Medullary lateral tegmental field: control of respiratory rate and vagal lung inflation afferent influences on sympathetic nerve discharge

2005 ◽  
Vol 288 (5) ◽  
pp. R1396-R1410 ◽  
Author(s):  
Shaun W. Phillips ◽  
Gerard L. Gebber ◽  
Susan M. Barman
Keyword(s):  
Respiratory Rate ◽  
Sympathetic Nerve ◽  
Artificial Ventilation ◽  
Critical Role ◽  
Lung Inflation ◽  
Chemical Inactivation ◽  
A Value ◽  
Relationship Of ◽  
The Relationship ◽  
Nerve Discharge

We used spectral analysis and event-triggered averaging to determine the effects of chemical inactivation of the medullary lateral tegmental field (LTF) on 1) the relationship of intratracheal pressure (ITP, an index of vagal lung inflation afferent activity) to sympathetic nerve discharge (SND) and phrenic nerve activity (PNA) and 2) central respiratory rate in paralyzed, artificially ventilated dial-urethane-anesthetized cats. ITP-SND coherence value at the frequency of artificial ventilation was significantly ( P < 0.05; n = 18) reduced from 0.73 ± 0.04 (mean ± SE) to 0.24 ± 0.04 after bilateral microinjection of muscimol into the LTF. Central respiratory rate was unexpectedly increased in 12 of these experiments (0.28 ± 0.03 vs. 0.95 ± 0.25 Hz). The ITP-PNA coherence value was variably affected by chemical inactivation of the LTF. It was unchanged when central respiratory rate was also not altered, decreased when respiratory rate was increased above the rate of artificial ventilation, and increased when respiratory rate was raised from a value below the rate of artificial ventilation to the same frequency as the ventilator. Chemical inactivation of the LTF increased central respiratory rate in four of six vagotomized cats but did not significantly affect the PNA-SND coherence value. These data demonstrate that the LTF 1) plays a critical role in mediating the effects of vagal lung inflation afferents on SND but not PNA, 2) helps maintain central respiratory rate in the physiological range, but 3) is not involved in the coupling of central respiratory and sympathetic circuits.

Relation Between Metacognitive Ability with Science Process Skills on Grade 8th Students in MTs Negeri 3 Parigi

2020 ◽  
Vol 3 (1) ◽  
pp. 8-13
Author(s):  
Moch. Munir ◽  
Amiruddin Kade ◽  
Muslimin Muslimin
Keyword(s):  
Research Result ◽  
Reverse Direction ◽  
Process Skills ◽  
Science Process Skills ◽  
A Value ◽  
Regression Test ◽  
Feasibility Test ◽  
Relationship Of ◽  
The Relationship ◽  
Academic Year

This study aims to determine the relations between metacognitive to science process skills on grade VIII students MTs Negeri 3 Parigi. This research is descriptive, the approach used is a quantitative approach, manifested in the form of numbers analyzed by statistics and the results are described. The population is students of MTs Negeri 3 Parigi Academic Year 2017-2018 with a population of three classes, with a sample of 30 students. The instrument used is a metacognitive questionnaire consisting of 50 questions and an essay about science process skills 6 questions test. The result of the prerequisite test of the research result is all metacognitive indicators of normal and linear distributed and based on the regression feasibility test show that all data is feasible for regression test. The result of the regression test and test of determination to obtain a value which is not significant. Based on the results of the research analysis it can be concluded that the relationship of each metacognitive indicator to science process skills was not significant even there were metacognitive indicators that reverse direction significantly. The magnitude of the relationship of each metacognitive indicator with science process skills maximum 15.3%.  

scholarly journals HUBUNGAN POLA ASUH ORANG TUA TERHADAP PERILAKU BULLYING DI SMA N 1 BOLANGITANG

2019 ◽  
Author(s):  
fendi ntobuo
Keyword(s):  
Parenting Style ◽  
Significant Relationship ◽  
Total Population ◽  
P Value ◽  
Chi Square ◽  
Study Approach ◽  
A Value ◽  
Bullying Behavior ◽  
Relationship Of ◽  
The Relationship

One of negative behavior that is mostly done by adolescents is bullying, this behavior is prevalent in the school enviroment. Generally, the factor that influence bullying behavior are family factors, shool factor, peer factor. The focus was on the influence of parenting style because it has a correlation between parenting on an aggressive behavior. The purpose of this study was to determine the relationship of parenting to bullying behavior in Bolangitan 1 N Senior High study approach. The total population was 48 respondents. The result of study by using the Chi Square statistical tes tah there is a significant relationship between parenting of bullying behavior in Bolangitan N 1 School with a value (p value: 0,000). It can concluded there is a significant relationship between parenting style towards bullying behavior in Bolangitan 1 Senior High School. It suggest that counseling can be held about bullying behavior and its response to adolescents.

scholarly journals HUBUNGAN ACCESS BLOCK DENGAN PERBURUKAN KONDISI PASIEN DI INSTALASI GAWAT DARURAT RSUD ULIN BANJARMASIN

2020 ◽  
Vol 11 (1) ◽  
pp. 110-119
Author(s):  
Julianto Julianto ◽  
Izma Daud ◽  
Sari Milyati
Keyword(s):  
Research Method ◽  
Sampling Technique ◽  
P Value ◽  
Test Results ◽  
Hospital Emergency ◽  
Cross Sectional ◽  
Analytical Design ◽  
A Value ◽  
Relationship Of ◽  
The Relationship

Abstrak  Latar Belakang :Access block adalah situasi dimana pasien yang mengalami lama rawat di IGD 6 karena kurangnya akses ke ruang rawat inap dan kepadatan jumlah pasien yang tidak terkendali, dampaknya ditemukan bahwa semakin lama access block  semakin tinggi pula perburukan pasien dalam 24 jam.Tujuan : ini bertujuan untuk mengetahui hubungan access block dengan perburukan kondisi pasien di Instalasi Gawat Darurat RSUD Ulin Banjarmasin.Metode :Penelitian menggunakan desain analitik dengan pendekatan cross sectional. Jumlah sampel yang diambil berjumlah 40 orang dengan teknik pengambilan accidental sampling. Analisis data melalui uji spearman rank.Hasil : Hasil uji dipapatkan nilai p hitung 0,000 (0,05) ada hubungan antara access block dengan perburukan kondisi pasien di instalasi gawat darurat RSUD Ulin Banjarmasi.Simpulan: Berdasarka hasil penelitian Ada hubungan antara access block dengan perburukan kondisi pasien di Instalasi Gawat Darurat RSUD Ulin Banjarmasin dengan nilai P= 0,000 nilai α = 0,05 dengan nilai koefisien korelasi 0,588 Kata kunci: Access Block, Perburukan Pasien. Abstract Background :Access block is a situation where patients who experience length of stay in the ED 6 due to lack of access to the inpatient room and uncontrolled density of patients, it is found that the longer the access block the higher the deterioration of patients in 24 hours.Purpose: This study aims to determine the relationship of access block with deteriorating condition of patients in Emergency Installation Ulin Hospital Banjarmasin.Method : The research method uses an analytical design with a cross sectional approach. The number of samples taken is 40 people using the accidental sampling technique. Data analysis through spearman rank test.Result: The test results obtained p value calculated 0,000 (0.05) there is a relationship between the access block and deterioration of the patient's condition at the Ulin Banjarmasin Hospital emergency department.Conclusion: Based on the results of the study, there is a relationship between the access block and the worsening of the patient's condition at the Emergency Department of RSUD Ulin Banjarmasin with a value of P = 0.000 value α = 0.05 with a correlation coefficient value of 0.588. Keywords: Access Block, Patient worsening 

scholarly journals STATUS GIZI KURANG BERESIKO TERHADAP USIA MENARCHE PADA SISWI KELAS VI DI SDN 007 RAMBAH KABUPATEN ROKAN HULU

2021 ◽  
Vol 10 (1) ◽  
pp. 8-13
Author(s):  
Rahmi Fitria
Keyword(s):  
Nutritional Status ◽  
Reproductive Organs ◽  
Cross Sectional ◽  
A Value ◽  
Age Range ◽  
Relationship Of ◽  
The Relationship ◽  
Age Of Menarche ◽  
Regression Tests ◽  
Menarche Age

Menarche is a sign of the proper functioning of a woman's reproductive organs when having her first menstruation and is common in the age range of 10-16 years. Menarche is influenced by several factors, one of which is nutritional status. According to Noviyanti research (2016) nutrition affects a girl's sexual maturity so that it affects the slowness of menarche. Similarly, research conducted by Munda (2016) that students with overweight nutritional status faster experienced menarche compared to students who have normal nutritional status and underweight. This study aims to find out the relationship of nutritional status to the age of menarche grade VII students in Pesantren Bahrul Ulum. This research method uses descriptive method with cross sectional research design. This research was conducted in SDN 007 Rambah. The sample of this study amounted to 45 respondents. Data collection uses simple correlation and linear regression tests. The results of this study stated that the average nutritional status of grade VII students is 21.60Kg /m2, and the nutritional status of students is at least 16.90 Kg / m2 and the highest nutritional status is 27.60 Kg / m2 with an average age of menarche 12.11 years. The conclusion of this study is that there is no relationship of nutritional status with menarche age in grade VII students in Pesantren Bahrul Ulum with a value of p= 0.036.

scholarly journals Host Mediators in Gingival Crevicular Fluid: Implications for the Pathogenesis of Periodontal Disease

1992 ◽  
Vol 3 (1) ◽  
pp. 31-60 ◽  
Author(s):  
Ira B. Lamster ◽  
M. John Novak
Keyword(s):  
Immune Response ◽  
Periodontal Disease ◽  
Gingival Crevicular Fluid ◽  
Critical Role ◽  
Arachidonic Acid Metabolite ◽  
Reactive Oxygen Metabolites ◽  
Tissue Destruction ◽  
Crevicular Fluid ◽  
Relationship Of ◽  
The Relationship

During the past few years, a considerable number of studies have examined different aspects of the host response in gingival crevicular fluid (GCF), including the relationship of specific markers to the active phases of periodontal disease. Various indicators of the acute inflammatory response (the lysosomal enzymes P-glucuronidase and collagenase, the cytoplasmic enzyme aspartate aminotransferase, and the arachidonic acid metabolite PGE2) have been shown to be associated with clinical attachment loss in chronic adult periodontitis in man and experimental periodontitis in animal models. In contrast, the relationship of indicators of the humoral immune response in GCF to active periodontal disease is equivocal. Furthermore, a number of indicators of the cellular immune response have been identified recently in GCF (i.e., Interleukin-la, IL-1β, tumor necrosis factor-a), but their relationship to active phases of periodontal disease have not been studied. The polymorphonuclear leukocyte (PMN) is the cellular hallmark of acute inflammation. Evidence from the GCF studies suggests that hyperreactivity of these cells plays a critical role in the active phases of some forms of periodontal disease. Metabolic activation of PMN can be associated with a number of potentially destructive reactions. The major effector mechanism for tissue destruction that can be specifically identified with the PMN is the synergistic effect of the release of PMN proteases and the generation of reactive oxygen metabolites by these cells. Priming of the PMN, where the PMN response is enhanced by agents that do not initiate the response, may be an important mechanism for PMN activation in the crevicular environment; for example, cytokines such as IL-1β and TNF-a, and lipopolysaccharides released from subgingival Gram-negative bacteria, can serve this function. The hypothesis proposed here argues that in addition to the severe forms of periodontal disease that have been associated with qualitative or quantitative PMN defects, tissue destruction in the periodontum can be observed with hyperreactivity of these cells. These differing conclusions do not create a dilemma, but may represent opposite ends of a balance that is no longer in equilibrium.

Role of the brain stem in generating the 2- to 6-Hz oscillation in sympathetic nerve discharge

1993 ◽  
Vol 265 (5) ◽  
pp. R1026-R1035 ◽  
Author(s):  
S. Zhong ◽  
Z. S. Huang ◽  
G. L. Gebber ◽  
S. M. Barman
Keyword(s):  
Brain Stem ◽  
Sympathetic Nerve ◽  
Cervical Spinal Cord ◽  
Ventrolateral Medulla ◽  
Population Activity ◽  
A Value ◽  
Decerebrate Cats ◽  
The Brain ◽  
Nerve Discharge

We tested the hypothesis that brain stem circuits normally generate a 2- to 6-Hz oscillation in sympathetic nerve discharge (SND). Experiments were performed on baroreceptor-denervated decerebrate cats and urethan-anesthetized rats in which renal or splanchnic SND was recorded along with field potentials (population activity) from sites in the rostral ventrolateral medulla, medullary raphe, or medullary lateral tegmental field. Our major findings were as follows. 1) Population activity recorded from the three medullary regions contained a 2- to 6-Hz oscillation. 2) The 2- to 6-Hz oscillation in population activity recorded from some medullary sites was correlated to that in SND. Peak coherence in the 2- to 6-Hz band approached a value of 1 in some cases. 3) Whereas cervical spinal cord transection abolished or markedly reduced SND, the 2- to 6-Hz oscillation in medullary activity was essentially unchanged. These results support the view that the 2- to 6-Hz oscillation in SND can be generated in the brain stem of cats and rats.

scholarly journals Bacillus anthracis lethal toxin alters regulation of visceral sympathetic nerve discharge

2012 ◽  
Vol 112 (6) ◽  
pp. 1033-1040 ◽  
Author(s):  
A. A. Garcia ◽  
R. J. Fels ◽  
L. J. Mosher ◽  
M. J. Kenney
Keyword(s):  
Nervous System ◽  
Sympathetic Nervous System ◽  
Bacillus Anthracis ◽  
Sympathetic Nerve ◽  
Critical Role ◽  
Lethal Factor ◽  
Lethal Toxin ◽  
Arterial Blood ◽  
Sympathetic Nervous ◽  
Nerve Discharge

Bacillus anthracis infection is a pathophysiological condition that is complicated by progressive decreases in mean arterial pressure (MAP). Lethal toxin (LeTx) is central to the pathogenesis of B. anthracis infection, and the sympathetic nervous system plays a critical role in physiological regulation of acute stressors. However, the effect of LeTx on sympathetic nerve discharge (SND), a critical link between central sympathetic neural circuits and MAP regulation, remains unknown. We determined visceral (renal, splenic, and adrenal) SND responses to continuous infusion of LeTx [lethal factor (100 μg/kg) + protective antigen (200 μg/kg) infused at 0.5 ml/h for ≤6 h] and vehicle (infused at 0.5 ml/h) in anesthetized, baroreceptor-intact and baroreceptor (sinoaortic)-denervated (SAD) Sprague-Dawley rats. LeTx infusions produced an initial state of cardiovascular and sympathetic nervous system activation in intact and SAD rats. Subsequent to peak LeTx-induced increases in arterial blood pressure, intact rats demonstrated a marked hypotension that was accompanied by significant reductions in SND (renal and splenic) and heart rate (HR) from peak levels. After peak LeTx-induced pressor and sympathoexcitatory responses in SAD rats, MAP, SND (renal, splenic, and adrenal), and HR were progressively and significantly reduced, supporting the hypothesis that LeTx alters the central regulation of sympathetic nerve outflow. These findings demonstrate that the regulation of visceral SND is altered in a complex manner during continuous anthrax LeTx infusions and suggest that sympathetic nervous system dysregulation may contribute to the marked hypotension accompanying B. anthracis infection.

The Role of Unabsorbed Slack in Internal and Collaborative Innovation Processes — A Resource-Based Framework

2016 ◽  
Vol 13 (03) ◽  
pp. 1640007 ◽  
Author(s):  
Ulrich Lichtenthaler
Keyword(s):  
Critical Role ◽  
Slack Resources ◽  
Fine Grained ◽  
Collaborative Innovation ◽  
Relationship Of ◽  
The Impact ◽  
The Relationship ◽  
Unabsorbed Slack ◽  
Innovation Processes

Extant research has highlighted the critical role of unabsorbed slack resources in internal innovation processes. In recent years, many firms have continued to open up their innovation processes to actively collaborate with external partners. In light of a limited understanding of the determinants of collaborative innovation, we provide new theoretical arguments about the relationship of unabsorbed slack resources with internal and collaborative innovation processes. Specifically, we draw on resource-based and competence-based logic and develop a conceptual framework for intraorganizational and interorganizational innovation with propositions for the impact of unabsorbed slack resources on internal and external knowledge acquisition and commercialization processes. The arguments underscore the critical role of excess resources in collaborative innovation, and they highlight the need for a fine-grained examination of the impact of unabsorbed slack resources in innovation processes. The arguments are particularly important in light of a renewed interest in essential enablers and barriers to collaborative innovation processes.

scholarly journals Editor's Introduction: I. Writing Modern Art and Science – An Overview; II. Cubism, Futurism, and Ether Physics in the Early Twentieth Century

2004 ◽  
Vol 17 (4) ◽  
pp. 423-466 ◽  
Author(s):  
Linda Dalrymple Henderson
Keyword(s):  
Cultural Context ◽  
Modern Art ◽  
Critical Role ◽  
Art And Science ◽  
Radical Innovations ◽  
Science And Art ◽  
The 1960S ◽  
Relationship Of ◽  
Modern Artists ◽  
The Relationship

This issue of Science in Context presents a sampling of current work by art historians examining modern artists' engagement with science as well as the relationship of photography to both science and art. The essays' topics span the mid-to-later nineteenth century to the 1960s and, thus, in a series of case studies provide an introduction to aspects of artistic modernism. Indeed, it is impossible to understand fully many of the radical innovations of modern art without some knowledge of an artist's cultural context, and developments in science have often played a critical role in defining that milieu. Collected together, these essays also represent methodological models of historical work on art and science that serve as useful examples in this developing field.

scholarly journals Practical Evaluation of Methods for Detection and Specificity of Autoantibodies to Extractable Nuclear Antigens

2004 ◽  
Vol 11 (2) ◽  
pp. 297-301 ◽  
Author(s):  
Susan M. Orton ◽  
Amy Peace-Brewer ◽  
John L. Schmitz ◽  
Kristie Freeman ◽  
William C. Miller ◽  
...  
Keyword(s):  
Sensitivity And Specificity ◽  
Latent Class ◽  
Clinical Laboratory ◽  
Critical Role ◽  
Testing Method ◽  
Nuclear Antigens ◽  
Practical Evaluation ◽  
Relationship Of ◽  
The Relationship ◽  
Sample Set

ABSTRACT Detection and specificity of autoantibodies against extractable nuclear antigens (ENA) play a critical role in the diagnosis and management of autoimmune disease. Historically, the detection of these antibodies has employed double immunodiffusion (DID). Autoantibody specificity was correlated with diagnoses by this technique. Enzyme immunoassays have been developed by multiple manufacturers to detect and identify the specificity ENA autoantibodies. To address the relationship of ENA detection by DID and enzyme immunoassay, the performances of five immunoassays were compared. These included two DID and three enzyme-linked immunoassays (ELISA) (both screening and individual antigen profile kits). The sample set included 83 ENA-positive, antinuclear-antibody (ANA)-positive specimens, 77 ENA-negative, ANA-positive specimens, and 20 ENA- and ANA-negative specimens. Sensitivity and specificity were calculated by two methods: first, by using the in-house DID result as the reference standard, and second, by using latent class analysis, which evaluates each kit result independently. Overall, the results showed that the ELISA methods were more sensitive for detection of ENA autoantibodies than DID techniques, but presence and/or specific type of ENA autoantibody did not always correlate with the patient's clinical presentation. Regardless of the testing strategy an individual laboratory uses, clear communication with the clinical staff regarding the significance of a positive result is imperative. The laboratory and the clinician must both be aware of the sensitivity and specificity of each testing method in use in the clinical laboratory.

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