The Functional Neuroanatomy of Thematic Role and Locative Relational Knowledge

2007 ◽  
Vol 19 (9) ◽  
pp. 1542-1555 ◽  
Author(s):  
Denise H. Wu ◽  
Sara Waller ◽  
Anjan Chatterjee
Keyword(s):  
Conceptual Knowledge ◽  
Visual Motion ◽  
Critical Role ◽  
Temporal Cortex ◽  
Functional Neuroanatomy ◽  
Thematic Role ◽  
Point Of Entry ◽  
Relational Knowledge ◽  
Relational Concepts ◽  
The Relationship

Lexical-semantic investigations in cognitive neuroscience have focused on conceptual knowledge of concrete objects. By contrast, relational concepts have been largely ignored. We examined thematic role and locative knowledge in 14 left-hemisphere-damage patients. Relational concepts shift cognitive focus away from the object to the relationship between objects, calling into question the relevance of traditional sensory-functional accounts of semantics. If extraction of a relational structure is the critical cognitive process common to both thematic and locative knowledge, then damage to neural structures involved in such an extraction would impair both kinds of knowledge. If the nature of the relationship itself is critical, then functional neuroanatomical dissociations should occur. Using a new lesion analysis method, we found that damage to the lateral temporal cortex produced deficits in thematic role knowledge and damage to inferior fronto-parietal regions produced deficits in locative knowledge. In addition, we found that conceptual knowledge of thematic roles dissociates from its mapping onto language. These relational knowledge deficits were not accounted for by deficits in processing nouns or verbs or by a general deficit in making inferences. Our results are consistent with the hypothesis that manners of visual motion serve as a point of entry for thematic role knowledge and networks dedicated to eye gaze, whereas reaching and grasping serve as a point of entry for locative knowledge. Intermediary convergence zones that are topographically guided by these sensory-motor points of entry play a critical role in the semantics of relational concepts.

Functional Neuroanatomy of the Semantic System: Divisible by What?

1998 ◽  
Vol 10 (6) ◽  
pp. 766-777 ◽  
Author(s):  
C. J. Mummery ◽  
K. Patterson ◽  
J. R. Hodges ◽  
C. J. Price
Keyword(s):  
Conceptual Knowledge ◽  
Temporal Cortex ◽  
Brain Regions ◽  
Middle Temporal Gyrus ◽  
Conceptual System ◽  
Functional Neuroanatomy ◽  
Brain Organization ◽  
Differential Activation ◽  
Semantic System ◽  
Living Things

Studies of patients with brain damage suggest that specific brain regions may be differentially involved in representing/processing certain categories of conceptual knowledge. With regard to the dissociation that has received the most attention—between the domains of living things and artifacts—a debate continues as to whether these category-specific effects reflect neural implementation of categories directly or some more basic properties of brain organization. The present positron emission tomography (PET) study addressed this issue by probing explicitly for differential activation associated with written names of objects from the domains of living things or artifacts during similarity judgments about different attributes of these objects. Subjects viewed triads of written object names and selected one of two response words as more similar to a target word according to a specified perceptual attribute (typical color of the objects) or an associative attribute (typical location of the objects). The control task required a similarity judgment about the number of syllables in the target and response words. All tasks were performed under two different stimulus conditions: names of living things and names of artifacts. Judgments for both domains and both attribute types activated an extensive, distributed, left-hemisphere semantic system, but showed some differential activation-particularly as a function of attribute type. The left temporooccipito-parietal junction showed enhanced activity for judgments about object location, whereas the left anteromedial temporal cortex and caudate nucleus were differentially activated by color judgments. Smaller differences were seen for living and nonliving domains, the positive findings being largely consistent with previous studies using objects; in particular, words denoting artifacts produced enhanced activation in the left posterior middle temporal gyrus. These results suggest that, within a distributed conceptual system activated by words, the more prominent neural distinction relates to type of attribute.

XIST: A Meaningful Long Noncoding RNA in NSCLC Process

2020 ◽  
Vol 26 ◽  
Author(s):  
Yujie Shen ◽  
Yexiang Lin ◽  
Kai Liu ◽  
Jinlan Chen ◽  
Juanjuan Zhong ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Critical Role ◽  
Biological Functions ◽  
Potential Therapeutic Target ◽  
Considerable Evidence ◽  
Lncrna Xist ◽  
Nsclc Patients ◽  
The Relationship

Background: A number of studies have proposed that lncRNA XIST plays a role in the development and chemosensitivity of NSCLC. Besides, XIST may become a potential therapeutic target for NSCLC patients. The aim of this review is to reveal the biological functions and exact mechanisms of XIST in NSCLC. Methods: In this review, relevant researches involving in the relationship between XIST and NSCLC are collected through systematic retrieval of PubMed Results: XIST is an oncogene in NSCLC and is abnormally upregulated in NSCLC tissues. Considerable evidence has shown that XIST exerts a critical role in the proliferation, invasion, migration, apoptosis and chemosensitivity of NSCLC cells. XIST mainly functions as a ceRNA in NSCLC process, while XIST also functions at transcriptional levels. Conclusion: LncRNA XIST has potential to become a novel biomolecular marker of NSCLC and a therapeutic target for NSCLC.

scholarly journals Relationship between Emotional Intelligence and Violence Exerted, Received, and Perceived in Teen Dating Relationships

2021 ◽  
Vol 18 (5) ◽  
pp. 2284
Author(s):  
Cordelia Estevez-Casellas ◽  
Mª Dolores Gómez-Medina ◽  
Esther Sitges
Keyword(s):  
Emotional Intelligence ◽  
Social Relationships ◽  
Violent Behavior ◽  
Critical Role ◽  
Dating Relationships ◽  
Significant Relation ◽  
Violent Behaviors ◽  
Teen Dating ◽  
The Relationship

Emotional intelligence plays a critical role in adolescence since it involves a change towards psychological, social, and sexual maturity; a stage in which the foundations of intimate social relationships are established. Emotional competences regulate the quality of these relationships in adolescence and can provide protection against or facilitate the use of violence within them. Based on the above, this study aims to analyze the relationship between emotional intelligence and violence exercised, received, and perceived by adolescents in dating relationships. A sample of 254 subjects (43.1% men and 56.9% women) between 12 and 18 years old was analyzed through the Emotional Intelligence Questionnaires of BarOn ICE:NA and Violence Exercised Perceived and Received by Adolescents VERA. The results of the research have shown that there is a significant and inverse relation between the dimensions of emotional intelligence and the violence exercised by adolescents in their dating relationships, and a positive and significant relation between emotional intelligence and the perception of violent behavior. For this reason, the importance of educating people about emotional intelligence from childhood within both the academic and family sphere is highlighted. This is fundamental to preventing the appearance of such violent behaviors and promoting an adequate adaptation to the environment.

scholarly journals Potential mechanisms involving the immobilization of Cd, As and Cr during swine manure composting

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Hao-Nan Guo ◽  
Li-Xia Wang ◽  
Hong-Tao Liu
Keyword(s):  
Cation Exchange Capacity ◽  
Physicochemical Parameters ◽  
Redundancy Analysis ◽  
Critical Role ◽  
Swine Manure ◽  
Exchange Capacity ◽  
Bulking Agent ◽  
Initial Carbon ◽  
Acid Ratio ◽  
The Relationship

Abstract This study aims to investigate the relationship between key physicochemical parameters related to composting process and bioavailability of Cd, As and Cr during swine manure composting through regulating different initial carbon to nitrogen (C/N) ratios (15:1, 20:1, 25:1) and bulking agent types (straw, green waste). Results showed that higher initial C/N ratio of 20:1 or 25:1 and straw as bulking agent were optimal to reduce the bioavailability of Cd, As and Cr (62.4%, 20.6% and 32.2% reduction, respectively). Redundancy analysis implied that the bioavailability of Cd was significantly associated with total phosphorus and total nitrogen, deducing the formation of phosphate precipitation and biosorption might participated in the reaction process, while that of As and Cr were mainly influenced by organic matter (OM), cation exchange capacity (CEC) and OM, CEC, electric conductivity, respectively. A total of 48.5%, 64.6% and 62.2% of Cd, As and Cr redistribution information could be explained by the above parameters. Further correlation analysis revealed that bioavailable As and Cr were negatively correlated with humic acid to fulvic acid ratio. In summary, this study confirms that the mechanisms of phosphate precipitation, biosorption and humification played critical role in reducing Cd, As and Cr bioavailability during swine manure composting.

The gray matter volume of the right insula mediates the relationship between symptoms of depression/anxiety and sleep quality among college students

2019 ◽  
pp. 135910531986997 ◽  
Author(s):  
Huazhan Yin ◽  
Li Zhang ◽  
Dan Li ◽  
Lu Xiao ◽  
Mei Cheng
Keyword(s):  
College Students ◽  
Sleep Quality ◽  
Gray Matter ◽  
Emotional Processing ◽  
Gray Matter Volume ◽  
Critical Role ◽  
Symptoms Of Depression ◽  
Matter Volume ◽  
The Right ◽  
The Relationship

This study investigated the neuroanatomical basis of the association between depression/anxiety and sleep quality among 370 college students. The results showed that there was a significant correlation between sleep quality and depression/anxiety. Moreover, mediation results showed that the gray matter volume of the right insula mediated the relationship between depression/anxiety and sleep quality, which suggested that depression/anxiety may affect sleep quality through the right insula volume. These findings confirmed a strong link between sleep quality and depression/anxiety, while highlighting the volumetric variation in the right insula associated with emotional processing, which may play a critical role in improving sleep quality.

Medullary lateral tegmental field: control of respiratory rate and vagal lung inflation afferent influences on sympathetic nerve discharge

2005 ◽  
Vol 288 (5) ◽  
pp. R1396-R1410 ◽  
Author(s):  
Shaun W. Phillips ◽  
Gerard L. Gebber ◽  
Susan M. Barman
Keyword(s):  
Respiratory Rate ◽  
Sympathetic Nerve ◽  
Artificial Ventilation ◽  
Critical Role ◽  
Lung Inflation ◽  
Chemical Inactivation ◽  
A Value ◽  
Relationship Of ◽  
The Relationship ◽  
Nerve Discharge

We used spectral analysis and event-triggered averaging to determine the effects of chemical inactivation of the medullary lateral tegmental field (LTF) on 1) the relationship of intratracheal pressure (ITP, an index of vagal lung inflation afferent activity) to sympathetic nerve discharge (SND) and phrenic nerve activity (PNA) and 2) central respiratory rate in paralyzed, artificially ventilated dial-urethane-anesthetized cats. ITP-SND coherence value at the frequency of artificial ventilation was significantly ( P < 0.05; n = 18) reduced from 0.73 ± 0.04 (mean ± SE) to 0.24 ± 0.04 after bilateral microinjection of muscimol into the LTF. Central respiratory rate was unexpectedly increased in 12 of these experiments (0.28 ± 0.03 vs. 0.95 ± 0.25 Hz). The ITP-PNA coherence value was variably affected by chemical inactivation of the LTF. It was unchanged when central respiratory rate was also not altered, decreased when respiratory rate was increased above the rate of artificial ventilation, and increased when respiratory rate was raised from a value below the rate of artificial ventilation to the same frequency as the ventilator. Chemical inactivation of the LTF increased central respiratory rate in four of six vagotomized cats but did not significantly affect the PNA-SND coherence value. These data demonstrate that the LTF 1) plays a critical role in mediating the effects of vagal lung inflation afferents on SND but not PNA, 2) helps maintain central respiratory rate in the physiological range, but 3) is not involved in the coupling of central respiratory and sympathetic circuits.

scholarly journals The Relationship Between Social Support and Student Academic Involvement: The Mediating Role of School Belonging

2021 ◽  
pp. 082957352110347
Author(s):  
Luis Francisco Vargas-Madriz ◽  
Chiaki Konishi
Keyword(s):  
Social Support ◽  
High School ◽  
High School Students ◽  
Parental Support ◽  
Critical Role ◽  
School Belonging ◽  
School Students ◽  
Academic Involvement ◽  
The Relationship

Canada’s high school graduation rates are still low when compared to other members of the OECD. Previous studies have found academic involvement is associated with positive trajectories toward graduation, that social support promotes student engagement, and that school belonging could mediate this relationship. Still, little is known about the specificity of such mediation, especially in Québec. Therefore, this study examined the role of belonging as mediator of the relationship between social support and academic involvement. Participants ( N = 238) were high-school students from the Greater Montréal Area. All variables were measured by the School-Climate Questionnaire. Results from hierarchical multiple regressions indicated parental support had a direct relationship, whereas peer and teacher support had a mediated relationship by school belonging with academic involvement. Results highlight the critical role of school belonging in promoting academic involvement in relation to social support.

scholarly journals Titan Cells Confer Protection from Phagocytosis in Cryptococcus neoformans Infections

2012 ◽  
Vol 11 (6) ◽  
pp. 820-826 ◽  
Author(s):  
Laura H. Okagaki ◽  
Kirsten Nielsen
Keyword(s):  
Cryptococcus Neoformans ◽  
Critical Role ◽  
Cell Formation ◽  
Pulmonary Cryptococcosis ◽  
Content Type ◽  
Cell Production ◽  
Human Fungal Pathogen ◽  
Large Size ◽  
Large Particles ◽  
The Relationship

ABSTRACTThe human fungal pathogenCryptococcus neoformansproduces an enlarged “titan” cell morphology when exposed to the host pulmonary environment. Titan cells exhibit traits that promote survival in the host. Previous studies showed that titan cells are not phagocytosed and that increased titan cell production in the lungs results in reduced phagocytosis of cryptococcal cells by host immune cells. Here, the effect of titan cell production on host-pathogen interactions during early stages of pulmonary cryptococcosis was explored. The relationship between titan cell production and phagocytosis was found to be nonlinear; moderate increases in titan cell production resulted in profound decreases in phagocytosis, with significant differences occurring within the first 24 h of the infection. Not only were titan cells themselves protected from phagocytosis, but titan cell formation also conferred protection from phagocytosis to normal-size cryptococcal cells. Large particles introduced into the lungs were not phagocytosed, suggesting the large size of titan cells protects against phagocytosis. The presence of large particles was unable to protect smaller particles from phagocytosis, revealing that titan cell size alone is not sufficient to provide the observed cross-protection of normal-size cryptococcal cells. These data suggest that titan cells play a critical role in establishment of the pulmonary infection by promoting the survival of the entire population of cryptococcal cells.

TCAD Study of the Raised SiGe Source/Drain in 40nm PMOS

2015 ◽  
Vol 645-646 ◽  
pp. 70-74 ◽  
Author(s):  
Min Zhong ◽  
Yu Hang Zhao ◽  
Shou Mian Chen ◽  
Ming Li ◽  
Shao Hai Zeng ◽  
...  
Keyword(s):  
Computer Aided Design ◽  
Critical Role ◽  
Sige Layer ◽  
Strain Engineering ◽  
Effect Transistor ◽  
Simulation Results ◽  
Aided Design ◽  
The Relationship ◽  
Growth Experiments ◽  
Good Agreement

An embedded SiGe layer was applied in the source/drain areas (S/D) of a field-effect transistor to boost the performance in the p channels. Raised SiGe S/D plays a critical role in strain engineering. In this study, the relationship between the SiGe overfilling and the enhancement of channel stress was investigated. Systematic technology computer aided design (TCAD) simulations of the SiGe overfill height in a 40 nm PMOS were performed. The simulation results indicate that a moderate SiGe overfilling induces the highest stress in the channel. Corresponding epitaxial growth experiments were done and the obtained experimental data was in good agreement with the simulation results. The effect of the SiGe overfilling is briefly discussed. The results and conclusions presented within this paper might serve as useful references for the optimization of the embedded SiGe stressor for 40 nm logic technology node and beyond.

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