Changes in Profiles of Kawasaki Disease Noted over Time in Suzhou, China

Cardiology ◽  
2018 ◽  
Vol 141 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Ling Sun ◽  
Yunjia Tang ◽  
Ye Wang ◽  
Guanghui Qian ◽  
Wenhua Yan ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Large Scale ◽  
Disease Onset ◽  
Cervical Lymphadenopathy ◽  
Incidence Rates ◽  
Female Ratio ◽  
Reactive Protein ◽  
Immunoglobulin Treatment ◽  
Time Of Admission ◽  
Male To Female

Objectives: The purpose of the present study was to explore the changes in epidemiological, clinical and laboratory characteristics of Kawasaki disease (KD) over a 12-year period in this area. Methods: The medical records of KD patients hospitalized in the Children’s Hospital of Soochow University from January 2006 to December 2017 were retrospectively reviewed and analyzed. To elucidate the changes more clearly in these years, we divided all patients into three groups according to the time of admission, 5-year time intervals apart. Results: We found the number of KD had increased in recent years, although the age compositions had some variances. The male-to-female ratio peaked in patients aged 6–11 months and then decreased with ages. Incidence rates of clinical characteristics were almost the same except for cervical lymphadenopathy. Significant differences were noted in percentage of neutrophils, albumin, C-reactive protein, erythrocyte sedimentation rate (ESR) and platelets. However, only ESR and platelets were significantly different after adjusting the days of disease onset. A trend showing a shorter fever duration before intravenous immunoglobulin treatment was also noted. Conclusions: The number of KD was increasing annually. Our results were indicative of a possibly changed etiology of the disease. However, further large-scale long-term surveillance is warranted.

Epidemiologic Pictures of Kawasaki Disease in Japan: From the Nationwide Incidence Survey in 1991 and 1992

PEDIATRICS ◽  
1995 ◽  
Vol 95 (4) ◽  
pp. 475-479 ◽  
Author(s):  
Hiroshi Yanagawa ◽  
Mayumi Yashiro ◽  
Yosikazu Nakamura ◽  
Tomisaku Kawasaki ◽  
Hirohisa Kato
Keyword(s):  
Kawasaki Disease ◽  
Disease Onset ◽  
Incidence Rates ◽  
Descriptive Epidemiology ◽  
Female Ratio ◽  
Number Of Patients ◽  
Yearly Incidence ◽  
Male Female Ratio ◽  
History Of ◽  
Questionnaire Form

Objective. Since 1970, twelve nationwide epidemiologic surveys of Kawasaki disease (KD) have been conducted throughout Japan every two years to describe KD in Japan. By the end of 1992, a total of 116 848 cases were reported. This paper summarizes the statistical analysis of the latest survey for the 2-year period from January 1991 through December 1992. Method. A questionnaire form and diagnostic guidelines for KD were sent to all pediatric departments of hospitals with 100 or more beds throughout Japan and information was obtained on patients with KD diagnosed during the 2-year period from January 1991 through December 1992. Results. The summary of the results is: 1) the number of patients reported was 11 221 (6604 males and 4617 females; male/female ratio = 1.43) with a yearly incidence rate of 90 per 100 000 children <5 years old; 2) the monthly number of patients was higher in winter and summer, although the monthly difference was not marked; 3) age-specific incidence rates showed a unimodal peak at 1 year of age; 4) the proportion of patients with a family history of KD in a sibling was 1%; 5) the proportion of recurrent patients was 3%; 6) the proportion of patients with cardiac sequelae 1 month after disease onset was 13%; and 7) the number of patients who died was 9, which conforms to 0.08% of total patients. Conclusion. The incidence rates of KD in Japan are ten times higher than those reported in western countries and almost constant over 6 years. The descriptive epidemiology of the disease, which supports the infection theory, does not change for years.

Nationwide Survey on Kawasaki Disease in Japan

PEDIATRICS ◽  
1987 ◽  
Vol 80 (1) ◽  
pp. 58-62 ◽  
Author(s):  
Hiroshi Yanagawa ◽  
Tomisaku Kawasaki ◽  
Itsuzo Shigematsu
Keyword(s):  
Statistical Analysis ◽  
Kawasaki Disease ◽  
Incidence Rate ◽  
Disease Onset ◽  
Nationwide Survey ◽  
Cumulative Number ◽  
Female Ratio ◽  
Number Of Patients ◽  
Male To Female ◽  
Sibling Cases

Results of the statistical analysis of a nationwide survey of patients with Kawasaki disease diagnosed within a 2-year 6-month period, from July 1982 to December 1984, are as follows. (1) The cumulative number of patients reported by the end of 1984 was 63,399 (36,891 boys and 26,508 girls; male to female ratio 1.4). (2) There were two epidemic years, 1979 and 1982, in which the numbers of patients were more than twofold that of the previous years. (3) A curve plotted for age-specific incidence rate showed a unimodal peak at age 1 year. (4) Steroid therapy was used for 6.3% of the patients, aspirin for 89.8%, antibiotics for 57.6%, and γ-globulin for 11.4%. (5) The proportion of sibling cases was 1.4% and that of recurrent cases was 3.9% of all cases reported. (6) The incidence of cardiac sequelae in 1 month after disease onset was 17.2%.

scholarly journals Estimation of HIV incidence in two Brazilian municipalities, 2013

2016 ◽  
Vol 50 (0) ◽  
Author(s):  
Célia Landmann Szwarcwald ◽  
Orlando da Costa Ferreira Júnior ◽  
Ana Maria de Brito ◽  
Karin Regina Luhm ◽  
Clea Elisa Lopes Ribeiro ◽  
...  
Keyword(s):  
Total Population ◽  
Hiv Infections ◽  
Incidence Rates ◽  
Hiv Incidence ◽  
Female Ratio ◽  
Exposure Category ◽  
Two Cities ◽  
Population Subgroup ◽  
Sex With Men ◽  
Male To Female

ABSTRACT OBJECTIVE To estimate HIV incidence in two Brazilian municipalities, Recife and Curitiba, in the year of 2013. METHODS The method for estimating incidence was based on primary information, resulting from the Lag-Avidity laboratory test for detection of recent HIV infections, applied in a sample of the cases diagnosed in the two cities in 2013. For the estimation of the HIV incidence for the total population of the cities, the recent infections detected in the research were annualized and weighted by the inverse of the probability of HIV testing in 2013 among the infected and not diagnosed cases. After estimating HIV incidence for the total population, the incidence rates were estimated by sex, age group, and exposure category. RESULTS In Recife, 902 individuals aged 13 years and older were diagnosed with HIV infection. From these, 528 were included in the study, and the estimated proportion of recent infections was 13.1%. In Curitiba, 1,013 people aged 13 years and older were diagnosed, 497 participated in the study, and the proportion of recent infections was 10.5%. In Recife, the estimated incidence rate was 53.1/100,000 inhabitants of 13 years and older, while in Curitiba, it was 41.1/100,000, with male-to-female ratio of 3.5 and 2.4, respectively. We observed high rates of HIV incidence among men who have sex with men, of 1.47% in Recife and 0.92% in Curitiba. CONCLUSIONS The results obtained in the two cities showed that the group of men who have sex with men are disproportionately subject to a greater risk of new infections, and indicate that strategies to control the spread of the epidemic in this population subgroup are essential and urgent.

scholarly journals Incidence of aplastic anemia in Bangkok. The Aplastic Anemia Study Group

Blood ◽  
1991 ◽  
Vol 77 (10) ◽  
pp. 2166-2168 ◽  
Author(s):  
S Issaragrisil ◽  
C Sriratanasatavorn ◽  
A Piankijagum ◽  
S Vannasaeng ◽  
Y Porapakkham ◽  
...  
Keyword(s):  
Aplastic Anemia ◽  
Age Groups ◽  
Incidence Rates ◽  
Annual Incidence ◽  
Study Group ◽  
European Studies ◽  
Female Ratio ◽  
Peak Rate ◽  
Male To Female

Abstract The annual incidence of aplastic anemia in metropolitan Bangkok, Thailand, and its five suburban provinces was prospectively determined. All patients first diagnosed during the period from January through December 1989 who met specific clinical and pathologic criteria were included. Thirty-two cases were identified, yielding an overall incidence of 3.7 per million. The incidence rates for the age groups 0 through 24, 25 through 59, and over 60 years were 4.3, 3.2, and 2.1 per million, respectively; the highest rate, 7.2 per million, was found for individuals aged 15 to 24 years. The male-to-female ratio was 1.9. The incidence of aplastic anemia in Bangkok is higher than that reported in recent European studies. The peak rate in young persons is almost fourfold higher than in comparable recent western studies and suggests an environmental etiology peculiar to Thailand.

Rate of Metabolic Syndrome Among Patients with Facial Acanthosis Nigricans

2019 ◽  
Vol 47 (2) ◽  
pp. 12-16
Author(s):  
Abida Sultana ◽  
Mohammed Saiful Islam Bhuiyan ◽  
Md Mostaque Mahmud
Keyword(s):  
Metabolic Syndrome ◽  
Large Scale ◽  
Acanthosis Nigricans ◽  
Serum Insulin ◽  
Venous Blood ◽  
Insulin Level ◽  
Type Ii Diabetes Mellitus ◽  
Female Ratio ◽  
Medical University ◽  
Male To Female

Facial acanthosis nigricans (FAN) is an ignored dermatological entity. Nowadays it occurs more frequently than previous days may be due to changing economic and social status of our country. Aim of this study was to assess the rate of metabolic syndrome in cases of facial acanthosis nigricans. This observational study was conducted in the outpatient department (OPD) of dermatology and Venereology of Bangabandhu Sheikh Mujib Medical University (BSMMU) in the year 2017 among thirty clinically diagnosed cases of FAN. After taking their informed written consent; BMI, random plasma glucose, fasting lipid profile and serum insulin level was estimated in venous blood and recorded accordingly. To confirm metabolic syndrome we followed NCEP ATP III guideline (2005) where 3 of 5 positive criteria confirmed the diagnosis. All data was preserved in a secured computer device and was analyzed with SPSS program with appropriate statistical tools. Mean (±SD) age of patients was 35.63 ± 14.26 years and male to female ratio was 1:1.14. The mean BMI of cases was 33.73±3. We found 11 cases with hypertension, 8 with type II diabetes mellitus and 9 with dyslipidemia. Among the 30 cases of FAN 12 zygomatic type, 8 generalized type and 5 had band like pigmentation on the forehead. Twenty-three patients had acanthosis nigricans on both sides of body. According to our preset criteria we found 26.66% cases had metabolic syndrome. The rate of metabolic syndrome is higher in facial acanthosis nigricans patients. A further large scale study is recommended for strengthening this study findings. Bangladesh Med J. 2018 May; 47 (2): 12-16

Abstract 76: Clinical Usefulness Of Serum Procalcionin Level In Kawasaki Disease Children.

Circulation ◽  
2015 ◽  
Vol 131 (suppl_2) ◽  
Author(s):  
Hee Joung Choi ◽  
Tae Chan Kwon
Keyword(s):  
Kawasaki Disease ◽  
Bacterial Infection ◽  
Viral Infection ◽  
Systemic Inflammation ◽  
Clinical Usefulness ◽  
C Reactive Protein ◽  
Acute Phase Reactants ◽  
Reactive Protein ◽  
Significant Difference ◽  
Immunoglobulin Treatment

Purpose: Procalcitonin (PCT) is one of acute phase reactants such as C-reactive protein (CRP), and is likely to elevate in systemic inflammation, especially bacterial infection. As we know, the CRP level rise in the patients with high fever including Kawasaki disease (KD) and bacterial infection. So we investigated the clinical usefulness of serum PCT level in Kawasaki disease (KD), which is a systemic inflammation caused by vasculitis. Method: From August 2013 to June 2014, a total 336 patients were studied serum PCT level during hospitalization. We enrolled 41 patients of KD, 83 patients with viral infection, and 21 patients with bacterial infection. Result: The patients with KD had significantly higher mean age (24.4±18.1 months), mean body weight (12.1±3.9 Kg), and mean duration of fever prior to admission (4.4±1.8 days) than other patients (p<0.05). The serum PCT level, white blood cell (WBC) and platelet count, neutrophil proportion, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) were significantly higher in KD patients than viral infection patients (p<0.05). Although not statistically significant, the serum PCT level was lower in KD patients than bacterial infection patients, whereas the CRP was higher in KD patients than bacterial infection patients. No significant difference in serum PCT level was showed between complete KD patients and incomplete KD patients. Also there was no significant difference in serum PCT level between responders to an initial intravenous immunoglobulin treatment and nonresponders. Conclusion: Serum PCT level may help to differentiate KD from viral infection, but we did not find a significant difference in PCT level between KD and bacterial infection. And the utility of PCT level as clinical marker in KD may be limited.

scholarly journals Lung cancer epidemiology in North Sardinia, Italy

2013 ◽  
Vol 8 ◽  
Author(s):  
Panagiotis Paliogiannis ◽  
Federico Attene ◽  
Antonio Cossu ◽  
Mario Budroni ◽  
Rosaria Cesaraccio ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Control Strategies ◽  
Relative Survival ◽  
Mortality Rates ◽  
Incidence Rates ◽  
Female Ratio ◽  
Increasing Trend ◽  
Smoking Control ◽  
Epidemiological Characteristics ◽  
Male To Female

Background: The aim of this study was to analyze and describe the epidemiological characteristics and trends of lung cancer in North Sardinia, Italy, in the period 1992–2010. Methods: Data were obtained from the tumor registry of Sassari province which is a part of a wider registry web, coordinated today by the Italian Association for Tumor Registries. Results: The overall number of lung cancer cases registered was 4,325. The male-to-female ratio was 4.6:1 and the mean age 68.1 years for males and 67 years for females. The standardized incidence rates were 73.1/100,000 and 13.5/100,000 and the standardized mortality rates 55.7/100,000 and 9.9/100,000 for males and females, respectively. An increasing trend in incidence of lung cancer in women was evidenced. Conversely, incidence was found to decrease in males. Relative survival at 5 years from diagnosis was low (8.8% for males and 14.9% for females). Furthermore, an increase in mortality rates was observed in both sexes in the period under investigation. Conclusions: Our data show an increasing trend of lung cancer incidence in women in North Sardinia in the last decades. Conversely, a reduction of incidence rates was observed in males. Furthermore, a slightly increasing trend in mortality rates was observed in both sexes, suggesting the need to enhance smoking control strategies, consider adoption of effective surveillance policies, and improve diagnosis and treatment methods.

scholarly journals Objective findings in patients with multi-canal benign paroxysmal positional vertigo

2021 ◽  
pp. 014556132110666
Author(s):  
Yanhan Zhu ◽  
Xiaoming He ◽  
Mei Hu ◽  
Chun Mao ◽  
Zheng Liu ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Benign Paroxysmal Positional Vertigo ◽  
Disease Onset ◽  
Vestibular Disorder ◽  
Female Ratio ◽  
Positional Vertigo ◽  
Significant Difference ◽  
Peripheral Vestibular Disorder ◽  
Male To Female ◽  
Paroxysmal Positional Vertigo

Objective The study aimed to investigate the clinical characteristics of patients with multi-canal benign paroxysmal positional vertigo (MC-BPPV). Methods We performed a retrospective analysis of 927 patients with BPPV who were admitted to our hospital between January 1, 2016 and December 31, 2019. The clinical data of all patients were collected. The Dix-Hallpike, straight head-hanging, and supine Roll tests were performed in all patients. The nystagmus was recorded using videonystagmography. The clinical characteristics of patients with MC-BPPV and single canal BPPV (SC-BPPV) was analyzed and compared. Results Among 927 patients included, 49 (5.29%) patients had MC-BPPV, 878 (94.71%) patients had SC-BPPV. There were significant differences in the male to female ratio (1:3.90 vs 1:1.81, P < .05), mean age (62.47±12.51 vs 59.04±13.72, P < .05), as well as the ratio of cupulolithiasis to canalithiasis (1:1.45 vs 1:4.78, P < .01) between patients with MC-BPPV and SC-BPPV. The frequency of involvement of PC, HC, and AC were involved for 66 (67.35%), 23 (23.47%), and 9 (9.18%) times, respectively, in patients with MC-BPPV, which were involved in 581 (66.17%), 281 (32.0%), and 16 (1.82%) patients, respectively, in patients with SC-BPPV. No significant difference was found in the frequency of involvement of PC and HC between patients with MC-BPPV and SC-BPPV, while there was significant difference in the frequency of AC involvement between 2 groups ( P < .01). Ipsilateral PC-HC-BPPV (n = 18) and bilateral PC-BPPV (n=19) were the most common among patients with MC-BPPV. Twenty-six (53.06%) patients had ipsilateral MC-BPPV, 23 (46.94%) had bilateral MC-BPPV. Of the 26 patients with ipsilateral MC-BPPV, 7 patients combined with unilateral peripheral vestibular disorder. Conclusion Patients with MC-BPPV had a significantly older mean age at disease onset and a higher proportion of females compared with patients with SC-BPPV. Cupulolithiasis was more common in MC-BPPV. AC involvement was also much more common in MC-BPPV than in SC-BPPV.

Abstract 3: Kawasaki Disease in Algerian Children: A Clinical Study

Circulation ◽  
2015 ◽  
Vol 131 (suppl_2) ◽  
Author(s):  
Houda Boudiaf ◽  
Moussa Achir
Keyword(s):  
Kawasaki Disease ◽  
Cervical Lymphadenopathy ◽  
Epidemiological Data ◽  
Coronary Intervention ◽  
Unknown Etiology ◽  
Cardiac Complications ◽  
Tertiary Referral Hospital ◽  
Coronary Abnormalities ◽  
Coronary Aneurysms ◽  
Immunoglobulin Treatment

Background: Kawasaki disease (KD) is an acute multisystem vasculitis of unknown etiology that occurs predominantly in infants and young children. The incidence of KD is increasing worldwide ; however the epidemiological data available for Algerian patients remains insufficient Objective: To describe the demographic, clinical, and laboratory features of Algerian children with KD and to highlight the practical difficulties. Methods: This retrospective study included children admitted with Kawasaki disease at the only pediatric tertiary referral hospital in Algiers over a period of 8 years from January 2006 to December 2013. Results : 108 patients with KD, with a mean age of 31 months (range: 8-84 months)were identified. There were 63 boys and 45 girls (sex ratio: 1.4). The clinical data were similar to previously described studies, with some difference: the cervical lymphadenopathy was less frequent :25%(27/108). 22%( 24/108) of children had evidence of cardiac complications: 20%( 22/108) had coronary artery abnormalities ; one child had mitral regurgitation, one had pericardial effusion. Of the 22 children with coronary abnormalities , 9 had coronary dilatation, 13 had coronary aneurysms (10 small and medium, 3 giant). These abnormalities regressed in 13 cases on follow up. During this period, catheter and surgical coronary intervention were performed to treat coronary ischemia in one patient, two years after onset. The only independent variable for prediction of coronary involvement was fever duration at the time of initial presentation(p=0.016). The therapeutic used in this study included an immunoglobulin treatment for only 63%(69/108) of the children, half of which received it within the first ten days of the onset of the disease. Conclusion: This work demonstrates the necessity of a registry that will allow better appreciation of the incidence of this disease and improve the diagnosis and treatment of KD in Algeria

CLINICAL, PARACLINICAL FEATURES AND TREATMENT RESULT OF KAWASAKI DISEASE AT&NBSP; PEDIATRICS CENTER AT&NBSP; HUE CENTRAL HOSPITAL

2017 ◽  
pp. 30-35
Author(s):  
Hung Viet Phan ◽  
Ngoc Minh Chau Nguyen
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
Clinical Manifestations ◽  
Cervical Lymphadenopathy ◽  
Treatment Result ◽  
High Dose ◽  
Central Hospital ◽  
Key Words Kawasaki Disease ◽  
Immunoglobulin Treatment ◽  
Serum Crp

Objectives: To describe clinical and paraclinical features and treatment result of Kawasaki disease. Methods: The study is based on 34 children with Kawasaki disease treated at the Pediatric center of Hue Central Hospital from 1/2012-6/2013. Clinical examination, subclinical tests were done for each child at the time of diagnosis and every week after treatment. Results: 100% of children were under 5 years old, in which boys were more than girls, and 47.1% of patients lived in Hue. 100% of patients had fever over 5 days, bilateral conjunctivitis, changes in the mouth mucosa, changes in the peripheral extremities and rash. 41.2% of patients had cervical lymphadenopathy. Paraclinical manifestations were notably with 100% of patients had leukocytosis, 70.6% of patients had serum CRP levels > 30 mg/l, 55.9% of patients had ESR > 60 mm in first hour, 29.4% of patients had thrombocytosis over 500.000/mm3 at the time of positive diagnostic. 32.4% of patients had coronary artery lesions, 5.8% of patients had mitral regurgitation and pericardial effusion. 87.5% of patients had favorable progression after treatment with 1 single dose of gammaglobulin 2 g/kg. 12.5% of patients require treatment with second dose gammaglobulin. Conclusion: Kawasaki disease is very common in children <5 years old, the rate of coronary artery lesion is very high 32.4%. Favorable progression after treatment with high-dose gamaglobulin. Key words: Kawasaki disease, clinical manifestations; intravenous immunoglobulin treatment

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