Rate of Metabolic Syndrome Among Patients with Facial Acanthosis Nigricans

2019 ◽  
Vol 47 (2) ◽  
pp. 12-16
Author(s):  
Abida Sultana ◽  
Mohammed Saiful Islam Bhuiyan ◽  
Md Mostaque Mahmud
Keyword(s):  
Metabolic Syndrome ◽  
Large Scale ◽  
Acanthosis Nigricans ◽  
Serum Insulin ◽  
Venous Blood ◽  
Insulin Level ◽  
Type Ii Diabetes Mellitus ◽  
Female Ratio ◽  
Medical University ◽  
Male To Female

Facial acanthosis nigricans (FAN) is an ignored dermatological entity. Nowadays it occurs more frequently than previous days may be due to changing economic and social status of our country. Aim of this study was to assess the rate of metabolic syndrome in cases of facial acanthosis nigricans. This observational study was conducted in the outpatient department (OPD) of dermatology and Venereology of Bangabandhu Sheikh Mujib Medical University (BSMMU) in the year 2017 among thirty clinically diagnosed cases of FAN. After taking their informed written consent; BMI, random plasma glucose, fasting lipid profile and serum insulin level was estimated in venous blood and recorded accordingly. To confirm metabolic syndrome we followed NCEP ATP III guideline (2005) where 3 of 5 positive criteria confirmed the diagnosis. All data was preserved in a secured computer device and was analyzed with SPSS program with appropriate statistical tools. Mean (±SD) age of patients was 35.63 ± 14.26 years and male to female ratio was 1:1.14. The mean BMI of cases was 33.73±3. We found 11 cases with hypertension, 8 with type II diabetes mellitus and 9 with dyslipidemia. Among the 30 cases of FAN 12 zygomatic type, 8 generalized type and 5 had band like pigmentation on the forehead. Twenty-three patients had acanthosis nigricans on both sides of body. According to our preset criteria we found 26.66% cases had metabolic syndrome. The rate of metabolic syndrome is higher in facial acanthosis nigricans patients. A further large scale study is recommended for strengthening this study findings. Bangladesh Med J. 2018 May; 47 (2): 12-16

scholarly journals ACANTHOSIS NIGRICANS: A MARKER PREDICTING METABOLIC SYNDROME AMONG ADOLESCENTS AND ADULTS

2020 ◽  
pp. 1-4
Author(s):  
B. Shravya ◽  
P. Vidyasagar ◽  
Chinnapu Reddy
Keyword(s):  
Metabolic Syndrome ◽  
Selection Criteria ◽  
Acanthosis Nigricans ◽  
Hdl Cholesterol ◽  
Early Screening ◽  
Female Ratio ◽  
Adolescents And Adults ◽  
Low Hdl ◽  
Study Population ◽  
Male To Female

Introduction: Metabolic syndrome is a cluster of metabolic risk factors which includes central obesity, glucose intolerance, hyperinsulinemia, low HDL cholesterol, high triglycerides and hypertension. Acanthosis nigricans, the principal abnormality in metabolic syndrome (MetS), is an easily identifiable asymptomatic non-specific reaction pattern of skin characterized by thickened, hyperpigmented plaques associated with hyperinsulinemia. Aims and Objectives: To determine the prevalence of metabolic syndrome and AN in adolescent and adults and the association between benign acquired AN and metabolic syndrome. Materials and Methods: A sample of 40 patients selected from Dermatology outpatient department who satisfied the selection criteria to evaluate the prevalence of AN and its association with insulin resistance and the clustering of the MetS components. Epidemiological, clinical and anthropometric characteristics (height, weight, waist circumference) were measured and BMI was calculated. We used the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria for the diagnosis of metabolic syndrome. Results: The average age of the study population was 26.8 years, with male to female ratio of 1:1. The prevalence of acanthosis nigricans among females is greater than males, which also showed a positive correlation with increase in the age. BMI was higher in patients with metabolic syndrome than the patients without metabolic syndrome.There was a statistically significant correlation of increasing incidence of AN with each component of metabolic syndrome. Conclusion: There is an increased prevalence of MetS in the individuals with AN which was statistically highly significant. Hence, early screening of a simple clinical marker like AN is helpful in identification of MetS components.

scholarly journals Effectiveness of Liraglutide in Type II Diabetes Mellitus Management: Experience in Emirati Patients

2015 ◽  
Vol 8 ◽  
pp. CMED.S31756 ◽  
Author(s):  
Nasrullah K. Ghuman ◽  
Loai M. Saadah ◽  
Majdi S. Al Najjar ◽  
Duha Y. Shaheen ◽  
Shady I. AM ◽  
...  
Keyword(s):  
Standard Form ◽  
Type Ii Diabetes Mellitus ◽  
Military Hospital ◽  
Patient Visit ◽  
Female Ratio ◽  
P Values ◽  
Patients Âgés ◽  
Male To Female ◽  
Univariate Analyses

Objective To measure effectiveness of liraglutide in reducing glycated hemoglobin (HbA1C), weight, and systolic blood pressure (SBP) in Emirati patients. Design A retrospective cohort study. Setting Endocrinology clinic in a 300-bed military hospital. Patients A total of 152 patients who qualified for liraglutide between September 21, 2012, (first patient visit) and May 5, 2014 (last patient visit). Methods Team collected demographic and clinical data using a standard form. Data keeper performed univariate analyses to measure the effect of liraglutide in reducing the three outcomes of interest; namely, HbA1C, weight, and SBP. Results One hundred patients had at least the first visit in the clinic and 98 patients came for a second follow-up visit while on the medication. Adherence of clinicians to the internal criteria for prescribing liraglutide was 92%. Patients' ages were 47.9 ± 11.7 years. Male-to-female ratio was almost 1:1. Overall, in the paired analyses, HbA1C decreased from first to second visits (8.7 ± 1.9 vs. 7.6 ± 1.8, P < 0.0001) and remained unchanged in subsequent visits (eg, in visit 3, HbA1C was 7.4 ± 1.8). Patients lost an average of 1.3 kg between the first and second visits (99.3 ± 19.3 vs. 98.0 ± 19.5, P = 0.0003). The reduction in SBP between visits 1 and 2 was less (130.9 ± 15.8 vs. 129.9 ± 16.5, P = 0.5896). ANOVA yielded a significant reduction in HbA1C at 4 months and 6 months ( P values < 0.05). SBP dropped by about 3.6 mmHg and weight by about 2.3 kg ( P values > 0.05). Conclusions Liraglutide is effective in reducing HbA1C, weight, and to a lesser extent, SBP in Emirati patients.

scholarly journals Study of obstructive jaundice in adult: association between clinical diagnosis and operative "ndings

2019 ◽  
Vol 47 (1) ◽  
pp. 33-36
Author(s):  
Mohammad Golam Masum ◽  
ABM Sarwar Jahan ◽  
Md Rezwanul Haque Robbani ◽  
Fayed Chowdhuray ◽  
Mohammed Faroque Hossain
Keyword(s):  
Obstructive Jaundice ◽  
Clinical Diagnosis ◽  
Pancreatic Head ◽  
Serum Bilirubin Level ◽  
Female Ratio ◽  
Head Of The Pancreas ◽  
Average Rise ◽  
Operative Findings ◽  
Medical University ◽  
Male To Female

Obstructive jaundice is a condition in which there is blockage of the flow of bile out of the liver. To find out the correlation between clinical diagnosis and operative findings of patients having obstructive jaundice. This prospective observational study was conducted at the Department of Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka from January 2008 to April 2009. Fifty clinically diagnosed obstructive jaundice cases were enrolled in this study. A detailed history was taken and thorough physical examination was done. Also necessary haematological, biochemical, radiological and other special investigations were carried out.  In this study, mean age of the patients was 42.9 years and male to female ratio was 1:1.17. The most frequent cause was choledocholithiasis (40%), stricture of CBD (6.0%), retained stone (14.0%), parasitic obstruction (4.0%), carcinoma (30.0%) and other cause (6.0%). Serum bilirubin level was below 10mg/dl in all cases of stricture of CBD. It was above 15mg/dL in cases of carcinoma head of the pancreas. The rise of Serum alkaline phosphates level was up to 3 folds in cases with choledocholithiasis, biliary stricture and pancreatic head malignancy. The average rise in other cases was 1 to 2 folds. Sensitivity and specificity of pre operative clinical diagnosis of choledocholithiasis, carcinoma and retain stone was 86.4 & 96.4%, 92.3 & 91.9% and 71.4 & 95.3% respectively. Pre operative clinical diagnosis of obstructive jaundice is a good diagnosis tool in diagnosis of causes of obstructive jaundice. Bangladesh Med J. 2018 Jan; 47 (1): 33-36

scholarly journals Effects of Griseofulvin in the Treatment of Lichen Planus -A Study in BSMMU

1970 ◽  
Vol 6 (2) ◽  
pp. 86-88
Author(s):  
KG Sen ◽  
RM Hira ◽  
AZMM Islam ◽  
SK Sarker ◽  
MN Sarker ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Complete Response ◽  
Oral Lesion ◽  
Therapeutic Trial ◽  
Inflammatory Disorder ◽  
Oral Lesions ◽  
Female Ratio ◽  
Moderate Improvement ◽  
Medical University ◽  
Male To Female

Lichen Planus (LP) is an inflammatory disorder of skin, mucous membranes, nails and hair. There are various modalities of treatment but none is curative. This prospective therapeutic trial was done among patients with lichen planus at the outpatient department of Dermatology & Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka between November 2001 and April 2002. Total 20 patients were taken of them 12 were male and 8 were female with male to female ratio 3:2. Age of the patients was between 10 to 50 years. Patients were diagnosed clinically & confirmed histologically. They were treated with griseofulvin 500 mg daily for 6 months. Out of 20 patients, 8 had only oral lesions, of them 2 (25%) showed complete response, 3(37.5%) showed moderate improvement and 4 (37.5%) showed no response. Other 12 patients had lichen planus involving skin without oral mucosa, of them 4 (33.3%) showed moderate improvement, 4 (33.3%) showed no response and 4 (33.3%) patients worsens with treatment. So, success in patients with cutaneous lichen planus is less likely; however, griseofulvin may afford relief in selected patients with oral lesion. This study indicates that further prospective placebo controlled studies are needed to clarify the efficacy of griseofulvin in lichen planus. Key words: Lichen planus; Griseofulvin DOI: http://dx.doi.org/10.3329/fmcj.v6i2.9207 FMCJ 2011; 6(2): 86-88

scholarly journals Clinicopathological Profile of Rhabdomyosarcoma in Children

2012 ◽  
Vol 30 (3) ◽  
pp. 132-136
Author(s):  
Umme Habiba Begum ◽  
Afiqul Islam
Keyword(s):  
Head And Neck ◽  
Neck Region ◽  
Mass Lesion ◽  
Female Ratio ◽  
Head And Neck Region ◽  
Clinicopathological Profile ◽  
Common Clinical Presentation ◽  
The Common ◽  
Medical University ◽  
Male To Female

Objectives: To describe the clinical profile as well as  histopathological sub-types of Rhabdomyosarcoma in  children.Methods: A hospital base prospective observational study  was conducted among 20 diagnosed cases of  Rhabdomyosarcoma in children, those attending in  Hemato-Oncology department of Bangabandhu Sheikh  Mujib Medical University (BSMMU), Dhaka in the period  between January to December 2009.Results: The peak incidence of Rhabdomyosarcoma was  in 1-5 years of age group (n=9, 45%) with mean age 6.83  years with male to female ratio 5.66:1. The common sites  of primary tumor was in head and neck region (40%, n=08),  followed by genito-urinary tract, 30% (n=06), extremities  20% (n=04), trunk 10% (n=02). The most common clinical  presentation was mass lesion 100% (n=20), followed by local  pain 25% (n=05), urinary obstructions 15% (n=03)  dysphagia, chronic otorrhea, dysuria, haematuria, and  proptoses were 10% each (n=02, each); The histological  sub-types were Embryonal 60% (n=12), alveolar 30% (n=6),  and Botryoid 10% (n=02); Of Embryonal variety in head  and neck region 58.33% (n=7), and Genito-urinary sites  41.67% (n=5); of Alveolar variety in trunk 66.67% (n=4),  and in extremities33.33% (n=2), of Botryoid sub-type  frequency was equal in head - neck region and genitourinary  site 50% each (n=1).Conclusion: Children with Rhabdomyosarcoma presented mostly in 1 to 5 years of age, with mass lesion (100%),  predominantly in head and neck region (40%) and the  commonest histological sub-type was Embryonal variety  (60%). DOI: http://dx.doi.org/10.3329/jbcps.v30i3.12461 J Bangladesh Coll Phys Surg 2012; 30: 132-136

An audit of foeticide, neonaticide and infanticide: A retrospective study in the Department of Forensic Medicine, King Edward Medical University, Lahore

2022 ◽  
pp. 002581722110381
Author(s):  
Qasim Mehmood ◽  
Fatima Yasin ◽  
Arif Rasheed Malik
Keyword(s):  
Mental Illness ◽  
Retrospective Study ◽  
Head Injury ◽  
First Year ◽  
Female Ratio ◽  
Causative Factors ◽  
Socioeconomic Stress ◽  
First Year Of Life ◽  
Medical University ◽  
Male To Female

The deliberate killing of a foetus in the womb, or a child from the first 24 h of birth to one month of age, or within the first year of life, is called foeticide, neonaticide and infanticide, respectively. Socioeconomic stress, mental illness, gender selection, shame or fear of punishment of adultery or illegitimacy, grudge and jealousy with parents and negligent delivery by dai are major causative factors in such cases. This is a retrospective, descriptive, observational study, and the sample pool consisted of 35 cases. Foeticide cases were 42.9% of the total and the same percentage of cases were neonaticides, while 14.3% of cases were of infanticide. The male-to-female ratio was 1.26:1 and the major cause of death was head injury. The study shows a prevalence of foeticide and neonaticide as compared to infanticide. It also displays the prevalence of males in overall cases and a higher number of unknown cases in our setting.

Pattern of dermatophyte in Bangabandhu Sheikh Mujib Medical University

2012 ◽  
Vol 6 (2) ◽  
pp. 11-14 ◽  
Author(s):  
Mst. Rummana Rahim ◽  
Ahmed Abu Saleh ◽  
Md. Ruhul Amin Miah ◽  
Shaheda Anwar ◽  
Md. Muzibur Rahman
Keyword(s):  
Trichophyton Rubrum ◽  
Trichophyton Mentagrophytes ◽  
Age Group ◽  
Female Ratio ◽  
Epidermophyton Floccosum ◽  
Tinea Unguium ◽  
Medical University ◽  
Male To Female ◽  
Dermatophyte Species ◽  
Culture Positive

Dermatophytes are by far the most significant fungi because of their widespread involvement of population at large and their prevalence all over the world. This is an attempt to observe the spectrum of dermatophytes among the clinically suspected cases of dermatophytosis attending the outpatient department of Dermatology and Venereology, Bangabandhu Sheik Mujib Medical University, Dhaka. Three hundred and twenty clinically suspected cases of dermatophytosis were subjected to mycological studies. One hundred and five cases (32.8%) were positive for fungus in direct microscopy while 97(30.3%) were culture positive. Tinea unguium was the most common clinical type encountered followed by tinea corporis. Dermatophytosis was more common in the age group of 21-30 years. The male to female ratio was 1.54:1. Trichophyton rubrum 84(86.6%) was found common etiological dermatophyte species followed by Trichophyton mentagrophytes 8(8.2%) and Epidermophyton floccosum 5(5.2%).DOI: http://dx.doi.org/10.3329/bjmm.v6i2.19370 Bangladesh J Med Microbiol 2012; 06(02): 11-14

scholarly journals Pengaruh yoghurt dan soyghurt kayu manis (Cinnamomum burmannii) terhadap kadar glukosa darah, insulin serum, dan malondialdehyde tikus pra sindrom metabolik

2020 ◽  
Vol 8 (1) ◽  
pp. 60
Author(s):  
Ninik Rustanti ◽  
Vifin Zakiahtin Nafsih ◽  
Rosita Nur Avisha ◽  
Dewi Marfu’ah Kurniawati ◽  
Rachma Purwanti ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Blood Glucose ◽  
Cell Damage ◽  
Serum Insulin ◽  
Fasting Blood Glucose ◽  
Insulin Level ◽  
Control Group ◽  
Sprague Dawley ◽  
Control Group Design ◽  
The Difference

Background: Pre metabolic syndrome is characterized by two of five risk factors: central obesity, dyslipidemia, hypertension, and increased fasting blood glucose. Cinnamon yogurt and soygurt contain antioxidants and fiber which can improve insulin sensitivity and blood glucose homeostasis and prevent cell damage in pre-metabolic syndrome conditionsObjective: This study aimed to determine the effect of cinnamon yogurt and soygurt on fasting blood glucose (FBG), serum insulin, and malondialdehyde (MDA) levels in pre-metabolic syndrome rats.Method: This study was an experimental study with a pre and post-test control group design. The subjects were 15 male Sprague Dawley rats which were divided into 5 normal control mice (K) and 10 pre metabolic syndrome mice with a diet high in fat and fructose for group P1 (yogurt) and P2 (soygurt) each of 5 mice. The yogurt and soygurt were given as much as 3.4 ml / g BW for 28 days. FBG levels were measured by the GOD-PAP method, while serum insulin and MDA levels were by the ELISA method. Different tests before and after treatment using Paired t-test or Wilcoxon. The difference tests between groups using the One-Way ANOVA test or Kruskal Wallis.Results: There were no differences in FBG and MDA levels between groups after intervention (p> 0.05). The highest percentage reduction in FBG in the P2 (-11.59%), then P1 (-4.06%). The decrease in MDA levels in group P1 = 19.17%, and P2 = 15.44% lower than K = 24.43%. After the intervention, the insulin level in group P2 (0.46 ng / ml) was significantly higher than P1 (0.318 ng/ml), but both were not different from K (0.384 ng / ml).Conclusion: There was no significant effect on the administration of cinnamon yogurt and soygurt to FBG, serum insulin, and MDA levels.

scholarly journals Exxtraintestinal Manifestations of Crohn's Disease in Bangladesh

2013 ◽  
Vol 21 (2) ◽  
pp. 58-59
Author(s):  
Rajib Barua ◽  
Dewan Saifuddin Ahmed ◽  
ASMA Raihan ◽  
Mohammad Abul Kalam Azad ◽  
Sadesh Kumar Chakrovortty ◽  
...  
Keyword(s):  
Early Recognition ◽  
Individual Case ◽  
Asia Pacific ◽  
Aphthous Ulcer ◽  
Extraintestinal Manifestations ◽  
Extraintestinal Manifestation ◽  
Female Ratio ◽  
Important Differential Diagnosis ◽  
Medical University ◽  
Male To Female

Crohn’s disease has been considered to be uncommon in Asia Pacific region The study was undertaken to know the extraintestinal manifestations of Crohn’s disease in Bangladesh and to compare the result with that of other Asian and Western countries. This was an observational study consisting of patients seen in the department of gastroenterology, Bangabandhu Sheikh Mujib Medical University for 20 years (between 1991 and 2010). Individual case records were carefully reviewed with regard to gender, sex and extraintestinal manifestations. A total of 41 patients with Crohn’s disease were identified. 70.7% were male and 29.3% were female with male to female ratio was 2.4:1. Mean age was 34±11.8 years and peak age group was 21-30 years. The chief extraintestinal manifestations were arthritis, aphthous ulcer in the oral cavity, erythema nodosum and episcleritis. Arthritis was the most frequent among the extraintestinal manifestations. So, Crohn’s disease should be considered as an important differential diagnosis when a patient presents with bowel symptoms associated with extraintestinal manifestation and thus early recognition and treatment could be possible. DOI: http://dx.doi.org/10.3329/bjmed.v21i2.13611 Bangladesh J Medicine 2010; 21: 58-59

scholarly journals Clinical and Socio-Demographic Pattern of Beta Thalassaemia in Bangladesh

2020 ◽  
Vol 4 (1) ◽  
pp. 3-7
Author(s):  
Adnan Hasan Masud ◽  
Md. Kamrul Hasan ◽  
Saradindu Kanti Sinha ◽  
Kazi Mohammad Kamrul Islam ◽  
Md. Jalilur Rahman
Keyword(s):  
Tertiary Care ◽  
Cross Sectional ◽  
Female Ratio ◽  
Beta Thalassaemia ◽  
The Mean ◽  
Almost All ◽  
Hb Concentration ◽  
Medical University ◽  
Tertiary Care Hospitals ◽  
Male To Female

Beta thalassaemia is one of the most prevalent haemolytic disorders worldwide which poses serious economic burden to the society. Study on clinical and demographic pattern of this disorder will help the concern authorities to figure out the problem. This cross-sectional descriptive study was carried out to determine the socio-demographic and clinical characteristics as well as to find out the existence of other co-morbidities among the ?-thalassaemic patients (n-101). The study was carried out at the Department of Haematology, Bangabandhu Sheikh Mujib Medical University (BSMMU) from June 2010 to January 2011. Data were collected from 3 tertiary care hospitals of Dhaka city. Almost all the patients were young, age ranged from 10 to 32 years with the mean age of 16. Male to female ratio was almost equal (52.5:47.5) and 80% of the respondents were Muslims. Forty-five (45%) percent of patients were illiterate and 37% respondents had primary education only. Almost 90% were unmarried and majority had a family of 6-8 members. Forty-seven percent (47%) of patients had monthly income 5000-7000 BDT and 56% of the respondents were unemployed. The major clinical features were pallor (72.3%), palpitation (60%), and breathlessness (52.5%). The haemoglobin (Hb) concentration ranged from 7gm/dl to 12gm/dl and 57% patients had an Hb concentration of 8 gm/dl. Sixty percent of the respondents had jaundice with majority had enlarged spleen (86%) and some had enlarged liver too (23%). Ninety percent (90%) respondents had co-morbidities among which arrhythmia is more prevalent (54%).

Sign in / Sign up

Export Citation Format

Share Document