Abstract P013: Association Between Serum Chemerin Levels and Coronary Heart Disease: A Meta Analysis

Background: Chemerin is a novel adipokine linked with obesity, metabolic syndrome and chronic inflammatory diseases. It plays a pivotal role in modulating adipocyte differentiation, activation of macrophages and production of proinflammatory cytokines. It is hypothesized that chemerin promotes vascular remodeling and endothelial dysfunction leading to the development of coronary atherosclerosis. We conducted a meta-analysis to evaluate the relationship between serum chemerin levels and coronary heart disease (CHD). Methods: We searched MEDLINE, CINAHL and COCHRANE databases for studies reporting serum chemerin levels in the patients with CHD and healthy controls. We included case controls, cohort and cross-sectional studies. We calculated the weighted standardized mean difference (SMD) in serum chemerin levels between the CHD and control groups.We performed residual maximum likelihood meta-regression analysis on covariates age, BMI and female sex. Results: Our search strategy yielded 43 articles and we included 10 studies enrolling 2225 participants. The median age and body mass index(BMI) of the CHD group was 62 yrs (IQR 60-63) and 26 kg/m 2 (IQR 26-28) vs 61 yrs (IQR 58-62) and 26 kg/m 2 (IQR 24-27) in the control group. The median percentage of female population was lower in the CHD group at 39% (IQR 22-52) vs 49% (IQR 31-53) in the control group. The unweighted median serum chemerin levels in the CHD group were 33.3 ng/ml (IQR 25.4-63.2) compared to 29.8 ng/ml (IQR 15.2-38.2) in the control group. The SMD of serum chemerin level was 0.78 (95% CI 0.39 - 1.17) P <0.001 comparing those in the CHD group and control group. This association was not explained by age, BMI or sex. Conclusion: An elevated serum chemerin level is significantly associated with presence of CHD. Chemerin can potentially used as a novel biomarker and to risk stratify patients with CHD.

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Abstract P050: Association Between Circulating Selenium Levels and Primary Hypertension: A Meta-analysis

Hypertension ◽

10.1161/hyp.66.suppl_1.p050 ◽

2015 ◽

Vol 66 (suppl_1) ◽

Author(s):

Pradyumna Agasthi ◽

Sivakanth Aloor ◽

Vivek Yarlagadda ◽

Avantika Chenna ◽

Anekwe Onwuanyi

Keyword(s):

Meta Analysis ◽

Antioxidant Properties ◽

Primary Hypertension ◽

Control Group ◽

Serum Selenium ◽

Median Percentage ◽

Female Population ◽

Glutathione Peroxidases ◽

Serum Selenium Levels ◽

And Control

Background: Increasing evidence support the role of oxidative stress in the development of Primary hypertension (HTN). Selenium is an essential micronutrient with antioxidant properties mediated via selenoenzymes like glutathione peroxidases. It is hypothesized that selenium plays a role in blood pressure regulation and HTN prevention. We conducted a meta-analysis to evaluate the relationship between circulating selenium levels and HTN. Methods: We searched MEDLINE, CINAHL and COCHRANE databases for studies reporting serum selenium levels in the patients with HTN and healthy controls. We calculated the weighted standardized mean difference (SMD) in the serum selenium levels between the HTN and control groups. Results: Our search strategy yielded 313 articles and we included 10 studies enrolling 10420 participants. The median age of the HTN group was 57 yrs. (IQR 56-58) compared to 46 yrs. (IQR 42-50) in the control group. The median body mass index (BMI) in the HTN group was 28 kg/m2 (IQR 26-29) compared to 25 kg/m2 (IQR 25-27) in the control group. The median percentage of female population in the HTN group was 51 % (IQR 46-53) compared to 51 % (IQR 51-54) in the control group. The unweighted median serum selenium levels in the HTN group were 88 μg/l (IQR 83-113) compared to 95 μg/l (IQR 86-128) in the control group. The SMD of serum selenium level was -1.52 (95% CI -2.36, -0.67) P<0.001 comparing those in the HTN group and control group. Conclusion: Serum selenium levels are significantly and inversely associated with HTN and this association was not explained by age, sex or BMI. Further studies are needed to confirm this association by adjusting for potential confounders.

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Abstract 150: Association Between Serum Ghrelin Levels and Coronary Artery Disease: a Meta-analysis

Circulation Research ◽

10.1161/res.117.suppl_1.150 ◽

2015 ◽

Vol 117 (suppl_1) ◽

Author(s):

Pradyumna Agasthi ◽

Sivakanth Aloor ◽

Avantika Chenna ◽

Anekwe Onwuanyi

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Meta Analysis ◽

Control Group ◽

Cross Sectional ◽

Median Serum ◽

Artery Disease ◽

Differentiation And Proliferation ◽

And Control ◽

Serum Gh

Background: Ghrelin (GH) is a gastrointestinal endocrine peptide regulating multiple biological processes including adipogenesis, glucose metabolism, cell differentiation and proliferation. Recent studies demonstrated that GH inhibits pro-atherogenic changes in vessel wall via inhibition of nuclear factor - B activity, a transcriptional factor mediating production pro-inflammatory cytokines and adhesion molecule expression in the endothelium. The aim of the current study is to conduct a meta-analysis to evaluate the relationship between serum GH levels and coronary artery disease (CAD). Methods: We searched MEDLINE, CINHAL and COCHRANE databases for studies reporting serum GH levels in the CAD and non CAD study population. We included case controls, cohort and cross-sectional studies. We calculated the weighted standardized mean difference (SMD) in serum GH levels between the CAD and control groups. Results: Our search strategy yielded 285 articles and we included 10 studies enrolling 1855 participants. The median age of the CAD group was 62 yrs. (IQR 60 - 63) compared to 61 yrs. (IQR 58 - 65) in the control group. The median body mass index in the CAD group was 28 kg/m2 (IQR 27.9 - 28) compared to 27 kg/m2 (IQR 26 - 27) in the control group. The unweighted median serum GH levels in the CAD group were 0.66 ng/ml (IQR 0.3 - 1.6) compared to 0.76 ng/ml (IQR 0.38 - 4.9) in the control group. The SMD of GH level was -0.44 (95% CI -0.56,-0.31) p<0.001 comparing those in the CAD group and control group. Conclusion: Serum GH levels are significantly and inversely associated with CAD. Current findings warrant the need to further investigate the role of GH in the pathogenesis of CAD.

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The impact of clinical and population strategies on coronary heart disease mortality: an assessment of Rose’s big idea

BMC Public Health ◽

10.1186/s12889-021-12421-0 ◽

2022 ◽

Vol 22 (1) ◽

Author(s):

Mohadeseh Ahmadi ◽

Bruce Lanphear

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Prospective Studies ◽

Meta Analysis ◽

Coronary Heart Disease Mortality ◽

Cross Sectional ◽

Population Strategy ◽

Chd Risk Factors ◽

The Impact ◽

Clinical Strategy

Abstract Background Coronary heart disease (CHD), the leading cause of death worldwide, has declined in many affluent countries but it continues to rise in industrializing countries. Objective To quantify the relative contribution of the clinical and population strategies to the decline in CHD mortality in affluent countries. Design Meta-analysis of cross-sectional and prospective studies. Data sources PubMed and Web of Science from January 1, 1970 to December 31, 2019. Method We combined and analyzed data from 22 cross-sectional and prospective studies, representing 500 million people, to quantify the relative decline in CHD mortality attributable to the clinical strategy and population strategy. Result The population strategy accounted for 48% (range = 19 to 73%) of the decline in CHD deaths and the clinical strategy accounted for 42% (range = 25 to 56%), with moderate inconsistency of results across studies. Conclusion Since 1970, a larger fraction of the decline in CHD deaths in industrialized countries was attributable to reduction in CHD risk factors than medical care. Population strategies, which are more cost-effective than clinical strategies, are under-utilized.

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Abstract 147: Elevated Serum Resistin Levels are Associated with Angiographically Significant Coronary Artery Disease: A Meta-analysis.

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/atvb.36.suppl_1.147 ◽

2016 ◽

Vol 36 (suppl_1) ◽

Author(s):

Pradyumna Agasthi ◽

Sivakanth Aloor ◽

Srinadh Annangi ◽

Kalaivani Sivakumar ◽

Tirumala Rao Dammalapati ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Meta Analysis ◽

Elevated Serum ◽

Significant Coronary Artery Disease ◽

Control Group ◽

Resistin Level ◽

Serum Resistin Level ◽

Artery Disease ◽

And Control

Background: Resistin is a novel inflammatory cytokine secreted primarily by mononuclear inflammatory cells and adipocytes. It upregulates the expression of vascular adhesion molecules and stimulates smooth muscle cell proliferation, thereby contributing to atherogenesis in the vascular wall. We conducted a meta-analysis to evaluate the association between serum resistin levels and presence of angiographically significant coronary artery disease (CAD) in patients undergoing diagnostic coronary angiography (DCA). Methods: We searched MEDLINE, CINAHL and COCHRANE databases for studies reporting serum resistin levels in the patients with history of angina or positive stress test undergoing DCA. Patients with coronary stenosis > 50% in at least 1 coronary artery were considered to have significant CAD. They were included in the study group, and rest were included in control group. A calculation of weighted standardized mean difference (SMD) in serum resistin level between the CAD and control groups was conducted. Results: A literature search yielded 158 articles, but only 11 studies enrolling 3291 patients were included in the meta-analysis. The median age and body mass index (BMI) of the CAD group was 63 yrs (IQR 61-65) and 27 kg/m2 (IQR 25-29) versus 59 yrs (IQR 57-61) and 28 kg/m2 (IQR 26-29) in the control group. There were more females in the control group 48% (IQR 46-58) versus 27% (IQR 24-33) in CAD group. The unweighted median serum resistin levels in the CAD group were 5.7 ng/ml (IQR 4.1-16.1) vs 4.3 ng/ml (IQR 3.1-8.2) in the control group. The SMD of serum resistin level was 0.38 (95% CI 0.18- 0.57), P<0.001 comparing those in the CAD group and control group. None of the covariates (age, BMI and sex) accounted for statistical significance. Conclusion: An elevated serum resistin level is independently associated with the presence of angiographically significant CAD. Serum resistin levels can potentially be used as a biomarker for cardiac risk stratification.

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Metabolomics-Based Study of Clinical and Animal Plasma Samples in Coronary Heart Disease with Blood Stasis Syndrome

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2012/638723 ◽

2012 ◽

Vol 2012 ◽

pp. 1-6 ◽

Cited By ~ 6

Author(s):

Huihui Zhao ◽

Jianxin Chen ◽

Qi Shi ◽

Xueling Ma ◽

Yi Yang ◽

...

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Blood Stasis ◽

Principal Component ◽

Blood Stasis Syndrome ◽

Control Group ◽

Swine Model ◽

Plasma Samples ◽

Healthy Control ◽

And Control

The aim of this study is to explore a bridge connecting the mechanism basis and macro syndromes of coronary heart disease with experimental animal models. GC-MS technique was used to detect the metabolites of plasma samples in mini swine models with myocardial infarction (MI) and patients with unstable angina (UA). 30 metabolites were detected in the plasma samples of more than 50 percent of model group and control group in swine, while 37 metabolites were found in the plasma samples of UA patients and healthy control group. 21 metabolites in the plasma samples of swine model and 20 metabolites in patients with UA were found of significant value. Among which, 8 shared metabolites were found of low level expression in both swine model and UA patients. Independent Student’st-test, principal component analysis (PCA), and hierarchicalcluster analysis (HCA) were orderly applied to comprehend inner rules of variables in the data. The 8 shared metabolites could take place of the 21 or 20 metabolites in classification of swine model with MI and UA patients, which could be considered as a bridge connecting the mechanism basis and macrosyndromes of swine model with MI and UA patients.

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EFFECT OF PSYCHOEDUCATION ON ANXIETY IN PATIENTS WITH CORONARY HEART DISEASE

Belitung Nursing Journal ◽

10.33546/bnj.303 ◽

2017 ◽

Vol 3 (6) ◽

pp. 743-749

Author(s):

Yuli Sulistiyo ◽

Bedjo Santoso ◽

Shobirun Shobirun ◽

Soeharyo Hadisaputro ◽

Leni Latifah ◽

...

Keyword(s):

Cardiovascular Disease ◽

Coronary Heart Disease ◽

Heart Disease ◽

T Test ◽

Anxiety Level ◽

Control Group ◽

P Value ◽

The Mean ◽

Anxiety Levels ◽

And Control

Background: Cardiovascular heart disease still remains high in Indonesia. Various interventions have been implemented as an effort to deal with cardiovascular disease. However, little is known about intervention to reduce anxiety in patients with cardiovascular disease although anxiety is related to angina attack in this patient. Psychoeducation is considered effective in decreasing anxiety.Objective: To examine the effect of psychoeducation in decreasing anxiety in patients with coronary heart disease (CHD) at the General Hospital of Semarang.Methods: This was a quasy experimental design with pretest posttest control group design. The study was conducted in the inpatient wards of the General Hospital of Semarang on January 17 until March 8, 2017. Fifty-six respondents were recruited using consecutive sampling, with 28 assigned in the experiment and control group. Hamilton Anxiety Rating Scale (HARS) was used to measure anxiety levels. Paired t-test and Independent t-test were used for data analysis.Results: Paired test showed that there was a statistically significant effect of psychoeducation on anxiety level in the experiment group with p-value 0.001 (<0.05), and significant effect of given a brochure of CHD on the anxiety level in the control group with p-value 0.001 (<0.05). Independent t-test showed a statistically significant difference of anxiety level after intervention in the experiment and control group with p-value 0.001 (<0.05). The mean anxiety level in the experiment group (22.46) was lower than the mean anxiety level in the control group (41.54).Conclusion: Psychoeducation is effective in reducing anxiety levels in patients with CHD. It is suggested that psychoeducation can be used as one of nursing intervention in an effort to reduce anxiety in patients with CHD.

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The Efficacy of Fish Oil in Preventing Coronary Heart Disease: A Systematic Review and Meta-Analysis

10.20944/preprints202009.0497.v1 ◽

2020 ◽

Author(s):

Gaohong Wu ◽

Haifeng Geng ◽

Yue Jiang ◽

Wei Song ◽

Xueping Zhu ◽

...

Keyword(s):

Systematic Review ◽

Coronary Heart Disease ◽

Heart Disease ◽

Fish Oil ◽

Meta Analysis ◽

Secondary Outcome ◽

Control Group ◽

Randomized Controlled ◽

Significant Difference

To evaluate the efficacy of fish oil for protection against coronary heart disease (CHD), we conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) evaluating the use of fish oil for protection against CHD. We retrieved relevant articles published from January 1966 to January 2020 by searching the PubMed, EMBASE, Cochrane CENTRAL, and Web of Science databases. RCTs of fish oil in preventing CHD were selected. The study quality was evaluated using the Cochrane Risk of Bias tool with RevMan 5.3 software. The first selection involved 350 citations. After screening and evaluation of suitability, 19 RCTs adjusted for clustering were included in the meta-analysis. All selected manuscripts considered that fish oil was effective in preventing CHD, secondary outcome measures included angina, sepsis and death. Compared with the control group, fish oil may confer significant protection against CHD (odds ratio = 0.84; 95% confidence interval: 0.72–0.98). There was no significant difference in the incidence of secondary outcomes between the observation group and the control group (P > 0.05). The above results show that fish oil plays an important role in reducing CHD and cardiovascular events. However, because of the suboptimal quality of the studies included into the meta-analysis, these results do not justify adding fish oils systematically to the heavy pharmaceutical assortment already recommended in CHD patients.

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Effectiveness of education using ha-man module on self-efficacy of adults in preventing coronary heart disease

Bali Medika Jurnal ◽

10.36376/bmj.v8i3.178 ◽

2021 ◽

Vol 8 (3) ◽

pp. 294-299

Author(s):

Ni Kadek Ayu Suarningsih ◽

I Kadek Saputra

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Health Education ◽

Self Efficacy ◽

Intervention Group ◽

Control Group ◽

Educational Media ◽

Before And After ◽

Chd Risk Factors ◽

And Control

Every year, there is a significant increase in deaths caused by coronary heart disease (CHD). Many programs have been implemented to reduce the morbidity and mortality of CHD. Early detection and control of CHD risk factors is a challenge in educating adults about lifestyle changes. Also, it is recognized that self-efficacy is a vital factor in initiating and maintaining healthy behaviors. Health education is given as an effort to increase self-efficacy, but educational media that are innovative in promoting CHD health are limited. This study aimed to determine differences in the self-efficacy of adults in preventing coronary heart disease before and after given health education. This was a quasi-experimental study with a pretest-posttest control group design. The sample were 60 respondents which were grouped into 30 respondents in the intervention group and control group through purposive sampling. The HA-Man education intervention was given 3 times for a-week, self-efficacy was evaluated through a structured questionnaire interview. The results showed that there were differences in self-efficacy before and after intervention in the intervention group (p <0.05). This research is expected to provide information in the development of educational media in increasing awareness and self-efficacy of people who are at risk of CHD

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Detection of serum biochemical markers in elderly patients with type 2 diabetes mellitus and its relationship with coronary heart disease

10.32592/ircmj.2020.22.8.44 ◽

2020 ◽

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Coronary Heart Disease ◽

Type 2 Diabetes Mellitus ◽

Heart Disease ◽

Elderly Patients ◽

Control Group ◽

Disease Group ◽

And Control

Background and Aims: Coronary heart disease (CHD) is myocardial ischemia caused by coronary atherosclerosis and stenosis. This study aimed to investigate the relationship of CHD with glycated albumin (GA), glycosylated hemoglobin (HbA 1c), glucose (Glu), homocysteine (Hcy), triglyceride (TG), and apolipop protein A (apoA) levels in elderly patients with type 2 diabetes mellitus (T2DM). Moreover, it was attempted to predict which changes had a significant correlation with the occurrence of CHD in these biochemical indicators. Materials and Methods: This clinical cohort study included a total of 472 patients admitted to our hospital from June 2018 to June 2019. They were then divided into three groups of concurrent (n=168, T2DM complicated with CHD), DM (n=148, T2DM alone), and control (n=156, healthy individuals). Results: There were significant differences between the disease group (i.e., DM and concurrent groups) and control group in terms of GA (P=0.013, 28.58±8.01 vs. 15.77±1.44), HbA 1c (P=0.022, 9.5±1.5 vs. 5.5±0.5), Glu (P=0.012, 8.54±2.23 vs. 4.12±0.39), Hcy (P=0.031, 11.16±3.28 vs. 5.03±2.87), TG (P=0.021, 1.83±0.49 vs. 0.84±0.18), and apoA (P=0.031, 1.10±0.12 vs. 1.30±0.18). Moreover, GA (P=0.025, 27.14±6.34 vs. 28.58±8.01; concurrent group vs. DM group), HbA 1c (P=0.033, 8.3±1.2 vs. 9.5±1.5; concurrent group vs. DM group), Glu (P=0.019, 8.62±3.56 vs. 8.54±2.23; concurrent group vs. DM group), Hcy (P=0.031, 17.56±6.36 vs. 11.16±3.28; concurrent group vs. DM group), total cholesterol ([TC]; P=0.022, 3.06±0.20 vs. 3.69±0.29; concurrent group vs. DM group), and low-density lipoprotein ([LDL]; P=0.037, 2.57±1.02 vs. 3.40±1.17; concurrent group vs. DM group) in disease group (DM group and concurrent group) were higher than those in the control group; however, apoA (P=0.023, 0.95±0.12 vs. 1.10±0.12; concurrent group vs. DM group) in disease group was lower than that in the control group. Furthermore, there were significant differences between the disease and control groups in terms of GA, HbA 1c, Glu, Hcy, TC, LDL, and apoA (P<0.05). Pearson correlation analysis between DM and concurrent groups was performed on the clinical parameters with statistical differences, and GA was highly correlated with HbA 1c and Glu (P<0.01). Conclusion: High-risk patient screening with high levels of GA, Hcy, and apoA in elderly patients with T2DM can not only improve the symptoms of patients with targeted treatment but also reduce the incidence of CHD by timely intervention, which is of great significance to improve the quality of life of patients.

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Efficacy of Metoprolol Succinate Sustained Release Tablets Combined with Wenxin Granules in the Treatment of Coronary Heart Disease Arrhythmia

Journal of Clinical and Nursing Research ◽

10.26689/jcnr.v5i2.1904 ◽

2021 ◽

Vol 5 (2) ◽

Author(s):

Guangqing Zhao ◽

Liling Yao

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Sustained Release ◽

Adverse Reactions ◽

Control Group ◽

Observation Group ◽

Metoprolol Succinate ◽

Significant Difference ◽

Sustained Release Tablets ◽

And Control

Objective: To explore the effect of metoprolol succinate sustained-release tablets combined with Wenxin Granules in the treatment of coronary heart disease patients with arrhythmia. Methods: The research objects were 50 patients with arrhythmia who were treated in our hospital from September 2019 to September 2020. According to different treatment methods, they were divided into observation group (Wenxin Granule + metoprolol succinate treatment) and control group (metoprolol succinate treatment), 25 cases in each group. The curative effects of the two groups were compared. Results: After treatment, there was no significant difference in rnn50, RMSSD, sdnni and SDANN between the two groups (P>0.05). Compared with the control group, the SDNN in the observation group was higher than that in the control group (P< 0.05); Before treatment, there was no significant difference in the above indexes between the two groups (P>0.05); The effective rates of the observation group and the control group were 92.00% and 68.00% respectively, and the curative effect of the observation group was higher than that of the control group (P< 0.05); There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion: In the treatment of patients with coronary heart disease and arrhythmia, Wenxin Granule Combined with metoprolol succinate sustained-release tablets has significant effect, which can effectively improve the dynamic electrocardiogram indexes of patients, improve the clinical efficacy, and has high safety.

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