Abstract 29: Metabolomic Signatures of Sedentary Behavior and Cardiometabolic Traits in US Hispanics/Latinos: Hispanic Community Health Study / Study of Latinos (HCHS/SOL)

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Jin Choul Chai ◽  
Jee-Young Moon ◽  
Bing Yu ◽  
Guochong Chen ◽  
Mariaelisa Graff ◽  
...  
Keyword(s):  
Physical Activity ◽  
Sedentary Behavior ◽  
Blood Lipids ◽  
Cardiometabolic Risk ◽  
Vigorous Physical Activity ◽  
Health Study ◽  
Branched Chain ◽  
Positive Correlations ◽  
Underlying Mechanisms ◽  
Cardiometabolic Traits

Introduction: Sedentary behavior is associated with cardiometabolic risk independent of physical activity, but the underlying mechanisms are not fully understood. Hypothesis: Sedentary behavior may influence serum metabolite profiles which are associated with cardiometabolic risk factors. Methods: The analyses included 2711 participants (43% men) of the HCHS/SOL aged 18 to 74 years, free of CVD and other major chronic diseases. Serum metabolomics was performed using an untargeted approach. Physical activity and sedentary behavior were measured by accelerometer (Actical) for a 7-day period. Survey linear regressions were used to examine associations between sedentary behavior and metabolites. Metabolite scores were calculated by summing up z-scores of significant metabolites within the same sub-pathway. Results: Of 624 known metabolites, 95 were significantly associated with sedentary behavior ( P <0.05 after FDR correction), adjusting for socioeconomic and lifestyle factors including moderate to vigorous physical activity ( Figure 1A ). The majority of significant metabolites were clustered into 7 sub-pathways. Three sub-pathway scores (branched-chain amino acids [BCAA], acylcarnitine and medium-chain fatty acid metabolism) were positively associated with sedentary behavior, while the other 4 sub-pathway scores (acylcholine, plasmalogen, nicotinate, and arginine) were inversely associated with sedentary behavior. Among these scores, the BCAA score showed unfavorable correlations with all cardiometabolic traits including obesity measures, glycemic traits, blood lipids and blood pressure. The acylcholine score showed favorable correlations with obesity measures and glycemic traits, though positive correlations with blood lipids were observed ( Figure 1B) . Conclusions: Our study identified multiple serum metabolites associated with sedentary behavior independent of physical activity, suggesting potential mechanistic links between sedentary behavior and cardiometabolic diseases.

scholarly journals Objectively Measured Sedentary Behavior, Physical Activity, and Cardiometabolic Risk in Hispanic Youth: Hispanic Community Health Study/Study of Latino Youth

2018 ◽  
Vol 103 (9) ◽  
pp. 3289-3298 ◽  
Author(s):  
Garrett Strizich ◽  
Robert C Kaplan ◽  
Daniela Sotres-Alvarez ◽  
Keith M Diaz ◽  
Amber L Daigre ◽  
...  
Keyword(s):  
Physical Activity ◽  
Sedentary Behavior ◽  
Cardiometabolic Risk ◽  
Vigorous Physical Activity ◽  
Latino Youth ◽  
Health Study ◽  
Accelerometer Data ◽  
Linear Regression Models ◽  
Plasminogen Activator Inhibitor 1 ◽  
Wear Time

Abstract Context Time spent in moderate-to-vigorous physical activity (MVPA), but not in sedentary behavior (SB), is related to cardiometabolic risk among non-Hispanic white youth. Objective Examine associations of SB and MVPA with cardiometabolic risk factors among Hispanic/Latino youth. Design Cross-sectional analysis. Setting Four US communities. Participants Hispanic/Latino youth (N = 1,426) ages 8 to 16 years. Measurements Associations of MVPA and SB, measured using 7-day accelerometer data (independent variables), with markers of glucose and lipid metabolism, inflammation, and endothelial function (dependent variables), were assessed in multivariable linear regression models while adjusting for sociodemographic characteristics and accelerometer wear time. Additional models controlled for obesity measures. Results SB comprised a mean (SD) of 75% (13%) of accelerometer wear time; mean (SD) time of MVPA was 35 min/d (22 min/d). Deleterious levels of high-density lipoprotein–cholesterol (HDL-C), triglycerides, insulin resistance, C-reactive protein, and plasminogen activator inhibitor-1 were associated with lower levels of MVPA and higher levels of SB (all P &lt; 0.05). Associations of MVPA with log-transformed triglyceride concentrations (β per 15-min/d increment, −0.039; SE, 0.018; P = 0.037) and SB with HDL-C (β per 30-min/d increment, −0.63; SE, 0.26; P = 0.018), but not those with other markers, remained significant after adjusting for MVPA or SB and further adjustment for body mass index and waist circumference. Higher SB tertiles were associated with lower soluble receptor for advanced glycation end products in fully adjusted models (P for trend = 0.037). Conclusions Physiological precursors of diabetes and cardiovascular disease were associated with MVPA and SB among US Hispanic/Latino youth, a group that bears a disproportionate burden of metabolic disorders.

scholarly journals Are sedentary behavior and physical activity independently associated with cardiometabolic benefits? The Hispanic Community Health Study/Study of Latinos

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yasmin Mossavar-Rahmani ◽  
Simin Hua ◽  
Qibin Qi ◽  
Garrett Strizich ◽  
Daniela Sotres-Alvarez ◽  
...  
Keyword(s):  
Physical Activity ◽  
Community Health ◽  
Sedentary Behavior ◽  
Cardiometabolic Risk ◽  
Ldl Cholesterol ◽  
Vigorous Physical Activity ◽  
Health Benefits ◽  
Health Study ◽  
Cardiometabolic Disease ◽  
Hispanic Community

Abstract Background Whether physical activity can reduce cardiometabolic risk particularly in understudied populations such as US Hispanics/Latinos is of public health interest. We prospectively examined the association of physical activity and cardiometabolic biomarkers in n = 8049 participants of the Hispanic Community Health Study/Study of Latinos, a community-based cohort study of 16,415 adults aged 18–74 yr who self-identified as Hispanic/Latino from four US urban centers. Methods We assessed physical activity using accelerometry in 2008–2011 at visit 1. We assessed cardiometabolic biomarkers twice: once at visit 1 and collected a second measure in 2014–2017 at visit 2. We used survey linear regression models with changes in cardiometabolic markers as the dependent variables and quartiles of sedentary behavior or whether adults met guidelines for moderate-to-vigorous physical activity as the independent variables. Results In normoglycemic adults without cardiovascular disease, but not in adults with evidence of cardiometabolic disease, those who were in the lowest quartile for sedentary behavior (< 10.08 h/day) had a significant decline in mean LDL-cholesterol of − 3.94 mg/dL (95% CI: − 6.37, − 1.52) compared to adults in the highest quartile (≥13.0 h/day) who exhibited a significant increase in LDL-cholesterol of 0.14 mg/dL (95% CI, − 2.15,2.42) over the six year period (P < 0.02 in fully adjusted models.) There was also a trend toward lower mean increase in HbA1c comparing the lowest with the highest quartile of sedentary behavior. Overall regardless of glycemic level or evidence of cardiometabolic disease, adults who met guidelines for moderate-to-vigorous physical activity at visit 1, had significantly lower mean increases in level of fasting glucose compared to adults not meeting guidelines in fully adjusted models. Conclusions In this cohort of Hispanics/Latinos, being free of cardiometabolic disease and having low levels of sedentary behavior were associated with health benefits. Among all adults regardless of cardiometabolic disease, meeting guidelines for moderate-to-vigorous physical activity was associated with health benefits. Overall these data suggest that an active lifestyle may blunt the association of advancing age with worsening cardiometabolic risk factors.

Sedentary behavior moderates the relationship between physical activity and cardiometabolic risk in young Latino children

2021 ◽  
Author(s):  
Jamil A Malik ◽  
Jennifer Coto ◽  
Elizabeth R Pulgaron ◽  
Amber Daigre ◽  
Janine E Sanchez ◽  
...  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Sedentary Behavior ◽  
Low Income ◽  
Latent Variables ◽  
Cardiometabolic Risk ◽  
Vigorous Physical Activity ◽  
Cardiometabolic Risk Factors ◽  
Metabolic Risk ◽  
Latino Children

Abstract This study investigated the role of objectively measured moderate–vigorous physical activity (MVPA) and sedentary behavior on cardiometabolic risk factors of young Latino children. We hypothesized that MVPA would be associated with lower cardiometabolic risk when sedentary behavior is low. We studied 86 primarily low-income, Latino children using a cross-sectional study design. The study sample consisted of 51 girls and 35 boys, with mean age 5.6 (SD = .53) years. Physical activity was measured by accelerometry, anthropometric measures obtained, and fasting blood samples were used to measure cardiometabolic risk factors. Greater levels of sedentary behavior were associated with increased waist circumference (rs = .24, p &lt; .05) and metabolic risks. MVPA, however, had significant beneficial associations with all cardiometabolic risk factors (rs-range = −.20 to −.45, p &lt; .05) with the exception of plasma insulin. MVPA predicted latent variables representing anthropometric risk (β = −.57, p &lt; .01), cardiac risk (β = −.74, p &lt; .01), and metabolic risk (β = −.88, p &lt; .01). Sedentary behavior significantly moderated the effect of MVPA on anthropometric (β-interaction = .49, p &lt; .01), cardiac (β-interaction = .45, p &lt; .01), and metabolic risk (β-interaction = .77, p &lt; .01), such that more MVPA was associated with better health outcomes under conditions of lower sedentary behavior. The model explained 13%, 22%, and 45% variance in anthropometric, cardiac, and metabolic risk factors, respectively. Increased MVPA is associated with decreased cardiometabolic risk in young Latino children, particularly when sedentary behavior is low.

scholarly journals A Cross-Sectional Examination of Patterns of Sedentary Behavior and Cardiometabolic Risk in Community-Dwelling Adults Aged 55 Years and Older

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Kelsey L. McAlister ◽  
Daniela A. Rubin ◽  
Koren L. Fisher
Keyword(s):  
Physical Activity ◽  
Sedentary Behavior ◽  
Cardiometabolic Risk ◽  
Vigorous Physical Activity ◽  
Fasting Blood Glucose ◽  
Hdl Cholesterol ◽  
Community Dwelling ◽  
Convenience Sample ◽  
Sedentary Bouts ◽  
Older Populations

Introduction. Sedentary behavior (SB) is highly prevalent among older adults, with more than 25% engaging in 6 hours or more of SB daily. SB has been associated with several cardiometabolic biomarkers in younger adults; however, there is a paucity of research in older populations. This study examined associations between patterns of SB and cardiometabolic biomarkers in community-dwelling adults aged 55 years and older. Methods. Data were drawn from a convenience sample of 54 community-dwelling individuals (12 males, 42 females; mean age = 72.6 ± 6.8 years, range = 56–89 years). Cardiometabolic biomarkers assessed included systolic (SBP) and diastolic blood pressure (DBP), body mass index, waist circumference, and fasting blood glucose and cholesterol parameters. SB was assessed via accelerometry over a 7-day period, and measures included daily time in SB, number and length of sedentary bouts, the number and length of breaks between sedentary bouts, moderate-to-vigorous physical activity (MVPA), and light physical activity (LPA). Associations between the SB measures and each cardiometabolic risk factor were examined using separate stepwise multiple regression models, controlling for sex, MVPA, and accelerometer wear time. Isotemporal substitution models were used to examine the change in cardiometabolic outcomes when SB is replaced by an equal duration of either LPA or MVPA. Results. Adjusted regression analyses showed that daily sedentary time was positively associated with DBP (β = 0.052, ∆R2 = 0.112, p=0.022) and inversely associated with HDL cholesterol (β = −0.111, ∆R2 = 0.121, p=0.039). Sedentary bout length was also associated with DBP and HDL cholesterol (β = 0.575, ∆R2 = 0.152, p = 0.007; β = −1.529, ∆R2 = 0.196, p=0.007, respectively). Replacement of 10 minutes of SB a day with LPA was associated with improved DBP and HDL cholesterol (p≤0.05). No other significant associations (p≤0.05) were found. Conclusion. Sitting for prolonged periods of time without interruption is unfavorably associated with DBP and HDL cholesterol. Prospective studies should identify causal relationships and observe specific changes in cardiometabolic profiles in older populations.

scholarly journals Association of accelerometer-measured physical activity with kidney function in a Japanese population: the DOSANCO Health Study

2022 ◽  
Vol 23 (1) ◽  
Author(s):  
Sachiko Sasaki ◽  
Koshi Nakamura ◽  
Shigekazu Ukawa ◽  
Emiko Okada ◽  
Shiho Amagasa ◽  
...  
Keyword(s):  
Physical Activity ◽  
Regression Model ◽  
Sedentary Behavior ◽  
Kidney Function ◽  
Odds Ratio ◽  
Japanese Population ◽  
Vigorous Physical Activity ◽  
Community Dwelling ◽  
Activity Level ◽  
Health Study

Abstract Background Sedentary behavior and decreased physical activity are associated with reduced kidney function, yet most evidence is based on self-reported physical activity. This study investigated the association between accelerometer-based physical activity level and kidney function in a general Japanese population. Methods A cross-sectional study was conducted in 440 community-dwelling Japanese participants, aged 35–79 years. Time (min/d) was assessed for the following types of physical activity: sedentary behavior, light physical activity (LPA), and moderate-to-vigorous physical activity (MVPA). Kidney function was assessed using estimated glomerular filtration rate (eGFR). A linear regression model was employed to calculate the β coefficient of eGFR for a 60-min/d increase in sedentary behavior and LPA and a 10-min/d increase in MVPA. A logistic regression model was used to calculate the odds ratio for low eGFR (< 60 versus ≥60 mL/min/1.73m2) for a 60-min/d or 10-min/d increase in each physical activity type. Results MVPA time and eGFR were positively associated in both men and women, after adjusting for age, body mass index, and other clinical characteristics (Men: β, 0.91; P = 0.021; Women: β, 0.70; P = 0.034). In women, sedentary behavior and eGFR were inversely associated after adjusting for the same factors (β, − 1.06; P = 0.048). The odds ratio (95% confidence interval) for low eGFR associated with a 60-min increase in sedentary behavior was 1.65 (1.07–2.55) after adjusting for the same factors in women. Conclusion Longer sedentary behavior and shorter MVPA time were associated with lower kidney function in the Japanese population.

scholarly journals Cannabis use, sedentary behavior, and physical activity in a nationally representative sample of US adults

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Lydia Q. Ong ◽  
John Bellettiere ◽  
Citlali Alvarado ◽  
Paul Chavez ◽  
Vincent Berardi
Keyword(s):  
Physical Activity ◽  
Sedentary Behavior ◽  
Vigorous Physical Activity ◽  
Health Impact ◽  
Cannabis Use ◽  
Objective Measures ◽  
Health And Nutrition ◽  
Nationally Representative ◽  
The Relationship ◽  
Potential Public Health

Abstract Background Prior research examining the relationship between cannabis use, sedentary behavior, and physical activity has generated conflicting findings, potentially due to biases in the self-reported measures used to assess physical activity. This study aimed to more precisely explore the relationship between cannabis use and sedentary behavior/physical activity using objective measures. Methods Data were obtained from the 2005–2006 National Health and Nutrition Examination Survey. A total of 2,092 participants (ages 20–59; 48.8% female) had accelerometer-measured sedentary behavior, light physical activity, and moderate-to-vigorous physical activity. Participants were classified as light, moderate, frequent, or non-current cannabis users depending on how often they used cannabis in the previous 30 days. Multivariable linear regression estimated minutes in sedentary behavior/physical activity by cannabis use status. Logistic regression modeled self-reported moderate-to-vigorous physical activity in relation to current cannabis use. Results Fully adjusted regression models indicated that current cannabis users’ accelerometer-measured sedentary behavior did not significantly differ from non-current users. Frequent cannabis users engaged in more physical activity than non-current users. Light cannabis users had greater odds of self-reporting physical activity compared to non-current users. Conclusions This study is the first to evaluate the relationship between cannabis use and accelerometer-measured sedentary behavior and physical activity. Such objective measures should be used in other cohorts to replicate our findings that cannabis use is associated with greater physical activity and not associated with sedentary behavior in order to fully assess the potential public health impact of increases in cannabis use.

scholarly journals Relationship Between Meeting 24-Hour Movement Guidelines and Cardiometabolic Risk Factors in Children

2017 ◽  
Vol 14 (10) ◽  
pp. 779-784 ◽  
Author(s):  
Peter T. Katzmarzyk ◽  
Amanda E. Staiano
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Blood Pressure ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Cardiometabolic Risk ◽  
Vigorous Physical Activity ◽  
Density Lipoprotein ◽  
Cardiometabolic Risk Factors ◽  
Subcutaneous Adipose

Background:The purpose of this study was to evaluate the relationship between adherence to pediatric 24-hour movement guidelines (moderate to vigorous physical activity, sedentary behavior, and sleep) and cardiometabolic risk factors.Methods:The sample included 357 white and African American children aged 5–18 years. Physical activity, television viewing, and sleep duration were measured using questionnaires, and the 24-hour movement guidelines were defined as ≥60 minutes per day of moderate to vigorous physical activity on ≥5 days per week, ≤ 2 hours per day of television, and sleeping 9–11 hours per night (ages 5–13 y) or 8–10 hours per night (ages 14–18 y). Waist circumference, body fat, abdominal visceral and subcutaneous adipose tissue, blood pressure, fasting triglycerides, high-density lipoprotein cholesterol, and glucose were measured in a clinical setting.Results:A total of 26.9% of the sample met none of the guidelines, whereas 36.4%, 28.3%, and 8.4% of the sample met 1, 2, or all 3 guidelines, respectively. There were significant associations between the number of guidelines met and body mass index, visceral and subcutaneous adipose tissue, triglycerides, and glucose. There were no associations with blood pressure or high-density lipoprotein cholesterol.Conclusions:Meeting more components of the 24-hour movement guidelines was associated with lower levels of obesity and several cardiometabolic risk factors. Future efforts should consider novel strategies to simultaneously improve physical activity, sedentary time, and sleep in children.

scholarly journals Leading by Example: Association Between Mother and Child Objectively Measured Physical Activity and Sedentary Behavior

2020 ◽  
pp. 1-12
Author(s):  
Brad R. Julius ◽  
Amy M.J. O’Shea ◽  
Shelby L. Francis ◽  
Kathleen F. Janz ◽  
Helena Laroche
Keyword(s):  
Physical Activity ◽  
Sedentary Behavior ◽  
Low Income ◽  
Multivariate Regression ◽  
Sedentary Time ◽  
Vigorous Physical Activity ◽  
Mother And Child ◽  
Low Income Mothers ◽  
Objectively Measured ◽  
The Relationship

Purpose: The authors examined the relationship between mother and child activity. Methods: The authors compared moderate–vigorous physical activity (MVPA) and sedentary time of low-income mothers with obesity and their 6- to 12-year-old children on week (WD) and weekend (WE) days. A total of 196 mother–child pairs wore accelerometers simultaneously for a week. Mothers completed questionnaires. Spearman correlation and multivariate regression were used. Results: WE MVPA (accelerometry) was significantly correlated between mothers with children aged 6–7 (rs = .35) and daughters (rs = .27). Self-reported maternal PA time spent with one of their children was significantly correlated with the WE MVPA of all children (rs = .21) and children aged 8–10 (rs = .22) and with the WD MVPA of all children (rs = .15), children aged 8–10 (rs = .23), aged 11–12 (rs = .52), and daughters (rs = .37), and inversely correlated to the WD sedentary time of all children (rs = −.21), children aged 8–10 (rs = −.30), aged 11–12 (rs = −.34), daughters (rs = −.26), and sons (rs = −.22). In multivariate regression, significant associations were identified between reported child–mother PA time together and child MVPA and sedentary time (accelerometry). Conclusions: Mothers may influence the PA levels of their children with the strongest associations found in children aged 6–7 and daughters. Mother–child coparticipation in PA may lead to increased child MVPA and decreased sedentary behavior.

scholarly journals Impact of parents’ physical activity on preschool children’s physical activity: a cross-sectional study

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e4405 ◽  
Author(s):  
Chang Xu ◽  
Minghui Quan ◽  
Hanbin Zhang ◽  
Chenglin Zhou ◽  
PeiJie Chen
Keyword(s):  
Physical Activity ◽  
Sedentary Behavior ◽  
Vigorous Physical Activity ◽  
Cross Sectional Study ◽  
Maternal Influence ◽  
Activity Levels ◽  
Cross Sectional ◽  
Physical Activity Levels ◽  
Paternal Influence ◽  
Children’S Physical Activity

Purpose This study examined the associations of physical activity levels between parents and their pre-school children based on gender and weekday/weekend. Method A total of 247 parent-preschool child triads from Shanghai, China were analyzed. The children had a mean age of 57.5 ± 5.2 months. Both sedentary behavior and physical activity were measured in all participants using an ActiGraph GT3X+ accelerometer over seven consecutive days from Monday through the following Sunday. A multivariate regression model was derived to identify significant relationships between parental and child physical activity according to gender and weekday/weekend. Results There was a significant correlation between mothers’ and girls’ moderate-to-vigorous physical activity (MVPA) and total physical activity (TPA) on weekdays. Fathers’ MPVA levels correlated significantly with those of boys and girls, with paternal influence appearing to be stronger than maternal influence. However, there was not a significant correlation between fathers’ and children’s TPA. TPA levels of both mothers and fathers correlated with those of girls, but not with those of boys. Parental sedentary levels on the weekend correlated significantly with girls’ levels, but not with boys’ levels. Children’s physical activity levels on weekends were influenced more by fathers’ activity levels than by mothers’, while the opposite was observed on weekdays. Conclusion Sedentary behavior and physical activity levels of parents can strongly influence those of their preschool children, with maternal influence stronger during the weekdays and paternal influence stronger on the weekends. Parents’ activity levels influence girls’ levels more strongly than they influence boys’ levels.

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