Abstract 3276: Consumption Of Fatty Fish Is Negatively Associated With The Risk Of Acute Coronary Syndrome In Healthy Men

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Albert Marni Joensen ◽  
Lone J Bjerregaard ◽  
Claus Dethlefsen ◽  
Majken K Jensen ◽  
Søren P Johnsen ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Cohort Study ◽  
Fatty Fish ◽  
Healthy Men ◽  
Negatively Associated ◽  
Coronary Syndrome ◽  
Lean Fish ◽  
National Patient ◽  
Danish Cohort ◽  
Record Review

Consumption of fish has been reported to decrease coronary mortality among subjects with known coronary heart disease (CHD), whereas such an effect is less documented in healthy subjects. Few studies have distinguished between intake of fatty fish (defined as a content of long-chained n-3 polyunsaturated fatty acid, greater than 1 g per 100 g of fish) and intake of lean fish. Objective To assess the hypothesis that consumption of fatty fish is negatively associated with the risk of acute coronary syndrome (ACS) in healthy men. Methods In the Danish cohort-study Diet, Cancer and Health 27,178 men between 50 and 64 years of age were enrolled. In a validated food frequency questionnaire, participants gave information on dietary intake of fatty fish. During a mean follow-up period of 7.6 years, we identified all cases from this cohort (n=854) with an incident ACS-diagnosis in the Danish National Patient Registry. Diagnoses were verified through medical record review. In Cox proportional hazard models, we adjusted for several well established risk factors for CHD. Results Conclusion The risk of ACS was 30% lower among men in the highest 4 quintiles of fatty fish consumption, compared with men in the lowest quintile, in this large Danish cohort study. There was no dose-response association.

scholarly journals Dietary intake of total marine n-3 polyunsaturated fatty acids, eicosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid and the risk of acute coronary syndrome – a cohort study

2009 ◽  
Vol 103 (4) ◽  
pp. 602-607 ◽  
Author(s):  
Albert M. Joensen ◽  
Erik B. Schmidt ◽  
Claus Dethlefsen ◽  
Søren P. Johnsen ◽  
Anne Tjønneland ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Cohort Study ◽  
Dietary Intake ◽  
Healthy Subjects ◽  
Docosapentaenoic Acid ◽  
Pufa Intake ◽  
Negatively Associated ◽  
Coronary Syndrome ◽  
National Patient ◽  
Record Review

Dietary intake of marine n-3 PUFA has been negatively associated with the risk of CHD among subjects with known CHD, whereas an effect in healthy subjects is less documented. We assessed the hypothesis that dietary intake of marine n-3 PUFA is negatively associated with the risk of acute coronary syndrome (ACS) in healthy subjects. In the Danish Diet, Cancer and Health cohort study, 57 053 participants were enrolled. Dietary intake of total n-3 PUFA, including EPA, docosapentaenoic acid (DPA) and DHA, was assessed. During a mean follow-up period of 7·6 years, we identified all cases (n 1150) from this cohort with an incident ACS diagnosis in the Danish National Patient Registry or the Cause of Death Registry. Diagnoses were verified through medical record review. In Cox proportional hazard models, we adjusted for established risk factors for CHD. Men in the four highest quintiles of n-3 PUFA intake (>0·39 g n-3 PUFA per d) had a lower incidence of ACS compared with men in the lowest quintile. The hazard ratio was 0·83 (95 % CI 0·67, 1·03) when we compared men in the second lowest and lowest quintile of n-3 PUFA intake. Higher intake of n-3 PUFA did not strengthen this association. Associations for EPA, DPA and DHA were all negative, but less consistent. No convincing associations were found among women. In conclusion, we found borderline significant negative associations between the intake of marine n-3 PUFA and ACS among healthy men.

scholarly journals Association of fish consumption and dietary intake of marine n-3 PUFA with myocardial infarction in a prospective Danish cohort study

2016 ◽  
Vol 116 (1) ◽  
pp. 167-177 ◽  
Author(s):  
Anders Gammelmark ◽  
Michael S. Nielsen ◽  
Christian S. Bork ◽  
Søren Lundbye-Christensen ◽  
Anne Tjønneland ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cohort Study ◽  
Relative Risk ◽  
Dietary Intake ◽  
Fish Consumption ◽  
Fish Intake ◽  
Fatty Fish ◽  
High Intake ◽  
Lean Fish ◽  
Danish Cohort

AbstractSeveral studies have investigated the potential benefits of marine n-3 PUFA in CVD, generally suggesting a lower risk of CHD. However, recent trials have questioned these results. This study investigated the association of fish consumption with dietary intake of marine n-3 PUFA with incident myocardial infarction (MI). In a Danish cohort study, 57 053 subjects between 50 and 64 years of age were enrolled from 1993 to 1997. From national registries, we identified all cases of incident MI. Dietary fish consumption was assessed using a semi-quantitative food questionnaire, including twenty-six questions regarding fish intake. In addition, we calculated the intake of total and individual marine n-3 PUFA. During a median follow-up of 17·0 years, we identified 3089 cases of incident MI. For both men and women, a high intake of fatty fish was inversely related to incident MI. Thus, when comparing the highest and the lowest quintile of fatty fish intake, we found a 12 % lower relative risk of MI in men (hazard ratio (HR) 0·88; 95 % CI 0·77, 1·00) and a 22 % lower relative risk in women (HR 0·78; 95 % CI 0·63, 0·96) after adjustments. For women, similar associations were observed for individual and total marine n-3 PUFA. In contrast, intake of lean fish was not associated with MI. In conclusion, incident MI was inversely related to a high intake of fatty fish, but not lean fish. However, test for trends across quintiles was not statistically significant. In general, this study supports the view that consumption of fatty fish may protect against MI.

scholarly journals Use of ticagrelor and the risks of pneumonia and pneumonia-specific death in patients with non-acute coronary syndrome conditions: a population-based cohort study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Qi Feng ◽  
Man Fung Tsoi ◽  
Yue Fei ◽  
Ching Lung Cheung ◽  
Bernard M. Y. Cheung
Keyword(s):  
Acute Coronary Syndrome ◽  
Cohort Study ◽  
Hong Kong ◽  
Lower Risk ◽  
Population Based ◽  
Public Hospitals ◽  
Sensitivity Analyses ◽  
Coronary Syndrome ◽  
Matching Adjustment ◽  
Analysis Models

AbstractPrevious studies have shown that ticagrelor reduced risk of pneumonia in patients with acute coronary syndrome (ACS) compared to clopidogrel, however, its effect in patients with non-ACS cardiovascular diseases remains uncertain. The aim was to investigate the effect of ticagrelor on pneumonia and pneumonia-specific death compared to clopidogrel in non-ACS patients in Hong Kong. This was a population-based cohort study. We included consecutive patients using ticagrelor or clopidogrel admitted for non-ACS conditions in Hong Kong public hospitals from March 2012 to September 2019. Patients using both drugs were excluded. The outcomes of interest were incident pneumonia, all-cause death, and pneumonia-specific death. Multivariable survival analysis models were used to estimate the effects [hazard ratio (HR) and 95% confidence interval (CI)]. Propensity score matching, adjustment and weighting were performed as sensitivity analyses. In total, 90,154 patients were included (mean age 70.66 years, males 61.7%). The majority of them (97.2%) used clopidogrel. Ticagrelor was associated with a lower risk of incident pneumonia [0.59 (0.46–0.75)], all-cause death [0.83 (0.73–0.93)] and pneumonia-specific death [0.49 (0.36–0.67)]. Sensitivity analyses yielded similar results. Ticagrelor was associated with lower risk of all-cause death, pneumonia-specific death, and incident pneumonia in patients with non-ACS cardiovascular conditions, consistent with previous evidence in patients with ACS. This additional effect of anti-pneumonia should be considered when choosing a proper P2Y12 inhibitor for patients with high risk of pneumonia.

scholarly journals Association Between Subconjunctival Hemorrhage and Acute Coronary Syndrome: A 14-Year Nationwide Population-Based Cohort Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Ping-Hao Chiang ◽  
Jung-Nien Lai ◽  
Yun-Chi Chiang ◽  
Kai-Chieh Hu ◽  
Min-Yen Hsu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Coronary Syndrome ◽  
Cohort Study ◽  
Age Groups ◽  
Population Based ◽  
Research Database ◽  
Coronary Syndrome ◽  
Subconjunctival Hemorrhage ◽  
Related Risk ◽  
Patients With Diabetes

Purpose: Subconjunctival hemorrhage (SCH) is usually a benign ocular disorder that causes painless, redness under the conjunctiva. However, since SCH and acute coronary syndrome (ACS) share many vascular risk factors, studies have suggested that these two disorders may be significantly associated with each other, and evaluate the concomitance of ACS in patients with SCH.Methods: This population-based cohort study, enrolled 35,260 Taiwanese patients, and used the Taiwan National Health Insurance Research Database to identify patients with ACS and SCH. Outcomes were compared between the with and without SCH groups. The study population was followed until the date of ACS onset, the date of withdrawal, death, or December 31st 2013, whichever came first.Results: Of the 85,925 patients identified with SCH between 1996 and 2013, 68,295 were excluded based on the study's exclusion criteria, and a total of 17,630 patients with SCH who were diagnosed by ophthalmologists between 2000 and 2012 were eligible for analysis. After 1:1 propensity score matching for 5-year age groups, gender, and the index year, the results showed that SCH was more common in the 40–59 age group (53.82%) and females (58.66%). As for the ACS-related risk factors, patients with diabetes mellitus (aHR = 1.58, 95% CI = [1.38, 1.81]), hypertension (aHR = 1.71, 95% CI = [1.49, 1.96]) and patients taking aspirin (aHR = 1.67, 95% CI = [1.47, 1.90]) had a notably higher risk of ACS. However, it was found that there were no significant differences in the occurrence of ACS between the non-SCH and SCH patients.Conclusion: This results of this study regarding the risk factors and epidemiology of SCH and ACS were in keeping with previously reported findings. However, the results revealed no significant association between SCH and ACS.

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