scholarly journals Visual Analysis of Biomarkers Reveals Differences in Lipid Profiles and Liver Enzymes before and after Gastric Sleeve and Bypass

Obesity Facts ◽  
2021 ◽  
pp. 1-11
Author(s):  
Marijn Marthe Georgine van Berckel ◽  
Saskia L.M. van Loon ◽  
Arjen-Kars Boer ◽  
Volkher Scharnhorst ◽  
Simon W. Nienhuijs

<b><i>Introduction:</i></b> Bariatric surgery results in both intentional and unintentional metabolic changes. In a high-volume bariatric center, extensive laboratory panels are used to monitor these changes pre- and postoperatively. Consecutive measurements of relevant biochemical markers allow exploration of the health state of bariatric patients and comparison of different patient groups. <b><i>Objective:</i></b> The objective of this study is to compare biomarker distributions over time between 2 common bariatric procedures, i.e., sleeve gastrectomy (SG) and gastric bypass (RYGB), using visual analytics. <b><i>Methods:</i></b> Both pre- and postsurgical (6, 12, and 24 months) data of all patients who underwent primary bariatric surgery were collected retrospectively. The distribution and evolution of different biochemical markers were compared before and after surgery using asymmetric beanplots in order to evaluate the effect of primary SG and RYGB. A beanplot is an alternative to the boxplot that allows an easy and thorough visual comparison of univariate data. <b><i>Results:</i></b> In total, 1,237 patients (659 SG and 578 RYGB) were included. The sleeve and bypass groups were comparable in terms of age and the prevalence of comorbidities. The mean presurgical BMI and the percentage of males were higher in the sleeve group. The effect of surgery on lowering of glycated hemoglobin was similar for both surgery types. After RYGB surgery, the decrease in the cholesterol concentration was larger than after SG. The enzymatic activity of aspartate aminotransferase, alanine aminotransferase, and alkaline phosphate in sleeve patients was higher presurgically but lower postsurgically compared to bypass values. <b><i>Conclusions:</i></b> Beanplots allow intuitive visualization of population distributions. Analysis of this large population-based data set using beanplots suggests comparable efficacies of both types of surgery in reducing diabetes. RYGB surgery reduced dyslipidemia more effectively than SG. The trend toward a larger decrease in liver enzyme activities following SG is a subject for further investigation.

2016 ◽  
Vol 31 (1) ◽  
pp. 35-63 ◽  
Author(s):  
Kishore Singh ◽  
Peter Best

Purpose – The purpose of this paper is to demonstrate the technical feasibility of implementing multi-view visualization methods to assist auditors in reviewing the integrity of high-volume accounting transactions. Modern enterprise resource planning (ERP) systems record several thousands of transactions daily. This makes it difficult to find a few instances of anomalous activities among legitimate transactions. Although continuous auditing and continuous monitoring systems perform substantial analytics, they often produce lengthy reports that require painstaking post-analysis. Approaches that reduce the burden of excessive information are more likely to contribute to the overall effectiveness of the audit process. The authors address this issue by designing and testing the use of visualization methods to present information graphically, to assist auditors in detecting anomalous and potentially fraudulent accounts payable transactions. The strength of the authors ' approach is its capacity for discovery and recognition of new and unexpected insights. Design/methodology/approach – Data were obtained from the SAP enterprise (ERP) system of a real-world organization. A framework for performing visual analytics was developed and applied to the data to determine its usefulness and effectiveness in identifying anomalous activities. Findings – The paper provides valuable insights into understanding the use of different types of visualizations to effectively identify anomalous activities. Research limitations/implications – Because this study emphasizes asset misappropriation, generalizing these findings to other categories of fraud, such as accounts receivable, must be made with caution. Practical implications – This paper provides a framework for developing an automated visualization solution which may have implications in practice. Originality/value – This paper demonstrates the need to understand the effectiveness of visualizations in detecting accounting fraud. This is directly applicable to organizations investigating methods of improving fraud detection in their ERP systems.


2008 ◽  
Vol 4 (5) ◽  
pp. 647-650 ◽  
Author(s):  
Troy W. Ertelt ◽  
James E. Mitchell ◽  
Kathryn Lancaster ◽  
Ross D. Crosby ◽  
Kristine J. Steffen ◽  
...  

2019 ◽  
Vol 49 (1/2019) ◽  

Background and aims: Overweight and obese patients who undergo bariatric surgery require a rigorous clinical and paraclinical assessment both before and after the surgery at 3, 6, and 12 months.The present study aims the assessment of serum leptin levels and insulin resistance status in compliant bariatric patients to scheduled medical laboratory assessment at 6 months after surgery. Material and Method: The study included 109 eligible patients selected for bariatric surgery, 48 of whom attended the scheduled visit at 6 months after the surgery. Laboratory assessing regarded the insulin resistance by determining before meal the serum levels of leptin, glucose and insulin, as well as HOMA 1 and HOMA 2 indexes. Results: Patients who underwent bariatric treatment experienced a significant decrease in insulin resistance status. A higher percentage in the preoperative group was recorded in women, feature which was also recorded in the postoperative group that attended the scheduled visit at 6 months after surgery. Age is also an important factor that significantly influences the behavioral adherence to postoperative visits. Conclusions: Insulin resistance status improved significantly in 6 months after bariatric surgery among the fully compliant patients. The percentage of attendance at scheduled visits is higher among women, and decreases with age. Keywords: obesity surgery, leptin resistance, insulin resistance, HOMA index, compliance


GIS Business ◽  
2019 ◽  
Vol 14 (6) ◽  
pp. 96-104
Author(s):  
P. Sakthivel ◽  
S. Rajaswaminathan ◽  
R. Renuka ◽  
N. R.Vembu

This paper empirically discovered the inter-linkages between stock and crude oil prices before and after the subprime financial crisis 2008 by using Johansan co-integration and Granger causality techniques to explore both long and short- run relationships.  The whole data set of Nifty index, Nifty energy index, BSE Sensex, BSE energy index and oil prices are divided into two periods; before crisis (from February 15, 2005 to December31, 2007) and after crisis (from January 1, 2008 to December 31, 2018) are collected and analyzed. The results discovered that there is one-way causal relationship from crude oil prices to Nifty index, Nifty energy index, BSE Sensex and BSE energy index but not other way around in both periods. However, a bidirectional causality relationship between BSE Energy index and crude oil prices during post subprime financial crisis 2008. The co-integration results suggested that the absence of long run relationship between crude oil prices and market indices of BSE Sensex, BSE energy index, Nifty index and Nifty energy index before and after subprime financial crisis 2008.


Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 878
Author(s):  
Arnaud Bernard ◽  
Johanne Le Beyec-Le Bihan ◽  
Loredana Radoi ◽  
Muriel Coupaye ◽  
Ouidad Sami ◽  
...  

The aim of this study was to explore the impact of bariatric surgery on fat and sweet taste perceptions and to determine the possible correlations with gut appetite-regulating peptides and subjective food sensations. Women suffering from severe obesity (BMI > 35 kg/m2) were studied 2 weeks before and 6 months after a vertical sleeve gastrectomy (VSG, n = 32) or a Roux-en-Y gastric bypass (RYGB, n = 12). Linoleic acid (LA) and sucrose perception thresholds were determined using the three-alternative forced-choice procedure, gut hormones were assayed before and after a test meal and subjective changes in oral food sensations were self-reported using a standardized questionnaire. Despite a global positive effect of both surgeries on the reported gustatory sensations, a change in the taste sensitivity was only found after RYGB for LA. However, the fat and sweet taste perceptions were not homogenous between patients who underwent the same surgery procedure, suggesting the existence of two subgroups: patients with and without taste improvement. These gustatory changes were not correlated to the surgery-mediated modifications of the main gut appetite-regulating hormones. Collectively these data highlight the complexity of relationships between bariatric surgery and taste sensitivity and suggest that VSG and RYGB might impact the fatty taste perception differently.


2021 ◽  
Vol 11 (11) ◽  
pp. 4773
Author(s):  
Qiaoping Tian ◽  
Honglei Wang

High precision and multi information prediction results of bearing remaining useful life (RUL) can effectively describe the uncertainty of bearing health state and operation state. Aiming at the problem of feature efficient extraction and RUL prediction during rolling bearings operation degradation process, through data reduction and key features mining analysis, a new feature vector based on time-frequency domain joint feature is found to describe the bearings degradation process more comprehensively. In order to keep the effective information without increasing the scale of neural network, a joint feature compression calculation method based on redefined degradation indicator (DI) was proposed to determine the input data set. By combining the temporal convolution network with the quantile regression (TCNQR) algorithm, the probability density forecasting at any time is achieved based on kernel density estimation (KDE) for the conditional distribution of predicted values. The experimental results show that the proposed method can obtain the point prediction results with smaller errors. Compared with the existing quantile regression of long short-term memory network(LSTMQR), the proposed method can construct more accurate prediction interval and probability density curve, which can effectively quantify the uncertainty of bearing running state.


2021 ◽  
pp. 1-11
Author(s):  
Yanan Huang ◽  
Yuji Miao ◽  
Zhenjing Da

The methods of multi-modal English event detection under a single data source and isomorphic event detection of different English data sources based on transfer learning still need to be improved. In order to improve the efficiency of English and data source time detection, based on the transfer learning algorithm, this paper proposes multi-modal event detection under a single data source and isomorphic event detection based on transfer learning for different data sources. Moreover, by stacking multiple classification models, this paper makes each feature merge with each other, and conducts confrontation training through the difference between the two classifiers to further make the distribution of different source data similar. In addition, in order to verify the algorithm proposed in this paper, a multi-source English event detection data set is collected through a data collection method. Finally, this paper uses the data set to verify the method proposed in this paper and compare it with the current most mainstream transfer learning methods. Through experimental analysis, convergence analysis, visual analysis and parameter evaluation, the effectiveness of the algorithm proposed in this paper is demonstrated.


2021 ◽  
pp. 1098612X2098436
Author(s):  
Ashlyn G Williams ◽  
Ann E Hohenhaus ◽  
Kenneth E Lamb

Objectives Lymphoma is the most common feline hematopoietic malignancy. Incidence of renal lymphoma has not been reported as a subset of a large population of feline lymphoma cases. Previous studies have reported renal lymphoma as both a singular entity as well as a component of multicentric disease. The clinical presentation, diagnostic evaluation, therapy and outcomes related to renal lymphoma have not been reported since Mooney et al in 1987. This retrospective study aimed to describe the incidence of renal lymphoma, clinical signs, treatment and survival. Methods Using a database of cats diagnosed with lymphoma between January 2008 and October 2017, cats with renal lymphoma were selected for further analysis. Cases were retrospectively staged according to Mooney et al (1987) and Gabor et al (1998). Data collected included age, clinical signs, clinicopathologic data, diagnostic imaging findings, lymphoma diagnostic method(s), treatment protocol(s) and survival time. Analyses comparing median survival based on therapy administered, renal lymphoma vs multicentric lymphoma, central nervous system involvement, presence of azotemia, anemia and International Renal Interest Society (IRIS) stage at diagnosis were performed. Results From a population of 740 cats with lymphoma, 27 cats had renal lymphoma (incidence, 3.6%), and 14 of those cats had multicentric lymphoma. Fewer stage IV and V cases were identified in this data set compared with Mooney et al; however, not all cats were completely staged. Median survival (range) for cats receiving corticosteroids alone compared with those receiving an L-CHOP (L-asparaginase, vincristine, cyclophosphamide, doxorubicin, prednisolone)-based protocol was 50 days (20–1027 days) in the corticosteroid group and 203 days (44–2364 days) for the L-CHOP group ( P = 0.753) for cats that died secondary to lymphoma. Conclusions and relevance Neither clinical stage nor other factors were predictive of survival. Prospective studies are required to determine the optimal chemotherapy protocol.


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