Research ◽

10.1159/000500476 ◽

2019 ◽

Vol 53 (6) ◽

pp. 617-627 ◽

Cited By ~ 1

Author(s):

Vanessa Silva de Rezende ◽

Thiago Fonseca-Silva ◽

Clarissa Lopes Drumond ◽

Maria Letícia Ramos-Jorge ◽

Saul Martins Paiva ◽

...

Keyword(s):

Systematic Review ◽

Dental Caries ◽

Protective Factor ◽

Meta Analysis ◽

Scientific Evidence ◽

Research Question ◽

Caries Experience ◽

Eligibility Criteria ◽

Cross Sectional ◽

Newcastle Ottawa Scale

Studies have suggested that individuals affected by extrinsic black tooth stains have less dental caries experience in comparison to those without this condition. The aim of the present study was to perform a systematic review and meta-analysis to determine whether there is scientific evidence demonstrating that extrinsic black stains are a protective factor for the occurrence of dental caries. This systematic review was developed in accordance with the PRISMA statement and the research question was determined using the PECO strategy. Electronic searches were conducted in the PubMed, Science Direct, Virtual Health Library, Cochrane, Web of Science, and Google Scholar databases for relevant articles published up to September 2018. All articles included were submitted to an appraisal of methodological quality using the Newcastle-Ottawa Scale and the data were extracted for meta-analysis. The search strategy resulted in the retrieval of 9,108 publications. After the application of the eligibility criteria, 18 articles were selected for analysis, 13 of which were included in the meta-analysis. The meta-analysis demonstrated that individuals with extrinsic black stains involving primary (median, MD: –0.78 [–1.09; –0.48]; I2 = 44%) and permanent (MD: –0.50 [–0.93; –0.08]; I2 = 86%) teeth have a lower dental caries experience in comparison to those without this condition. Patients with extrinsic black tooth stains have a lower dental caries experience in cross-sectional studies.

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