scholarly journals Association Between Cytomegalovirus Infection and Bad Obstetric Outcomes in Women from Kirkuk

2014 ◽  
Vol 3 (1) ◽  
pp. 29
Author(s):  
Hala Mohamed Majeed Hassan ◽  
Abdulghani Mohamed Alsamarai ◽  
Zainab Khalil Aljumaili ◽  
Amina Hamed Alobaidi ◽  
Ferah Ghali Alsalihi
Keyword(s):  
Viral Infections ◽  
Obstetric Outcomes ◽  
Control Group ◽  
Serum Samples ◽  
Previous Pregnancy ◽  
Obstetric History ◽  
Significant Difference ◽  
Animal Exposure ◽  
Age Range ◽  
And Control

<p>The human cytomegalovirus (CMV) is one of the common viral infections worldwide that represent a major causes of congenital infections. To determine the seroprevalence of CMV in women with bad obstetric history and sociodemographic characteristics that may influence the seropositivity, a case<strong> </strong>control descriptive prospective study  was conducted in Kirkuk, Iraq. A 838 women with age range from 14 to 48 were included in the study. Of the total, 547 women were with bad obstetric history(BOH) and 291 women with normal previous pregnancy as control group. All the serum samples collected from the study and control groups were tested for CMV IgM and IgG antibodies by ELISA kits. CMV IgM seroprevalence was higher in women with BOH.<strong> </strong>CMV IgG seroprevalence was with no significant  difference between BOH and control. CMV IgG seroprevalence significantly influenced by age, education, smoking, and family size. However, CMV IgM seroprevalence significantly associated with pregnancy, residence, and animal exposure. Odd ratio confirmed the association between CMV IgG and age, crowding index, residence, smoking, and number of abortion in women with BOH.  In addition, current CMV infection significantly associated with residence in women with BOH.</p>

Association Between Cytomegalovirus Infection and Bad Obstetric Outcomes in Women from Kirkuk

2014 ◽  
Vol 3 (1) ◽  
pp. 29 ◽  
Author(s):  
Hala Mohamed Majeed Hassan ◽  
Abdulghani Mohamed Alsamarai ◽  
Zainab Khalil Aljumaili ◽  
Amina Hamed Alobaidi ◽  
Ferah Ghali Alsalihi
Keyword(s):  
Viral Infections ◽  
Obstetric Outcomes ◽  
Control Group ◽  
Serum Samples ◽  
Previous Pregnancy ◽  
Obstetric History ◽  
Significant Difference ◽  
Animal Exposure ◽  
Age Range ◽  
And Control

<p>The human cytomegalovirus (CMV) is one of the common viral infections worldwide that represent a major causes of congenital infections. To determine the seroprevalence of CMV in women with bad obstetric history and sociodemographic characteristics that may influence the seropositivity, a case<strong> </strong>control descriptive prospective study  was conducted in Kirkuk, Iraq. A 838 women with age range from 14 to 48 were included in the study. Of the total, 547 women were with bad obstetric history(BOH) and 291 women with normal previous pregnancy as control group. All the serum samples collected from the study and control groups were tested for CMV IgM and IgG antibodies by ELISA kits. CMV IgM seroprevalence was higher in women with BOH.<strong> </strong>CMV IgG seroprevalence was with no significant  difference between BOH and control. CMV IgG seroprevalence significantly influenced by age, education, smoking, and family size. However, CMV IgM seroprevalence significantly associated with pregnancy, residence, and animal exposure. Odd ratio confirmed the association between CMV IgG and age, crowding index, residence, smoking, and number of abortion in women with BOH.  In addition, current CMV infection significantly associated with residence in women with BOH.</p>

scholarly journals Association of the waist-hip ratio with plasma adiponectin related to coronary artery disease

2018 ◽  
Vol 17 (2) ◽  
pp. 290-295
Author(s):  
Premtim Rashiti ◽  
Ibrahim Behluli ◽  
Albiona Bytyçi
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Medical Science ◽  
Control Group ◽  
Serum Samples ◽  
Waist Hip Ratio ◽  
Significant Difference ◽  
Artery Disease ◽  
A Prospective Study ◽  
And Control

Objective: By enrolling a prospective study of 82 patients that underwent non-urgent coronary angiography for coronary artery disease (CAD), it is aimed to investigate the correlation between adiponectin and waist-hip-ratio with severity of CAD.Materials and methods: The results of the angiography, divided the patients into two groups, patients admitted with a diagnosis of CAD and non-CAD. In the conducted hospital based research, two groups were involved: the study group with documented angiographically CAD and control group without angiographic evidence of CAD. Some of the baseline adiponectin levels in stored serum samples of all patients, anthropometric and biochemical risk factors were assessed in both groups.Result and discussion: As the result, we have seen the presence of CAD that was associated with current smoking, male gender, waist–hip ratio (WHR).While, no significant difference between median adiponectin levels at baseline were observed between cases and controls.Conclusion: There is a significant positive correlation between waist - hip ratio and presence of severity of coronary artery disease.Bangladesh Journal of Medical Science Vol.17(2) 2018 p.290-295

Parvovirus B19 Seroprevalence in Women with Bad Obstetric History in Kirkuk.

2021 ◽  
Vol 20 ◽  
Author(s):  
Abdulghani Mohamed Alsamarai ◽  
Hala Majeed Hassan ◽  
Mohamed Almoustafa Alsamarai ◽  
Zainab Khalil Aljumaili
Keyword(s):  
Parvovirus B19 ◽  
Acute Infection ◽  
Large Family ◽  
Normal Pregnancy ◽  
Arab Countries ◽  
Obstetric Outcomes ◽  
Control Group ◽  
Significant Difference ◽  
Remote Infection ◽  
Animal Exposure

Background: In Iraqi community, abnormal pregnancy form a major social ans psychological and health problem. The underlying etiology of this health phenomenon was varied and includes sets of infections and autoimmune diseases. Globally human parvovirus 19 infection is common and the infection attribute to bad obstetric outcomes. Global maternal parvovirus B19 remote infection rate was with a range of 13.2% to 97.9%, while the range of acute infection was 0.5% to 97.9%. In Arab countries, the IgG seroprevalence was 53.3% to 74%, while IgM seroprevalence range was 2.2% to 84%. Objective: To evaluate the role of Parvovirus B19 as an etiology of bad obstetric outcome in women in Kirkuk, Iraq. Materials and Methods: Descriptive Case Control Study. Women included in the study were recruited from Kirkuk General Hospital and their age ranged from 14 to 48 years. A 663 women were included in the study and 237 of them were none pregnant, while the pregnant were 215. Additionally, the study included 211 women with inevitable abortion. A control group (306 women) women with history of normal pregnancy (Pregnant=149; non-pregnant=157). Clinical and laboratory investigations were conducted on all patients and control groups to exclude other causes [7]. Medical and obstetric data and demographic characteristics gathered through interview according to previously designed questionnaire [7]. ELISA kits were used to determine Parvovirus B19 IgM and IgG antibodies. Results: The overall parvovirus seroprevalence was 93% and with no significant difference between women with normal (89.5%) and those with abnormal (93.1%) pregnancy outcomes . In addition, parvovirus IgM overall seroprevalence was 56.3%. Furthermore, current parvovirus infection was higher in women with BOH (52.6%) than that in women with normal pregnancy (49.7%) outcomes. Parvovirus IgM seroprevalence was 52.6% in women with BOH and 49.7% in women with normal pregnancy, however, the difference was not statistically significant. In contrast, the acute infection with parvovirus was significantly (X2=11.8, P=0.001) lower in women with normal pregnancy (49.7%) than in those with inevitable abortion (64.9%), While IgG seroprevalence difference was not significant between the two groups. Infection seroprevalence was more frequent in housewife, uneducated women, large family size, non-smoker, rural area, non animal exposure, repeated abortion, congenital anomalies, and anaemia. Conclusion: Parvovirus B19 infection may be with bad obstetric outcomes if occurred during pregnancy and OR confirm a significant association of the infection with parvovirus with smoking, occupation, crowding index, education, animal exposure and number of repeated abortion.

scholarly journals Pediatric Functional Constipation and Whey Protein: A Randomized Clinical Trial

2021 ◽  
pp. 45-55
Author(s):  
Fateme Motavasselian ◽  
Majid Emtiazy ◽  
Mehrdad Shakiba ◽  
Majid Aflatoonian
Keyword(s):  
Whey Protein ◽  
Gastrointestinal Disease ◽  
Protein A ◽  
Intervention Group ◽  
Functional Constipation ◽  
Control Group ◽  
P Value ◽  
Significant Difference ◽  
Age Range ◽  
And Control

Background: Functional constipation is a chronic gastrointestinal disease in children. Pharmacological treatment of constipation is mostly based on the prescription of laxatives. In addition to this treatment, complementary therapies were also proposed to treat constipation. In this study, the effect of whey protein in the treatment of constipation was investigated. Method and Materials: A total of 56 children with functional constipation within the age range of 1 to 16 years were included in the study. Patients were randomly divided into the intervention (n=28) and control (n=28) groups. The intervention group received 15 g whey protein and the control group received 15 g placebo. Both groups received 0.4 - 0.8 gr/kg PEG powder. The amount of PEG was adjusted every four days based on having soft stools. Demographic information were collected and recorded. Furthermore, fecal consistency, stool frequency, symptoms of stool retention, fecal incontinence, and abdominal pain were recorded prior to the intervention and at the second and fourth weeks of the intervention. Results: All patients had soft daily stools at the end of the intervention. At the end of the fourth week, the mean required amounts of PEG powder were respectively 0.62 and 0.28 g/kg in the control and intervention groups, which showed a significant difference (p value ≤0.001). Conclusion: Based on these findings, whey protein is safe and can improve constipation. However, more studies with larger sample size and longer follow-up period are needed to confirm the results of this study.

scholarly journals Reduction of Inflammatory C3 and C4 Complement Proteins in Severe COVID-19 Patients

2020 ◽  
Author(s):  
Ali Ghazavi ◽  
Ghasem Mosayebi ◽  
Nafiesh Keshavarzian ◽  
Somayeh Rabiemajd ◽  
Ali Ganji
Keyword(s):  
Blood Cells ◽  
Viral Infections ◽  
White Blood Cells ◽  
Control Group ◽  
Serum Samples ◽  
Complement Proteins ◽  
And Control ◽  
The Complement System ◽  
Shed Light

Abstract Background: The complement system, consisting of more than 20 soluble proteins, has a key role in innate immunity and inflammation that eliminates pathogens and viral infections. Therefore, we investigated the titer of C3, C4, and total IgG in the serum of the non-severe and severe COVID-19 patients. Methods: For this purpose, peripheral blood samples were collected from 30 non-sever, 30 severe COVID-19 patients, and 30 healthy individuals with similar age and sex as the control group. The amount of total IgG, C3, and C4 were analyzed in the serum samples. Also, white blood cells, platelets (PLTs), and lymphocytes were counted by the auto-analyzer. Results: White blood cells had no difference between patients and control groups. The results showed a significant decrease in lymphocyte and PLTs in COVID-19 patients compare to control. Complement proteins including C3 and C4 were increased in non-severe COVID-19 patients than the other groups. Total IgG showed a notable decrease in severe patients. In conclusion, the level of C3 and C4 complement proteins were increased in non-severe-COVID-19 patients; however, in the severe COVID-19 patients their concentrations were decreased. Conclusion: However, inflammatory C3 and C4 complement factors increase in non-severe COVID-19, it decreased in the severe patients that may be because of more consumption by the formation of the immune complex. These results can shed light on the inflammatory role of C3 and C4 proteins in various phases of the disease and could provide a basis for further exploration of the pathophysiological significance and can suggest them for specific interventions.

scholarly journals Analysis of Vascular Endothelial Growth Factor (VEGF) -634C/G and +936C/T Polymorphisms and Serum VEGF Levels in Women Suffering From Preeclampsia

2021 ◽  
Author(s):  
Sayed hojjat Hosseini ◽  
Ata Ghadiria ◽  
Abdolah Mousavi Salehi ◽  
Saber Rokhafrooz ◽  
Mahin Najafian ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Control Group ◽  
Vascular Endothelial ◽  
Vegf Gene ◽  
Serum Samples ◽  
Significant Difference ◽  
Pcr Rflp ◽  
Gestational Week ◽  
And Control ◽  
Endothelial Growth Factor

Abstract Preeclampsia (PE) is a syndrome related with pregnancy and characterized by hypertension and proteinuria, occurring in approximately 6-8% of pregnancies and accounting for approximately 40% of premature births. This study aimed to investigate the polymorphisms of -634C/G and +936C/T in VEGF gene and their relationship with serum VEGF levels in pregnant women with PE. In this case-control study, peripheral blood samples were collected from 135 women with PE and 135 normal pregnant women as the control group. DNA was extracted using the phenol-chloroform method. Then, the polymorphisms of VEGF gene were detected by PCR-RFLP method using specific primers. Besides, VEGF concentrations were measured by ELISA method on serum samples and control subjects using ELISA kits. In this research, maternal age, gestational week, maternal hemoglobin and BMI were significantly correlated with the likelihood of PE, while the occurrence season variable was not effective in PE among the pregnant women. There was no significant difference in the two polymorphisms of -634C/G and +936C/T in VEGF gene between the two groups. Also, the serum VEGF level in PE patients was significantly higher than the normal group (P<0.001). Despite a significant increase in serum VEGF concentrations in women with PE, it seems that -634C/G and +936C/T polymorphisms of VEGF gene are not related with the onset of PE. Further studies are required to fully understand the risk factors related to preeclampsia syndrome.

scholarly journals The relevance of antral follicle count (AFC) as a marker of ovarian reserve in normal and infertile women in a tertiary care centre in Central India

2018 ◽  
Vol 7 (11) ◽  
pp. 4711
Author(s):  
Prasanta K. Nayak ◽  
Chandrima Mukherjee ◽  
Subarna Mitra
Keyword(s):  
Ovarian Reserve ◽  
Local Population ◽  
Antral Follicle ◽  
Antral Follicle Count ◽  
Control Group ◽  
Antral Follicles ◽  
Infertile Women ◽  
Significant Difference ◽  
Age Range ◽  
And Control

Background: The objective of the present study was to establish the role of AFC as a marker of ovarian reserve in fertility-proven and in sub-fertile Indian women, and to establish the baseline cut-off AFC values for Indian women.Methods: This is an Observational Case-Control type of study. Test subjects (n=30, age range 20-35 years) were selected randomly from all the women coming to our Out-Patient Department with Primary Infertility. Healthy female volunteers (n=30, age range 20-35years) were recruited from the local population. Statistics: Student t test was applied to compare the mean Antral Follicle count between the case and control group. Pearson correlation test was applied to assess the correlation between age and AFC for case and control group.Results: The results of the study show that there is a significant difference between the number of antral follicles between fertile and infertile women (p < 0.001). The baseline cut-off for successful pregnancy was established as an AFC of 12. There exists negative correlation (r = -0.249) between age and AFC case group indicating as the age increases AFC decreases.Conclusions: The findings from this study help in strengthening the idea that AFC serves as a marker for ovarian reserve. Our observation indicates that the number of antral follicles is lower in the subfertile patients as compared to the fertile group (in all age groups), in view of the significantly lower median AFC in women of the former group (P < 0.001).

scholarly journals Fascioliasis and COVID-19: A Case-Control Study in Iran

2021 ◽  
Author(s):  
Fatemeh Balazadeh ◽  
Mohammad Zibaei ◽  
Aliehsan Heidari ◽  
Hadis Rastad ◽  
Farzaneh Firoozeh
Keyword(s):  
Immune Responses ◽  
Fasciola Hepatica ◽  
Cross Sectional Study ◽  
Control Group ◽  
Serum Samples ◽  
Cross Sectional ◽  
Significant Difference ◽  
Healthy Control ◽  
And Gender ◽  
And Control

Abstract Background: Human Fascioliasis is a zoonotic infection caused by the adult stage of Fasciola species. Fasciola hepatica is a parasite that, following living in its vertebrate host, reduces the host's inflammatory immune responses to infectious diseases, including COVID-19. Therefore, because of the completely unproven and limited data on this issue, we decided to evaluate the prevalence of antibodies against this parasite in patients admitted to the hospital due to relatively severe symptoms of COVID-19.Methods: This cross-sectional study was conducted on the serum samples of 182 patients with COVID-19 disease who were diagnosed by PCR test and 210 healthy subjects in Alborz Province, Iran between March and June 2020. Anti-Fasciola antibodies status was determined in all serum samples, using ELISA technique. A self-developed questionnaire was used to measure demographic information.Results: The frequency of Fasciola infection was found to be significantly higher in COVID-19 patients as compared to healthy control (n = 4, 2.2%, n = 9, 4.3%; respectively) (P = 0.041). There was no significant difference between COVID-19 patients and control group in age, education, and gender (P > 0.05).Conclusions: This study indicates that a significant association between Fasciola hepatica seropositivity and COVID-19 disease. Our finding suggests that Fasciola infection may be able to lead to decreased immune responses, thereby reducing the severity and symptoms of COVID-19 disease.

scholarly journals Detection of Alpha-1 antitrypsin and Interleukin-8 in meningitis patients

2019 ◽  
Vol 7 (1) ◽  
pp. 1-10
Author(s):  
Samir K. Abbas ◽  
Mayada N. Iqbal ◽  
Nahlah G. Abdul Majeed
Keyword(s):  
Viral Infections ◽  
Spinal Fluid ◽  
Interleukin 8 ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
High Concentration ◽  
Significant Difference ◽  
Medical City ◽  
Alpha 1 Antitrypsin ◽  
And Control

Meningitis is a meninges inflammation and the subarachnoid cerebrum spinal fluid that surrounds the spinal cord and brain. Infantile meningitisis a major cause of morbidity & mortality in various parts of the world; it is earnest disorder owing to the nearness of the location to the brain andspinal cord. It can be caused by virtually any organism; in general viral infections are more common than bacterial, fungal and parasitic infectionsrespectively. Objective: investigation of the Interleukin-8 (IL-8) and Alaph-1 Antitrypsin in the cerebrum spinal fluid of meningitis patients.Material and Method: A study was done at the Medical city and Al-kadimia hospitals included 47 and 20 beings of Patients and Control groupswith an overall age range between 11 days to 6 years old. According to the causative agents of the disease, they were divided into three groups:bacterial, viral and control groups. All subjects were monitored for the IL-8 by Enzyme Linked Immunosorbent Assay (ELISA) and Alaph-1Anti-trypsin by Single Radial Immunodiffusion assay (SRIA) in the cerebrospinal fluid the data was analyzed via using SPSS (chi-squire test)program (version 22). Results and discussion: The results revealed the presence of an elevation concentration of IL-8 among meningitis diseasepatients (484.0695 pg/ml ), high concentration of IL-8 seemed in bacterial meningitis (825.3250pg/ml) when compared with its level in viralmeningitis (142.8143pg ml) ( p= 0.002) and control group ( 56.3409 pg/ml) (p=0.00) but no significant difference was found between viral andcontrol groups (p= 0.679). Alpha 1 antitrypsin results appeared high concentration of (21.6462 mg/ dl) and (16.4000 mg/ dl) in bacterial and viralmeningitis groups in sequentially, and that concentrations showed differences arrived significantly. The statistical analysis of this research showeda correlation between IL-8 levels and both of neutrophil and lymphocyte in meningitis patients. IL-8 had significant correlation with lymphocyte(p=0.02) in viral group while no significant correlation was appeared between IL-8 and neutrophil. In bacterial group, lymphocytes with IL-8 hadweak correlation, in contrary the correlation between neutrophil and IL-8 revealed the significantly correlation (p=0.01). No correlation was establish concerning the Alpha-1 antitrypsin and the cell’s numbers and types. Conclusion: A study indicated that Alpha 1 antitrypsin and IL-8 playedan important role in meningitis disease.

scholarly journals Investigation of Preeclampsia Using Raman Spectroscopy

2012 ◽  
Vol 27 ◽  
pp. 239-252 ◽  
Author(s):  
Günay Başar ◽  
Uğur Parlatan ◽  
Şeyma Şeninak ◽  
Tuba Günel ◽  
Ali Benian ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Discriminant Analysis ◽  
Linear Discriminant Analysis ◽  
Principal Component ◽  
Component Analysis ◽  
Control Group ◽  
Serum Samples ◽  
Linear Discriminant ◽  
Significant Difference ◽  
And Control

Preeclampsia is associated with increased perinatal morbidity and mortality. There have been numerous efforts to determine preeclampsia biomarkers by means of biophysical, biochemical, and spectroscopic methods. In this study, the preeclampsia and control groups were compared via band component analysis and multivariate analysis using Raman spectroscopy as an alternative technique. The Raman spectra of serum samples were taken from nine preeclamptic, ten healthy pregnant women. The Band component analysis and principal component analysis-linear discriminant analysis were applied to all spectra after a sensitive preprocess step. Using linear discriminant analysis, it was found that Raman spectroscopy has a sensitivity of 78% and a specificity of 90% for the diagnosis of preeclampsia. Via the band component analysis, a significant difference in the spectra of preeclamptic patients was observed when compared to the control group. 19 Raman bands exhibited significant differences in intensity, while 11 of them decreased and eight of them increased. This difference seen in vibrational bands may be used in further studies to clarify the pathophysiology of preeclampsia.

Sign in / Sign up

Export Citation Format

Share Document