Synthesis and Characterization of Yttrium-Doped Hydroxyapatite Nanoparticles and Their Potential Antimicrobial Activity

2021 ◽  
Vol 11 (11) ◽  
pp. 2087-2096
Author(s):  
Obaid Albulym ◽  
Omer Kaygili ◽  
Mai S. A. Hussien ◽  
H. Y. Zahran ◽  
Mona Kilany ◽  
...  
Keyword(s):  
Fourier Transforms ◽  
Sol Gel ◽  
Antimicrobial Properties ◽  
Spectroscopic Properties ◽  
Inhibitory Effect ◽  
Hydroxyapatite Nanoparticles ◽  
X Ray Diffraction ◽  
Diffusion Technique ◽  
Doping Effects ◽  
Bacteria And Fungi

This study reports a detailed analysis of the yttrium doping effects into hydroxyapatite (HAp) nano-structures at different amounts (e.g., 0, 1, 2.5, 5, 7.5, 10, and 15%) on the structural, spectroscopic, dielectric, and antimicrobial properties. For this purpose, seven HAp samples having the Y-contents mentioned above were prepared using the microwave-assisted sol-gel precipitation technique. The structure of synthesized samples was fully described via X-ray diffraction (XRD), scanning electron microscopy (SEM), and Fourier transforms infrared (FTIR). Raman spectroscopy and dielectric measurements were used to characterize the spectroscopic properties. Furthermore, the samples’ antimicrobial features have been assisted through the agar disk diffusion technique. This study showed that the crystallinity decreased with the adding of Y-ions inside the HAp matrix. The Y-contents have influenced the crystallite size, lattice parameters, dislocation density, lattice strain, and unit cell volume. The surface morphology is composed of the agglomerated smaller particles. Remarkable changes in the dielectric properties were observed with the adding of Y-ions. The alternating current conductivity obeys the Jonscher’s relation. Y-doped hydroxyapatite nanoparticles have a considerable inhibitory effect against bacteria and fungi (Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Candida albicans). The Y-doped hydroxyapatite nanoparticles are a promising material for bone cement engineering with a potential bio-activity

Acrylate copolymers containing benzimidazolium moieties: synthesis and antimicrobial applications

e-Polymers ◽  
2014 ◽  
Vol 14 (6) ◽  
pp. 391-396 ◽  
Author(s):  
Muhammad Jawwad Saif ◽  
Jamil Anwar ◽  
Nazeran Idrees ◽  
Naveed Athir ◽  
Tanvir Hussain Bokhari ◽  
...  
Keyword(s):  
Allyl Bromide ◽  
Antimicrobial Properties ◽  
Inhibitory Effect ◽  
Dimethyl Formamide ◽  
Monomer Reactivity Ratios ◽  
Linearization Methods ◽  
Growth Inhibitory ◽  
Monomer Feed ◽  
Formamide Solution ◽  
Bacteria And Fungi

AbstractThe allylic monomer N-allyl-N-butylbenzimidazolium bromide (ABBB) was synthesized by reacting allyl bromide with benzimidazole and subsequent quaternization with 1-bromobutane. Copolymers of ABBB with butyl acrylate (BA) were prepared in dimethyl formamide solution at 70°C using a free-radical polymerization technique with different monomer feed ratios. Monomer reactivity ratios for the ABBB-BA pairs were evaluated by the Fineman-Ross (r1=0.40; r2=1.49) and Kelen-Tüdõs (r1=0.36; r2=1.46) linearization methods. Thermal behavior of the copolymers of different compositions was evaluated by thermogravimetric analysis. The copolymers were tested for antimicrobial properties against selected strains of bacteria and fungi and were found to be active against the strains. The growth-inhibitory effect of the copolymers varied according to the composition of the polymer: the effect increased with increasing content of the substituted benzimidazolium group in the polymer chain.

Inhibitory Effect of Hydroxyapatite Nanoparticles on K562 Cells

2011 ◽  
Vol 685 ◽  
pp. 352-356 ◽  
Author(s):  
Hong Lian Dai ◽  
Pei Chen ◽  
Yin Chao Han ◽  
Xin Yu Wang ◽  
Shi Pu Li
Keyword(s):  
Myeloid Leukemia ◽  
K562 Cells ◽  
Inhibitory Effect ◽  
Inhibition Mechanism ◽  
Hydroxyapatite Nanoparticles ◽  
X Ray Diffraction ◽  
Transmission Electron ◽  
Cell Changes ◽  
Crystallization Degree

HAP Nanoparticles Was Synthesized by Homogeneous Precipitation. the Size Distribution, Crystallization Degree and Morphology of the Precipitation Were Characterized by Laser Granularity Instrument, X-Ray Diffraction (XRD), and Transmission Electron Microscope (TEM) Respectively. the Prepared HAP Nanoparticles Were Used for the Treatment of Human Chronic Myeloid Leukemia K562 Cells. the Inhibition Effect of the Nanoparticles on the Proliferation of K562 Cells Was Measured by MTT Assay and Growth Curve Test. the Results Showed that the HAP Nanoparticles Inhibit the Proliferation of K562 Cells Dramatically in Vitro. the Likely Inhibition Mechanism of HAP Nanoparticles on the K562 Cells Is that the Nanoparticles Entered into the Dells, Induced a Series of Cell Changes, through Cell Death of Apoptosis, Oncosis and Autoschizis, Thus Led to the Death of K562 Cells.

Effect of Methyl Cellulose on Apatite Formation of a Sol-Gel Derived Bioactive Glass/Titania Nanostructure Composite

2014 ◽  
Vol 925 ◽  
pp. 82-83
Author(s):  
Mojtaba Nasr-Esfahani ◽  
Marzieh Omid-Bakhtiari ◽  
Muhamad Kashif
Keyword(s):  
Bioactive Glass ◽  
Fourier Transforms ◽  
Sol Gel ◽  
Methyl Cellulose ◽  
Titania Nanoparticles ◽  
Apatite Formation ◽  
X Ray Diffraction ◽  
Application Range ◽  
Ft Ir ◽  
Electron Microanalysis

In order to widen the application range of bioactive glass (BG), we prepared a bioactive glass as a composite matrix, strengthened by titania nanoparticles. The prepared composites had different amounts of both bioactive glass (49S) and titania in the weight percents of 1:3, 1:1 and 3:1, respectively. Bioactive glass sols (49S) in the system (SiO2CaOP2O5) were prepared following the solgel technique, then a solution of 2 wt% methylcellulose was added and stirred at room temperature. Precalcinated TiO2 nanopowder was dispersed in the sol and the prepared mixture was fired at 600 °C. The inhomogeneity problem in preparation of composite powder was overcome by using methylcellulose (MC) as a dispersant. The nanostructure composites were characterized using X-ray diffraction (XRD) and Fourier transforms infrared spectroscopy (FT-IR). The microstructure of the surfaces of the different composites was examined by scanning electron microanalysis (SEM) to verify the apatite formation. The results led us to the conclusion that the addition of MC reinforces the composites and increases the formation of an apatite layer in the presence of BG and titania content.

scholarly journals The Anti-biofilm Activity of Nanometric Zinc doped Bioactive Glass against Putative Periodontal Pathogens: An in vitro Study

2018 ◽  
Vol 4 (1) ◽  
pp. 95-107
Author(s):  
Nasrin Esfahanizadeh ◽  
Mohammad Reza Nourani ◽  
Abbas Bahador ◽  
Nasrin Akhondi ◽  
Mostafa Montazeri
Keyword(s):  
Biofilm Formation ◽  
Sol Gel ◽  
Antimicrobial Properties ◽  
In Vitro Study ◽  
Inhibitory Effect ◽  
Antibiofilm Activity ◽  
Periodontal Pathogens ◽  
Microplate Reader ◽  
45S5 Bioglass

Abstract Colonization of periodontal pathogens on the surgical sites is one of the primary reasons for the failure of regenerative periodontal therapies. Bioactive glasses (BGs) owing to their favorable structural and antimicrobial properties have been proposed as promising materials for the reconstruction of periodontal and peri-implant bone defects. This study aimed to investigate the antibiofilm activity of zinc-doped BG (Zn/BG) compared with 45S5 Bioglass® (BG®) on putative periodontal pathogens. In this in vitro experimental study, the nano BG doped with 5-mol% zinc and BG® were synthesized by sol-gel method. Mono-species biofilms of Aggregatibacter actinomycetemcomitans (A. a), Porphyromonas gingivalis (P. g), and Prevotella intermedia (P. i)were prepared separately in a well-containing microplate. After 48 hours of exposure to generated materials at 37°C, the anti-biofilm potential of the samples was studied by measuring the optical density (OD) at 570nm wavelengths with a microplate reader. Two-way ANOVA then analyzed the results. Both Zn/BG and BG® significantly reduced the biofilm formation ability of all examined strains after 48 hours of incubation (P=0.0001). Moreover, the anti-biofilm activity of Zn/BG was significantly stronger than BG® (P=0.0001), which resulted in the formation of a weak biofilm (OD<1) compared with a moderately adhered biofilm observed with BG® (1<OD<2). Zn/BG showed a significant inhibitory effect on the biofilm formation of all examined periodontal pathogens. Given the enhanced regenerative and anti-biofilm properties of this novel biomaterial, further investigations are required for its implementation in clinical situations.

scholarly journals ANTIMICROBIAL PROPERTIES OF LANTHANUM ALUMINATE NANOPARTICLES

2016 ◽  
Vol 3 (1) ◽  
pp. 1-5
Author(s):  
Gayathri S ◽  
Ranjithkumar R ◽  
Balaganesh A.S ◽  
Chandar Shekar B
Keyword(s):  
Fungal Pathogens ◽  
Pathogenic Bacteria ◽  
Sol Gel ◽  
Trichoderma Viride ◽  
Antimicrobial Properties ◽  
Maximum Activity ◽  
Paper Disk ◽  
Filter Paper Disk ◽  
Test Organisms ◽  
Bacteria And Fungi

The sol-gel route synthesized LA-NPs were tested for antimicrobial properties against different human pathogenic bacteria and fungi. The test organisms used were clinical isolates viz., Streptococcus pyogenes, Staphylococcus aureus, Escherichia coli, Klebsiella nemoniae and the human fungal pathogens like Candida albicans and Trichoderma viride. The LA- NPs achieved maximum activity against S. aureus compared with other three tested organisms such as S. pyogenes, E. coli and K. pneumonia. It also showed very good antimicrobial properties against studied fungi. At the concentration 1 mg/ml LA-NPs impregnated filter paper disk achieved maximum activity against human pathogen.

Antimicrobial Activity of Ga-Doped Hydroxyapatite Nanostructures: Synthesis, Morphological, Spectroscopic, and Dielectric Properties

2019 ◽  
Vol 9 (7) ◽  
pp. 881-889 ◽  
Author(s):  
Obaid Albulym ◽  
Omer Kaygili ◽  
Mai S. A. Hussien ◽  
H. Y. Zahran ◽  
Mona Kilany ◽  
...  
Keyword(s):  
Dielectric Properties ◽  
Sol Gel ◽  
Alternating Current ◽  
Inhibitory Effect ◽  
X Ray Diffraction ◽  
Carbonate Group ◽  
Ftir Technique ◽  
Gel Technique ◽  
Ga Content ◽  
Ft Raman

In the present paper, seven samples of hydroxyapatite (HAp) nanoparticles doped with different amounts (e.g., 0%, 1%, 3%, 6%, 9%, 12%, and 15% [wt.]) of Ga-ions were synthesized at low temperature using the microwave-assisted sol–gel technique. FT-Raman/Fourier-transform infrared (FTIR) technique, X-ray diffraction (XRD), dielectric/alternating current conductivity measurements, scanning electron microscopy, and antimicrobial tests were utilized in order to characterize the synthesized samples. The Ga content was observed to affect the crystallite size as well as the crystallinity of HAp. Variations were observed in the lattice parameters, lattice strain, and dislocation density. FTIR analysis revealed that HAp structure possessed the carbonate group. Thus all samples have promising medical applications, as this group improves the bioactivity of HAp. Dielectric properties, as well as the alternating current electrical conductivity, were also observed to be affected by the Ga content. Furthermore, the present study demonstrated that the Ga-doped HAp nanostructures exerted a considerable inhibitory effect on bacteria (Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli) and fungi (Candida albicans). Therefore, the Gadoped HAp nanostructures are proposed as a promising candidate for applications in the field of bone cement engineering.

Electrospun Fibers Incorporated With Hydroxyapatite Nanoparticles and Graphene Nanoflakes for Bone Scaffolding

2012 ◽  
Author(s):  
A. Jabbarnia ◽  
V. R. Patlolla ◽  
H. E. Misak ◽  
R. Asmatulu
Keyword(s):  
Bone Growth ◽  
Sol Gel ◽  
Electrical Potential ◽  
Hydroxyapatite Nanoparticles ◽  
X Ray Diffraction ◽  
X Ray ◽  
Pump Speed ◽  
Analysis Techniques ◽  
Graphene Nanoflakes ◽  
Nanocomposite Fibers

Sol-gel driven hydroxyapatite (HA) nanoparticles and graphene nanoflakes were incorporated with polycaprolactone (PCL) at different concentrations, and then electrospun at various spinning conditions, such as distance, electrical potential, viscosity and pump speed. The HA nanoparticles were initially amorphous, so they were annealed at elevated temperature (750 °C) for two hours to make them crystalline. Scanning electron microscopy and X-ray diffraction analysis techniques were conducted on the produced nanocomposite fibers. The studies showed that the HA nanoparticles (20–50 nm) and graphene were well distributed in the PCL fibers (500 nm to 5 μm). We believed that such nanoscale biomaterials can accelerate the bone growth and bone regeneration for many patients who are seeking solutions.

scholarly journals Synthesis, Characterization and Antibacterial Activities of New Bivalent Complexes of Transition Metals

2019 ◽  
Vol 31 (9) ◽  
pp. 1926-1930
Author(s):  
Veenu Chugh ◽  
Sangeeta Sharma ◽  
Rimpi Mehani Ne'e Chopra
Keyword(s):  
Magnetic Measurements ◽  
Antimicrobial Properties ◽  
Antibacterial Activities ◽  
Molar Conductance ◽  
Spectral Studies ◽  
X Ray Diffraction ◽  
Gram Positive Bacteria ◽  
Diffusion Technique ◽  
Complexes Of Transition Metals ◽  
Thermal Stability Of

This paper describes the synthesis, spectral studies and antimicrobial properties of the complexes with the formula [M(C30H24N4O2)Cl2], where M = Fe(II), Co(II), Ni(II), Zn(II) and Cu(II). These complexes were prepared by yield effective template condensation of hexamethylenediamine and 2,2-dihydroxyindane-1,3-dione(ninhydrin). The synthesized complexes were characterized by elemental analysis, infrared spectra, thermogravimetric analysis, Mass spectrum, 13C NMR, molar conductance, electronic spectra, magnetic measurements. TGA and X-ray diffraction studies were used to ascertain the crystal structure and thermal stability of the complexes. The antimicrobial properties of complexes against two Gram-positive bacteria and two Gram-negative bacteria were evaluated by Agar well diffusion technique. Streptomycin and chloramphenicol were taken as standard antibiotics. The results shows that some of the complexes have potential to act as antibacterial agents.

Fluorine Doping Effects on the Electric Property of BiFeO3 Thin Films

2014 ◽  
Vol 624 ◽  
pp. 161-164
Author(s):  
Fang Long Xu ◽  
Peng Jun Zhao ◽  
Jia Qi Zhang ◽  
Xin Qian Xiong
Keyword(s):  
Thin Films ◽  
Direct Evidence ◽  
Sol Gel ◽  
Electric Polarization ◽  
Rhombohedral Structure ◽  
X Ray Diffraction ◽  
Glass Substrates ◽  
Doping Effects ◽  
Ito Glass ◽  
Multiferroic Oxides

F doping BiFeO3-xFx (x=0, 0.02, 0.04, 0.06, 0.08) thin films were successfully fabricated on ITO/glass substrates by sol-gel method. X-ray diffraction analysis indicated that the un-doped BiFeO3 and F doping BiFeO3 thin films presented rhombohedral structure with the space group R3c. F-doping is found to significantly enhance the dielectric constant and decrease the leakage current density for x=0.08 compared with x=0. This study provides direct evidence that the multiferroic characteristics of BiFeO3 are sensitive to the anion doping, such as F, providing a convenient alternative to manipulate the electric polarization in multiferroic oxides.

scholarly journals Cotton Terry Textiles with Photo- and Bio-Activity in a Model Study and Real Conditions

Materials ◽  
2020 ◽  
Vol 13 (15) ◽  
pp. 3334
Author(s):  
Beata Gutarowska ◽  
Justyna Szulc ◽  
Edyta Matyjas-Zgondek ◽  
Piotr Kulpiński ◽  
Katarzyna Pielech-Przybylska ◽  
...  
Keyword(s):  
Antimicrobial Properties ◽  
Test Method ◽  
X Ray Diffraction ◽  
Zno Nps ◽  
Textile Materials ◽  
E Coli ◽  
Model Study ◽  
Color Differences ◽  
Number Of Microorganisms ◽  
Bacteria And Fungi

The aim of the study was to assess the photocatalytic (decompose staining particles, K/S values, the color differences, CIE L*a*b* color) and antimicrobial properties of textiles modified with TiO2 and ZnO nanoparticles (NPs) confirmed by X-ray diffraction, dynamic light scattering, SEM-EDX) in visible light conditions. The antimicrobial effectiveness of modified textiles under model conditions has been reported against 5 microorganisms: Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Candida albicans, Aspergillus niger (AATCC Test Method 100-2004). In real conditions in bathrooms, significant biostatic activity was shown on the surface of the modified towels. The number of microorganisms decreased by 1–5 log to the level of 0–5 CFU/cm2 in the case of bacteria: Enterobacteriaceae, Enterococcus, the coli group and E. coli, Pseudomonas. Statistically significant reduction of the total number of bacteria and fungi (by 1 log), and the concentration of gases (NO2, CO2, CO) in the air of bathrooms was determined. The removal or reduction of volatile organic compounds (VOCs) concentration (SPME-GC-MS analysis) in the air above the modified towels has also been determined. It was found that the lighting type (natural, artificial), time (1.5 and 7 h/day), air humidity (RH = 36–67%) and light intensity (81–167 lux) are important for the efficiency of photocatalysis. Textile materials modified with TiO2 and ZnO NPs can be used as self-cleaning towels. They can also help purify air from microorganisms, VOCs and undesirable gases.

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